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Howard Young

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Zuoxiang Xiao; Howard A Young; Feng Zhu; Timothy Back; Sandra Burkett; Travis Cohoon; Mahesh Datla; Romina Goldszmid; Qun Jiang; Fanching Lin; Kristen Pike; David S Schrump; Na-Young Song; Zhonghe Sun; Giorgio Trinchieri; Jami Willette-Brown; Robert H Wiltrout; Kwok-Kin Wong; Xiaolin Wu; Sichuan Xi; Yinling Hu
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Deborah L Hodge; Della Reynolds; Natalia S Baez; Fabio M Cerbán; Silvia G Correa; Howard A Young; Maria Cecilia Rodriguez-Galan
MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.
Howard A Young
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2013: Zuoxiang Xiao; Howard A Young; Feng Zhu; Timothy Back; Sandra Burkett; Travis Cohoon; Mahesh Datla; Romina Goldszmid; Qun Jiang; Fanching Lin; Kristen Pike; David S Schrump; Na-Young Song; Zhonghe Sun; Giorgio Trinchieri; Jami Willette-Brown; Robert H Wiltrout; Kwok-Kin Wong; Xiaolin Wu; Sichuan Xi; Yinling Hu
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Cancer cell 2013;23(4):527-40.
2012: Deborah L Hodge; Della Reynolds; Natalia S Baez; Fabio M Cerbán; Silvia G Correa; Howard A Young; Maria Cecilia Rodriguez-Galan
MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.
European journal of immunology 2012;42(10):2644-54.
2012: Howard A Young
Scientific Apps are here (and more will be coming).
Cytokine 2012;59(1):1-2.
2011: Stanislaw J Kaczmarczyk; Kalavathy Sitaraman; Howard A Young; Stephen H Hughes; Deb K Chatterjee
Protein delivery using engineered virus-like particles.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):16998-7003.
2011: Xing Zhang; Terrence W Brann; Ming Zhou; Jun Yang; Raphael M Oguariri; Kristy B Lidie; Hiromi Imamichi; Da-Wei Huang; Richard A Lempicki; Michael Baseler; Timothy D Veenstra; Howard A Young; H Clifford Lane; Tomozumi Imamichi
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(8):4541-5.
2011: M Raza Zaidi; Sean Davis; Frances P Noonan; Cari Graff-Cherry; Teresa S Hawley; Robert L Walker; Lionel Feigenbaum; Elaine Fuchs; Lyudmila Lyakh; Howard A Young; Thomas Hornyak; Heinz Arnheiter; Giorgio Trinchieri; Paul S Meltzer; Edward C De Fabo; Glenn Merlino
Interferon-γ links ultraviolet radiation to melanomagenesis in mice.
Nature 2011;469(7331):548-53.
2010: Ram Savan; Tim Chan; Howard A Young
Lentiviral gene transduction in human and mouse NK cell lines.
Methods in molecular biology (Clifton, N.J.) 2010;612():209-21.
2009: Catriona H T Miller; Stephen G Maher; Howard A Young
Clinical Use of Interferon-gamma.
Annals of the New York Academy of Sciences 2009;1182():69-79.
2009: Maria Cecilia Rodriguez-Galan; Della Reynolds; Silvia G Correa; Pablo Iribarren; Morihiro Watanabe; Howard A Young
Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):740-8.
2009: Deborah L Hodge; Jun Yang; Matthew D Buschman; Paul M Schaughency; Hong Dang; William Bere; Yili Yang; Ram Savan; Jeffrey Subleski; Xiao-Ming Yin; Thomas P Loughran; Howard A Young
Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias.
Cancer research 2009;69(9):3986-94.
2009: Ram Savan; Sarangan Ravichandran; Jack R Collins; Masahiro Sakai; Howard A Young
Structural conservation of interferon gamma among vertebrates.
Cytokine & growth factor reviews 2009;20(2):115-24.
2009: Howard A Young
Cytokine multiplex analysis.
