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Richard Youle

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TOP 3
Chiu-Hui Huang; Michael Lazarou; Richard J Youle
Sequestration and autophagy of mitochondria do not cut proteins across the board.
Michael Lazarou; Derek P Narendra; Ephrem Tekle; Soojay Banerjee; Seok Min Jin; Richard J Youle
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
Catherine L Nezich; Richard J Youle
Make or break for mitochondria.

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All Publications

2013: Chiu-Hui Huang; Michael Lazarou; Richard J Youle
Sequestration and autophagy of mitochondria do not cut proteins across the board.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6252-3.
2013: Michael Lazarou; Derek P Narendra; Ephrem Tekle; Soojay Banerjee; Seok Min Jin; Richard J Youle
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
The Journal of cell biology 2013;200(2):163-72.
2013: Catherine L Nezich; Richard J Youle
Make or break for mitochondria.
eLife 2013;2():e00804.
2012: Marc P Lussier; Yukiko Nasu-Nishimura; Albert Neutzner; Roger A Nicoll; Bruce E Herring; Mariusz Karbowski; Richard J Youle; Katherine W Roche
Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19426-31.
2012: Richard J Youle; Alexander M van der Bliek
Mitochondrial fission, fusion, and stress.
Science (New York, N.Y.) 2012;337(6098):1062-5.
2012: C Wang; Richard J Youle
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.
Oncogene 2012;31(26):3177-89.
2012: Seok Min Jin; Richard J Youle
PINK1- and Parkin-mediated mitophagy at a glance.
Journal of cell science 2012;125(Pt 4):795-9.
2012: Michael Lazarou; Seok Min Jin; Lesley A Kane; Richard J Youle
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.
Developmental cell 2012;22(2):320-33.
2011: Lesley A Kane; Richard J Youle
PINK1 and Parkin flag Miro to direct mitochondrial traffic.
Cell 2011;147(4):721-3.
2011: Kye-Young Kim; Audrey Noguchi; Alan T Remaley; Sarah E Rusk; M Hasina Akter; Marcelo Amar; Alexander V Bocharov; Alexandra Cohen; Tomas L Eggerman; Robert J Huang; Danielle Springer; Mark V Stevens; Der Fen Suen; Richard J Youle; Michael N Sack
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.
The Journal of clinical investigation 2011;121(9):3701-12.
2011: Joung Hyuck Joo; Aashish Joshi; Chang Hwa Jung; Do-Hyung Kim; John L Cleveland; Frank C Dorsey; Kristin M Hennessy-Walters; Rekha Iyengar; Kelly McCastlain; Paul A Ney; Stephanie M Prater; Kristie L Rose; Meredith A Steeves; Der Fen Suen; Craig B Thompson; Chia-Ying Yang; Richard J Youle; Ji Zhang; Mondira Kundu
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.
Molecular cell 2011;43(4):572-85.
2011: Jean-Claude Martinou; Richard J Youle
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.
Developmental cell 2011;21(1):92-101.
2011: Derek P Narendra; Richard J Youle
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control.
Antioxidants & redox signaling 2011;14(10):1929-38.
2011: Frank Edlich; Soojay Banerjee; Motoshi Suzuki; Megan Cleland; Damien Arnoult; Chunxin Wang; Albert Neutzner; Nico Tjandra; Richard J Youle
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.
Cell 2011;145(1):104-16.
2011: Albert Neutzner; Melanie Neutzner; Anne-Sophie Benischke; Seung-Wook Ryu; Stephan Frank; Richard J Youle; Mariusz Karbowski
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.
The Journal of biological chemistry 2011;286(10):8633-43.
2011: Megan Cleland; Kristi Norris; Mariusz Karbowski; C Wang; Der Fen Suen; S Jiao; N M George; X Luo; Z Li; Richard J Youle
Bcl-2 family interaction with the mitochondrial morphogenesis machinery.
Cell death and differentiation 2011;18(2):235-47.
2011: Richard J Youle; Derek P Narendra
Mechanisms of mitophagy.
Nature reviews. Molecular cell biology 2011;12(1):9-14.
