Steven Younkin

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Relkin Norman R; Szabo Paul; Adamiak Basia; Burgut Tuna; Monthe Carmen; Lent Richard W; Younkin Steven; Younkin Linda; Schiff Richard; Weksler Marc E
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.
Finch NiCole; Baker Matt; Crook Richard; Swanson Katie; Kuntz Karen; Surtees Rebecca; Bisceglio Gina; Rovelet-Lecrux Anne; Boeve Bradley; Petersen Ronald C; Dickson Dennis W; Younkin Steven G; Deramecourt Vincent; Crook Julia; Graff-Radford Neill R; Rademakers Rosa
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members.
Carrasquillo Minerva M; Zou Fanggeng; Pankratz V Shane; Wilcox Samantha L; Ma Li; Walker Louise P; Younkin Samuel G; Younkin Curtis S; Younkin Linda H; Bisceglio Gina D; Ertekin-Taner Nilufer; Crook Julia E; Dickson Dennis W; Petersen Ronald C; Graff-Radford Neill R; Younkin Steven G
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.

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All Publications

2009: Relkin Norman R; Szabo Paul; Adamiak Basia; Burgut Tuna; Monthe Carmen; Lent Richard W; Younkin Steven; Younkin Linda; Schiff Richard; Weksler Marc E
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.
Neurobiology of aging 2009;30(11):1728-36.
2009: Finch NiCole; Baker Matt; Crook Richard; Swanson Katie; Kuntz Karen; Surtees Rebecca; Bisceglio Gina; Rovelet-Lecrux Anne; Boeve Bradley; Petersen Ronald C; Dickson Dennis W; Younkin Steven G; Deramecourt Vincent; Crook Julia; Graff-Radford Neill R; Rademakers Rosa
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members.
Brain : a journal of neurology 2009;132(Pt 3):583-91.
2009: Carrasquillo Minerva M; Zou Fanggeng; Pankratz V Shane; Wilcox Samantha L; Ma Li; Walker Louise P; Younkin Samuel G; Younkin Curtis S; Younkin Linda H; Bisceglio Gina D; Ertekin-Taner Nilufer; Crook Julia E; Dickson Dennis W; Petersen Ronald C; Graff-Radford Neill R; Younkin Steven G
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Nature genetics 2009;41(2):192-8.
2009: Grear Karrie E; Ling I-Fang; Simpson James F; Furman Jennifer L; Simmons Christopher R; Peterson Shawn L; Schmitt Frederick A; Markesbery William R; Liu Qiang; Crook Julia E; Younkin Steven G; Bu Guojun; Estus Steven
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain.
Molecular neurodegeneration 2009;4():46.
2008: Ringman J M; Younkin S G; Pratico D; Seltzer W; Cole G M; Geschwind D H; Rodriguez-Agudelo Y; Schaffer B; Fein J; Sokolow S; Rosario E R; Gylys K H; Varpetian A; Medina L D; Cummings J L
Biochemical markers in persons with preclinical familial Alzheimer disease.
Neurology 2008;71(2):85-92.
2008: Kim Jungsu; Miller Victor M; Levites Yona; West Karen Jansen; Zwizinski Craig W; Moore Brenda D; Troendle Fredrick J; Bann Maralyssa; Verbeeck Christophe; Price Robert W; Smithson Lisa; Sonoda Leilani; Wagg Kayleigh; Rangachari Vijayaraghavan; Zou Fanggeng; Younkin Steven G; Graff-Radford Neill; Dickson Dennis; Rosenberry Terrone; Golde Todd E
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(23):6030-6.
2008: Zhu Haiyan; Taylor Jennie W; Bennett David A; Younkin Steven G; Estus Steven
Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease.
Neurobiology of aging 2008;29(5):793-4.
2008: Zou Fanggeng; Gopalraj Rangaraj K; Lok Johann; Zhu Haiyan; Ling I-Fang; Simpson James F; Tucker H Michael; Kelly Jeremiah F; Younkin Samuel G; Dickson Dennis W; Petersen Ronald C; Graff-Radford Neill R; Bennett David A; Crook Julia E; Younkin Steven G; Estus Steven
Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease.
Human molecular genetics 2008;17(7):929-35.