Methods in molecular biology (Clifton, N.J.) 2009;511():85-105.
2008: Dehui Duan; Dina M Sigano; James A Kelley; Christopher C Lai; Nancy E Lewin; Noemi Kedei; Megan L Peach; Jeewoo Lee; Thushara P Abeyweera; Susan A Rotenberg; Hee Kim; Young Ho Kim; Saïd El Kazzouli; Jae-Uk Chung; Howard A Young; Matthew R Young; Alyson Baker; Nancy H Colburn; Adriana Haimovitz-Friedman; Jean-Philip Truman; Damon Parrish; Jeffrey Deschamps; Nicholas A Perry; Robert J Surawski; Peter M Blumberg; Victor E Marquez
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Journal of medicinal chemistry 2008;51(17):5198-220.
2008: Robin Winkler-Pickett; Howard A Young; James M Cherry; John Diehl; John Wine; Timothy Back; William E Bere; Anna T Mason; John R Ortaldo
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4495-506.
2007: John R Ortaldo; Anna Mason; Jami Willette-Brown; Francis W Ruscetti; John Wine; Timothy Back; Terri Stull; E William Bere; Lionel Feigenbaum; Robin Winkler-Pickett; Howard A Young
Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.
Cellular immunology 2007;249(1):8-19.
2007: Cyril Berthet; Maria Cecilia Rodriguez-Galan; Deborah L Hodge; John Gooya; Véronique Pascal; Howard A Young; Jonathan Keller; Rémy Bosselut; Philipp Kaldis
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
Molecular and cellular biology 2007;27(14):5079-89.
2006: Deborah L Hodge; Jeffrey Subleski; Della A Reynolds; Matthew D Buschman; William B Schill; Mark W Burkett; Anatoli Malyguine; Howard A Young
The proinflammatory cytokine interleukin-18 alters multiple signaling pathways to inhibit natural killer cell death.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006;26(10):706-18.
2006: M Adachi; Reiko Kurotani; Keiichirou Morimura; Yatrik M Shah; M Sanford; Blair B Madison; Deborah L Gumucio; H E Marin; Jeffrey M Peters; Howard A Young; Frank J Gonzalez
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.
Gut 2006;55(8):1104-13.
2006: Vincenzo Coppola; Colleen A Barrick; Sara Bobisse; Maria Cecilia Rodriguez-Galan; Michela Pivetta; Della Reynolds; O M Zack Howard; Mary Ellen Palko; Pedro F Esteban; Howard A Young; Antonio Rosato; Lino Tessarollo
The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.
Molecular and cellular biology 2006;26(14):5249-58.
2006: Rivkah Gonsky; Richard Deem; Jay H Bream; Howard A Young; Stephan R Targan
An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.
Genes and immunity 2006;7(5):342-51.
2006: John R Ortaldo; Howard A Young
IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes.
Seminars in immunology 2006;18(3):193-6.
2006: Howard A Young; Michael G Tovey
TL1A: a mediator of gut inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8303-4.
2006: Howard A Young
Unraveling the pros and cons of interferon-gamma gene regulation.
Immunity 2006;24(5):506-7.
2006: John R Ortaldo; Robin Winkler-Pickett; JON WIGGINTON; Meagan Horner; Earl W Bere; Anna T Mason; Narayan Bhat; James Cherry; Michael Sanford; Deborah L Hodge; Howard A Young
Regulation of ITAM-positive receptors: role of IL-12 and IL-18.
Blood 2006;107(4):1468-75.
2006: Howard A Young; John Ortaldo
Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells.
Cell research 2006;16(1):20-4.
2005: Maria Cecilia Rodriguez-Galán; Jay H Bream; Andrew Farr; Howard A Young
Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2796-804.
2005: Lyudmila A Lyakh; Michael Sanford; Sebel Chekol; Howard A Young; Anita B Roberts
TGF-beta and vitamin D3 utilize distinct pathways to suppress IL-12 production and modulate rapid differentiation of human monocytes into CD83+ dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2061-70.
