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Michael Young

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Dragana Rogulja; Michael W Young
Control of sleep by cyclin A and its regulator.
Heather A King; Brian R Crane; André Hoelz; Michael W Young
Structure of an enclosed dimer formed by the Drosophila period protein.
Lino Saez; J Stieglitz; Mary Derasmo; Pablo Meyer; Michael W Young
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein.

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All Publications

2012: Dragana Rogulja; Michael W Young
Control of sleep by cyclin A and its regulator.
Science (New York, N.Y.) 2012;335(6076):1617-21.
2011: Heather A King; Brian R Crane; André Hoelz; Michael W Young
Structure of an enclosed dimer formed by the Drosophila period protein.
Journal of molecular biology 2011;413(3):561-72.
2011: Lino Saez; J Stieglitz; Mary Derasmo; Pablo Meyer; Michael W Young
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein.
Genetics 2011;188(3):591-600.
2008: Herman Wijnen; Michael W Young
The right period for a Siesta.
Neuron 2008;60(6):943-6.
2008: Saul Kivimäe; Lino Saez; Michael W Young
Activating PER repressor through a DBT-directed phosphorylation switch.
PLoS biology 2008;6(7):e183.
2008: Tatsumori Sekine; Terumi Yamaguchi; Kunikatsu Hamano; Michael W Young; Masami Shimoda; Lino Saez
Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.
Journal of biological rhythms 2008;23(1):3-15.
2008: Catharine E Boothroyd; Michael W Young
The in(put)s and out(put)s of the Drosophila circadian clock.
Annals of the New York Academy of Sciences 2008;1129():350-7.
2007: Pablo Meyer; Michael W Young
The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock.
Journal of biological rhythms 2007;22(4):283-90.
2007: Catharine Boothroyd; Herman Wijnen; Felix Naef; Lino Saez; Michael W Young
Integration of light and temperature in the regulation of circadian gene expression in Drosophila.
PLoS genetics 2007;3(4):e54.
2007: Edmund C Schwartz; Lino Saez; Michael W Young; Tom W Muir
Post-translational enzyme activation in an animal via optimized conditional protein splicing.
Nature chemical biology 2007;3(1):50-4.
2006: Herman Wijnen; Felix Naef; Catharine Boothroyd; Adam Claridge-Chang; Michael W Young
Control of daily transcript oscillations in Drosophila by light and the circadian clock.
PLoS genetics 2006;2(3):e39.
2006: Pablo Meyer; Lino Saez; Michael W Young
PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock.
Science (New York, N.Y.) 2006;311(5758):226-9.
2006: Herman Wijnen; Michael W Young
Interplay of circadian clocks and metabolic rhythms.
Annual review of genetics 2006;40():409-48.
2005: Shawn A Cyran; Georgia Yiannoulos; Anna M Buchsbaum; Lino Saez; Michael W Young; Justin Blau
The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(22):5430-7.
2005: Herman Wijnen; Felix Naef; Michael W Young
Molecular and statistical tools for circadian transcript profiling.
Methods in enzymology 2005;393():341-65.
2004: Emily Harms; Saul Kivimäe; Michael W Young; Lino Saez
Posttranscriptional and posttranslational regulation of clock genes.
Journal of biological rhythms 2004;19(5):361-73.
2004: Michael W Young
An ultradian clock shapes genome expression in yeast.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1118-9.
2003: Shawn A Cyran; Anna M Buchsbaum; Karen L Reddy; Meng-Chi Lin; Nicholas R J Glossop; Paul E Hardin; Michael W Young; Robert V Storti; Justin Blau
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.
Cell 2003;112(3):329-41.
2003: Emily Harms; Michael W Young; Lino Saez
CK1 and GSK3 in the Drosophila and mammalian circadian clock.
Novartis Foundation symposium 2003;253():267-77; discussion 102-9, 277-84.
2002: Michael W Young
Big ben rings in a lesson on biological clocks.
Neuron 2002;36(6):1001-5.
2002: Toby Lieber; Simon Kidd; Michael W Young
kuzbanian-mediated cleavage of Drosophila Notch.
Genes & development 2002;16(2):209-21.
2002: Herman Wijnen; Catharine Boothroyd; Michael W Young; Adam Claridge-Chang
Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.
Annals of medicine 2002;34(5):386-93.
2001: Adam Claridge-Chang; Herman Wijnen; Felix Naef; Catharine Boothroyd; Nikolaus Rajewsky; Michael W Young
Circadian regulation of gene expression systems in the Drosophila head.
Neuron 2001;32(4):657-71.
2001: Michael W Young; Steve A Kay
Time zones: a comparative genetics of circadian clocks.
