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Alan Brockman

Research Profile

Disorders

Chemicals & Drugs

Geographic Areas

Thailand

Physiology

Procedures

Drug Therapy, Combination

Concepts & Ideas

Living Beings

Infants

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Publications

TOP 3
Verena Ilona Carrara; Julien Zwang; Elizabeth A Ashley; Ric Price; Kasia Stepniewska; Marion Barends; Alan Brockman; Timothy JC Anderson; Rose McGready; Lucy Phaiphun; Stephane Proux; Michele van Vugt; Robert Hutagalung; Khin Maung Lwin; Aung Pyae Phyo; Piyanuch Preechapornkul; Mallika Imwong; Sasithon Pukrittayakamee; Pratap Singhasivanon; Nicholas J White; François Nosten
Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment.
B Russell; F Chalfein; B Prasetyorini; Enny Kenangalem; K Piera; Rossarin Suwanarusk; Alan Brockman; P Prayoga; P Sugiarto; Qin Cheng; Emiliana Tjitra; Nicholas Anstey; Ric Price
Determinants of in vitro drug susceptibility testing of Plasmodium vivax.
A Ratcliff; H Siswantoro; Enny Kenangalem; M Wuwung; Alan Brockman; M D Edstein; F Laihad; EP Ebsworth; Nicholas Anstey; Emiliana Tjitra; Ric Price
Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia.