2005: John R Ortaldo; Howard A Young
Mouse Ly49 NK receptors: balancing activation and inhibition.
Molecular immunology 2005;42(4):445-50.
2004: Achara Srisodsai; Reiko Kurotani; Yoshihiko Chiba; Faruk Sheikh; Howard A Young; Raymond P Donnelly; Shioko Kimura
Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.
The Journal of biological chemistry 2004;279(52):54358-68.
2004: Rivkah Gonsky; Richard Deem; Jay H Bream; Howard A Young; Stephan R Targan
Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6241-7.
2004: Xia Zhang; Maria Cecilia Rodriguez-Galán; Jeffrey Subleski; John R Ortaldo; Deborah L Hodge; Ji-Ming Wang; Osamu Shimozato; Della A Reynolds; Howard A Young
Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.
Blood 2004;104(10):3276-84.
2004: Jay H Bream; Deborah L Hodge; Rivkah Gonsky; Rosanne Spolski; Warren J Leonard; Stephanie Krebs; Stephan R Targan; Akio Morinobu; John O'Shea; Howard A Young
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
The Journal of biological chemistry 2004;279(39):41249-57.
2004: Josip Blonder; Maria Cecilia Rodriguez-Galan; King C Chan; David A Lucas; Li-Rong Yu; Thomas P Conrads; Haleem J Issaq; Howard A Young; Timothy D Veenstra
Analysis of murine natural killer cell microsomal proteins using two-dimensional liquid chromatography coupled to tandem electrospray ionization mass spectrometry.
Journal of proteome research 2004;3(4):862-70.
2004: Josip Blonder; Maria Cecilia Rodriguez-Galan; David A Lucas; Howard A Young; Haleem J Issaq; Timothy D Veenstra; Thomas P Conrads
Proteomic investigation of natural killer cell microsomes using gas-phase fractionation by mass spectrometry.
Biochimica et biophysica acta 2004;1698(1):87-95.
2004: Ana M Gamero; Howard A Young; Robert Wiltrout
Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?
Cancer cell 2004;5(2):111-2.
2004: John R Ortaldo; Howard A Young; Robin Winkler-Pickett; Earl W Bere; William Murphy; Robert Wiltrout
Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):943-53.
2004: Julia W Albright; Jay H Bream; Earl W Bere; Howard A Young; Robin Winkler-Pickett; John R Ortaldo
Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2.
Experimental gerontology 2004;39(1):73-82.
2003: Christophe Chevillard; Carole Eboumbou Moukoko; Nasr-Eldin M A Elwali; Jay H Bream; Bourema Kouriba; Laurent Argiro; Siddig A Rahoud; Adil Mergani; Sandrine Henri; jean gaudart; Qurashi Mohamed-Ali; Howard A Young; Alain Dessein
IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni).
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5596-601.
2003: Llewellyn H Mason; Jami Willette-Brown; Stephen K Anderson; W Gregory Alvord; Richard L Klabansky; Howard A Young; John R Ortaldo
Receptor glycosylation regulates Ly-49 binding to MHC class I.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4235-42.
2003: Shin-ichiroh Saitoh; Sandra Odom; Gregorio Gomez; Connie L Sommers; Howard A Young; Juan Rivera; Lawrence E Samelson
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.
The Journal of experimental medicine 2003;198(5):831-43.
2003: Jay H Bream; Rafael E Curiel; Cheng-Rong Yu; Charles E Egwuagu; Michael J Grusby; Thomas M Aune; Howard A Young
IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.
Blood 2003;102(1):207-14.
2003: Rivkah Gonsky; Richard Deem; Howard A Young; Stephan R Targan
CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.
European journal of immunology 2003;33(5):1152-62.
2003: John R Ortaldo; Howard A Young
Expression of IFN-gamma upon triggering of activating Ly49D NK receptors in vitro and in vivo: costimulation with IL-12 or IL-18 overrides inhibitory receptors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1763-9.
