FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Stephen Young

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Physiology

Mutation

Anatomy

Co-author Network

Publications

TOP 3
Claudio J Villanueva; Jiexin Wang; Kevin Wroblewski; Feng Xu; Stephen G Young; Yiping Tu; Laurent Vergnes; Brian G Drew; Loren G Fong; Andrea L Hevener; Cynthia Hong; Yan Hu; Xu Peng; Karen Reue; Enrique Saez; Peter Tontonoz
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.
Stephen G Young; Brandon S J Davies; Hea-Jin Jung; Shao H Yang; Loren G Fong
Targeting protein prenylation in progeria.
Hea-Jin Jung; John M Lee; Shao H Yang; Stephen G Young; Loren G Fong
Nuclear lamins in the brain - new insights into function and regulation.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Stephen Young (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Claudio J Villanueva; Jiexin Wang; Kevin Wroblewski; Feng Xu; Stephen G Young; Yiping Tu; Laurent Vergnes; Brian G Drew; Loren G Fong; Andrea L Hevener; Cynthia Hong; Yan Hu; Xu Peng; Karen Reue; Enrique Saez; Peter Tontonoz
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.
Cell metabolism 2013;17(3):423-35.
2013: Stephen G Young; Brandon S J Davies; Hea-Jin Jung; Shao H Yang; Loren G Fong
Targeting protein prenylation in progeria.
Science translational medicine 2013;5(171):171ps3.
2013: Hea-Jin Jung; John M Lee; Shao H Yang; Stephen G Young; Loren G Fong
Nuclear lamins in the brain - new insights into function and regulation.
Molecular neurobiology 2013;47(1):290-301.
2012: Brandon S J Davies; Loren G Fong; Peter Gin; Chris N Goulbourne; Kirsten A Turlo; Sue Vaughan; David J Vaux; Richard H Barnes; Anne P Beigneux; André Bensadoun; Stephen G Young
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells.
Journal of lipid research 2012;53(12):2690-7.
2012: Li Zhang; Stephen G Young; Loren G Fong; Karen Reue; Peter Tontonoz
Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(11):2541-6.
2012: Jennifer R Dwyer; Loren G Fong; Jessica M Lee; E Atti; David N Brindley; Lauren S Csaki; Pieter J De Jong; Jay Dewald; Jimmy Donkor; Sotirios Tetradis; Laurent Vergnes; Yuko Yoshinaga; Stephen G Young; Peixiang Zhang; Karen Reue
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):E2486-95.
2012: Peter Gin; Chris N Goulbourne; Shelly Tat; Constance V Voss; Oludotun Adeyo; Anne P Beigneux; André Bensadoun; Brandon S J Davies; Loren G Fong; Stephen G Young
Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1.
Human molecular genetics 2012;21(13):2961-72.
2012: Sandy Y Chang; Emily Farber; Douglas A Andres; Christine A Hrycyna; Sarah E Hudon-Miller; Hea-Jin Jung; John M Lee; H Peter Spielmann; Thangaiah Subramanian; Shao H Yang; Stephen G Young; Loren G Fong
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.
Journal of lipid research 2012;53(6):1176-82.
2012: Hea-Jin Jung; Samuel J Pleasure; Tao Sun; Shao H Yang; Stephen G Young; Richard H Barnes; Anne P Beigneux; Youngshik Choe; Catherine Coffinier; Brandon S J Davies; Janet Hong; Loren G Fong
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):E423-31.
2012: Michael M Weinstein; Richard H Barnes; Anne P Beigneux; Brandon S J Davies; Ryan Davis; Loren G Fong; Christopher N Goulbourne; Karen Reue; Peter Tontonoz; Yiping Tu; Steven M Watkins; Stephen G Young
Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):230-5.
2012: Brandon S J Davies; Loren G Fong; Anne P Beigneux; Stephen G Young
New wrinkles in lipoprotein lipase biology.
Current opinion in lipidology 2012;23(1):35-42.
2012: Rakel Nyrén; Thomas Olivecrona; Evelina Vorrsjö; Stephen G Young; Yusuf Ali; Anastasia Barmina; André Bensadoun; Chuchun L Chang; Lisa Juntti-Berggren; Per Lindström; Gunilla Olivecrona
Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency.
BMC physiology 2012;12():14.
2011: Catherine Coffinier; Pieter J de Jong; Loren G Fong; Hea-Jin Jung; Chika Nobumori; Karen Reue; Yiping Tu; Laurent Vergnes; Yuko Yoshinaga; Richard H Barnes; Sandy Chang; Stephen G Young
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.
Molecular biology of the cell 2011;22(23):4683-93.
2011: Parth Patwari; Eric E Schadt; Stephen G Young; Ann Marie Zavacki; Yongzhao Zhang; William A Chutkow; David E Cohen; Radu Dobrin; Valur Emilsson; Loren G Fong; P. Reed larsen; Samuel Lee; Alessandro Marsili; Richard T Lee
The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
Cell metabolism 2011;14(5):671-83.
2011: Shao H Yang; Catherine Coffinier; Loren G Fong; Hea-Jin Jung; Stephen G Young
Are B-type lamins essential in all mammalian cells?
Nucleus (Austin, Tex.) 2011;2(6):562-9.
2011: Stephen G Young; André Bensadoun; Brandon S J Davies; Loren G Fong; Peter Gin; Karen Reue; Peter Tontonoz; Constance V Voss; Michael M Weinstein; Anne P Beigneux
GPIHBP1, an endothelial cell transporter for lipoprotein lipase.
Journal of lipid research 2011;52(11):1869-84.
2011: Constance V Voss; Brandon S J Davies; Shelly Tat; Peter Gin; Loren G Fong; Christopher Pelletier; Charlene D Mottler; André Bensadoun; Anne P Beigneux; Stephen G Young
Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7980-4.
2011: Elena Scotti; Cynthia Hong; Yuko Yoshinaga; Yiping Tu; Yan Hu; Noam Zelcer; Rima Boyadjian; Pieter J de Jong; Stephen G Young; Loren G Fong; Peter Tontonoz
Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.
Molecular and cellular biology 2011;31(9):1885-93.
2011: Valerie L R M Verstraeten; Lana A Peckham; Michelle Olive; Brian C Capell; Francis S Collins; Elizabeth G Nabel; Stephen G Young; Loren G Fong; Jan Lammerding
Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4997-5002.
