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Bao-Zhu Yu

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Bao-Zhu Yu; Shi Bai; Otto G Berg; Mahendra K Jain
Allosteric effect of amphiphile binding to phospholipase A(2).
Otto G Berg; Bao-Zhu Yu; Mahendra K Jain
Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
Bao-Zhu Yu; Rajani Kaimal; Shi Bai; Khalid A El Sayed; Suren A Tatulian; Rafael Apitz-Castro; Mahendra K Jain; Ruitang Deng; Otto G Berg
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.

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All Publications

2009: Bao-Zhu Yu; Shi Bai; Otto G Berg; Mahendra K Jain
Allosteric effect of amphiphile binding to phospholipase A(2).
Biochemistry 2009;48(14):3219-29.
2009: Otto G Berg; Bao-Zhu Yu; Mahendra K Jain
Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
Biochemistry 2009;48(14):3209-18.
2009: Bao-Zhu Yu; Rajani Kaimal; Shi Bai; Khalid A El Sayed; Suren A Tatulian; Rafael Apitz-Castro; Mahendra K Jain; Ruitang Deng; Otto G Berg
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
Journal of natural products 2009;72(1):24-8.
2007: Bao-Zhu Yu; Rafael Apitz-Castro; Mahendra K Jain; Otto G Berg
Role of 57-72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A(2): regulation of fat and cholesterol homeostasis.
Biochimica et biophysica acta 2007;1768(10):2478-90.
2006: Yu-Cheng Tsai; Bao-Zhu Yu; Yu-Zhen Wang; Junghuei Chen; Mahendra K Jain
Desolvation map of the i-face of phospholipase A2.
Biochimica et biophysica acta 2006;1758(5):653-65.
2005: Bao-Zhu Yu; Tatyana Polenova; Mahendra K Jain; Otto G Berg
Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover.
Biochimica et biophysica acta 2005;1712(2):137-51.
2005: Bao-Zhu Yu; Ying H Pan; Marcel J W Janssen; Brian J Bahnson; Mahendra K Jain
Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns.
Biochemistry 2005;44(9):3369-79.
2004: Otto G Berg; Bao-Zhu Yu; Cherry Chang; Karl A Koehler; Mahendra K Jain
Cooperative binding of monodisperse anionic amphiphiles to the i-face: phospholipase A2-paradigm for interfacial binding.
Biochemistry 2004;43(25):7999-8013.
2004: Otto G Berg; Bao-Zhu Yu; Rafael Apitz-Castro; Mahendra K Jain
Phosphatidylinositol-specific phospholipase C forms different complexes with monodisperse and micellar phosphatidylcholine.
Biochemistry 2004;43(7):2080-90.
2003: Bao-Zhu Yu; Rafael Apitz-Castro; Ming-Daw Tsai; Mahendra K Jain
Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.
Biochemistry 2003;42(20):6293-301.
2002: Ying H Pan; Bao-Zhu Yu; Otto G Berg; Mahendra K Jain; Brian J Bahnson
Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
Biochemistry 2002;41(50):14790-800.
2002: Ying H Pan; Bao-Zhu Yu; Alan G Singer; Farideh Ghomashchi; Gérard Lambeau; Michael H Gelb; Mahendra K Jain; Brian J Bahnson
Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
The Journal of biological chemistry 2002;277(32):29086-93.
2002: Bao-Zhu Yu; David Zakim; Mahendra K Jain
Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles.
Biochimica et biophysica acta 2002;1583(1):122-32.
2001: T M Epstein; Bao-Zhu Yu; Ying H Pan; S P Tutton; Badri P Maliwal; Mahendra K Jain; Brian J Bahnson
The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure.
Biochemistry 2001;40(38):11411-22.
2000: Bao-Zhu Yu; Ming-Jye Poi; Udupi A Ramagopal; R Jain; Suryanarayanarao Ramakumar; Otto G Berg; Ming-Daw Tsai; K Sekar; Mahendra K Jain
Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.
Biochemistry 2000;39(40):12312-23.
2000: Bao-Zhu Yu; Marcel J W Janssen; HM Verheij; Mahendra K Jain
Control of the chemical step by leucine-31 of pancreatic phospholipase A2.
Biochemistry 2000;39(19):5702-11.
1999: Bao-Zhu Yu; Otto G Berg; Mahendra K Jain
Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles.
Biochemistry 1999;38(32):10449-56.
1999: Bao-Zhu Yu; J Rogers; Ming-Daw Tsai; C Pidgeon; Mahendra K Jain
Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis, and activation.
Biochemistry 1999;38(15):4875-84.
1998: Bao-Zhu Yu; J Rogers; G R Nicol; Klaus H Theopold; K Seshadri; S Vishweshwara; Mahendra K Jain
Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2.
Biochemistry 1998;37(36):12576-87.
1998: Y Lin; Farideh Ghomashchi; Robert Nielsen; Y Snitko; Bao-Zhu Yu; S K Han; Wonhwa Cho; David C Wilton; Mahendra K Jain; Bruce H Robinson; Michael H Gelb
Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics.
Biochemical Society transactions 1998;26(3):341-5.
1998: J Rogers; Bao-Zhu Yu; Ming-Daw Tsai; Otto G Berg; Mahendra K Jain
Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2.
Biochemistry 1998;37(26):9549-56.
1998: Farideh Ghomashchi; Y Lin; Mark Hixon; Bao-Zhu Yu; R Annand; Mahendra K Jain; Michael H Gelb
Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
Biochemistry 1998;37(19):6697-710.
1998: Otto G Berg; Yolanda Cajal; G L Butterfoss; R L Grey; M Asunción Alsina; Bao-Zhu Yu; Mahendra K Jain
Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid.
Biochemistry 1998;37(19):6615-27.
1997: Otto G Berg; J Rogers; Bao-Zhu Yu; J Yao; L S Romsted; Mahendra K Jain
Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces.
Biochemistry 1997;36(47):14512-30.
1997: Bao-Zhu Yu; J Rogers; G Ranadive; S Baker; David C Wilton; Rafael Apitz-Castro; Mahendra K Jain
Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates.
Biochemistry 1997;36(41):12400-11.
1997: Bao-Zhu Yu; Farideh Ghomashchi; Yolanda Cajal; R R Annand; Otto G Berg; Michael H Gelb; Mahendra K Jain
Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2.
Biochemistry 1997;36(13):3870-81.
1997: K Sekar; Bao-Zhu Yu; J Rogers; J Lutton; Xiaoping Liu; X Chen; Ming-Daw Tsai; Mahendra K Jain; Muttaiya Sundaralingam
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.
Biochemistry 1997;36(11):3104-14.
1996: J Rogers; Bao-Zhu Yu; S V Serves; G M Tsivgoulis; D N Sotiropoulos; P V Ioannou; Mahendra K Jain
Kinetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2.
Biochemistry 1996;35(29):9375-84.
1995: T Bayburt; Bao-Zhu Yu; I Street; Farideh Ghomashchi; F Laliberté; Hélène Perrier; Z Wang; R Homan; Mahendra K Jain; Michael H Gelb
Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2.
Analytical biochemistry 1995;232(1):7-23.
1995: Mahendra K Jain; Bao-Zhu Yu; J M Rogers; A E Smith; E T Boger; R L Ostrander; A L Rheingold
Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius.
Phytochemistry 1995;39(3):537-47.
1993: Mahendra K Jain; Bao-Zhu Yu; Otto G Berg
Relationship of interfacial equilibria to interfacial activation of phospholipase A2.
Biochemistry 1993;32(42):11319-29.
1993: Bao-Zhu Yu; Otto G Berg; Mahendra K Jain
The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2.
Biochemistry 1993;32(25):6485-92.
1993: T Bayburt; Bao-Zhu Yu; H K Lin; J Browning; Mahendra K Jain; Michael H Gelb
Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors.
Biochemistry 1993;32(2):573-82.
1992: Mahendra K Jain; Farideh Ghomashchi; Bao-Zhu Yu; T Bayburt; D Murphy; D Houck; J Brownell; J C Reid; J E Solowiej; S M Wong
Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2.
Journal of medicinal chemistry 1992;35(19):3584-6.
1992: Mahendra K Jain; Bao-Zhu Yu; J Rogers; Michael H Gelb; Ming-Daw Tsai; EK Hendrickson; HS Hendrickson
Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover.
Biochemistry 1992;31(34):7841-7.
1992: J Rogers; Bao-Zhu Yu; Mahendra K Jain
Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase A2.
Biochemistry 1992;31(26):6056-62.
1991: Mahendra K Jain; W J Tao; J Rogers; C Arenson; H Eibl; Bao-Zhu Yu
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues.
Biochemistry 1991;30(42):10256-68.
1991: Farideh Ghomashchi; Bao-Zhu Yu; E D Mihelich; Mahendra K Jain; Michael H Gelb
Kinetic characterization of phospholipase A2 modified by manoalogue.
Biochemistry 1991;30(40):9559-69.
1991: Mahendra K Jain; G Ranadive; Bao-Zhu Yu; H M Verheij
Interfacial catalysis by phospholipase A2: monomeric enzyme is fully catalytically active at the bilayer interface.
Biochemistry 1991;30(29):7330-40.
1991: Farideh Ghomashchi; Bao-Zhu Yu; Otto G Berg; Mahendra K Jain; Michael H Gelb
Interfacial catalysis by phospholipase A2: substrate specificity in vesicles.
Biochemistry 1991;30(29):7318-29.
1991: Mahendra K Jain; Bao-Zhu Yu; J Rogers; G N Ranadive; Otto G Berg
Interfacial catalysis by phospholipase A2: dissociation constants for calcium, substrate, products, and competitive inhibitors.
Biochemistry 1991;30(29):7306-17.
1991: Otto G Berg; Bao-Zhu Yu; J Rogers; Mahendra K Jain
Interfacial catalysis by phospholipase A2: determination of the interfacial kinetic rate constants.
Biochemistry 1991;30(29):7283-97.
1989: Mahendra K Jain; Bao-Zhu Yu; Arkadiusz Kozubek
Binding of phospholipase A2 to zwitterionic bilayers is promoted by lateral segregation of anionic amphiphiles.
Biochimica et biophysica acta 1989;980(1):23-32.
1989: Bao-Zhu Yu; Mahendra K Jain
Segregation of anionic lipophiles in bilayers monitored by binding of cationic dye NK-529.
Biochimica et biophysica acta 1989;980(1):15-22.