2002: Michael H Kershaw; Gang Wang; Jennifer A Westwood; Russell K Pachynski; H Lee Tiffany; Francesco M Marincola; Ena Wang; Howard A Young; Philip M Murphy; Patrick Hwu
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2.
Human gene therapy 2002;13(16):1971-80.
2002: Xia Zhang; Howard A Young
PPAR and immune system--what do we know?
International immunopharmacology 2002;2(8):1029-44.
2002: Deborah L Hodge; William B Schill; Ji Ming Wang; Isaac Blanca; Della A Reynolds; John R Ortaldo; Howard A Young
IL-2 and IL-12 alter NK cell responsiveness to IFN-gamma-inducible protein 10 by down-regulating CXCR3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6090-8.
2002: Buka Samten; Paritosh Ghosh; Ae-Kyung Yi; Stephen E Weis; David L Lakey; Rivkah Gonsky; Usha R Pendurthi; Benjamin Wizel; Yueru Zhang; Ming Zhang; Jianhua Gong; Marilyn Fernandez; Hassan Safi; Ramakrishna Vankayalapati; Howard A Young; Peter F Barnes
Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3520-6.
2002: Deborah L Hodge; Alfredo Martinez; John G Julias; Lynn S Taylor; Howard A Young
Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control.
Molecular and cellular biology 2002;22(6):1742-53.
2002: Osamu Shimozato; John R Ortaldo; Kristin L Komschlies; Howard A Young
Impaired NK cell development in an IFN-gamma transgenic mouse: aberrantly expressed IFN-gamma enhances hematopoietic stem cell apoptosis and affects NK cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1746-52.
2002: Lyudmila A Lyakh; Gary K Koski; Howard A Young; Sally E Spence; Peter A Cohen; Nancy R Rice
Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14(+) monocytes cultured under serum-free conditions.
Blood 2002;99(2):600-8.
2002: Josef Bodor; Jana Bodorova; Catherine V Bare; Deborah L Hodge; Howard A Young; Ronald E Gress
Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes.
European journal of immunology 2002;32(1):203-12.
2001: Isaac Blanca; Earl W Bere; Howard A Young; John R Ortaldo
Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6132-9.
2001: Jong-Keuk Lee; Timothy C Back; Kristin L Komschlies; F W Ruscetti; Howard A Young; Robert Wiltrout
Hematopoietic switch from lymphoid to granulocytic development in 3LL tumor-bearing mice.
In vivo (Athens, Greece) 2001;15(4):255-63.
2001: John R Ortaldo; Earl W Bere; D Hodge; Howard A Young
Activating Ly-49 NK receptors: central role in cytokine and chemokine production.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4994-9.
2001: JON WIGGINTON; JW Park; M Eilene Gruys; Howard A Young; Cheryl Jorcyk; Timothy C Back; MJ Brunda; R M Strieter; J Ward; Jeffrey E Green; Robert Wiltrout
Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1156-68.
2000: Réjean Lapointe; John F Toso; C Butts; Howard A Young; Patrick Hwu
Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes.
European journal of immunology 2000;30(11):3291-8.
2000: Patrick Hwu; MX Du; Réjean Lapointe; M Do; Milton Taylor; Howard A Young
Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3596-9.
2000: Rivkah Gonsky; Richard Deem; Jay H Bream; D H Lee; Howard A Young; Stephan R Targan
Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1399-407.
2000: Gregory A Taylor; Carmen M Collazo; George S Yap; K Nguyen; T A Gregorio; L S Taylor; B Eagleson; L Secrest; Eileen Southon; S W Reid; Lino Tessarollo; M Bray; Daniel W McVicar; Kristin L Komschlies; Howard A Young; Christine A Biron; Alan Sher; George Vande Woude
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):751-5.