Nature reviews. Genetics 2001;2(9):702-15.
2001: A Betz; N Lampen; S Martinek; Michael W Young; James E Darnell
A Drosophila PIAS homologue negatively regulates stat92E.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9563-8.
2001: S Martinek; S Inonog; A S Manoukian; Michael W Young
A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock.
Cell 2001;105(6):769-79.
2001: Brian Kloss; A Rothenfluh; Michael W Young; Lino Saez
Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock.
Neuron 2001;30(3):699-706.
2000: Michael W Young
Life's 24-hour clock: molecular control of circadian rhythms in animal cells.
Trends in biochemical sciences 2000;25(12):601-6.
2000: S Martinek; Michael W Young
Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats.
Genetics 2000;156(4):1717-25.
2000: A Rothenfluh; M Abodeely; Michael W Young
Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.
Current biology : CB 2000;10(21):1399-402.
2000: A Rothenfluh; M Abodeely; JL Price; Michael W Young
Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.
Genetics 2000;156(2):665-75.
2000: Shengkan Jin; S Martinek; W S Joo; Jennifer Wortman; Nebojsa Mirkovic; Andrej Sali; M D Yandell; Nikola P Pavletich; Michael W Young; Arnold J Levine
Identification and characterization of a p53 homologue in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7301-6.
2000: A Rothenfluh; Michael W Young; Lino Saez
A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.
Neuron 2000;26(2):505-14.
2000: Michael W Young
Circadian rhythms. Marking time for a kingdom.
Science (New York, N.Y.) 2000;288(5465):451-3.
2000: Michael W Young
The tick-tock of the biological clock.
Scientific American 2000;282(3):64-71.
1999: Justin Blau; Michael W Young
Cycling vrille expression is required for a functional Drosophila clock.
Cell 1999;99(6):661-71.
1999: Michael W Young
Molecular control of circadian behavioral rhythms.
Recent progress in hormone research 1999;54():87-94; discussion 94-5.
1998: Simon Kidd; Toby Lieber; Michael W Young
Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos.
Genes & development 1998;12(23):3728-40.
1998: AM Sangoram; Lino Saez; Marina P Antoch; Nicholas Gekakis; David Staknis; A Whiteley; Ethan M Fruechte; Martha Hotz Vitaterna; Kazuhiro Shimomura; D P King; Michael W Young; Charles J Weitz; Joseph S Takahashi
Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.
Neuron 1998;21(5):1101-13.
1998: Brian Kloss; JL Price; Lino Saez; Justin Blau; A Rothenfluh; Cedric Wesley; Michael W Young
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.
Cell 1998;94(1):97-107.
1998: JL Price; Justin Blau; A Rothenfluh; M Abodeely; Brian Kloss; Michael W Young
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.
Cell 1998;94(1):83-95.
1998: Michael W Young
The molecular control of circadian behavioral rhythms and their entrainment in Drosophila.
Annual review of biochemistry 1998;67():135-52.
1997: M P Myers; A Rothenfluh; M Chang; Michael W Young
Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein.
Nucleic acids research 1997;25(23):4710-4.
1997: Michael W Young; Cedric Wesley
Diverse roles for the Notch receptor in the development of D. melanogaster.
Perspectives on developmental neurobiology 1997;4(4):345-55.
1996: Lino Saez; Michael W Young
Regulation of nuclear entry of the Drosophila clock proteins period and timeless.
Neuron 1996;17(5):911-20.
1996: M P Myers; K Wager-Smith; A Rothenfluh-Hilfiker; Michael W Young
Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock.
Science (New York, N.Y.) 1996;271(5256):1736-40.
1996: Michael W Young; K Wager-Smith; L Vosshall; Lino Saez; M P Myers
Molecular anatomy of a light-sensitive circadian pacemaker in Drosophila.
Cold Spring Harbor symposia on quantitative biology 1996;61():279-84.
1995: Nicholas Gekakis; Lino Saez; A M Delahaye-Brown; M P Myers; Amita Sehgal; Michael W Young; Charles J Weitz
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.
Science (New York, N.Y.) 1995;270(5237):811-5.
1995: Amita Sehgal; A Rothenfluh-Hilfiker; Melissa Hunter-Ensor; Y Chen; M P Myers; Michael W Young
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.
Science (New York, N.Y.) 1995;270(5237):808-10.
1995: M P Myers; K Wager-Smith; Cedric Wesley; Michael W Young; Amita Sehgal
Positional cloning and sequence analysis of the Drosophila clock gene, timeless.
Science (New York, N.Y.) 1995;270(5237):805-8.