2010: Atsushi Tanaka; Megan Cleland; Shan Xu; Derek P Narendra; Der Fen Suen; Mariusz Karbowski; Richard J Youle
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.
The Journal of cell biology 2010;191(7):1367-80.
2010: Seok Min Jin; Michael Lazarou; Chunxin Wang; Lesley A Kane; Derek P Narendra; Richard J Youle
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.
The Journal of cell biology 2010;191(5):933-42.
2010: Derek Narendra; Lesley A Kane; David N Hauser; Ian M Fearnley; Richard J Youle
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.
Autophagy 2010;6(8):1090-106.
2010: Lesley A Kane; Richard J Youle
Mitochondrial fission and fusion and their roles in the heart.
Journal of molecular medicine (Berlin, Germany) 2010;88(10):971-9.
2010: Der Fen Suen; Derek P Narendra; Atsushi Tanaka; Giovanni Manfredi; Richard J Youle
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11835-40.
2010: Yong-Yea Park; Seungmin Lee; Mariusz Karbowski; Albert Neutzner; Richard J Youle; Hyeseong Cho
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1.
Journal of cell science 2010;123(Pt 4):619-26.
2010: Derek P Narendra; Seok Min Jin; Atsushi Tanaka; Der Fen Suen; Clement A Gautier; Jie Shen; Mark Cookson; Richard J Youle
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
PLoS biology 2010;8(1):e1000298.
2009: Tatiana K Rostovtseva; Hacene Boukari; Antonella Antignani; Brian Shiu; Soojay Banerjee; Albert Neutzner; Richard J Youle
Bax activates endophilin B1 oligomerization and lipid membrane vesiculation.
The Journal of biological chemistry 2009;284(49):34390-9.
2009: Derek Narendra; Atsushi Tanaka; Der Fen Suen; Richard J Youle
Parkin-induced mitophagy in the pathogenesis of Parkinson disease.
Autophagy 2009;5(5):706-8.
2009: Chunxin Wang; Richard J Youle
The role of mitochondria in apoptosis*.
Annual review of genetics 2009;43():95-118.
2008: Derek Narendra; Atsushi Tanaka; Der Fen Suen; Richard J Youle
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
The Journal of cell biology 2008;183(5):795-803.
2008: Kristi Norris; Richard J Youle
Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins.
Journal of virology 2008;82(13):6232-43.
2008: Der Fen Suen; Kristi Norris; Richard J Youle
Mitochondrial dynamics and apoptosis.
Genes & development 2008;22(12):1577-90.
2008: Antonella Antignani; Richard J Youle
Endosome fusion induced by diphtheria toxin translocation domain.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8020-5.
2008: Atsushi Tanaka; Richard J Youle
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
Molecular cell 2008;29(4):409-10.
2008: Claudia Zanna; Anna Ghelli; Anna Maria Porcelli; Mariusz Karbowski; Richard J Youle; Simone Schimpf; Bernd Wissinger; Marcello Pinti; Andrea Cossarizza; Sara Vidoni; Maria Lucia Valentino; Michela Rugolo; Valerio Carelli
OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.
Brain : a journal of neurology 2008;131(Pt 2):352-67.
2008: Richard J Youle; Andreas Strasser
The BCL-2 protein family: opposing activities that mediate cell death.
Nature reviews. Molecular cell biology 2008;9(1):47-59.
2007: Mariusz Karbowski; Albert Neutzner; Richard J Youle
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division.
The Journal of cell biology 2007;178(1):71-84.
2007: Antonella Antignani; Richard J Youle
The cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), can deliver Bcl-XL as an extracellular fusion protein to protect cells from apoptosis and retain differentiation induction.
The Journal of biological chemistry 2007;282(15):11246-54.
2007: Richard J Youle
Cell biology. Cellular demolition and the rules of engagement.
Science (New York, N.Y.) 2007;315(5813):776-7.
2007: Albert Neutzner; Richard J Youle; Mariusz Karbowski
Outer mitochondrial membrane protein degradation by the proteasome.
Novartis Foundation symposium 2007;287():4-14; discussion 14-20.
2006: Antonella Antignani; Richard J Youle
How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?