2000: Jong-Keuk Lee; Thomas J Sayers; Alan D Brooks; Timothy C Back; Howard A Young; Kristin L Komschlies; JON WIGGINTON; Robert Wiltrout
IFN-gamma-dependent delay of in vivo tumor progression by Fas overexpression on murine renal cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):231-9.
1999: T Hoshino; Robert Wiltrout; Howard A Young
IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5070-7.
1999: Jay H Bream; Howard A Young; N Rice; M P Martin; M W Smith; M Carrington; S J O'Brien
CCR5 promoter alleles and specific DNA binding factors.
Science (New York, N.Y.) 1999;284(5412):223.
1999: Cheng-Rong Yu; John R Ortaldo; Rafael E Curiel; Howard A Young; Stephen K Anderson; P Gosselin
Role of a STAT binding site in the regulation of the human perforin promoter.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2785-90.
1999: T Hoshino; Robin Winkler-Pickett; Anna T Mason; John R Ortaldo; Howard A Young
IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):51-9.
1998: Cheng-Rong Yu; Howard A Young; John R Ortaldo
Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells.
Journal of leukocyte biology 1998;64(2):245-58.
1998: Cheng-Rong Yu; Robert A Kirken; Maria Grazia Malabarba; Howard A Young; John R Ortaldo
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):218-27.
1997: A Sica; L Dorman; V Viggiano; M Cippitelli; P Ghosh; N Rice; Howard A Young
Interaction of NF-kappaB and NFAT with the interferon-gamma promoter.
The Journal of biological chemistry 1997;272(48):30412-20.
1997: R E Curiel; R Lahesmaa; J Subleski; M Cippitelli; R A Kirken; Howard A Young; P Ghosh
Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene.
European journal of immunology 1997;27(8):1982-7.
1997: Howard A Young; D M Klinman; Della A Reynolds; K J Grzegorzewski; A Nii; Jerrold M Ward; Robin Winkler-Pickett; John R Ortaldo; J J Kenny; Kristin L Komschlies
Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies.
Blood 1997;89(2):583-95.
1996: M Cippitelli; J Ye; V Viggiano; A Sica; P Ghosh; A Gulino; A Santoni; Howard A Young
Retinoic acid-induced transcriptional modulation of the human interferon-gamma promoter.
The Journal of biological chemistry 1996;271(43):26783-93.
1996: J Ye; M Cippitelli; L Dorman; John R Ortaldo; Howard A Young
The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element.
Molecular and cellular biology 1996;16(9):4744-53.
1996: Howard A Young
Regulation of interferon-gamma gene expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):563-8.
1996: P Ghosh; A Sica; M Cippitelli; J Subleski; R Lahesmaa; Howard A Young; N R Rice
Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway.
The Journal of biological chemistry 1996;271(13):7700-4.
1996: S L Giardina; J D Coffman; Howard A Young; S J Potter; J L Frey; John R Ortaldo; S K Anderson
Association of the expression of an SR-cyclophilin with myeloid cell differentiation.
Blood 1996;87(6):2269-74.
1995: P Ghosh; Kristin L Komschlies; M Cippitelli; Dan Longo; J Subleski; J Ye; A Sica; Howard A Young; Robert Wiltrout; Augusto C Ochoa
Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth.
Journal of the National Cancer Institute 1995;87(19):1478-83.
1995: J Ye; John R Ortaldo; K Conlon; R Winkler-Pickett; Howard A Young
Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line.
Journal of leukocyte biology 1995;58(2):225-33.
1995: Anna T Mason; Daniel W McVicar; C A Smith; Howard A Young; Carl Ware; John R Ortaldo
Regulation of NK cells through the 80-kDa TNFR (CD120b).
Journal of leukocyte biology 1995;58(2):249-55.
1995: M Cippitelli; A Sica; V Viggiano; J Ye; P Ghosh; Michael J Birrer; Howard A Young
Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun.
The Journal of biological chemistry 1995;270(21):12548-56.
1995: K Conlon; J Osborne; C Morimoto; John R Ortaldo; Howard A Young
Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes.