2011: Shao H Yang; Sandy Y Chang; Shuxun Ren; Yibin Wang; Douglas A Andres; H Peter Spielmann; Loren G Fong; Stephen G Young
Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.
Human molecular genetics 2011;20(3):436-44.
2011: Laurent Vergnes; Robert Chin; Stephen G Young; Karen Reue
Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.
The Journal of biological chemistry 2011;286(1):380-90.
2011: Brandon S J Davies; Richard H Barnes; Catherine Coffinier; Hea-Jin Jung; Shao H Yang; Stephen G Young; Loren G Fong
Investigating the purpose of prelamin A processing.
Nucleus (Austin, Tex.) 2011;2(1):4-9.
2011: Peter Gin; Anne P Beigneux; Constance Voss; Brandon S J Davies; Jennifer A Beckstead; Robert O Ryan; André Bensadoun; Loren G Fong; Stephen G Young
Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(1):176-82.
2010: Tove Olafsen; Stephen G Young; Brandon S J Davies; Anne P Beigneux; Vania E Kenanova; Constance Voss; Glen Young; Koon-Pong Wong; Richard H Barnes; Yiping Tu; Michael M Weinstein; Chika Nobumori; Sung-Cheng Huang; Ira J Goldberg; André Bensadoun; Anna M Wu; Loren G Fong
Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning.
The Journal of biological chemistry 2010;285(50):39239-48.
2010: Xiao Shu; Lisa Nelbach; Michael M Weinstein; Braydon L Burgess; Jennifer A Beckstead; Stephen G Young; Robert O Ryan; Trudy M Forte
Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(12):2504-9.
2010: Michael M Weinstein; Yiping Tu; Anne P Beigneux; Brandon S J Davies; Peter Gin; Constance Voss; Rosemary L Walzem; Karen Reue; Peter Tontonoz; André Bensadoun; Loren G Fong; Stephen G Young
Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(11):2106-13.
2010: Catherine Coffinier; Loren G Fong; Stephen G Young
LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.
Nucleus (Austin, Tex.) 2010;1(5):407-11.
2010: Brandon S J Davies; Anne P Beigneux; Richard H Barnes; Yiping Tu; Peter Gin; Michael M Weinstein; Chika Nobumori; Rakel Nyrén; Ira Goldberg; Gunilla Olivecrona; André Bensadoun; Stephen G Young; Loren G Fong
GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.
Cell metabolism 2010;12(1):42-52.
2010: Catherine Coffinier; Hea-Jin Jung; Ziwei Li; Chika Nobumori; Ui Jeong Yun; Emily A Farber; Brandon S Davies; Michael M Weinstein; Shao H Yang; Jan Lammerding; Javad N Farahani; Laurent A Bentolila; Loren G Fong; Stephen G Young
Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
The Journal of biological chemistry 2010;285(27):20818-26.
2010: Brandon S J Davies; Richard H Barnes; Yiping Tu; Shuxun Ren; Douglas A Andres; H Peter Spielmann; Jan Lammerding; Yibin Wang; Stephen G Young; Loren G Fong
An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.
Human molecular genetics 2010;19(13):2682-94.
2010: Gunilla Olivecrona; Ewa Ehrenborg; Henrik Semb; Elena Makoveichuk; Anna Lindberg; Michael R Hayden; Peter Gin; Brandon S J Davies; Michael M Weinstein; Loren G Fong; Anne P Beigneux; Stephen G Young; Thomas Olivecrona; Olle Hernell
Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia.
Journal of lipid research 2010;51(6):1535-45.
2010: Roger Lee; Sandy Y Chang; Hung Trinh; Yiping Tu; Andrew C White; Brandon S J Davies; Martin O Bergo; Loren G Fong; William E Lowry; Stephen G Young
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.
Human molecular genetics 2010;19(8):1603-17.
2010: Meng Liu; Anna-Karin M Sjogren; Christin Karlsson; Mohamed X Ibrahim; Karin M E Andersson; Frida J Olofsson; Annika M Wahlstrom; Martin Dalin; Huiming Yu; Zhenggang Chen; Shao H Yang; Stephen G Young; Martin O Bergo
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6471-6.
2010: Catherine Coffinier; Sandy Y Chang; Chika Nobumori; Yiping Tu; Emily A Farber; Julia I Toth; Loren G Fong; Stephen G Young
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5076-81.
2010: Shao H Yang; Sandy Y Chang; Douglas A Andres; H Peter Spielmann; Stephen G Young; Loren G Fong
Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.
Journal of lipid research 2010;51(2):400-5.
2010: Joseph Bishop; Maria Rita Passos-Bueno; Loren Fong; Kristin I Stanford; Jon C Gonzales; Erika Yeh; Stephen G Young; Andre Bensadoun; Joseph L Witztum; Jeffrey D Esko; Karen S Moulton
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans.
PloS one 2010;5(11):e13919.
2010: Michael M Weinstein; Liya Yin; Yiping Tu; Xuping Wang; Xiaohui Wu; Lawrence W Castellani; Rosemary Walzem; Aldons J Lusis; Loren G Fong; Anne P Beigneux; Stephen G Young
Chylomicronemia elicits atherosclerosis in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(1):20-3.
2009: Anne P Beigneux; Peter Gin; Brandon S J Davies; Michael M Weinstein; André Bensadoun; Loren G Fong; Stephen G Young
Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase.
The Journal of biological chemistry 2009;284(44):30240-7.
2009: Lai N Chan; Courtenay Hart; Lea Guo; Tamara Nyberg; Brandon S J Davies; Loren G Fong; Stephen G Young; Brian J Agnew; Fuyuhiko Tamanoi
A novel approach to tag and identify geranylgeranylated proteins.
Electrophoresis 2009;30(20):3598-606.
2009: Kye Won Park; Hironori Waki; Woo-Kyun Kim; Brandon S J Davies; Stephen G Young; Farhad Parhami; Peter Tontonoz
The small molecule phenamil induces osteoblast differentiation and mineralization.
Molecular and cellular biology 2009;29(14):3905-14.