2008: Kotilinek Linda A; Westerman Marcus A; Wang Qinwen; Panizzon Kimberly; Lim Giselle P; Simonyi Agnes; Lesne Sylvain; Falinska Agnieszka; Younkin Linda H; Younkin Steven G; Rowan Michael; Cleary James; Wallis Roi Ann; Sun Grace Y; Cole Greg; Frautschy Sally; Anwyl Roger; Ashe Karen H
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity.
Brain : a journal of neurology 2008;131(Pt 3):651-64.
2008: Ertekin-Taner N; Younkin L H; Yager D M; Parfitt F; Baker M C; Asthana S; Hutton M L; Younkin S G; Graff-Radford N R
Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families.
Neurology 2008;70(8):596-606.
2008: Park Laibaik; Zhou Ping; Pitstick Rose; Capone Carmen; Anrather Josef; Norris Erin H; Younkin Linda; Younkin Steven; Carlson George; McEwen Bruce S; Iadecola Costantino
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1347-52.
2007: Jankowsky Joanna L; Younkin Linda H; Gonzales Victoria; Fadale Daniel J; Slunt Hilda H; Lester Henry A; Younkin Steven G; Borchelt David R
Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice.
The Journal of biological chemistry 2007;282(31):22707-20.
2007: Ma Huifang; Lesné Sylvain; Kotilinek Linda; Steidl-Nichols Jill V; Sherman Mathew; Younkin Linda; Younkin Steven; Forster Colleen; Sergeant Nicolas; Delacourte André; Vassar Robert; Citron Martin; Kofuji Paulo; Boland Linda M; Ashe Karen H
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8167-72.
2007: Graff-Radford Neill R; Crook Julia E; Lucas John; Boeve Bradley F; Knopman David S; Ivnik Robert J; Smith Glenn E; Younkin Linda H; Petersen Ronald C; Younkin Steven G
Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease.
Archives of neurology 2007;64(3):354-62.
2006: Elesber Ahmad A; Bonetti Piero O; Woodrum Julie E; Zhu Xiang-Yang; Lerman Lilach O; Younkin Steven G; Lerman Amir
Bosentan preserves endothelial function in mice overexpressing APP.
Neurobiology of aging 2006;27(3):446-50.
2006: Harigaya Yasuo; Tomidokoro Yasushi; Ikeda Masaki; Sasaki Atsushi; Kawarabayashi Takeshi; Matsubara Etsuro; Kanai Mitsuyasu; Saido Takaomi C; Younkin Steven G; Shoji Mikio
Type-specific evolution of amyloid plaque and angiopathy in APPsw mice.
Neuroscience letters 2006;395(1):37-41.
2005: Jankowsky Joanna L; Slunt Hilda H; Gonzales Victoria; Savonenko Alena V; Wen Jason C; Jenkins Nancy A; Copeland Neal G; Younkin Linda H; Lester Henry A; Younkin Steven G; Borchelt David R
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
PLoS medicine 2005;2(12):e355.
2005: Rees Tina M; Berson Amit; Sklan Ella H; Younkin Linda; Younkin Steven; Brimijoin Stephen; Soreq Hermona
Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.
Current Alzheimer research 2005;2(3):291-300.
2005: Jankowsky Joanna L; Melnikova Tatiana; Fadale Daniel J; Xu Guilian M; Slunt Hilda H; Gonzales Victoria; Younkin Linda H; Younkin Steven G; Borchelt David R; Savonenko Alena V
Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(21):5217-24.
2005: Wang Deng-Shun; Lipton Richard B; Katz Mindy J; Davies Peter; Buschke Herman; Kuslansky Gail; Verghese Joe; Younkin Steven G; Eckman Chris; Dickson Dennis W
Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging.
Journal of neuropathology and experimental neurology 2005;64(5):378-85.
2005: Park Laibaik; Anrather Josef; Zhou Ping; Frys Kelly; Pitstick Rose; Younkin Steven; Carlson George A; Iadecola Costantino
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(7):1769-77.
2005: Ertekin-Taner Nilüfer; Ronald James; Feuk Lars; Prince Jonathan; Tucker Michael; Younkin Linda; Hella Maria; Jain Shushant; Hackett Alyssa; Scanlin Leah; Kelly Jason; Kihiko-Ehman Muthoni; Neltner Matthew; Hersh Louis; Kindy Mark; Markesbery William; Hutton Michael; de Andrade Mariza; Petersen Ronald C; Graff-Radford Neill; Estus Steve; Brookes Anthony J; Younkin Steven G
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Human molecular genetics 2005;14(3):447-60.