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All Publications

2009: Verena Ilona Carrara; Julien Zwang; Elizabeth A Ashley; Ric Price; Kasia Stepniewska; Marion Barends; Alan Brockman; Timothy JC Anderson; Rose McGready; Lucy Phaiphun; Stephane Proux; Michele van Vugt; Robert Hutagalung; Khin Maung Lwin; Aung Pyae Phyo; Piyanuch Preechapornkul; Mallika Imwong; Sasithon Pukrittayakamee; Pratap Singhasivanon; Nicholas J White; François Nosten
Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment.
PloS one 2009;4(2):e4551.
2008: B Russell; F Chalfein; B Prasetyorini; Enny Kenangalem; K Piera; Rossarin Suwanarusk; Alan Brockman; P Prayoga; P Sugiarto; Qin Cheng; Emiliana Tjitra; Nicholas Anstey; Ric Price
Determinants of in vitro drug susceptibility testing of Plasmodium vivax.
Antimicrobial agents and chemotherapy 2008;52(3):1040-5.
2007: A Ratcliff; H Siswantoro; Enny Kenangalem; M Wuwung; Alan Brockman; M D Edstein; F Laihad; EP Ebsworth; Nicholas Anstey; Emiliana Tjitra; Ric Price
Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2007;101(4):351-9.
2007: Bart Janssens; M van Herp; L Goubert; S Chan; S Uong; S Nong; D Socheat; Alan Brockman; E A Ashley; Wim Van Damme
A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.
Tropical medicine & international health : TM & IH 2007;12(2):251-9.
2007: Elizabeth A Ashley; Kasia Stepniewska; Niklas Lindegårdh; Rose McGready; Anna Annerberg; Robert Hutagalung; Thida Singtoroj; Gilvary Hla; Alan Brockman; Stephane Proux; Jahser Wilahphaingern; Pratap Singhasivanon; Nicholas J White; François Nosten
Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.
Tropical medicine & international health : TM & IH 2007;12(2):201-8.
2007: Elizabeth A Ashley; Kasia Stepniewska; Niklas Lindegårdh; Anna Annerberg; Am Kham; Alan Brockman; Pratap Singhasivanon; Nicholas J White; François Nosten
How much fat is necessary to optimize lumefantrine oral bioavailability?
Tropical medicine & international health : TM & IH 2007;12(2):195-200.
2007: Mayfong Mayxay; Marion Barends; Alan Brockman; Anchalee Jaidee; Shalini Nair; Dan Sudimack; Tiengkham Pongvongsa; Samlane Phompida; Rattanaxay Phetsouvanh; Timothy JC Anderson; Nicholas J White; Paul N Newton
In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).
The American journal of tropical medicine and hygiene 2007;76(2):245-50.
2007: Rossarin Suwanarusk; Bruce Russell; Marina Chavchich; Ferryanto Chalfein; Enny Kenangalem; Varakorn Kosaisavee; Budi Prasetyorini; Kim A Piera; Marion Barends; Alan Brockman; Usa Lek-Uthai; Nicholas Anstey; Emiliana Tjitra; François Nosten; Qin Cheng; Ric Price
Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms.
PloS one 2007;2(10):e1089.
2007: Kasia Stepniewska; Kesinee Chotivanich; Alan Brockman; Nicholas P J Day; Nicholas J White
Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.
Malaria journal 2007;6():4.
2007: Anne-Catrin Uhlemann; Rose McGready; Elizabeth A Ashley; Alan Brockman; Pratap Singhasivanon; Sanjeev Krishna; Nicholas J White; François Nosten; Ric Price
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand.
The Journal of infectious diseases 2007;195(1):134-41.
2006: Verena Ilona Carrara; Supakit Sirilak; Janjira Thonglairuam; Chaiporn Rojanawatsirivet; Stephane Proux; Valery Gilbos; Alan Brockman; Elizabeth A Ashley; Rose McGready; Srivicha Krudsood; Somjai Leemingsawat; Sornchai Looareesuwan; Pratap Singhasivanon; Nicholas White; François Nosten
Deployment of early diagnosis and mefloquine-artesunate treatment of falciparum malaria in Thailand: the Tak Malaria Initiative.
PLoS medicine 2006;3(6):e183.
2006: Ric Price; Anne-Catrin Uhlemann; Michele van Vugt; Alan Brockman; Robert Hutagalung; Shalini Nair; Denae Nash; Pratap Singhasivanon; Timothy JC Anderson; Sanjeev Krishna; Nicholas J White; François Nosten
Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(11):1570-7.
2005: Chutima Kumkhaek; Kooruethai Phra-Ek; Laurent Rénia; Pratap Singhasivanon; Sornchai Looareesuwan; Chakrit Hirunpetcharat; Nicholas J White; Alan Brockman; Anne Charlotte Grüner; Nicolas Lebrun; Ali Alloueche; François Nosten; Srisin Khusmith; Georges Snounou
Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure?
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3935-9.
2005: Timothy JC Anderson; Shalini Nair; Huang Qin; Sittaporn Singlam; Alan Brockman; Lucy Paiphun; François Nosten
Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
Antimicrobial agents and chemotherapy 2005;49(6):2180-8.
2005: Paul N Newton; Jean-François Chaulet; Alan Brockman; Wirongrong Chierakul; Arjen M Dondorp; Ronatrai Ruangveerayuth; Sornchai Looareesuwan; Cyril Mounier; Nicholas J White
Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.
Antimicrobial agents and chemotherapy 2005;49(4):1622-5.