2009: Loren G Fong; Timothy A Vickers; Emily A Farber; Christine Choi; Ui Jeong Yun; Yan Hu; Shao H Yang; Catherine Coffinier; Roger Lee; Liya Yin; Brandon S J Davies; Douglas A Andres; H Peter Spielmann; C Frank Bennett; Stephen G Young
Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Human molecular genetics 2009;18(13):2462-71.
2009: Anne P Beigneux; Remco Franssen; André Bensadoun; Peter Gin; Kristan Melford; Jorge Peter; Rosemary Walzem; Michael M Weinstein; Brandon S J Davies; Jan A Kuivenhoven; John J P Kastelein; Loren G Fong; Geesje M Dallinga-Thie; Stephen G Young
Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):956-62.
2009: Shao H Yang; Martin O Bergo; Emily Farber; Xin Qiao; Loren G Fong; Stephen G Young
Caution! Analyze transcripts from conditional knockout alleles.
Transgenic research 2009;18(3):483-9.
2009: Anne P Beigneux; Brandon S J Davies; André Bensadoun; Loren G Fong; Stephen G Young
GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.
Journal of lipid research 2009;50 Suppl():S57-62.
2009: Brandon S J Davies; Loren G Fong; Shao H Yang; Catherine Coffinier; Stephen G Young
The posttranslational processing of prelamin A and disease.
Annual review of genomics and human genetics 2009;10():153-74.
2008: Michael M Weinstein; Liya Yin; Anne P Beigneux; Brandon S J Davies; Peter Gin; Kristine Estrada; Kristan Melford; Joseph R Bishop; Jeffrey D Esko; Geesje M Dallinga-Thie; Loren G Fong; André Bensadoun; Stephen G Young
Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.
The Journal of biological chemistry 2008;283(50):34511-8.
2008: Brandon S J Davies; Hironori Waki; Anne P Beigneux; Emily A Farber; Michael M Weinstein; DAMIEN WILPITZ; Li-Jung Tai; Ronald M Evans; Loren G Fong; Peter Tontonoz; Stephen G Young
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.
Molecular endocrinology (Baltimore, Md.) 2008;22(11):2496-504.
2008: Peter Gin; Liya Yin; Brandon S J Davies; Michael M Weinstein; Robert O Ryan; André Bensadoun; Loren G Fong; Stephen G Young; Anne P Beigneux
The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons.
The Journal of biological chemistry 2008;283(43):29554-62.
2008: Shao H Yang; Douglas A Andres; H Peter Spielmann; Stephen G Young; Loren G Fong
Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.
The Journal of clinical investigation 2008;118(10):3291-300.
2008: Sarah E Hudon; Catherine Coffinier; Susan Michaelis; Loren G Fong; Stephen G Young; Christine A Hrycyna
HIV-protease inhibitors block the enzymatic activity of purified Ste24p.
Biochemical and biophysical research communications 2008;374(2):365-8.
2008: Kaori Minehira; Stephen G Young; Claudio J Villanueva; Laxman Yetukuri; Matej Oresic; Marc K Hellerstein; Robert V Farese; Jay D Horton; Frederic Preitner; Bernard Thorens; Luc Tappy
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
Journal of lipid research 2008;49(9):2038-44.
2008: Annika Wahlstrom; Briony A Cutts; Meng Liu; Annika Lindskog; Christin Karlsson; Anna-Karin M Sjogren; Karin M E Andersson; Stephen G Young; Martin O Bergo
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.
Blood 2008;112(4):1357-65.
2008: Anne P Beigneux; Peter Gin; Brandon S J Davies; Michael M Weinstein; André Bensadoun; Robert O Ryan; Loren G Fong; Stephen G Young
Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase.
Journal of lipid research 2008;49(6):1312-21.
2008: Yan Qun Chen; Ming-Shang Kuo; Shuyu Li; Hai H Bui; David A Peake; Philip E Sanders; Stefan J Thibodeaux; Shaoyou Chu; Yue-Wei Qian; Yang Zhao; David S Bredt; David E Moller; Robert J Konrad; Anne P Beigneux; Stephen G Young; Guoqing Cao
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
The Journal of biological chemistry 2008;283(15):10048-57.
2008: Catherine Coffinier; Sarah E Hudon; Roger Lee; Emily A Farber; Chika Nobumori; Jeffrey H Miner; Douglas A Andres; H Peter Spielmann; Christine A Hrycyna; Loren G Fong; Stephen G Young
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.
The Journal of biological chemistry 2008;283(15):9797-804.
2008: Shao H Yang; Xin Qiao; Emily A Farber; Sandy Y Chang; Loren G Fong; Stephen G Young
Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele.
The Journal of biological chemistry 2008;283(11):7094-9.
2008: Murielle M Véniant; Anne P Beigneux; André Bensadoun; Loren G Fong; Stephen G Young
Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.
Current drug targets 2008;9(3):174-89.
2008: Gengshu Wu; Chieko Aoyama; Stephen G Young; Dennis E Vance
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis.
The Journal of biological chemistry 2008;283(3):1456-62.
2008: Martin O Bergo; Annika Wahlstrom; Loren G Fong; Stephen G Young
Genetic analyses of the role of RCE1 in RAS membrane association and transformation.
Methods in enzymology 2008;438():367-89.
2008: Shao H Yang; Xin Qiao; Loren G Fong; Stephen G Young
Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.
Biochimica et biophysica acta 2008;1781(1-2):36-9.
2007: Peter Gin; Anne P Beigneux; Brandon Davies; Madeline F Young; Robert O Ryan; André Bensadoun; Loren G Fong; Stephen G Young
Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution.
Biochimica et biophysica acta 2007;1771(12):1464-8.
2007: Jin-A Lee; Anne P Beigneux; S Tariq Ahmad; Stephen G Young; Fen-Biao Gao
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration.
Current biology : CB 2007;17(18):1561-7.
2007: Casey L Moulson; Loren G Fong; Jennifer M Gardner; Emily A Farber; Gloriosa Go; Annalisa Passariello; Dorothy K Grange; Stephen G Young; Jeffrey H Miner
Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.
Human mutation 2007;28(9):882-9.
2007: Catherine Coffinier; Sarah E Hudon; Emily A Farber; Sandy Y Chang; Christine A Hrycyna; Stephen G Young; Loren G Fong
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13432-7.
2007: Stephen G Young; Brandon S J Davies; Loren G Fong; Peter Gin; Michael M Weinstein; André Bensadoun; Anne P Beigneux
GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons.