2004: Chiocco Matthew J; Kulnane Laura Shapiro; Younkin Linda; Younkin Steve; Evin Geneviève; Lamb Bruce T
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
The Journal of biological chemistry 2004;279(50):52535-42.
2004: Tucker H Michael; Simpson James; Kihiko-Ehmann Muthoni; Younkin Linda H; McGillis Joseph P; Younkin Steven G; Degen Jay L; Estus Steven
Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice.
Neuroscience letters 2004;368(3):285-9.
2004: Krezowski Joseph; Knudson Danielle; Ebeling Christine; Pitstick Rose; Giri Ranjit K; Schenk Dale; Westaway David; Younkin Linda; Younkin Steven G; Ashe Karen Hsiao; Carlson George A
Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.
Human molecular genetics 2004;13(18):1989-97.
2004: Wen Paul H; Hof Patrick R; Chen Xiaoping; Gluck Karen; Austin Gregory; Younkin Steven G; Younkin Linda H; DeGasperi Rita; Gama Sosa Miguel A; Robakis Nikolaos K; Haroutunian Vahram; Elder Gregory A
The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
Experimental neurology 2004;188(2):224-37.
2004: Kawarabayashi Takeshi; Shoji Mikio; Younkin Linda H; Wen-Lang Lin; Dickson Dennis W; Murakami Tetsuro; Matsubara Etsuro; Abe Koji; Ashe Karen Hsiao; Younkin Steven G
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(15):3801-9.
2004: Ertekin-Taner Nilüfer; Allen Mariet; Fadale Daniel; Scanlin Leah; Younkin Linda; Petersen Ronald C; Graff-Radford Neill; Younkin Steven G
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.
Human mutation 2004;23(4):334-42.
2004: Ikarashi Yasushi; Harigaya Yasuo; Tomidokoro Yasushi; Kanai Mitsuyasu; Ikeda Masaki; Matsubara Etsuro; Kawarabayashi Takeshi; Kuribara Hisashi; Younkin Steven G; Maruyama Yuji; Shoji Mikio
Decreased level of brain acetylcholine and memory disturbance in APPsw mice.
Neurobiology of aging 2004;25(4):483-90.
2004: Ohno Masuo; Sametsky Evgeny A; Younkin Linda H; Oakley Holly; Younkin Steven G; Citron Martin; Vassar Robert; Disterhoft John F
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Neuron 2004;41(1):27-33.
2004: Jankowsky Joanna L; Fadale Daniel J; Anderson Jeffrey; Xu Guilian M; Gonzales Victoria; Jenkins Nancy A; Copeland Neal G; Lee Michael K; Younkin Linda H; Wagner Steven L; Younkin Steven G; Borchelt David R
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Human molecular genetics 2004;13(2):159-70.
2003: Bornebroek Marjolijn; De Jonghe Chris; Haan Joost; Kumar-Singh Samir; Younkin Steve; Roos Raymund; Van Broeckhoven Christine
Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration.
Neurobiology of disease 2003;14(3):619-23.
2003: Ertekin-Taner Nilüfer; Ronald James; Asahara Hideaki; Younkin Linda; Hella Maria; Jain Shushant; Gnida Eugene; Younkin Samuel; Fadale Daniel; Ohyagi Yasumasa; Singleton Adam; Scanlin Leah; de Andrade Mariza; Petersen Ronald; Graff-Radford Neill; Hutton Michael; Younkin Steven
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Human molecular genetics 2003;12(23):3133-43.
2003: Ertekin-Taner Nilüfer; Ronald James; Asahara Hideaki; Younkin Linda; Hella Maria; Jain Shushant; Gnida Eugene; Younkin Samuel; Fadale Daniel; Ohyagi Yasumasa; Singleton Adam; Scanlin Leah; de Andrade Mariza; Petersen Ronald; Graff-Radford Neill; Hutton Michael; Younkin Steven
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Human molecular genetics 2003;12(23):3133-43.
2003: Lehman Emily J H; Kulnane Laura Shapiro; Gao Yuan; Petriello Michelle C; Pimpis Karen M; Younkin Linda; Dolios Georgia; Wang Rong; Younkin Steven G; Lamb Bruce T
Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.