European journal of immunology 1995;25(3):644-8.
1995: S L Giardina; S K Anderson; T J Sayers; William Chambers; G A Palumbo; Howard A Young; John R Ortaldo
Selective loss of NK cytotoxicity in antisense NK-TR1 rat LGL cell lines. Abrogation of antibody-independent tumor and virus-infected target cell killing.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):80-7.
1994: Howard A Young; P Ghosh; J Ye; James A Lederer; A Lichtman; J R Gerard; L Penix; C B Wilson; Ann J Melvin; M E McGurn
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3603-10.
1994: J Ye; P Ghosh; M Cippitelli; J Subleski; K J Hardy; John R Ortaldo; Howard A Young
Characterization of a silencer regulatory element in the human interferon-gamma promoter.
The Journal of biological chemistry 1994;269(41):25728-34.
1994: L A Eader; L Gusella; L Dorman; Howard A Young
Induction of multiple cytokine gene expression and IRF-1 mRNA by flavone acetic acid in a murine macrophage cell line.
Cellular immunology 1994;157(1):211-22.
1994: William Murphy; Scott K Durum; M R Anver; Douglass K Ferris; Daniel W McVicar; John O'Shea; S K Ruscetti; M R Smith; Howard A Young; Dan Longo
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1004-14.
1994: P Ghosh; A Sica; Howard A Young; J Ye; J L Franco; Robert Wiltrout; Dan Longo; N R Rice; Kristin L Komschlies
Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy.
Cancer research 1994;54(11):2969-72.
1993: Howard A Young; N A Jenkins; N G Copeland; S Simek; M I Lerman; B Zbar; G Glenn; John R Ortaldo; S K Anderson
Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9.
Genomics 1993;16(2):548-9.
1993: P Ghosh; T H Tan; N R Rice; A Sica; Howard A Young
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1696-700.
1992: John R Ortaldo; G M Glenn; Howard A Young; J L Frey
Natural killer (NK) cell lytic dysfunction and putative NK cell receptor expression abnormality in members of a family with chromosome 3p-linked von Hippel-Lindau disease.
Journal of the National Cancer Institute 1992;84(24):1897-903.
1992: K C Conlon; Augusto C Ochoa; William Kopp; John R Ortaldo; W J Urba; Dan Longo; Howard A Young
Enhanced lymphokine production and lymphokine receptor expression in multiple antibody-stimulated human CD4+ peripheral blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3278-89.
1992: T H Tan; G P Huang; A Sica; P Ghosh; Howard A Young; Dan Longo; N R Rice
Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.
Molecular and cellular biology 1992;12(9):4067-75.
1992: A Sica; T H Tan; N Rice; M Kretzschmar; P Ghosh; Howard A Young
The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1740-4.
1991: H Futami; L A Eader; Kristin L Komschlies; R Bull; M E Gruys; John R Ortaldo; Howard A Young; Robert Wiltrout
Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes.
Cancer research 1991;51(24):6596-602.
1991: M J Smyth; Y Norihisa; J R Gerard; Howard A Young; John R Ortaldo
IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets.
Cellular immunology 1991;138(2):390-403.
1991: John R Ortaldo; Robin Winkler-Pickett; H Yagita; Howard A Young
Comparative studies of CD3- and CD3+ CD56+ cells: examination of morphology, functions, T cell receptor rearrangement, and pore-forming protein expression.
Cellular immunology 1991;136(2):486-95.
1991: R T Winkler-Pickett; Howard A Young; A Kuta; John R Ortaldo
Analysis of rat natural killer cytotoxic factor (NKCF): mechanism of action and relationship to other cytotoxic/cytostatic factors.
Cellular immunology 1991;135(1):42-54.
1991: M J Smyth; S L Strobl; Howard A Young; John R Ortaldo; Augusto C Ochoa
Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3289-97.
1991: H Futami; A M Pilaro; M E Gruys; T C Back; Howard A Young; Robert Wiltrout
In vivo distribution and cytokine gene expression by enriched mouse LAK effector cells.