Current opinion in lipidology 2007;18(4):389-96.
2007: Julie Y Ji; Richard T Lee; Laurent Vergnes; Loren G Fong; Colin L Stewart; Karen Reue; Stephen G Young; Qiuping Zhang; Catherine M Shanahan; Jan Lammerding
Cell nuclei spin in the absence of lamin b1.
The Journal of biological chemistry 2007;282(27):20015-26.
2007: Whittemore G Tingley; Ludmila Pawlikowska; Jonathan G Zaroff; Taeryn Kim; Trieu Nguyen; Stephen G Young; Karen Vranizan; Pui-Yan Kwok; Mary A Whooley; Bruce R Conklin
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8461-6.
2007: Anna-Karin M Sjogren; Karin M E Andersson; Meng Liu; Briony A Cutts; Christin Karlsson; Annika Wahlstrom; Martin Dalin; Carolyn Weinbaum; Patrick J Casey; Andrej Tarkowski; Birgitta Swolin; Stephen G Young; Martin O Bergo
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
The Journal of clinical investigation 2007;117(5):1294-304.
2007: Anne P Beigneux; Brandon S J Davies; Peter Gin; Michael M Weinstein; Emily A Farber; Xin Qiao; Franklin Peale; Stuart Bunting; Rosemary Walzem; Jinny S Wong; William S Blaner; Zhi-Ming Ding; Kristan Melford; Nuttaporn Wongsiriroj; Xiao Shu; Frederic J de Sauvage; Robert O Ryan; Loren G Fong; André Bensadoun; Stephen G Young
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.
Cell metabolism 2007;5(4):279-91.
2007: Annika Wahlstrom; Briony A Cutts; Christin Karlsson; Karin M E Andersson; Meng Liu; Anna-Karin M Sjogren; Birgitta Swolin; Stephen G Young; Martin O Bergo
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease.
Blood 2007;109(2):763-8.
2007: Alex S Nord; Karen Vranizan; Whittemore Tingley; Alexander C Zambon; Kristina Hanspers; Loren G Fong; Yan Hu; Peter Bacchetti; Thomas E Ferrin; Patricia C Babbitt; Scott W Doniger; William C Skarnes; Stephen G Young; Bruce R Conklin
Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
PloS one 2007;2(7):e617.
2006: Stephen G Young; Margarita Meta; Shao H Yang; Loren G Fong
Prelamin A farnesylation and progeroid syndromes.
The Journal of biological chemistry 2006;281(52):39741-5.
2006: Margarita Meta; Shao H Yang; Martin O Bergo; Loren G Fong; Stephen G Young
Protein farnesyltransferase inhibitors and progeria.
Trends in molecular medicine 2006;12(10):480-7.
2006: Jan Lammerding; Loren G Fong; Julie Y Ji; Karen Reue; Colin L Stewart; Stephen G Young; Richard T Lee
Lamins A and C but not lamin B1 regulate nuclear mechanics.
The Journal of biological chemistry 2006;281(35):25768-80.
2006: Zachary Weil; Alex S Huang; Anne P Beigneux; Paul M Kim; Mark E Molliver; Seth Blackshaw; Stephen G Young; Randy J Nelson; Solomon H Snyder
Behavioural alterations in male mice lacking the gene for D-aspartate oxidase.
Behavioural brain research 2006;171(2):295-302.
2006: Shao H Yang; Margarita Meta; Xin Qiao; David Frost; Joy Bauch; Catherine Coffinier; Sharmila Majumdar; Martin O Bergo; Stephen G Young; Loren G Fong
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.
The Journal of clinical investigation 2006;116(8):2115-21.
2006: Kaori Minehira-Castelli; Scott W Leonard; Quinn M Walker; Maret G Traber; Stephen G Young
Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues.
Journal of lipid research 2006;47(8):1733-8.
2006: Anne P Beigneux; Laurent Vergnes; Xin Qiao; Steven Quatela; Ryan Davis; Steven M Watkins; Rosalind A Coleman; Rosemary Walzem; Mark Philips; Karen Reue; Stephen G Young
Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.
Journal of lipid research 2006;47(4):734-44.
2006: Laurent Vergnes; Anne P Beigneux; Ryan Davis; Steven M Watkins; Stephen G Young; Karen Reue
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.
Journal of lipid research 2006;47(4):745-54.
2006: Loren G Fong; David Frost; Margarita Meta; Xin Qiao; Shao H Yang; Catherine Coffinier; Stephen G Young
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.
Science (New York, N.Y.) 2006;311(5767):1621-3.
2006: Alex S Huang; Anne P Beigneux; Zachary Weil; Paul M Kim; Mark E Molliver; Seth Blackshaw; Randy J Nelson; Stephen G Young; Solomon H Snyder
D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(10):2814-9.
2006: Rineke Steenbergen; Terry S Nanowski; Randy Nelson; Stephen G Young; Jean E Vance
Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice.
Biochimica et biophysica acta 2006;1761(3):313-23.
2006: Loren G Fong; Jennifer K Ng; Jan Lammerding; Timothy A Vickers; Margarita Meta; Nathan Coté; Bryant J Gavino; Xin Qiao; Sandy Y Chang; Stephanie R Young; Shao H Yang; Colin L Stewart; Richard T Lee; C Frank Bennett; Martin O Bergo; Stephen G Young
Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
The Journal of clinical investigation 2006;116(3):743-52.
2006: Yan Xie; Elizabeth P Newberry; Stephen G Young; Sylvie Robine; Robert L Hamilton; Jinny S Wong; Jianyang Luo; Susan Kennedy; Nicholas O Davidson
Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency.
The Journal of biological chemistry 2006;281(7):4075-86.
2006: Alex S Nord; Patricia J Chang; Bruce R Conklin; Antony V Cox; Courtney A Harper; Geoffrey G Hicks; Conrad C Huang; Susan J Johns; Michiko Kawamoto; Songyan Liu; Elaine C Meng; John H Morris; Janet Rossant; Patricia Ruiz; William C Skarnes; Philippe Soriano; William L Stanford; Doug Stryke; Harald von Melchner; Wolfgang Wurst; Ken-ichi Yamamura; Stephen G Young; Patricia C Babbitt; Thomas E Ferrin
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
Nucleic acids research 2006;34(Database issue):D642-8.