2005: Robert Hutagalung; Lucy Paiphun; Elizabeth A Ashley; Rose McGready; Alan Brockman; Kyaw Lay Thwai; Pratap Singhasivanon; Thomas Jelinek; Nicholas J White; François Nosten
A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand.
Malaria journal 2005;4():46.
2004: Elizabeth A Ashley; Srivicha Krudsood; Lucy Phaiphun; Siripan Srivilairit; Rose McGready; Wattana Leowattana; Robert Hutagalung; Polrat Wilairatana; Alan Brockman; Sornchai Looareesuwan; François Nosten; Nicholas J White
Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
The Journal of infectious diseases 2004;190(10):1773-82.
2004: Ric Price; Anne-Catrin Uhlemann; Alan Brockman; Rose McGready; Elizabeth A Ashley; Lucy Phaipun; Rina Patel; Kenneth Laing; Sornchai Looareesuwan; Nicholas J White; François Nosten; Sanjeev Krishna
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.
Lancet 2004;364(9432):438-47.
2004: Chutima Kumkhaek; Kooruethai Phra-ek; Pratap Singhasivanon; Sornchai Looareesuwan; Chakrit Hirunpetcharat; Alan Brockman; Anne Charlotte Grüner; Nicolas Lebrun; Laurent Rénia; François Nosten; Georges Snounou; Srisin Khusmith
A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from western Thailand.
The Southeast Asian journal of tropical medicine and public health 2004;35(2):281-7.
2004: Rose McGready; Billie B Davison; Kasia Stepniewska; Thein Cho; Htee Shee; Alan Brockman; Rachanee Udomsangpetch; Sornchai Looareesuwan; Nicholas J White; Steven R Meshnick; François Nosten
The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission.
The American journal of tropical medicine and hygiene 2004;70(4):398-407.
2004: Francesco Checchi; Patrice PIOLA; Cara Kosack; Elisa Ardizzoni; Derryck Klarkowski; Eric Kwezi; Gerardo Priotto; Suna Balkan; Nathan Bakyaita; Alan Brockman; Jean-Paul Guthmann
Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.
Tropical medicine & international health : TM & IH 2004;9(4):445-50.
2004: Alan Brockman; Sittaporn Singlam; Lucy Phiaphun; Sornchai Looareesuwan; Nicholas J White; François Nosten
Field evaluation of a novel colorimetric method--double-site enzyme-linked lactate dehydrogenase immunodetection assay--to determine drug susceptibilities of Plasmodium falciparum clinical isolates from northwestern Thailand.
Antimicrobial agents and chemotherapy 2004;48(4):1426-9.
2004: Frank Smithuis; Ingrid van den Broek; Nina Katterman; Moe Kyaw Kyaw; Alan Brockman; Saw Lwin; Nicholas J White
Optimising operational use of artesunate-mefloquine: a randomised comparison of four treatment regimens.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2004;98(3):182-92.
2003: Mayfong Mayxay; Paul N Newton; Maniphone Khanthavong; Pongvongsa Tiengkham; Rattanaxay Phetsouvanh; Samlane Phompida; Alan Brockman; Nicholas J White
Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;37(8):1021-8.
2003: Shalini Nair; Jeff T Williams; Alan Brockman; Lucy Paiphun; Mayfong Mayxay; Paul N Newton; Jean-Paul Guthmann; Frank Smithuis; Tran Tinh Hien; Nicholas J White; François Nosten; Timothy JC Anderson
A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites.
Molecular biology and evolution 2003;20(9):1526-36.
2003: S Chaorattanakawee; O Natalang; Hathairad Hananantachai; mathieu nacher; Alan Brockman; Srivicha Krudsood; Sornchai Looareesuwan; Jintana Patarapotikul
Storage duration and polymerase chain reaction detection of Plasmodium falciparum from blood spots on filter paper.
The American journal of tropical medicine and hygiene 2003;69(1):42-4.
2003: S Chaorattanakawee; O Natalang; Hathairad Hananantachai; mathieu nacher; Alan Brockman; François Nosten; Sornchai Looareesuwan; Jintana Patarapotikul
Trichuris trichiura infection is associated with the multiplicity of Plasmodium falciparum infections, in Thailand.
Annals of tropical medicine and parasitology 2003;97(2):199-202.
2002: Michele van Vugt; Elisabetta Leonardi; Lucy Phaipun; Thra Slight; Kyaw Lay Thway; Rose McGready; Alan Brockman; Leopoldo Villegas; Sornchai Looareesuwan; Nicholas J White; François Nosten
Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;35(12):1498-504.
2002: Rose McGready; Alan Brockman; Thein Cho; Martin A Levesque; Ariana N Tkachuk; Steven R Meshnick; François Nosten
Haemozoin as a marker of placental parasitization.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(6):644-6.
2002: Jean-Paul Guthmann; S Kasparian; Rattanaxay Phetsouvanh; Nicolas Nathan; M Garcia; Samlane Phompida; Alan Brockman; M Gastellu; Dominique Legros
The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos.
Annals of tropical medicine and parasitology 2002;96(6):553-7.
2002: Shalini Nair; Alan Brockman; Lucy Paiphun; François Nosten; Timothy JC Anderson
Rapid genotyping of loci involved in antifolate drug resistance in Plasmodium falciparum by primer extension.
International journal for parasitology 2002;32(7):852-8.
