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Andrew Young

Research Profile

Chemicals & Drugs

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Physiology

Gastric Emptying

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Publications

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Bronislava R Gedulin; Pamela A Smith; Carolyn M Jodka; Kim Chen; Sunil Bhavsar; Loretta L Nielsen; David G Parkes; Andrew A Young
Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration.
Bronislava R Gedulin; Carolyn M Jodka; Kathrin Herrmann; Andrew A Young
Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
Christine M Mack; C X Moore; Carolyn M Jodka; SP Bhavsar; J K Wilson; Julie A Hoyt; J L Roan; C Vu; Kevin D Laugero; David G Parkes; Andrew A Young
Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures.

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All Publications

2008: Bronislava R Gedulin; Pamela A Smith; Carolyn M Jodka; Kim Chen; Sunil Bhavsar; Loretta L Nielsen; David G Parkes; Andrew A Young
Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration.
International journal of pharmaceutics 2008;356(1-2):231-8.
2006: Bronislava R Gedulin; Carolyn M Jodka; Kathrin Herrmann; Andrew A Young
Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
Regulatory peptides 2006;137(3):121-7.
2006: Christine M Mack; C X Moore; Carolyn M Jodka; SP Bhavsar; J K Wilson; Julie A Hoyt; J L Roan; C Vu; Kevin D Laugero; David G Parkes; Andrew A Young
Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures.
International journal of obesity (2005) 2006;30(9):1332-40.
2005: Andrew A Young; Carolyn M Jodka; Richard Pittner; David G Parkes; Bronislava R Gedulin
Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats.
Regulatory peptides 2005;130(1-2):19-26.
2005: Bronislava R Gedulin; P Smith; K S Prickett; M Tryon; S Barnhill; J Reynolds; Loretta L Nielsen; David G Parkes; Andrew A Young
Dose-response for glycaemic and metabolic changes 28 days after single injection of long-acting release exenatide in diabetic fatty Zucker rats.
Diabetologia 2005;48(7):1380-5.
2005: Bronislava R Gedulin; Svetlana E Nikoulina; Pamela A Smith; George Gedulin; Loretta L Nielsen; Alain D Baron; David G Parkes; Andrew A Young
Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight.
Endocrinology 2005;146(4):2069-76.
2004: Richard Pittner; C X Moore; SP Bhavsar; Bronislava R Gedulin; Pamela A Smith; Carolyn M Jodka; David G Parkes; J R Paterniti; V P Srivastava; Andrew A Young
Effects of PYY[3-36] in rodent models of diabetes and obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(8):963-71.
2004: Loretta L Nielsen; Andrew A Young; David G Parkes
Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.
Regulatory peptides 2004;117(2):77-88.
2001: Ramona A Silvestre; Jovita Rodríguez-Gallardo; Carolyn M Jodka; David G Parkes; Richard Pittner; Andrew A Young; José Marco
Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas.
American journal of physiology. Endocrinology and metabolism 2001;280(3):E443-9.
1999: Andrew A Young; Bronislava R Gedulin; SP Bhavsar; Noni L Bodkin; Carolyn M Jodka; B Hansen; M Denaro
Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).
Diabetes 1999;48(5):1026-34.
1998: Bronislava R Gedulin; Andrew A Young
Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats.
Diabetes 1998;47(1):93-7.
1997: Bronislava R Gedulin; T J Rink; Andrew A Young
Dose-response for glucagonostatic effect of amylin in rats.
Metabolism: clinical and experimental 1997;46(1):67-70.
1996: W Vine; K Beaumont; Bronislava R Gedulin; Richard Pittner; C X Moore; T J Rink; Andrew A Young
Comparison of the in vitro and in vivo pharmacology of adrenomedullin, calcitonin gene-related peptide and amylin in rats.
European journal of pharmacology 1996;314(1-2):115-21.
1996: Richard Pittner; D Wolfe-Lopez; Andrew A Young; K Beaumont
Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin.
British journal of pharmacology 1996;117(5):847-52.
1996: Andrew A Young; Bronislava R Gedulin; T J Rink
Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake.
Metabolism: clinical and experimental 1996;45(1):1-3.
1995: Andrew A Young; M W Wang; Bronislava R Gedulin; T J Rink; Richard Pittner; K Beaumont
Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity.
Metabolism: clinical and experimental 1995;44(12):1581-9.
1995: W Vine; P Smith; R LaChappell; T J Rink; Andrew A Young