2005: Rineke Steenbergen; Terry S Nanowski; Anne P Beigneux; Agnes Kulinski; Stephen G Young; Jean E Vance
Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.
The Journal of biological chemistry 2005;280(48):40032-40.
2005: Stephen G Young; Loren G Fong; Susan Michaelis
Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.
Journal of lipid research 2005;46(12):2531-58.
2005: Julia I Toth; Shao H Yang; Xin Qiao; Anne P Beigneux; Michael H Gelb; Casey L Moulson; Jeffrey H Miner; Stephen G Young; Loren G Fong
Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12873-8.
2005: Shao H Yang; Martin O Bergo; Julia I Toth; Xin Qiao; Yan Hu; Salemiz Sandoval; Margarita Meta; Pravin Bendale; Michael H Gelb; Stephen G Young; Loren G Fong
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10291-6.
2005: Shao H Yang; Anuraag Shrivastav; Cynthia Kosinski; Rajendra K Sharma; Miao-Hsueh Chen; Luc Berthiaume; Luanne L Peters; Pao-Tien Chuang; Stephen G Young; Martin O Bergo
N-myristoyltransferase 1 is essential in early mouse development.
The Journal of biological chemistry 2005;280(19):18990-5.
2005: Matthias Schneider; Joseph L Witztum; Stephen G Young; Erwin H Ludwig; Elizabeth R Miller; Sotirios Tsimikas; Linda K Curtiss; Santica M Marcovina; John M Taylor; Richard M Lawn; Thomas L Innerarity; Robert E Pitas
High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins.
Journal of lipid research 2005;46(4):769-78.
2005: Paul E Richardson; Medha Manchekar; Nassrin Dashti; Martin K Jones; Anne P Beigneux; Stephen G Young; Stephen C Harvey; Jere P Segrest
Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle.
Biophysical journal 2005;88(4):2789-800.
2004: Loren G Fong; Jennifer K Ng; Margarita Meta; Nathan Coté; Shao H Yang; Colin L Stewart; Terry Sullivan; Andrew Burghardt; Sharmila Majumdar; Karen Reue; Martin O Bergo; Stephen G Young
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18111-6.
2004: Laurent Vergnes; Miklós Péterfy; Martin O Bergo; Stephen G Young; Karen Reue
Lamin B1 is required for mouse development and nuclear integrity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10428-33.
2004: William C Skarnes; Harald von Melchner; Wolfgang Wurst; Geoff Hicks; Alex S Nord; Tony Cox; Stephen G Young; Patricia Ruiz; Phil Soriano; Marc Tessier-Lavigne; Bruce R Conklin; William L Stanford; Janet Rossant
A public gene trap resource for mouse functional genomics.
Nature genetics 2004;36(6):543-4.
2004: Aaron E Cozen; Hideaki Moriwaki; Michal Kremen; Mary Beth DeYoung; Helén L Dichek; Katherine I Slezicki; Stephen G Young; Murielle Véniant; David A Dichek
Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death.
Circulation 2004;109(17):2129-35.
2004: Anne P Beigneux; Cynthia Kosinski; Bryant J Gavino; Jay D Horton; William C Skarnes; Stephen G Young
ATP-citrate lyase deficiency in the mouse.
The Journal of biological chemistry 2004;279(10):9557-64.
2004: Martin O Bergo; Hsiao D Lieu; Bryant J Gavino; Patricia Ambroziak; James C Otto; Patrick J Casey; Quinn M Walker; Stephen G Young
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
The Journal of biological chemistry 2004;279(6):4729-36.
2004: Martin O Bergo; Bryant J Gavino; Christine Hong; Anne P Beigneux; Martin McMahon; Patrick J Casey; Stephen G Young
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
The Journal of clinical investigation 2004;113(4):539-50.
2003: Abigail L Aiyagari; Brigit R Taylor; Vikas Aurora; Stephen G Young; Kevin Shannon
Hematologic effects of inactivating the Ras processing enzyme Rce1.
Blood 2003;101(6):2250-2.
2003: Hsiao D Lieu; Shannon K Withycombe; Quinn M Walker; James X Rong; Rosemary Walzem; Jinny S Wong; Robert L Hamilton; Edward A Fisher; Stephen G Young
Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.
Circulation 2003;107(9):1315-21.
2003: Doug Stryke; Michiko Kawamoto; Conrad C Huang; Susan J Johns; Leslie A King; Courtney A Harper; Elaine C Meng; Roy E Lee; Alice Yee; Larry L'Italien; Pao-Tien Chuang; Stephen G Young; William C Skarnes; Patricia C Babbitt; Thomas E Ferrin
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research 2003;31(1):278-81.
2003: Sally P A McCormick; Catherine Y Y Liu; Stephen G Young; Lars B Nielsen
Manipulating large insert clones for transgenesis.
Methods in molecular biology (Clifton, N.J.) 2003;209():105-23.
2002: Martin O Bergo; Bryant J Gavino; Rineke Steenbergen; Benedicte Sturbois; Albert F Parlow; David A Sanan; William C Skarnes; Jean E Vance; Stephen G Young
Defining the importance of phosphatidylserine synthase 2 in mice.
The Journal of biological chemistry 2002;277(49):47701-8.
2002: Anne P Beigneux; Shannon K Withycombe; Jennifer A. Digits; William Tschantz; Carolyn A Weinbaum; Stephen M Griffey; Martin O Bergo; Patrick J Casey; Stephen G Young
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver.
The Journal of biological chemistry 2002;277(41):38358-63.
2002: Martin O Bergo; Bryant J Gavino; Jed Ross; Walter K Schmidt; Christine Hong; Lonnie V Kendall; Andreas Mohr; Margarita Meta; Harry K Genant; Yebin Jiang; Erik R Wisner; Nicholas van Bruggen; Richard A D Carano; Susan Michaelis; Stephen M Griffey; Stephen G Young
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13049-54.
2002: Anne P Beigneux; Alan Hofmann; Stephen G Young
Human CYP7A1 deficiency: progress and enigmas.
The Journal of clinical investigation 2002;110(1):29-31.
2002: Johan Björkegren; Anne P Beigneux; Martin O Bergo; Jacquelyn J Maher; Stephen G Young
Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.
The Journal of biological chemistry 2002;277(7):5476-83.