Current opinion in cell biology 2006;18(6):685-9.
2006: Mariusz Karbowski; Kristi Norris; Megan Cleland; Seon-Yong Jeong; Richard J Youle
Role of Bax and Bak in mitochondrial morphogenesis.
Nature 2006;443(7112):658-62.
2006: Shirley B House; Milan Rusnak; Xiu-Huai Liu; Richard J Youle; Harold Gainer
Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture.
Experimental neurology 2006;200(1):267-71.
2005: Yoshinori Takahashi; Mariusz Karbowski; Hirohito Yamaguchi; Aslamuzzaman Kazi; Jie Wu; Said M Sebti; Richard J Youle; Hong-Gang Wang
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.
Molecular and cellular biology 2005;25(21):9369-82.
2005: Richard J Youle; Mariusz Karbowski
Mitochondrial fission in apoptosis.
Nature reviews. Molecular cell biology 2005;6(8):657-63.
2005: Motoshi Suzuki; Albert Neutzner; Nico Tjandra; Richard J Youle
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
The Journal of biological chemistry 2005;280(22):21444-52.
2005: Albert Neutzner; Richard J Youle
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(19):18598-603.
2005: Antonella Antignani; Richard J Youle
A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad.
Biochemistry 2005;44(10):4074-82.
2005: Richard J Youle
Morphology of mitochondria during apoptosis: worms-to-beetles in worms.
Developmental cell 2005;8(3):298-9.
2004: A C P Carvalho; J Sharpe; TR Rosenstock; A F V Teles; Richard J Youle; Soraya S Smaili
Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation.
Cell death and differentiation 2004;11(12):1265-76.
2004: Yang-Ja Lee; Seon-Yong Jeong; Mariusz Karbowski; Carolyn L Smith; Richard J Youle
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.
Molecular biology of the cell 2004;15(11):5001-11.
2004: Mariusz Karbowski; Seon-Yong Jeong; Richard J Youle
Endophilin B1 is required for the maintenance of mitochondrial morphology.
The Journal of cell biology 2004;166(7):1027-39.
2004: Damien Arnoult; Laura M Bartle; Anna Skaletskaya; Delphine Poncet; Naoufal Zamzami; Peter U Park; Juanita Sharpe; Richard J Youle; Victor S Goldmacher
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7988-93.
2004: Seon-Yong Jeong; Brigitte R Gaume; Yang-Ja Lee; Yi-Te Hsu; Seung-Wook Ryu; Soo-Han Yoon; Richard J Youle
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers.
The EMBO journal 2004;23(10):2146-55.
2004: Tatiana K Rostovtseva; Bruno Antonsson; Motoshi Suzuki; Richard J Youle; Marco Colombini; Sergey M Bezrukov
Bid, but not Bax, regulates VDAC channels.
The Journal of biological chemistry 2004;279(14):13575-83.
2004: Juanita C Sharpe; Damien Arnoult; Richard J Youle
Control of mitochondrial permeability by Bcl-2 family members.
Biochimica et biophysica acta 2004;1644(2-3):107-13.
2004: Mariusz Karbowski; Damien Arnoult; Hsiuchen Chen; David C Chan; Carolyn L Smith; Richard J Youle
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis.
The Journal of cell biology 2004;164(4):493-9.
2003: Motoshi Suzuki; Seon-Yong Jeong; Mariusz Karbowski; Richard J Youle; Nico Tjandra
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.
Journal of molecular biology 2003;334(3):445-58.
2003: Damien Arnoult; Brigitte R Gaume; Mariusz Karbowski; Juanita C Sharpe; Francesco Cecconi; Richard J Youle
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.
The EMBO journal 2003;22(17):4385-99.
2003: Mariusz Karbowski; Richard J Youle
Dynamics of mitochondrial morphology in healthy cells and during apoptosis.
Cell death and differentiation 2003;10(8):870-80.
2003: Damien Arnoult; Mariusz Karbowski; Richard J Youle
Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor.
Cell death and differentiation 2003;10(7):845-9.
2003: Ansgar Santel; Stephan Frank; Brigitte R Gaume; Michael Herrler; Richard J Youle; Margaret T Fuller
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.
