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John Young

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Cell Line

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Amino Acid Sequences

Physiology

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Anthrax

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Publications

TOP 3
Claire V Reeves; Joy Y Vink; Xing Wang; John A T Young; Valeriya Y Borisenko; Pelisa C Charles-Horvath; Jan K Kitajewski
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity.
Diane Thomas; Susan L Welkos; Christopher Cote; Marianne Manchester; John Naughton; John A T Young
Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment.
Suchita Bhattacharyya; Thomas J Hope; John A T Young
Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions.

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All Publications

2012: Claire V Reeves; Joy Y Vink; Xing Wang; John A T Young; Valeriya Y Borisenko; Pelisa C Charles-Horvath; Jan K Kitajewski
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity.
PloS one 2012;7(4):e34862.
2012: Diane Thomas; Susan L Welkos; Christopher Cote; Marianne Manchester; John Naughton; John A T Young
Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment.
PloS one 2012;7(4):e34611.
2011: Suchita Bhattacharyya; Thomas J Hope; John A T Young
Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions.
Virology 2011;419(1):1-9.
2011: Karen E Ocwieja; Troy L Brady; Keshet Ronen; Alyssa Huegel; Shoshannah Roth; Torsten Schaller; Leo C James; Greg J Towers; John A T Young; Sumit K Chanda; Renate König; Nirav Malani; Charles C Berry; Frederic D Bushman
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.
PLoS pathogens 2011;7(3):e1001313.
2011: Naveen K Jha; Olga Latinovic; Erik Martin; Gennadiy Novitskiy; Mariana Marin; Kosuke Miyauchi; John Naughton; John A T Young; Gregory Melikian
Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion.
PLoS pathogens 2011;7(1):e1001260.
2010: Jiwon Choi; John A T Young; Edward M Callaway
Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor-ligand bridge protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(38):16703-8.
2010: James W Bruce; Michael Hierl; John A T Young; Paul Ahlquist
Cellular transcription factor ZASC1 regulates murine leukemia virus transcription.
Journal of virology 2010;84(15):7473-83.
2010: Renate König; Silke Stertz; Yingyao Zhou; Atsushi Inoue; H-Heinrich Hoffmann; Suchita Bhattacharyya; Judith G Alamares; Donna M Tscherne; Mila B Ortigoza; Yuhong Liang; Qinshan Gao; Shane E Andrews; Sourav Bandyopadhyay; Paul De Jesus; Buu P Tu; Lars Pache; Crystal Shih; Anthony Orth; Ghislain Bonamy; Loren Miraglia; Trey Ideker; Adolfo García-Sastre; John A T Young; Peter Palese; Megan L Shaw; Sumit K Chanda
Human host factors required for influenza virus replication.
Nature 2010;463(7282):813-7.
2009: Gisou van der Goot; John A T Young
Receptors of anthrax toxin and cell entry.
Molecular aspects of medicine 2009;30(6):406-12.
2009: Frederic D Bushman; Nirav Malani; Jason Fernandes; Iván D'Orso; Gerard Cagney; Tracy L Diamond; Honglin Zhou; Daria J Hazuda; Amy S Espeseth; Renate König; Sourav Bandyopadhyay; Trey Ideker; Stephen P Goff; Nevan J Krogan; Alan D Frankel; John A T Young; Sumit K Chanda
Host cell factors in HIV replication: meta-analysis of genome-wide studies.
PLoS pathogens 2009;5(5):e1000437.
2009: Shilpi Sharma; Diane Thomas; John M Marlett; Marianne Manchester; John A T Young
Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor.
Antimicrobial agents and chemotherapy 2009;53(3):1210-2.
2008: James W Bruce; Paul Ahlquist; John A T Young
The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment.
PLoS pathogens 2008;4(11):e1000207.
2008: Patricia L Ryan; John A T Young
Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.
PloS one 2008;3(3):e1817.
2008: Kasturi Haldar; Grant McFadden; John A T Young
Change in the editorial leadership of PLoS Pathogens.
PLoS pathogens 2008;4(1):e15.
2007: Darly J Manayani; Diane Thomas; Kelly Dryden; Vijay Reddy; Marc E Siladi; John M Marlett; Godfrey Rainey; Michael E Pique; Heather M Scobie; Mark Yeager; John A T Young; Marianne Manchester; Anette Schneemann
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine.
PLoS pathogens 2007;3(10):1422-31.