Human molecular genetics 2003;12(22):2949-56.
2003: Rees T; Hammond P I; Soreq H; Younkin S; Brimijoin S
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex.
Neurobiology of aging 2003;24(6):777-87.
2003: McMahon Beth M; Stewart Jennifer; Fauq Abdul; Younkin Steven; Younkin Linda; Richelson Elliott
Peptide nucleic acids targeted to the amyloid precursor protein.
Journal of molecular neuroscience : MN 2003;20(3):261-5.
2002: McMahon Beth M; Stewart Jennifer; Fauq Abdul; Younkin Steven; Younkin Linda; Richelson Elliott
Using peptide nucleic acids as gene-expression modifiers to reduce beta-amyloid levels.
Journal of molecular neuroscience : MN 2002;19(1-2):71-6.
2002: Kotilinek Linda A; Bacskai Brian; Westerman Marcus; Kawarabayashi Takeshi; Younkin Linda; Hyman Bradley T; Younkin Steven; Ashe Karen H
Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6331-5.
2002: Arvanitakis Zoe; Lucas John A; Younkin Linda H; Younkin Steven G; Graff-Radford Neill R
Serum creatinine levels correlate with plasma amyloid Beta protein.
Alzheimer disease and associated disorders 2002;16(3):187-90.
2002: Niwa Kiyoshi; Kazama Ken; Younkin Linda; Younkin Steven G; Carlson George A; Iadecola Costantino
Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein.
American journal of physiology. Heart and circulatory physiology 2002;283(1):H315-23.
2002: Amtul Zareen; Lewis Patrick A; Piper Sian; Crook Richard; Baker Matt; Findlay Kirk; Singleton Andrew; Hogg Marion; Younkin Linda; Younkin Steven G; Hardy John; Hutton Michael; Boeve Bradley F; Tang-Wai David; Golde Todd E
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Westerman Marcus A; Cooper-Blacketer Deirdre; Mariash Ami; Kotilinek Linda; Kawarabayashi Takeshi; Younkin Linda H; Carlson George A; Younkin Steven G; Ashe Karen H
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1858-67.
2002: Niwa Kiyoshi; Kazama Ken; Younkin Steven G; Carlson George A; Iadecola Costantino
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.
Neurobiology of disease 2002;9(1):61-8.
2002: Wahrle Suzanne; Das Pritam; Nyborg Andrew C; McLendon Chris; Shoji Mikio; Kawarabayashi Takeshi; Younkin Linda H; Younkin Steven G; Golde Todd E
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Neurobiology of disease 2002;9(1):11-23.
2002: Basun Hans; Nilsberth Camilla; Eckman Christopher; Lannfelt Lars; Younkin Steven
Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine.
Dementia and geriatric cognitive disorders 2002;14(3):156-60.
2001: Clarke N J; Crow F W; Younkin S; Naylor S
Analysis of in vivo-derived amyloid-beta polypeptides by on-line two-dimensional chromatography-mass spectrometry.
Analytical biochemistry 2001;298(1):32-9.
2001: Das P; Murphy M P; Younkin L H; Younkin S G; Golde T E
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
Neurobiology of aging 2001;22(5):721-7.
2001: Yu H; Saura C A; Choi S Y; Sun L D; Yang X; Handler M; Kawarabayashi T; Younkin L; Fedeles B; Wilson M A; Younkin S; Kandel E R; Kirkwood A; Shen J
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.
Neuron 2001;31(5):713-26.
2001: Nilsberth C; Westlind-Danielsson A; Eckman C B; Condron M M; Axelman K; Forsell C; Stenh C; Luthman J; Teplow D B; Younkin S G; Näslund J; Lannfelt L
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
Nature neuroscience 2001;4(9):887-93.
2001: Tomidokoro Y; Harigaya Y; Matsubara E; Ikeda M; Kawarabayashi T; Shirao T; Ishiguro K; Okamoto K; Younkin S G; Shoji M
Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.
The Journal of pathology 2001;194(4):500-6.
2001: Haugabook S J; Yager D M; Eckman E A; Golde T E; Younkin S G; Eckman C B
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta).
Journal of neuroscience methods 2001;108(2):171-9.