Journal of cell science 2003;116(Pt 13):2763-74.
2003: Stephan Frank; Everett G Robert; Richard J Youle
Scission, spores, and apoptosis: a proposal for the evolutionary origin of mitochondria in cell death induction.
Biochemical and biophysical research communications 2003;304(3):481-6.
2003: Yi-Te Hsu; Qi Hou; Eugene Cymbalyuk; Richard J Youle
Generation and characterization of species-specific anti-Bcl-X(L) monoclonal antibodies.
Hybridoma and hybridomics 2003;22(2):91-5.
2002: Mariusz Karbowski; Yang-Ja Lee; Brigitte R Gaume; Seon-Yong Jeong; Stephan Frank; Amotz Nechushtan; Ansgar Santel; Margaret Fuller; Carolyn L Smith; Richard J Youle
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.
The Journal of cell biology 2002;159(6):931-8.
2002: Shailendra K Saxena; Ravi Sirdeshmukh; Wojciech Ardelt; Stanislaw M Mikulski; Kuslima Shogen; Richard J Youle
Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family.
The Journal of biological chemistry 2002;277(17):15142-6.
2002: Makoto Ichinose; Xiu-Huai Liu; Naoshi Hagihara; Richard J Youle
Extracellular Bad fused to toxin transport domains induces apoptosis.
Cancer research 2002;62(5):1433-8.
2002: Stephen P Christiansen; Daniel Peterson; Thu To; Richard J Youle; Linda K McLoon
Long-term effects of ricin-mAb 35 on extraocular muscles of rabbits: potential treatment for strabismus.
Investigative ophthalmology & visual science 2002;43(3):679-85.
2001: Xiu-Huai Liu; R. John Collier; Richard J Youle
Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein.
The Journal of biological chemistry 2001;276(49):46326-32.
2001: Stephan Frank; Brigitte R Gaume; Elke Bergmann-Leitner; Wolfgang W Leitner; E G Robert; F Catez; Carolyn L Smith; Richard J Youle
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
Developmental cell 2001;1(4):515-25.
2001: Soraya S Smaili; Yi-Te Hsu; K M Sanders; James T Russell; Richard J Youle
Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential.
Cell death and differentiation 2001;8(9):909-20.
2001: Amotz Nechushtan; Carolyn L Smith; I Lamensdorf; S H Yoon; Richard J Youle
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis.
The Journal of cell biology 2001;153(6):1265-76.
2001: Demetres Leonidas; Ester Boix; RJ Prill; Motoshi Suzuki; R Turton; K Minson; Ganesh Jawahar Swaminathan; Richard J Youle; K Ravi Acharya
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.
The Journal of biological chemistry 2001;276(18):15009-17.
2000: M Suzuki; Richard J Youle; N Tjandra
Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell 2000;103(4):645-54.
2000: Stephen P Christiansen; A Sandnas; RJ Prill; Richard J Youle; Linda K McLoon
Acute effects of the skeletal muscle-specific immunotoxin ricin-mAb 35 on extraocular muscles of rabbits.
Investigative ophthalmology & visual science 2000;41(11):3402-9.
2000: Soraya S Smaili; Yi-Te Hsu; Richard J Youle; James T Russell
Mitochondria in Ca2+ signaling and apoptosis.
Journal of bioenergetics and biomembranes 2000;32(1):35-46.
2000: N Hagihara; Stuart Walbridge; A W Olson; Edward H Oldfield; Richard J Youle
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.
Cancer research 2000;60(2):230-4.
1999: Xiu-Huai Liu; JC Castelli; Richard J Youle
Receptor-mediated uptake of an extracellular Bcl-x(L) fusion protein inhibits apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9563-7.
1999: gorka basañez; Amotz Nechushtan; O Drozhinin; Alexandr Chanturiya; E Choe; S Tutt; KA Wood; Yi-Te Hsu; Joshua Zimmerberg; Richard J Youle
Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5492-7.
1999: Amotz Nechushtan; Carolyn L Smith; Yi-Te Hsu; Richard J Youle
Conformation of the Bax C-terminus regulates subcellular location and cell death.