Lactate production from the rat hindlimb is increased after glucose administration and is suppressed by a selective amylin antagonist: evidence for action of endogenous amylin in skeletal muscle.
Biochemical and biophysical research communications 1995;216(2):554-9.
1995: K Beaumont; C X Moore; Richard Pittner; K S Prickett; L S Gaeta; T J Rink; Andrew A Young
Differential antagonism of amylin's metabolic and vascular actions with amylin receptor antagonists.
Canadian journal of physiology and pharmacology 1995;73(7):1025-9.
1995: K Beaumont; Richard Pittner; C X Moore; D Wolfe-Lopez; K S Prickett; Andrew A Young; T J Rink
Regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved.
British journal of pharmacology 1995;115(5):713-5.
1995: Andrew A Young; Bronislava R Gedulin; W Vine; A Percy; T J Rink
Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin.
Diabetologia 1995;38(6):642-8.
1995: Richard Pittner; D Wolfe-Lopez; Andrew A Young; T J Rink
Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle.
FEBS letters 1995;365(1):98-100.
1994: Andrew A Young; Bronislava R Gedulin; L S Gaeta; K S Prickett; K Beaumont; E Larson; T J Rink
Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. Evidence for a metabolic role of endogenous amylin.
FEBS letters 1994;343(3):237-41.
1993: Andrew A Young; P Carlo; P Smith; D Wolfe-Lopez; Richard Pittner; M W Wang; T Rink
Evidence for release of free glucose from muscle during amylin-induced glycogenolysis in rats.
FEBS letters 1993;334(3):317-21.
1993: K Beaumont; M A Kenney; Andrew A Young; T J Rink
High affinity amylin binding sites in rat brain.
Molecular pharmacology 1993;44(3):493-7.
1993: Andrew A Young; G J Cooper; P Carlo; T J Rink; M W Wang
Response to intravenous injections of amylin and glucagon in fasted, fed, and hypoglycemic rats.
The American journal of physiology 1993;264(6 Pt 1):E943-50.
1993: Andrew A Young; T J Rink; M W Wang
Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene-related peptide-I (CGRP alpha) in the fasted, anaesthetized rat.
Life sciences 1993;52(21):1717-26.
1992: Andrew A Young; Bronislava R Gedulin; D Wolfe-Lopez; H E Greene; T J Rink; G J Cooper
Amylin and insulin in rat soleus muscle: dose responses for cosecreted noncompetitive antagonists.
The American journal of physiology 1992;263(2 Pt 1):E274-81.
1992: Andrew A Young; P Carlo; T J Rink; M W Wang
8-37hCGRP, an amylin receptor antagonist, enhances the insulin response and perturbs the glucose response to infused arginine in anesthetized rats.
Molecular and cellular endocrinology 1992;84(1-2):R1-5.
1992: M W Wang; P Carlo; Mark S Fineman; T J Rink; Andrew A Young
Induction of acute hyperglycemia, hyperlactemia and hypocalcemia in fed and fasted BALB/c mice by intravenous amylin injection.
Endocrine research 1992;18(4):321-32.
1991: M W Wang; P Carlo; T J Rink; Andrew A Young
Amylin is more potent and more effective than glucagon in raising plasma glucose concentration in fasted, anesthetized rats.
Biochemical and biophysical research communications 1991;181(3):1288-93.
1991: Bronislava R Gedulin; G J Cooper; Andrew A Young
Amylin secretion from the perfused pancreas: dissociation from insulin and abnormal elevation in insulin-resistant diabetic rats.
Biochemical and biophysical research communications 1991;180(2):782-9.
1991: Andrew A Young; L B Crocker; D Wolfe-Lopez; G J Cooper
Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.
FEBS letters 1991;287(1-2):203-5.
1991: Andrew A Young; DM Mott; K Stone; G J Cooper
Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat.
FEBS letters 1991;281(1-2):149-51.
1989: Hannele Yki-Järvinen; agostino consoli; N Nurjhan; Andrew A Young; J E Gerich
Mechanism for underestimation of isotopically determined glucose disposal.
Diabetes 1989;38(6):744-51.
1988: Andrew A Young; Clifton Bogardus; D Wolfe-Lopez; DM Mott
Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage.
Diabetes 1988;37(3):303-8.
1988: Andrew A Young; Clifton Bogardus; K Stone; DM Mott
Insulin response of components of whole-body and muscle carbohydrate metabolism in humans.
The American journal of physiology 1988;254(2 Pt 1):E231-6.
1987: S Lillioja; DM Mott; J K Zawadzki; Andrew A Young; W G Abbott; William C Knowler; Peter H Bennett; P Moll; Clifton Bogardus
In vivo insulin action is familial characteristic in nondiabetic Pima Indians.
Diabetes 1987;36(11):1329-35.
1987: W G Abbott; S Lillioja; Andrew A Young; J K Zawadzki; Hannele Yki-Järvinen; L Christin; B V Howard
Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population.
Diabetes 1987;36(8):897-904.