2002: Martin O Bergo; Patricia Ambroziak; Cria Gregory; Amanda George; James C Otto; Edward Kim; Hiroki Nagase; Patrick J Casey; Allan Balmain; Stephen G Young
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
Molecular and cellular biology 2002;22(1):171-81.
2001: J Bjorkegren; Murielle Véniant; SK Kim; Shannon K Withycombe; P A Wood; Marc K Hellerstein; Richard A Neese; Stephen G Young
Lipoprotein secretion and triglyceride stores in the heart.
The Journal of biological chemistry 2001;276(42):38511-7.
2001: Murielle Véniant; Shannon K Withycombe; Stephen G Young
Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1567-70.
2001: GK Leung; Walter K Schmidt; Martin O Bergo; Bryant J Gavino; D H Wong; A Tam; M N Ashby; Susan Michaelis; Stephen G Young
Biochemical studies of Zmpste24-deficient mice.
The Journal of biological chemistry 2001;276(31):29051-8.
2001: Jonathan D Lowenson; E Kim; Stephen G Young; Steven Clarke
Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice.
The Journal of biological chemistry 2001;276(23):20695-702.
2001: Martin O Bergo; GK Leung; Patricia Ambroziak; James C Otto; Patrick J Casey; Anita Q Gomes; Miguel C Seabra; Stephen G Young
Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
The Journal of biological chemistry 2001;276(8):5841-5.
2000: Murielle Véniant; M A Sullivan; SK Kim; Patricia Ambroziak; A Chu; M D Wilson; Marc K Hellerstein; Lawrence L Rudel; Rosemary Walzem; Stephen G Young
Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100.
The Journal of clinical investigation 2000;106(12):1501-10.
2000: E J Cheesman; Rebecca J Sharp; CH Zlot; Catherine Y Y Liu; S Taylor; Santica M Marcovina; Stephen G Young; Sally P A McCormick
An analysis of the interaction between mouse apolipoprotein B100 and apolipoprotein(a).
The Journal of biological chemistry 2000;275(36):28195-200.
2000: Martin O Bergo; GK Leung; Patricia Ambroziak; James C Otto; Patrick J Casey; Stephen G Young
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.
The Journal of biological chemistry 2000;275(23):17605-10.
2000: GK Leung; Murielle Véniant; SK Kim; CH Zlot; M Raabe; Johan Björkegren; Richard A Neese; Marc K Hellerstein; Stephen G Young
A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.
The Journal of biological chemistry 2000;275(11):7515-20.
1999: Edward Kim; J D Lowenson; S Clarke; Stephen G Young
Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase.
The Journal of biological chemistry 1999;274(29):20671-8.
1999: M Raabe; Murielle Véniant; M A Sullivan; CH Zlot; Johan Björkegren; Lars B Nielsen; Jinny S Wong; Robert L Hamilton; Stephen G Young
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.
The Journal of clinical investigation 1999;103(9):1287-98.
1999: Murielle Véniant; Lars B Nielsen; Jan Borén; Stephen G Young
Lipoproteins containing apolipoprotein B-100 are secreted by the heart.
Trends in cardiovascular medicine 1999;9(3-4):103-7.
1999: Lars B Nielsen; M Sullivan; TM Vanni-Reyes; I J Goldberg; Stephen G Young
The DNA sequences required for apolipoprotein B expression in the heart are distinct from those required for expression in the intestine.
Journal of molecular and cellular cardiology 1999;31(4):695-703.
1999: Edward Kim; Patricia Ambroziak; James C Otto; B Taylor; M Ashby; Kevin Shannon; Patrick J Casey; Stephen G Young
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
The Journal of biological chemistry 1999;274(13):8383-90.
1999: J Gosling; Sarah Slaymaker; L Gu; S Tseng; CH Zlot; Stephen G Young; Barrett J Rollins; Israel F Charo
MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.
The Journal of clinical investigation 1999;103(6):773-8.
1999: Murielle Véniant; Edward Kim; S McCormick; Jan Borén; Lars B Nielsen; M Raabe; Stephen G Young
Insights into apolipoprotein B biology from transgenic and gene-targeted mice.
The Journal of nutrition 1999;129(2S Suppl):451S-455S.
1999: CH Zlot; LM Flynn; Murielle Véniant; Edward Kim; M Raabe; Sally P A McCormick; Patricia Ambroziak; L M McEvoy; Stephen G Young
Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice.
Journal of lipid research 1999;40(1):76-84.
1998: Edward Kim; Patricia Ambroziak; Murielle Véniant; Robert L Hamilton; Stephen G Young
A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene.
The Journal of biological chemistry 1998;273(51):33977-84.
1998: M Raabe; Edward Kim; Murielle Véniant; Lars B Nielsen; Stephen G Young
Using genetically engineered mice to understand apolipoprotein-B deficiency syndromes in humans.
Proceedings of the Association of American Physicians 1998;110(6):521-30.
1998: Murielle Véniant; CH Zlot; Rosemary Walzem; V Pierotti; Robert Driscoll; David A Dichek; Joachim Herz; Stephen G Young
Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.
The Journal of clinical investigation 1998;102(8):1559-68.
1998: Lars B Nielsen; D Kahn; Thomas Duell; Heinz-Ulrich G Weier; S Taylor; Stephen G Young
Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes. An intestine-specific enhancer element is located between 54 and 62 kilobases 5' to the structural gene.
The Journal of biological chemistry 1998;273(34):21800-7.
1998: Robert L Hamilton; Jinny S Wong; CM Cham; L B Nielsen; Stephen G Young
Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency.
Journal of lipid research 1998;39(8):1543-57.
1998: Lyn Powell-Braxton; Murielle Véniant; R D Latvala; K I Hirano; Wesley Won; Jed Ross; N Dybdal; Constance Zlot; Stephen G Young; N O Davidson
A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.
Nature medicine 1998;4(8):934-8.
1998: M Raabe; LM Flynn; CH Zlot; Jinny S Wong; Murielle Véniant; Robert L Hamilton; Stephen G Young
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8686-91.
1998: Lars B Nielsen; Murielle Véniant; Jan Borén; M Raabe; Jinny S Wong; Carmen Tam-Amersdorfer; LM Flynn; TM Vanni-Reyes; MD Gunn; I J Goldberg; Robert L Hamilton; Stephen G Young
Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins.