Biotherapy (Dordrecht, Netherlands) 1991;3(3):219-32.
1990: M C Galli; M J Smyth; Howard A Young; C W Reynolds; John R Ortaldo
Differential regulation of interleukin-1 gene expression in human CD3- large granular lymphocytes.
Cellular immunology 1990;131(1):184-90.
1990: M J Smyth; John R Ortaldo; W Bere; H Yagita; K Okumura; Howard A Young
IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1159-66.
1990: M J Smyth; John R Ortaldo; Y Shinkai; H Yagita; M Nakata; K Okumura; Howard A Young
Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.
The Journal of experimental medicine 1990;171(4):1269-81.
1990: W H Gotlieb; L Takacs; Howard A Young; L Gusella; Scott K Durum
Growth of immature (double negative) rat thymocytes in the presence of IL-1.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2072-81.
1990: K F Mace; R L Hornung; Robert Wiltrout; Howard A Young
Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer.
Cancer research 1990;50(6):1742-7.
1990: M R Smith; Kathrin Muegge; Jonathan Keller; H F Kung; Howard A Young; Scott K Durum
Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1777-82.
1990: V C Ciccarone; J Chrivia; K J Hardy; Howard A Young
Identification of enhancer-like elements in human IFN-gamma genomic DNA.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):725-30.
1989: M Beckwith; C M Moratz; Howard A Young; B J Mathieson
Analysis of isotype switch variants of a Qa-5 specific hybridoma.
Journal of immunological methods 1989;123(2):249-57.
1989: Kathrin Muegge; T M Williams; J Kant; Michael Karin; R Chiu; A Schmidt; U Siebenlist; Howard A Young; Scott K Durum
Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Science (New York, N.Y.) 1989;246(4927):249-51.
1989: Howard A Young; Kristin L Komschlies; V Ciccarone; M Beckwith; M Rosenberg; N A Jenkins; N G Copeland; Scott K Durum
Expression of human IFN-gamma genomic DNA in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2389-94.
1989: John R Ortaldo; Howard A Young; Luigi Varesio
Modulation of CD3- large granular lymphocyte functions by agonist and antagonists of protein kinase C: effects on NK and lymphokine-activated killer activity and production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):366-71.
1989: S Sakamoto; B J Mathieson; Kristin L Komschlies; N K Bhat; Howard A Young
The methylation state of the T cell antigen receptor beta chain gene in subpopulations of mouse thymocytes.
European journal of immunology 1989;19(5):873-9.
1989: N K Bhat; Kristin L Komschlies; S Fujiwara; Robert J Fisher; B J Mathieson; T A Gregorio; Howard A Young; J W Kasik; K Ozato; TS Papas
Expression of ets genes in mouse thymocyte subsets and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):672-8.
1989: S Sakamoto; John R Ortaldo; Howard A Young
Analysis of the methylation state of the T cell receptor beta chain gene in T cells and large granular lymphocytes.
The Journal of biological chemistry 1989;264(1):251-8.
1988: B Tartakovsky; A Finnegan; Kathrin Muegge; D T Brody; E J Kovacs; M R Smith; J A Berzofsky; Howard A Young; Scott K Durum
IL-1 is an autocrine growth factor for T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3863-7.
1988: L Takács; E J Kovacs; M R Smith; Howard A Young; Scott K Durum
Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(9):3081-95.
1988: S L Giardina; Howard A Young; C R Faltynek; E S Jaffe; J W Clark; R G Steis; W J Urba; B J Mathieson; H Gralnick; J Lawrence
Rearrangement of both immunoglobulin and T-cell receptor genes in a prolymphocytic variant of hairy cell leukemia patient resistant to interferon-alpha.
Blood 1988;72(5):1708-16.
1988: R L Hornung; Howard A Young; W J Urba; Robert Wiltrout
Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta.
Journal of the National Cancer Institute 1988;80(15):1226-31.