The EMBO journal 1999;18(9):2330-41.
1999: VM Vasandani; JC Castelli; J S Hott; Shailendra K Saxena; Stanislaw M Mikulski; Richard J Youle
Interferon enhances the activity of the anticancer ribonuclease, onconase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(5):447-54.
1999: Motoshi Suzuki; Shailendra K Saxena; Ester Boix; RJ Prill; VM Vasandani; Jane E Ladner; Cynthia Sung; Richard J Youle
Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction.
Nature biotechnology 1999;17(3):265-70.
1998: Yi-Te Hsu; Richard J Youle
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations.
The Journal of biological chemistry 1998;273(17):10777-83.
1998: JC Castelli; Bret A Hassel; A Maran; Jayashree M Paranjape; J A Hewitt; Xiao-Ling Li; Yi-Te Hsu; Robert H Silverman; Richard J Youle
The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis.
Cell death and differentiation 1998;5(4):313-20.
1998: J S Hott; Marinos C Dalakas; Cynthia Sung; Mark Hallett; Richard J Youle
Skeletal muscle-specific immunotoxin for the treatment of focal muscle spasm.
Neurology 1998;50(2):485-91.
1998: JC Castelli; KA Wood; Richard J Youle
The 2-5A system in viral infection and apoptosis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1998;52(9):386-90.
1998: Edward H Oldfield; Richard J Youle
Immunotoxins for brain tumor therapy.
Current topics in microbiology and immunology 1998;234():97-114.
1997: DW Laske; Richard J Youle; Edward H Oldfield
Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors.
Nature medicine 1997;3(12):1362-8.
1997: K G Wolter; Yi-Te Hsu; Carolyn L Smith; Amotz Nechushtan; X G Xi; Richard J Youle
Movement of Bax from the cytosol to mitochondria during apoptosis.
The Journal of cell biology 1997;139(5):1281-92.
1997: DW Laske; Karin M Muraszko; Edward H Oldfield; Hetty L DeVroom; Cynthia Sung; Robert L Dedrick; T R Simon; J Colandrea; C Copeland; D Katz; L Greenfield; E S Groves; L L Houston; Richard J Youle
Intraventricular immunotoxin therapy for leptomeningeal neoplasia.
Neurosurgery 1997;41(5):1039-49; discussion 1049-51.
1997: JC Castelli; Bret A Hassel; KA Wood; Xiao-Ling Li; K Amemiya; Marinos C Dalakas; Paul F Torrence; Richard J Youle
A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system.
The Journal of experimental medicine 1997;186(6):967-72.
1997: Yi-Te Hsu; Richard J Youle
Nonionic detergents induce dimerization among members of the Bcl-2 family.
The Journal of biological chemistry 1997;272(21):13829-34.
1997: Yi-Te Hsu; K G Wolter; Richard J Youle
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3668-72.
1996: V M Vasandani; Y N Wu; Stanislaw M Mikulski; Richard J Youle; Cynthia Sung
Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily.
Cancer research 1996;56(18):4180-6.
1996: S K Saxena; M Gravell; Y N Wu; Stanislaw M Mikulski; Kuslima Shogen; Wojciech Ardelt; Richard J Youle
Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease.
The Journal of biological chemistry 1996;271(34):20783-8.
1996: E Boix; Y Wu; V M Vasandani; S K Saxena; Wojciech Ardelt; Jane E Ladner; Richard J Youle
Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity.
Journal of molecular biology 1996;257(5):992-1007.
1996: Richard J Youle
Immunotoxins for central nervous system malignancy.
Seminars in cancer biology 1996;7(2):65-70.
1995: K A Wood; Richard J Youle
The role of free radicals and p53 in neuron apoptosis in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5851-7.
1995: Y Wu; S K Saxena; Wojciech Ardelt; M Gadina; Stanislaw M Mikulski; Claudia De Lorenzo; Giuseppe D'Alessio; Richard J Youle
A study of the intracellular routing of cytotoxic ribonucleases.
The Journal of biological chemistry 1995;270(29):17476-81.
1994: K A Wood; Richard J Youle
Apoptosis and free radicals.
Annals of the New York Academy of Sciences 1994;738():400-7.