Circulation 1998;98(1):13-6.
1998: Edward Kim; Stephen G Young
Genetically modified mice for the study of apolipoprotein B.
Journal of lipid research 1998;39(4):703-23.
1998: Edward Kim; CM Cham; Murielle Véniant; Patricia Ambroziak; Stephen G Young
Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene.
The Journal of clinical investigation 1998;101(6):1468-77.
1998: Jan Borén; Murielle Véniant; Stephen G Young
Apo B100-containing lipoproteins are secreted by the heart.
The Journal of clinical investigation 1998;101(6):1197-202.
1998: Helén L Dichek; Walter J Brecht; J Fan; Zhong-Sheng Ji; Sally P A McCormick; H Akeefe; L Conzo; David A Sanan; Karl H Weisgraber; Stephen G Young; John M Taylor; Robert W Mahley
Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.
The Journal of biological chemistry 1998;273(4):1896-903.
1997: M J Wu; L W Chen-Liu; Q Xiao; Martin L Phillips; J Elovson; M F Linton; Stephen G Young; Verne N Schumaker
Secretion from cell culture of HDL and VLDL bearing apoB-33 with a large internal deletion.
Journal of lipid research 1997;38(12):2473-82.
1997: Lars B Nielsen; Sally P A McCormick; V Pierotti; Carmen Tam-Amersdorfer; MD Gunn; H Shizuya; Stephen G Young
Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.
The Journal of biological chemistry 1997;272(47):29752-8.
1997: Sally P A McCormick; J K Ng; CM Cham; S Taylor; Santica M Marcovina; J P Segrest; R E Hammer; Stephen G Young
Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein.
The Journal of biological chemistry 1997;272(38):23616-22.
1997: Murielle Véniant; V Pierotti; DL Newland; CM Cham; David A Sanan; Rosemary Walzem; Stephen G Young
Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
The Journal of clinical investigation 1997;100(1):180-8.
1997: E Kim; J D Lowenson; D C MacLaren; S Clarke; Stephen G Young
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6132-7.
1997: J Kreuzer; A L White; T J Knott; Ming-Len Jien; Margarete Mehrabian; J Scott; Stephen G Young; Margaret Haberland
Amino terminus of apolipoprotein B suffices to produce recognition of malondialdehyde-modified low density lipoprotein by the scavenger receptor of human monocyte-macrophages.
Journal of lipid research 1997;38(2):324-42.
1997: Thomas Duell; Lars B Nielsen; A Jones; Stephen G Young; Heinz-Ulrich G Weier
Construction of two near-kilobase resolution restriction maps of the 5' regulatory region of the human apolipoprotein B gene by quantitative DNA fiber mapping (QDFM).
Cytogenetics and cell genetics 1997;79(1-2):64-70.
1996: Robert V Farese; Murielle Véniant; CM Cham; L M Flynn; V Pierotti; Jeanne F Loring; M Traber; S Ruland; R S Stokowski; D Huszar; Stephen G Young
Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6393-8.
1996: Sally P A McCormick; J K Ng; Murielle Véniant; Jan Borén; V Pierotti; L M Flynn; D S Grass; Stephen G Young
Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene.
The Journal of biological chemistry 1996;271(20):11963-70.
1996: K Hirano; Stephen G Young; R V Farese; J Ng; E Sande; C Warburton; Lyn Powell-Braxton; Nicholas O Davidson
Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48.
The Journal of biological chemistry 1996;271(17):9887-90.
1996: Robert V Farese; Sylvaine Cases; S L Ruland; H J Kayden; Jinny S Wong; Stephen G Young; Robert L Hamilton
A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice.
Journal of lipid research 1996;37(2):347-60.
1996: Sally P A McCormick; K R Peterson; R E Hammer; C H Clegg; Stephen G Young
Generation of transgenic mice from yeast artificial chromosome DNA that has been modified by gene targeting.
Trends in cardiovascular medicine 1996;6(1):16-24.
1996: Stephen G Young; Elaine Krul; S McCormick; Robert V Farese; MacRae F Linton
Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia.
Methods in enzymology 1996;263():120-45.
1995: Stephen G Young; CM Cham; Robert E Pitas; B J Burri; A Connolly; L Flynn; Anuradha S Pappu; Jinny S Wong; Robert L Hamilton; Robert V Farese
A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
The Journal of clinical investigation 1995;96(6):2932-46.
1995: F P Mancini; D L Newland; Vincent Mooser; J Murata; Santica Marcovina; Stephen G Young; Robert E Hammer; David A Sanan; Helen H Hobbs
Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1911-6.
1995: J Fan; Sally P A McCormick; R M Krauss; S Taylor; R Quan; John M Taylor; Stephen G Young
Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1889-99.
1995: Sally P A McCormick; J K Ng; S Taylor; L M Flynn; R E Hammer; Stephen G Young
Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10147-51.
1995: Wulf Palinski; Rajendra K Tangirala; E Miller; Stephen G Young; Joseph L Witztum
Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1569-76.
1995: D A Purcell-Huynh; Robert V Farese; D F Johnson; L M Flynn; V Pierotti; D L Newland; MacRae F Linton; David A Sanan; Stephen G Young
Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
The Journal of clinical investigation 1995;95(5):2246-57.
1995: Robert V Farese; S L Ruland; L M Flynn; R P Stokowski; Stephen G Young
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1774-8.
1994: Sally P A McCormick; MacRae F Linton; H H Hobbs; S Taylor; L K Curtiss; Stephen G Young
Expression of human apolipoprotein B90 in transgenic mice. Demonstration that apolipoprotein B90 lacks the structural requirements to form lipoprotein.
The Journal of biological chemistry 1994;269(39):24284-9.
1994: Kay S Arnold; Maureen E Balestra; R M Krauss; L K Curtiss; Stephen G Young; Thomas L Innerarity
Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.
Journal of lipid research 1994;35(8):1469-76.
1994: Stephen G Young; B Bihain; L M Flynn; David A Sanan; M Ayrault-Jarrier; B Jacotot
Asymptomatic homozygous hypobetalipoproteinemia associated with apolipoprotein B45.2.
Human molecular genetics 1994;3(5):741-4.
1994: Stephen G Young; Robert V Farese; V R Pierotti; S Taylor; D S Grass; MacRae F Linton
Transgenic mice expressing human apoB100 and apoB48.