2001: Ertekin-Taner N; Graff-Radford N; Younkin L H; Eckman C; Adamson J; Schaid D J; Blangero J; Hutton M; Younkin S G
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees.
Genetic epidemiology 2001;21(1):19-30.
2001: Golde T E; Younkin S G
Presenilins as therapeutic targets for the treatment of Alzheimer's disease.
Trends in molecular medicine 2001;7(6):264-9.
2001: Kawarabayashi T; Younkin L H; Saido T C; Shoji M; Ashe K H; Younkin S G
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(2):372-81.
2001: Younkin S G
Amyloid beta vaccination: reduced plaques and improved cognition.
Nature medicine 2001;7(1):18-9.
2001: Haugabook S J; Le T; Yager D; Zenk B; Healy B M; Eckman E A; Prada C; Younkin L; Murphy P; Pinnix I; Onstead L; Sambamurti K; Golde T E; Dickson D; Younkin S G; Eckman C B
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):16-18.
2000: Ertekin-Taner N; Graff-Radford N; Younkin L H; Eckman C; Baker M; Adamson J; Ronald J; Blangero J; Hutton M; Younkin S G
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Science (New York, N.Y.) 2000;290(5500):2303-4.
2000: Harigaya Y; Saido T C; Eckman C B; Prada C M; Shoji M; Younkin S G
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.
Biochemical and biophysical research communications 2000;276(2):422-7.
2000: Niwa K; Younkin L; Ebeling C; Turner S K; Westaway D; Younkin S; Ashe K H; Carlson G A; Iadecola C
Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9735-40.
2000: Fagan A M; Younkin L H; Morris J C; Fryer J D; Cole T G; Younkin S G; Holtzman D M
Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.
Annals of neurology 2000;48(2):201-10.
2000: Golde T E; Eckman C B; Younkin S G
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):172-87.
2000: Greenberg S M; Cho H S; O'Donnell H C; Rosand J; Segal A Z; Younkin L H; Younkin S G; Rebeck G W
Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy.
Annals of the New York Academy of Sciences 2000;903():144-9.
2000: Ohyagi Y; Yamada T; Nishioka K; Clarke N J; Tomlinson A J; Naylor S; Nakabeppu Y; Kira J; Younkin S G
Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.
Neuroreport 2000;11(1):167-71.
2000: Palacino J J; Berechid B E; Alexander P; Eckman C; Younkin S; Nye J S; Wolozin B
Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.
The Journal of biological chemistry 2000;275(1):215-22.
1999: Refolo L M; Eckman C; Prada C M; Yager D; Sambamurti K; Mehta N; Hardy J; Younkin S G
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
Journal of neurochemistry 1999;73(6):2383-8.
1999: Benzing W C; Wujek J R; Ward E K; Shaffer D; Ashe K H; Younkin S G; Brunden K R
Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice.
Neurobiology of aging 1999;20(6):581-9.
1999: Sambamurti K; Sevlever D; Koothan T; Refolo L M; Pinnix I; Gandhi S; Onstead L; Younkin L; Prada C M; Yager D; Ohyagi Y; Eckman C B; Rosenberry T L; Younkin S G
Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein.
The Journal of biological chemistry 1999;274(38):26810-4.
1999: Chapman P F; White G L; Jones M W; Cooper-Blacketer D; Marshall V J; Irizarry M; Younkin L; Good M A; Bliss T V; Hyman B T; Younkin S G; Hsiao K K
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.
Nature neuroscience 1999;2(3):271-6.
1999: Iadecola C; Zhang F; Niwa K; Eckman C; Turner S K; Fischer E; Younkin S; Borchelt D R; Hsiao K K; Carlson G A
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.
Nature neuroscience 1999;2(2):157-61.
1998: De Jonghe C; Zehr C; Yager D; Prada C M; Younkin S; Hendriks L; Van Broeckhoven C; Eckman C B
Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.
Neurobiology of disease 1998;5(4):281-6.
1998: Grünberg J; Walter J; Eckman C; Capell A; Schindzielorz A; Younkin S; Mehta N; Hardy J; Haass C
Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Neuroreport 1998;9(14):3293-9.
1998: Citron M; Eckman C B; Diehl T S; Corcoran C; Ostaszewski B L; Xia W; Levesque G; St George Hyslop P; Younkin S G; Selkoe D J
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: Clarke N J; Tomlinson A J; Ohyagi Y; Younkin S; Naylor S
Detection and quantitation of cellularly derived amyloid beta peptides by immunoprecipitation-HPLC-MS.