1994: Dianne L Newton; P J Nicholls; Susanna M Rybak; Richard J Youle
Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv.
The Journal of biological chemistry 1994;269(43):26739-45.
1994: J J Lin; Dianne L Newton; Stanislaw M Mikulski; H F Kung; Richard J Youle; Susanna M Rybak
Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease.
Biochemical and biophysical research communications 1994;204(1):156-62.
1994: Richard J Youle; Y N Wu; Stanislaw M Mikulski; Kuslima Shogen; R S Hamilton; D Newton; Giuseppe D'Alessio; M Gravell
RNase inhibition of human immunodeficiency virus infection of H9 cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6012-6.
1994: Y N Wu; M Gadina; J H Tao-Cheng; Richard J Youle
Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins.
The Journal of cell biology 1994;125(4):743-53.
1994: D W Laske; O Ilercil; A Akbasak; Richard J Youle; Edward H Oldfield
Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice.
Journal of neurosurgery 1994;80(3):520-6.
1994: Dianne L Newton; Stuart Walbridge; Stanislaw M Mikulski; Wojciech Ardelt; Kuslima Shogen; Steven J Ackerman; Susanna M Rybak; Richard J Youle
Toxicity of an antitumor ribonuclease to Purkinje neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(2):538-44.
1994: O Ilercil; D W Laske; Stuart Walbridge; K Muaszko; Edward H Oldfield; Richard J Youle
Neurotoxicity of immunotoxins.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;21(2-3):379-86.
1994: M Gadina; Dianne L Newton; Susanna M Rybak; Y N Wu; Richard J Youle
Humanized immunotoxins.
Therapeutic immunology 1994;1(1):59-64.
1993: K A Wood; B Dipasquale; Richard J Youle
In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum.
Neuron 1993;11(4):621-32.
1993: Karin M Muraszko; Cynthia Sung; Stuart Walbridge; L Greenfield; Robert L Dedrick; Edward H Oldfield; Richard J Youle
Pharmacokinetics and toxicology of immunotoxins administered into the subarachnoid space in nonhuman primates and rodents.
Cancer research 1993;53(16):3752-7.
1993: Y Wu; Stanislaw M Mikulski; Wojciech Ardelt; Susanna M Rybak; Richard J Youle
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity.
The Journal of biological chemistry 1993;268(14):10686-93.
1993: Cynthia Sung; Robert L Dedrick; W A Hall; P A Johnson; Richard J Youle
The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography.
Cancer research 1993;53(9):2092-9.
1993: P J Nicholls; V G Johnson; S M Andrew; H R Hoogenboom; Jef Raus; Richard J Youle
Characterization of single-chain antibody (sFv)-toxin fusion proteins produced in vitro in rabbit reticulocyte lysate.
The Journal of biological chemistry 1993;268(7):5302-8.
1993: V G Johnson; P J Nicholls; W H Habig; Richard J Youle
The role of proline 345 in diphtheria toxin translocation.
The Journal of biological chemistry 1993;268(5):3514-9.
1993: Richard J Youle; D Newton; Y N Wu; M Gadina; Susanna M Rybak
Cytotoxic ribonucleases and chimeras in cancer therapy.
Critical reviews in therapeutic drug carrier systems 1993;10(1):1-28.
1992: B Dipasquale; Richard J Youle
Programmed cell death in heterokaryons. A study of the transfer of apoptosis between nuclei.
The American journal of pathology 1992;141(6):1471-9.
1992: S K Saxena; Susanna M Rybak; Richard Davey; Richard J Youle; E J Ackerman
Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily.
The Journal of biological chemistry 1992;267(30):21982-6.
1992: Dianne L Newton; O Ilercil; D W Laske; E Oldfield; Susanna M Rybak; Richard J Youle
Cytotoxic ribonuclease chimeras. Targeted tumoricidal activity in vitro and in vivo.
The Journal of biological chemistry 1992;267(27):19572-8.
1992: Susanna M Rybak; H R Hoogenboom; Dianne L Newton; Jef Raus; Richard J Youle
Rational immunotherapy with ribonuclease chimeras. An approach toward humanizing immunotoxins.