Current opinion in lipidology 1994;5(2):94-101.
1994: Stephen G Young; R K Koduri; R K Austin; D J Bonnet; R S Smith; L K Curtiss
Definition of a nonlinear conformational epitope for the apolipoprotein B-100-specific monoclonal antibody, MB47.
Journal of lipid research 1994;35(3):399-407.
1994: Sally P A McCormick; MacRae F Linton; Stephen G Young
Expression of P1 DNA in mammalian cells and transgenic mice.
Genetic analysis, techniques and applications 1994;11(5-6):158-64.
1993: MacRae F Linton; Robert V Farese; G Chiesa; D S Grass; P Chin; R E Hammer; H H Hobbs; Stephen G Young
Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).
The Journal of clinical investigation 1993;92(6):3029-37.
1993: G Chiesa; D F Johnson; Z Yao; T L Innerarity; Robert W Mahley; Stephen G Young; R H Hammer; Helen H Hobbs
Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.
The Journal of biological chemistry 1993;268(32):23747-50.
1993: S M Synder; J F Terdiman; B Caan; K R Feingold; S T Hubl; R S Smith; Stephen G Young
Relationship of apolipoprotein E phenotypes to hypocholesterolemia.
The American journal of medicine 1993;95(5):480-8.
1993: MacRae F Linton; Robert V Farese; Stephen G Young
Familial hypobetalipoproteinemia.
Journal of lipid research 1993;34(4):521-41.
1993: Stephen G Young; Clive R Pullinger; B R Zysow; H Hofmann-Radvani; M F Linton; Robert V Farese; J F Terdiman; S M Snyder; S M Grundy; G L Vega
Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length.
Journal of lipid research 1993;34(3):501-7.
1992: MacRae F Linton; V Pierotti; Stephen G Young
Reading-frame restoration with an apolipoprotein B gene frameshift mutation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11431-5.
1992: Robert V Farese; L M Flynn; Stephen G Young
Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.
The Journal of clinical investigation 1992;90(1):256-61.
1992: Robert V Farese; MacRae F Linton; Stephen G Young
Apolipoprotein B gene mutations affecting cholesterol levels.
Journal of internal medicine 1992;231(6):643-52.
1992: Robert V Farese; A Garg; V R Pierotti; Gloria Lena Vega; Stephen G Young
A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia.
Journal of lipid research 1992;33(4):569-77.
1991: MacRae F Linton; Robert G Gish; S T Hubl; E Bütler; C Esquivel; W I Bry; J K Boyles; Mark Wardell; Stephen G Young
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
The Journal of clinical investigation 1991;88(1):270-81.
1991: R W Davis; V R Pierotti; S J Lauer; S T Hubl; J W McLean; J L Witztum; Stephen G Young
Lipoproteins in pinnipeds: analysis of a high molecular weight form of apolipoprotein E.
Journal of lipid research 1991;32(6):1013-23.
1991: F K Welty; S T Hubl; V R Pierotti; Stephen G Young
A truncated species of apolipoprotein B (B67) in a kindred with familial hypobetalipoproteinemia.
The Journal of clinical investigation 1991;87(5):1748-54.
1991: Stephen G Young; MacRae F Linton
Genetic abnormalities in apolipoprotein B.
Trends in cardiovascular medicine 1991;1(2):59-65.
1991: Z M Yao; B D Blackhart; MacRae F Linton; S M Taylor; Stephen G Young; B J McCarthy
Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.
The Journal of biological chemistry 1991;266(5):3300-8.
1990: ST Kunitake; Stephen G Young; G C Chen; Clive R Pullinger; S Zhu; R J Pease; J Scott; P Hass; J Schilling; John P Kane
Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content.
The Journal of biological chemistry 1990;265(34):20739-46.
1990: Stephen G Young
Recent progress in understanding apolipoprotein B.
Circulation 1990;82(5):1574-94.
1990: Stephen G Young; S T Hubl; R S Smith; S M Snyder; J F Terdiman
Familial hypobetalipoproteinemia caused by a mutation in the apolipoprotein B gene that results in a truncated species of apolipoprotein B (B-31). A unique mutation that helps to define the portion of the apolipoprotein B molecule required for the formation of buoyant, triglyceride-rich lipoproteins.
The Journal of clinical investigation 1990;85(3):933-42.
1989: Stephen G Young; S T Hubl; D A Chappell; R S Smith; F Claiborne; S M Snyder; J F Terdiman
Familial hypobetalipoproteinemia associated with a mutant species of apolipoprotein B (B-46).
The New England journal of medicine 1989;320(24):1604-10.
1989: Stephen G Young; S T Hubl
An ApaLI restriction site polymorphism is associated with the MB19 polymorphism in apolipoprotein B.
Journal of lipid research 1989;30(3):443-9.
1989: Stephen G Young; Joseph L Witztum; T E Carew; R W Krauss; F T Lindgren
Colestipol-induced changes in LDL composition and metabolism. II. Studies in humans.
Journal of lipid research 1989;30(2):225-38.
1989: Joseph L Witztum; D Simmons; Daniel Steinberg; W F Beltz; R Weinreb; Stephen G Young; P Lester; N Kelly; J Juliano
Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride.
Circulation 1989;79(1):16-28.
1988: Karl H Weisgraber; Thomas L Innerarity; Yvonne Newhouse; Stephen G Young; Kay S Arnold; R M Krauss; Gloria Lena Vega; Scott M Grundy; Robert W Mahley
Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9758-62.
1988: Stephen G Young; S T Northey; B J McCarthy
Low plasma cholesterol levels caused by a short deletion in the apolipoprotein B gene.
Science (New York, N.Y.) 1988;241(4865):591-3.
1988: J E Bird; K Milhoan; C B Wilson; Stephen G Young; C A Mundy; Sampath Parthasarathy; Roland C Blantz
Ischemic acute renal failure and antioxidant therapy in the rat. The relation between glomerular and tubular dysfunction.
The Journal of clinical investigation 1988;81(5):1630-8.
1987: Thomas L Innerarity; Stephen G Young; K S Poksay; Robert W Mahley; R S Smith; R W Milne; Y L Marcel; Karl H Weisgraber
Structural relationship of human apolipoprotein B48 to apolipoprotein B100.
The Journal of clinical investigation 1987;80(6):1794-8.