2007: Ian R Wickersham; David C Lyon; Richard J O Barnard; Takuma Mori; Stefan Finke; Karl-Klaus Conzelmann; John A T Young; Edward M Callaway
Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons.
Neuron 2007;53(5):639-47.
2007: Heather M Scobie; John M Marlett; Godfrey Rainey; D Borden Lacy; R. John Collier; John A T Young
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation.
PloS one 2007;2(3):e329.
2007: John A T Young; R. John Collier
Anthrax toxin: receptor binding, internalization, pore formation, and translocation.
Annual review of biochemistry 2007;76():243-65.
2007: Angeline Rose Babel; James Bruce; John A T Young
The hr1 and fusion peptide regions of the subgroup B avian sarcoma and leukosis virus envelope glycoprotein influence low pH-dependent membrane fusion.
PloS one 2007;2(1):e171.
2006: Heather M Scobie; Darran J Wigelsworth; John M Marlett; Diane Thomas; Godfrey Rainey; D Borden Lacy; Marianne Manchester; R. John Collier; John A T Young
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.
PLoS pathogens 2006;2(10):e111.
2006: Heather M Scobie; John A T Young
Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding.
PloS one 2006;1():e99.
2005: Joshua T Wolfe; Bryan A Krantz; Godfrey Rainey; John A T Young; R. John Collier
Whole-cell voltage clamp measurements of anthrax toxin pore current.
The Journal of biological chemistry 2005;280(47):39417-22.
2005: James W Bruce; Kenneth A Bradley; Paul Ahlquist; John A T Young
Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication.
Journal of virology 2005;79(20):12969-78.
2005: Heather M Scobie; Diane Thomas; John M Marlett; Giuseppe Destito; Darran J Wigelsworth; R. John Collier; John A T Young; Marianne Manchester
A soluble receptor decoy protects rats against anthrax lethal toxin challenge.
The Journal of infectious diseases 2005;192(6):1047-51.
2005: Godfrey Rainey; Darran J Wigelsworth; Patricia L Ryan; Heather M Scobie; R. John Collier; John A T Young
Receptor-specific requirements for anthrax toxin delivery into cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13278-83.
2005: John A T Young
PLoS Pathogens--a high-impact journal for pathogen research.
PLoS pathogens 2005;1(1):e12.
2005: Sara Klucking; Asha S Collins; John A T Young
Avian sarcoma and leukosis virus cytopathic effect in the absence of TVB death domain signaling.
Journal of virology 2005;79(13):8243-8.
2005: Gregory Melikian; Richard J O Barnard; Levon Abrahamyan; Walther Mothes; John A T Young
Imaging individual retroviral fusion events: from hemifusion to pore formation and growth.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8728-33.
2005: Heather M Scobie; John A T Young
Interactions between anthrax toxin receptors and protective antigen.
Current opinion in microbiology 2005;8(1):106-12.
2004: Richard J O Barnard; Shakti Narayan; Geethanjali Dornadula; Michael D Miller; John A T Young
Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral uncoating.
Journal of virology 2004;78(19):10433-41.
2004: Godfrey Rainey; John A T Young
Antitoxins: novel strategies to target agents of bioterrorism.
Nature reviews. Microbiology 2004;2(9):721-6.
2004: John A T Young; Andrew Dillin
MAPping innate immunity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12781-2.
2004: Kwang-Il Lim; Shakti Narayan; John A T Young; John Yin
Effects of lipid rafts on dynamics of retroviral entry and trafficking: Quantitative analysis.
Biotechnology and bioengineering 2004;86(6):650-60.
2004: Shakti Narayan; John A T Young
Reconstitution of retroviral fusion and uncoating in a cell-free system.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7721-6.
2004: D Borden Lacy; Darran J Wigelsworth; Heather M Scobie; John A T Young; R. John Collier
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6367-72.
2004: Gregory Melikian; Richard J O Barnard; Ruben M Markosyan; John A T Young; Fredric S Cohen
Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth.
Journal of virology 2004;78(7):3753-62.
2004: Sara Klucking; John A T Young
Amino acid residues Tyr-67, Asn-72, and Asp-73 of the TVB receptor are important for subgroup E avian sarcoma and leukosis virus interaction.
Virology 2004;318(1):371-80.
2003: Kenneth A Bradley; Jeremy Mogridge; G Jonah; A Rainey; Sarah Batty; John A T Young
Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions.
The Journal of biological chemistry 2003;278(49):49342-7.
2003: Xuemei Yu; Qing-Yin Wang; Ying Guo; Klavs Dolmer; John A T Young; Peter G W Gettins; Li Rong
Kinetic analysis of binding interaction between the subgroup A Rous sarcoma virus glycoprotein SU and its cognate receptor Tva: calcium is not required for ligand binding.
Journal of virology 2003;77(13):7517-26.
2003: Heather M Scobie; Godfrey Rainey; Kenneth A Bradley; John A T Young
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5170-4.
2003: Kenneth A Bradley; John A T Young
Anthrax toxin receptor proteins.
Biochemical pharmacology 2003;65(3):309-14.
2003: Shakti Narayan; Richard J O Barnard; John A T Young
Two retroviral entry pathways distinguished by lipid raft association of the viral receptor and differences in viral infectivity.
Journal of virology 2003;77(3):1977-83.
2003: R. John Collier; John A T Young
Anthrax toxin.
Annual review of cell and developmental biology 2003;19():45-70.
2003: Richard J O Barnard; John A T Young
Alpharetrovirus envelope-receptor interactions.
Current topics in microbiology and immunology 2003;281():107-36.
2002: Sara Klucking; Heather B Adkins; John A T Young
Resistance to infection by subgroups B, D, and E avian sarcoma and leukosis viruses is explained by a premature stop codon within a resistance allele of the tvb receptor gene.
Journal of virology 2002;76(15):7918-21.
2002: Yuling Chi; Felipe Diaz-Griffero; Chenguang Wang; John A T Young; Jurgen Brojatsch
An NF-kappa B-dependent survival pathway protects against cell death induced by TVB receptors for avian leukosis viruses.
Journal of virology 2002;76(11):5581-7.
2002: Daniel J Knauss; John A T Young
A fifteen-amino-acid TVB peptide serves as a minimal soluble receptor for subgroup B avian leukosis and sarcoma viruses.
Journal of virology 2002;76(11):5404-10.
2002: John A T Young; John R Collier
Attacking anthrax.
Scientific American 2002;286(3):48-50, 54-9.
2002: Sophie Snitkovsky; John A T Young
Targeting retroviral vector infection to cells that express heregulin receptors using a TVA-heregulin bridge protein.
Virology 2002;292(1):150-5.
2001: Kenneth A Bradley; Jeremy Mogridge; Michael Mourez; R. John Collier; John A T Young
Identification of the cellular receptor for anthrax toxin.
Nature 2001;414(6860):225-9.
2001: HB Adkins; S C Blacklow; John A T Young
Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses.
Journal of virology 2001;75(8):3520-6.
2001: Sophie Snitkovsky; Thomas M J Niederman; Richard C Mulligan; John A T Young
Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein.
Journal of virology 2001;75(3):1571-5.
2000: Jurgen Brojatsch; J Naughton; HB Adkins; John A T Young
TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors.
Journal of virology 2000;74(24):11490-4.
2000: Walther Mothes; A L Boerger; S Narayan; J M Cunningham; John A T Young
Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein.
Cell 2000;103(4):679-89.
2000: Sophie Snitkovsky; Thomas M J Niederman; B S Carter; Richard C Mulligan; John A T Young
A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor.
Journal of virology 2000;74(20):9540-5.
2000: HB Adkins; Jurgen Brojatsch; John A T Young
Identification and characterization of a shared TNFR-related receptor for subgroup B, D, and E avian leukosis viruses reveal cysteine residues required specifically for subgroup E viral entry.
Journal of virology 2000;74(8):3572-78.
1999: A L Boerger; Sophie Snitkovsky; John A T Young
Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9867-72.
1998: Sophie Snitkovsky; John A T Young
Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7063-8.
1998: E J Smith; Jurgen Brojatsch; J Naughton; John A T Young
The CAR1 gene encoding a cellular receptor specific for subgroup B and D avian leukosis viruses maps to the chicken tvb locus.
Journal of virology 1998;72(4):3501-3.
1997: HB Adkins; Jurgen Brojatsch; J Naughton; Melissa M Rolls; Jean M Pesola; John A T Young
Identification of a cellular receptor for subgroup E avian leukosis virus.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11617-22.
1996: Jurgen Brojatsch; J Naughton; Melissa M Rolls; K Zingler; John A T Young
CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis.
Cell 1996;87(5):845-55.