FEBS letters 1998;430(3):419-23.
1998: Younkin S G
The role of A beta 42 in Alzheimer's disease.
Journal of physiology, Paris 1998;92(3-4):289-92.
1998: Davis J A; Naruse S; Chen H; Eckman C; Younkin S; Price D L; Borchelt D R; Sisodia S S; Wong P C
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Neuron 1998;20(3):603-9.
1998: Murai H; Pierce J E; Raghupathi R; Smith D H; Saatman K E; Trojanowski J Q; Lee V M; Loring J F; Eckman C; Younkin S; McIntosh T K
Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.
The Journal of comparative neurology 1998;392(4):428-38.
1998: Mehta N D; Refolo L M; Eckman C; Sanders S; Yager D; Perez-Tur J; Younkin S; Duff K; Hardy J; Hutton M
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
1998: Holcomb L; Gordon M N; McGowan E; Yu X; Benkovic S; Jantzen P; Wright K; Saad I; Mueller R; Morgan D; Sanders S; Zehr C; O'Campo K; Hardy J; Prada C M; Eckman C; Younkin S; Hsiao K; Duff K
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Nature medicine 1998;4(1):97-100.
1997: Younkin S G
The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43).
Rinsho shinkeigaku = Clinical neurology 1997;37(12):1099.
1997: Eckman C B; Mehta N D; Crook R; Perez-tur J; Prihar G; Pfeiffer E; Graff-Radford N; Hinder P; Yager D; Zenk B; Refolo L M; Prada C M; Younkin S G; Hutton M; Hardy J
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Human molecular genetics 1997;6(12):2087-9.
1997: Zhang F; Eckman C; Younkin S; Hsiao K K; Iadecola C
Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7655-61.
1997: McPhie D L; Lee R K; Eckman C B; Olstein D H; Durham S P; Yager D; Younkin S G; Wurtman R J; Neve R L
Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.
The Journal of biological chemistry 1997;272(40):24743-6.
1997: Carlson G A; Borchelt D R; Dake A; Turner S; Danielson V; Coffin J D; Eckman C; Meiners J; Nilsen S P; Younkin S G; Hsiao K K
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.
Human molecular genetics 1997;6(11):1951-9.
1997: Lamb B T; Call L M; Slunt H H; Bardel K A; Lawler A M; Eckman C B; Younkin S G; Holtz G; Wagner S L; Price D L; Sisodia S S; Gearhart J D
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Human molecular genetics 1997;6(9):1535-41.
1996: Ho L; Fukuchi K i; Younkin S G
The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.
The Journal of biological chemistry 1996;271(48):30929-34.
1996: Borchelt D R; Thinakaran G; Eckman C B; Lee M K; Davenport F; Ratovitsky T; Prada C M; Kim G; Seekins S; Yager D; Slunt H H; Wang R; Seeger M; Levey A I; Gandy S E; Copeland N G; Jenkins N A; Price D L; Younkin S G; Sisodia S S
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Neuron 1996;17(5):1005-13.
1996: Duff K; Eckman C; Zehr C; Yu X; Prada C M; Perez-tur J; Hutton M; Buee L; Harigaya Y; Yager D; Morgan D; Gordon M N; Holcomb L; Refolo L; Zenk B; Hardy J; Younkin S
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
1996: Hsiao K; Chapman P; Nilsen S; Eckman C; Harigaya Y; Younkin S; Yang F; Cole G
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.
Science (New York, N.Y.) 1996;274(5284):99-102.
1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Fukuchi K; Ho L; Younkin S G; Kunkel D D; Ogburn C E; LeBoeuf R C; Furlong C E; Deeb S S; Nochlin D; Wegiel J; Wisniewski H M; Martin G M
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice.
The American journal of pathology 1996;149(1):219-27.
1996: Turner R S; Suzuki N; Chyung A S; Younkin S G; Lee V M
Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation.
The Journal of biological chemistry 1996;271(15):8966-70.
1996: Kawarabayashi T; Shoji M; Sato M; Sasaki A; Ho L; Eckman C B; Prada C M; Younkin S G; Kobayashi T; Tada N; Matsubara E; Iizuka T; Harigaya Y; Kasai K; Hirai S
Accumulation of beta-amyloid fibrils in pancreas of transgenic mice.