1995: L B Vosshall; Michael W Young
Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells.
Neuron 1995;15(2):345-60.
1994: L B Vosshall; J L Price; Amita Sehgal; Lino Saez; Michael W Young
Block in nuclear localization of period protein by a second clock mutation, timeless.
Science (New York, N.Y.) 1994;263(5153):1606-9.
1994: Amita Sehgal; J L Price; B Man; Michael W Young
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.
Science (New York, N.Y.) 1994;263(5153):1603-6.
1994: Cedric Wesley; M P Myers; Michael W Young
Rapid sequential walking from termini of cosmid, P1 and YAC inserts.
Nucleic acids research 1994;22(3):538-9.
1993: D Lyman; Michael W Young
Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10395-9.
1993: T Lieber; S Kidd; E Alcamo; V Corbin; Michael W Young
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
Genes & development 1993;7(10):1949-65.
1992: Lino Saez; Michael W Young; Mary K Baylies; G Gasic; Thaddeus A Bargiello; david spray
Per--no link to gap junctions.
Nature 1992;360(6404):542.
1992: T Lieber; Cedric Wesley; E Alcamo; B Hassel; J F Krane; J A Campos-Ortega; Michael W Young
Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro.
Neuron 1992;9(5):847-59.
1992: Mary K Baylies; L B Vosshall; Amita Sehgal; Michael W Young
New short period mutations of the Drosophila clock gene per.
Neuron 1992;9(3):575-81.
1992: Amita Sehgal; J Price; Michael W Young
Ontogeny of a biological clock in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1423-7.
1991: V Corbin; A M Michelson; Susan M Abmayr; V Neel; E Alcamo; T Maniatis; Michael W Young
A role for the Drosophila neurogenic genes in mesoderm differentiation.
Cell 1991;67(2):311-23.
1991: Amita Sehgal; B Man; J L Price; L B Vosshall; Michael W Young
New clock mutations in Drosophila.
Annals of the New York Academy of Sciences 1991;618():1-10.
1989: S Kidd; Mary K Baylies; G P Gasic; Michael W Young
Structure and distribution of the Notch protein in developing Drosophila.
Genes & development 1989;3(8):1113-29.
1988: Lino Saez; Michael W Young
In situ localization of the per clock protein during development of Drosophila melanogaster.
Molecular and cellular biology 1988;8(12):5378-85.
1987: Mark R Kelley; S Kidd; Walter A Deutsch; Michael W Young
Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.
Cell 1987;51(4):539-48.
1987: Thaddeus A Bargiello; Lino Saez; Mary K Baylies; G Gasic; Michael W Young; david spray
The Drosophila clock gene per affects intercellular junctional communication.
Nature 1987;328(6132):686-91.
1987: Mark R Kelley; S Kidd; R L Berg; Michael W Young
Restriction of P-element insertions at the Notch locus of Drosophila melanogaster.
Molecular and cellular biology 1987;7(4):1545-8.
1987: Mary K Baylies; Thaddeus A Bargiello; F R Jackson; Michael W Young
Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.
Nature 1987;326(6111):390-2.
1986: S Kidd; Michael W Young
Transposon-dependent mutant phenotypes at the Notch locus of Drosophila.
Nature 1986;323(6083):89-91.
1986: S Kidd; Mark R Kelley; Michael W Young
Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.
Molecular and cellular biology 1986;6(9):3094-108.
1986: F R Jackson; Thaddeus A Bargiello; S H Yun; Michael W Young
Product of per locus of Drosophila shares homology with proteoglycans.
Nature 1986;320(6058):185-8.
1985: H S Shin; Thaddeus A Bargiello; B T Clark; F R Jackson; Michael W Young
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates.
Nature 1985;317(6036):445-8.
1985: Michael W Young; F R Jackson; H S Shin; Thaddeus A Bargiello
A biological clock in Drosophila.
Cold Spring Harbor symposia on quantitative biology 1985;50():865-75.
1984: Thaddeus A Bargiello; F R Jackson; Michael W Young
Restoration of circadian behavioural rhythms by gene transfer in Drosophila.
Nature 1984;312(5996):752-4.
1984: Thaddeus A Bargiello; Michael W Young
Molecular genetics of a biological clock in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(7):2142-6.
1983: S Kidd; T J Lockett; Michael W Young
The Notch locus of Drosophila melanogaster.
Cell 1983;34(2):421-33.
1982: H E Schwartz; T J Lockett; Michael W Young
Analysis of transcripts from two families of nomadic DNA.
Journal of molecular biology 1982;157(1):49-68.
1981: Michael W Young; H E Schwartz
Nomadic gene families in Drosophila.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():629-40.