Cell biophysics 1992;21(1-3):121-38.
1992: Dianne L Newton; R Wales; P T Richardson; Stuart Walbridge; S K Saxena; E J Ackerman; Lynne M Roberts; J Michael Lord; Richard J Youle
Cell surface and intracellular functions for ricin galactose binding.
The Journal of biological chemistry 1992;267(17):11917-22.
1992: Susanna M Rybak; H R Hoogenboom; Harry M Meade; Jef Raus; D Schwartz; Richard J Youle
Humanization of immunotoxins.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3165-9.
1992: P J Nicholls; Richard J Youle
The structure of Pseudomonas exotoxin A as a guide to rational design.
Targeted diagnosis and therapy 1992;7():439-46.
1992: P J Nicholls; Richard J Youle
The structure of diphtheria toxin as a guide to rational design.
Targeted diagnosis and therapy 1992;7():339-63.
1991: B Dipasquale; Ann M Marini; Richard J Youle
Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons.
Biochemical and biophysical research communications 1991;181(3):1442-8.
1991: S K Saxena; Susanna M Rybak; G Winkler; Harry M Meade; P McGray; Richard J Youle; E J Ackerman
Comparison of RNases and toxins upon injection into Xenopus oocytes.
The Journal of biological chemistry 1991;266(31):21208-14.
1991: Susanna M Rybak; S K Saxena; E J Ackerman; Richard J Youle
Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins.
The Journal of biological chemistry 1991;266(31):21202-7.
1991: Cynthia Sung; D Wilson; Richard J Youle
Comparison of protein synthesis inhibition kinetics and cell killing induced by immunotoxins.
The Journal of biological chemistry 1991;266(22):14159-62.
1991: F S Jin; Richard J Youle; V G Johnson; Joseph Shiloach; R Fass; Dan Longo; S H Bridges
Suppression of the immune response to immunotoxins with anti-CD4 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1806-11.
1991: Richard J Youle
Mutations in diphtheria toxin to improve immunotoxin selectivity and understand toxin entry into cells.
Seminars in cell biology 1991;2(1):39-45.
1990: Cynthia Sung; Richard J Youle; Robert L Dedrick
Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding.
Cancer research 1990;50(22):7382-92.
1990: C J Riedel; Karin M Muraszko; Richard J Youle
Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5051-5.
1990: C J Wrobel; D C Wright; Robert L Dedrick; Richard J Youle
Diphtheria toxin effects on brain-tumor xenografts. Implications for protein-based brain-tumor chemotherapy.
Journal of neurosurgery 1990;72(6):946-50.
1990: W A Hall; Marsha J Merrill; Stuart Walbridge; Richard J Youle
Epidermal growth factor receptors on ependymomas and other brain tumors.
Journal of neurosurgery 1990;72(4):641-6.
1989: V G Johnson; Richard J Youle
A point mutation of proline 308 in diphtheria toxin B chain inhibits membrane translocation of toxin conjugates.
The Journal of biological chemistry 1989;264(30):17739-44.
1989: V G Johnson; C Wrobel; D Wilson; J Zovickian; L Greenfield; Edward H Oldfield; Richard J Youle
Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia.
Journal of neurosurgery 1989;70(2):240-8.
1988: J Zovickian; Richard J Youle
Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia.
Journal of neurosurgery 1988;68(5):767-74.
1988: V G Johnson; D Wilson; L Greenfield; Richard J Youle
The role of the diphtheria toxin receptor in cytosol translocation.
The Journal of biological chemistry 1988;263(3):1295-300.
1988: Richard J Youle; L Greenfield; V G Johnson
Genetic engineering of immunotoxins.
Cancer treatment and research 1988;37():113-22.
1987: L Greenfield; V G Johnson; Richard J Youle
Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity.
Science (New York, N.Y.) 1987;238(4826):536-9.
1987: J Zovickian; V G Johnson; Richard J Youle
Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin.
Journal of neurosurgery 1987;66(6):850-61.
1987: M Colombatti; V G Johnson; H A Skopicki; B Fendley; M S Lewis; Richard J Youle
Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(10):3339-44.