Neurobiology of aging 1996;17(2):215-22.
1995: Hsiao K K; Borchelt D R; Olson K; Johannsdottir R; Kitt C; Yunis W; Xu S; Eckman C; Younkin S; Price D
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.
Neuron 1995;15(5):1203-18.
1995: Shaffer L M; Dority M D; Gupta-Bansal R; Frederickson R C; Younkin S G; Brunden K R
Amyloid beta protein (A beta) removal by neuroglial cells in culture.
Neurobiology of aging 1995;16(5):737-45.
1995: Biere A L; Ostaszewski B; Zhao H; Gillespie S; Younkin S G; Selkoe D J
Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing.
Neurobiology of disease 1995;2(3):177-87.
1995: Gravina S A; Ho L; Eckman C B; Long K E; Otvos L; Younkin L H; Suzuki N; Younkin S G
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).
The Journal of biological chemistry 1995;270(13):7013-6.
1995: Younkin S G
Evidence that A beta 42 is the real culprit in Alzheimer's disease.
Annals of neurology 1995;37(3):287-8.
1994: Nakamura T; Shoji M; Harigaya Y; Watanabe M; Hosoda K; Cheung T T; Shaffer L M; Golde T E; Younkin L H; Younkin S G
Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease.
Annals of neurology 1994;36(6):903-11.
1994: Younkin S G
The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.
The Tohoku journal of experimental medicine 1994;174(3):217-23.
1994: Suzuki N; Cheung T T; Cai X D; Odaka A; Otvos L; Eckman C; Golde T E; Younkin S G
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
Science (New York, N.Y.) 1994;264(5163):1336-40.
1993: Wertkin A M; Turner R S; Pleasure S J; Golde T E; Younkin S G; Trojanowski J Q; Lee V M
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9513-7.
1993: Golde T E; Cai X D; Shoji M; Younkin S G
Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():103-8.
1993: Cai X D; Golde T E; Younkin S G
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.
Science (New York, N.Y.) 1993;259(5094):514-6.
1993: Whitehouse P J; Landreth G; Younkin S
Molecular biology of Alzheimer's disease.
Molecular genetic medicine 1993;3():95-137.
1992: Estus S; Golde T E; Younkin S G
Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives.
Annals of the New York Academy of Sciences 1992;674():138-48.
1992: Gillespie S L; Golde T E; Younkin S G
Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation.
Biochemical and biophysical research communications 1992;187(3):1285-90.
1992: Golde T E; Estus S; Younkin L H; Selkoe D J; Younkin S G
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science (New York, N.Y.) 1992;255(5045):728-30.
1991: Lowery D E; Pasternack J M; Gonzalez-DeWhitt P A; Zürcher-Neely H; Tomich C C; Altman R A; Fairbanks M B; Heinrikson R L; Younkin S G; Greenberg B D
Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties.
The Journal of biological chemistry 1991;266(29):19842-50.
1991: Younkin S G
Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP).
Brain pathology (Zurich, Switzerland) 1991;1(4):253-62.
1991: Kalaria R N; Golde T E; Cohen M L; Younkin S G
Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier.
Annals of the New York Academy of Sciences 1991;640():145-8.
1990: Palmert M R; Usiak M; Mayeux R; Raskind M; Tourtellotte W W; Younkin S G
Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease.
Neurology 1990;40(7):1028-34.
1990: Podlisny M B; Mammen A L; Schlossmacher M G; Palmert M R; Younkin S G; Selkoe D J
Detection of soluble forms of the beta-amyloid precursor protein in human plasma.
Biochemical and biophysical research communications 1990;167(3):1094-101.
1990: Golde T E; Estus S; Usiak M; Younkin L H; Younkin S G
Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.
Neuron 1990;4(2):253-67.
1989: Pasternack J M; Abraham C R; Van Dyke B J; Potter H; Younkin S G
Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.
The American journal of pathology 1989;135(5):827-34.
1989: Palmert M R; Siedlak S L; Podlisny M B; Greenberg B; Shelton E R; Chan H W; Usiak M; Selkoe D J; Perry G; Younkin S G
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Biochemical and biophysical research communications 1989;165(1):182-8.