2001: Rose McGready; Thein Cho; Leopoldo Villegas; Alan Brockman; Michele van Vugt; Sornchai Looareesuwan; Nicholas J White; François Nosten
Randomized comparison of quinine-clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(6):651-6.
2000: Rose McGready; Alan Brockman; Thein Cho; D Cho; Michele van Vugt; Christine Luxemburger; Tan Chongsuphajaisiddhi; Nicholas J White; François Nosten
Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(6):689-93.
2000: Timothy JC Anderson; Bernhard Haubold; Jeff T Williams; J G Estrada-Franco; L Richardson; René Mollinedo; Moses J Bockarie; John Mokili; Sungano Mharakurwa; N French; J Whitworth; I D Velez; Alan Brockman; François Nosten; marcelo Urbano ferreira; Karen P Day
Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum.
Molecular biology and evolution 2000;17(10):1467-82.
2000: Michele van Vugt; Sornchai Looareesuwan; Polrat Wilairatana; Rose McGready; Leopoldo Villegas; I Gathmann; R Mull; Alan Brockman; Nicholas J White; François Nosten
Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):545-8.
2000: Alan Brockman; Ric Price; Michele van Vugt; Donald Heppner; D Walsh; Prasit Sookto; Theera Wimonwattrawatee; Sornchai Looareesuwan; N J White; François Nosten
Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):537-44.
2000: François Nosten; Michele van Vugt; Ric Price; Christine Luxemburger; K L Thway; Alan Brockman; Rose McGready; Feiko O ter Kuile; Sornchai Looareesuwan; Nicholas J White
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study.
Lancet 2000;356(9226):297-302.
1999: Ric Price; C Cassar; Alan Brockman; M Duraisingh; Michele van Vugt; Nicholas J White; François Nosten; Sanjeev Krishna
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.
Antimicrobial agents and chemotherapy 1999;43(12):2943-9.
1999: Richard E L Paul; Alan Brockman; Ric Price; Christine Luxemburger; Nicholas J White; S Looareesuwan; François Nosten; Karen P Day
Genetic analysis of Plasmodium falciparum infections on the north-western border of Thailand.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93(6):587-93.
1999: M V Vugt; Polrat Wilairatana; B Gemperli; I Gathmann; Lucy Phaipun; Alan Brockman; Christine Luxemburger; Nicholas J White; François Nosten; Sornchai Looareesuwan
Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 1999;60(6):936-42.
1999: Alan Brockman; Richard E L Paul; Timothy JC Anderson; I Hackford; Lucy Phaiphun; Sornchai Looareesuwan; François Nosten; Karen P Day
Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand.
The American journal of tropical medicine and hygiene 1999;60(1):14-21.
1998: Ric Price; Michele van Vugt; François Nosten; Christine Luxemburger; Alan Brockman; Lucy Phaipun; Tan Chongsuphajaisiddhi; N White
Artesunate versus artemether for the treatment of recrudescent multidrug-resistant falciparum malaria.
The American journal of tropical medicine and hygiene 1998;59(6):883-8.
1998: Christine Luxemburger; Alan Brockman; K Silamut; François Nosten; Michele van Vugt; F Gimenez; Tan Chongsuphajaisiddhi; Nicholas J White
Two patients with falciparum malaria and poor in vivo responses to artesunate.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(6):668-9.
1998: M Fried; François Nosten; Alan Brockman; B J Brabin; Patrick Duffy
Maternal antibodies block malaria.
Nature 1998;395(6705):851-2.
1998: Richard E L Paul; I Hackford; Alan Brockman; C Muller-Graf; R Price; Christine Luxemburger; Nicholas J White; François Nosten; Karen P Day
Transmission intensity and Plasmodium falciparum diversity on the northwestern border of Thailand.
The American journal of tropical medicine and hygiene 1998;58(2):195-203.
1998: Michele van Vugt; Alan Brockman; B Gemperli; Christine Luxemburger; I Gathmann; C Royce; Thra Slight; Sornchai Looareesuwan; Nicholas J White; François Nosten
Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria.
Antimicrobial agents and chemotherapy 1998;42(1):135-9.
1997: Sricharoen Migasena; Donald Heppner; Dennis E Kyle; Tan Chongsuphajaisiddhi; Daniel M Gordon; Pravan Suntharasamai; Barnyen Permpanich; Alan Brockman; P Pitiuttutham; Chansuda Wongsrichanalai; P Srisuriya; Benjaluck Phonrat; K Pavanand; C Viravan; W Ripley Ballou
SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand.
Acta tropica 1997;67(3):215-27.
1997: François Nosten; Christine Luxemburger; Dennis E Kyle; Daniel M Gordon; W Ripley Ballou; J C Sadoff; Alan Brockman; Barnyen Permpanich; Tan Chongsuphajaisiddhi; Donald Heppner
Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia.
The American journal of tropical medicine and hygiene 1997;56(5):526-32.
1995: Ric Price; François Nosten; Christine Luxemburger; A Kham; Alan Brockman; Tan Chongsuphajaisiddhi; Nicholas J White
Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(5):523-7.