1989: Palmert M R; Podlisny M B; Witker D S; Oltersdorf T; Younkin L H; Selkoe D J; Younkin S G
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6338-42.
1988: Palmert M R; Podlisny M B; Witker D S; Oltersdorf T; Younkin L H; Selkoe D J; Younkin S G
Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques.
Biochemical and biophysical research communications 1988;156(1):432-7.
1988: Palmert M R; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Usiak M F; Younkin L H; Younkin S G
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
Science (New York, N.Y.) 1988;241(4869):1080-4.
1988: Cohen M L; Golde T E; Usiak M F; Younkin L H; Younkin S G
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1227-31.
1988: Younkin L H; McTiernan C F; Younkin S G
Effect of fibrillation on acetylcholinesterase mRNA in cultured embryonic rat myotubes.
Experimental cell research 1988;174(1):279-81.
1986: Younkin S G; Goodridge B; Katz J; Lockett G; Nafziger D; Usiak M F; Younkin L H
Molecular forms of acetylcholinesterases in Alzheimer's disease.
Federation proceedings 1986;45(13):2982-8.
1986: Brockman S K; Younkin S G
Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes.
Brain research 1986;376(2):409-11.
1986: Brockman S K; Usiak M F; Younkin S G
Assembly of monomeric acetylcholinesterase into tetrameric and asymmetric forms.
The Journal of biological chemistry 1986;261(3):1201-7.
1984: Newman J R; Virgin J B; Younkin L H; Younkin S G
Turnover of acetylcholinesterase in innervated and denervated rat diaphragm.
The Journal of physiology 1984;352():305-18.
1984: Brockman S K; Younkin L H; Younkin S G
The effect of spontaneous electromechanical activity on the metabolism of acetylcholinesterase in cultured embryonic rat myotubes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(1):131-40.
1982: Brockman S K; Przybylski R J; Younkin S G
Cellular localization of the molecular forms of acetylcholinesterase in cultured embryonic rat myotubes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(12):1775-85.
1982: Collins P L; Younkin S G
Effect of denervation on the molecular forms of acetylcholinesterase in rat diaphragm.
The Journal of biological chemistry 1982;257(22):13638-44.
1982: Younkin S G; Rosenstein C; Collins P L; Rosenberry T L
Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm.
The Journal of biological chemistry 1982;257(22):13630-7.
1982: Younkin S G; Younkin L H; Zoller M; Rosenstein C
Partial purification by vacuum distillation of a factor that increases the junctional acetylcholinesterase of organ cultured rat diaphragm.
Brain research 1982;249(1):192-4.
1982: Brett R S; Younkin S G; Konieczkowski M; Slugg R M
Accelerated degradation of junctional acetylcholine receptor-alpha-bungarotoxin complexes in denervated rat diaphragm.
Brain research 1982;233(1):133-42.
1981: Olek A; Younkin S; Slugg R M; Konieczkowski M; Robbins N
A transient increase in junctional acetylcholine receptors after denervation.
Brain research 1981;214(2):429-32.
1979: Jänig W; Spencer W A; Younkin S G
Spatial and temporal features of afferent inhibition of thalamocortical relay cells.
Journal of neurophysiology 1979;42(5):1450-60.
1979: Davey B; Younkin L H; Younkin S G
Neural control of skeletal muscle cholinesterase: a study using organ-cultured rat muscle.
The Journal of physiology 1979;289():501-15.
1978: DeCoursey T E; Younkin S G; Bryant S H
Neural control of chloride conductance in rat extensor digitorum longus muscle.
Experimental neurology 1978;61(3):705-9.
1978: Younkin S G; Brett R S; Davey B; Younkin L
Substances moved by axonal transport and released by nerve stimulation have an innervation-like effect on muscle.
Science (New York, N.Y.) 1978;200(4347):1292-5.
1978: Davey B; Younkin S G
Effect of nerve stump length on cholinesterase in denervated rat diaphragm.
Experimental neurology 1978;59(1):168-75.
1977: Tiedt T N; Wisler P L; Younkin S G
Neurotrophic regulation of resting membrane potential and acetylcholine sensitivity in rat extensor digitorum longus muscle.
Experimental neurology 1977;57(3):766-91.
1974: Younkin S G
An analysis of the role of calcium in facilitation at the frog neuromuscular junction.
The Journal of physiology 1974;237(1):1-14.

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