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Christopher Broder

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Zhongyu Zhu; Christopher C Broder; Weizao Chen; Rui Gong; Prabakaran Ponraj; Dimiter S Dimitrov
Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.
Gerald V Quinnan; Pengfei Zhang; Hong Chen; Ming Dong; Yan-Ru Feng; Mark Lewis; Christopher C Broder
Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins.
Yee Peng Chan; Somnath Dutta; Yan-Ru Feng; Michael Flora; Min Lu; Dimitar B Nikolov; georgios skiniotis; Lin-Fa Wang; Kai Xu; Lianying Yan; Jennifer Barr; Christopher C Broder
Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins.

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All Publications

2013: Zhongyu Zhu; Christopher C Broder; Weizao Chen; Rui Gong; Prabakaran Ponraj; Dimiter S Dimitrov
Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.
Virologica Sinica 2013;28(2):71-80.
2013: Gerald V Quinnan; Pengfei Zhang; Hong Chen; Ming Dong; Yan-Ru Feng; Mark Lewis; Christopher C Broder
Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins.
PloS one 2013;8(3):e59803.
2012: Yee Peng Chan; Somnath Dutta; Yan-Ru Feng; Michael Flora; Min Lu; Dimitar B Nikolov; georgios skiniotis; Lin-Fa Wang; Kai Xu; Lianying Yan; Jennifer Barr; Christopher C Broder
Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins.
Journal of virology 2012;86(21):11457-71.
2012: Katharine N Bossart; Douglas Brining; Christopher C Broder; Yee Peng Chan; Friederike Feldmann; Heinz Feldmann; Yan-Ru Feng; Joan B Geisbert; Andrew C Hickey; Rachel LaCasse; Barry Rockx; Dana Scott; Thomas W Geisbert
A Hendra virus G glycoprotein subunit vaccine protects African green monkeys from Nipah virus challenge.
Science translational medicine 2012;4(146):146ra107.
2012: Christopher C Broder
Henipavirus outbreaks to antivirals: the current status of potential therapeutics.
Current opinion in virology 2012;2(2):176-87.
2012: Michelle L Colgrave; Yan-Ru Feng; Katharine N Bossart; Christopher C Broder; Yee Peng Chan; Dimitar B Nikolov; Brian J Shiell; Hayley J Snelling; Kai Xu; Wojtek P Michalski
Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus.
Glycobiology 2012;22(4):572-84.
2012: Deborah L Steffen; Kai Xu; Dimitar B Nikolov; Christopher C Broder
Henipavirus mediated membrane fusion, virus entry and targeted therapeutics.
Viruses 2012;4(2):280-308.
2012: Tzanko S Stantchev; Christopher C Broder; Carla R Lankford; Mark Paciga; Franziska Schwartzkopff; Kathleen A Clouse
Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection.
Retrovirology 2012;9():97.
2012: Kai Xu; Lianying Yan; Kanagalaghatta R Rajashankar; Christopher C Broder; Yee Peng Chan; Dimple Khetawat; Momchil V Kolev; Dimitar B Nikolov
New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.
PloS one 2012;7(11):e48742.
2012: Christopher C Broder; Thomas W Geisbert; Deborah Middleton; Dimitar B Nikolov; Jackie Pallister; Lin-Fa Wang; Kai Xu; Katharine N Bossart
Immunization strategies against henipaviruses.
Current topics in microbiology and immunology 2012;359():197-223.
2011: Katharine N Bossart; Douglas Brining; Christopher C Broder; Julie Callison; Yee Peng Chan; Antony S Dimitrov; Dimiter S Dimitrov; Friederike Feldmann; Heinz Feldmann; Yan-Ru Feng; Joan B Geisbert; Thomas W Geisbert; Andrew C Hickey; Dana Scott; Yanping Wang; Lianying Yan; Zhongyu Zhu; Barry Rockx
A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge.
Science translational medicine 2011;3(105):105ra103.
2011: Junfa Yuan; Lin-Fa Wang; Christopher C Broder; Dimple Khetawat; Glenn Marsh; Zhengli Shi
Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection.
The Journal of general virology 2011;92(Pt 9):2142-52.
2011: Jackie Pallister; Jean Payne; Rachel Robinson; Lin-Fa Wang; John R White; Manabu Yamada; Yee Peng Chan; Yan-Ru Feng; Jessica Haining; Reuben Klein; Deborah Middleton; Christopher C Broder
A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge.
Vaccine 2011;29(34):5623-30.
2011: Jessica Celigoy; Yan-Ru Feng; Gerald V Quinnan; Benjamin Ramirez; Li Rong; Lin Tao; Lianying Yan; Christopher C Broder; Michael Caffrey
Probing the HIV gp120 envelope glycoprotein conformation by NMR.
The Journal of biological chemistry 2011;286(27):23975-81.
2010: Gabriel N Defang; Dimple Khetawat; Christopher C Broder; Gerald V Quinnan
Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system.
Vaccine 2010;29(2):212-20.
2010: Barry Rockx; Katharine N Bossart; Friederike Feldmann; Joan B Geisbert; Andrew C Hickey; Douglas Brining; Julie Callison; David Safronetz; Andrea Marzi; Lisa Kercher; Dan Long; Christopher C Broder; Heinz Feldmann; Thomas W Geisbert
A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment.
Journal of virology 2010;84(19):9831-9.
2010: Derek Dube; Kathryn L Schornberg; Charles J Shoemaker; Sue E Delos; Tzanko S Stantchev; Kathleen A Clouse; Christopher C Broder; Judith M White
Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(38):16637-42.
2010: Bharat Khurana; Lei Zhuang; Prasun K Moitra; Tzanko S Stantchev; Christopher C Broder; Mary Lou Cutler; Peter D'Arpa
Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.
Virology journal 2010;7():332.
2010: Dimple Khetawat; Christopher C Broder
A functional henipavirus envelope glycoprotein pseudotyped lentivirus assay system.
Virology journal 2010;7():312.
2010: Thomas W Geisbert; Kathleen M Daddario-DiCaprio; Andrew C Hickey; Mark A Smith; Yee Peng Chan; Lin-Fa Wang; Joseph J Mattapallil; Joan B Geisbert; Katharine N Bossart; Christopher C Broder
Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection.
PloS one 2010;5(5):e10690.
2009: Katharine N Bossart; Zhongyu Zhu; Deborah Middleton; Jessica Klippel; Gary Crameri; John Bingham; Jennifer McEachern; Diane Green; Timothy J Hancock; Yee Peng Chan; Andrew C Hickey; Dimiter S Dimitrov; Lin-Fa Wang; Christopher C Broder
A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection.
PLoS pathogens 2009;5(10):e1000642.
2009: Prabakaran Ponraj; Zhongyu Zhu; Xiaodong Xiao; Arya Biragyn; Antony S Dimitrov; Christopher C Broder; Dimiter S Dimitrov
Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.
Expert opinion on biological therapy 2009;9(3):355-68.
2009: Jorge C G Blanco; Lioubov M Pletneva; Lindsay Wieczorek; Dimple Khetawat; Tzanko S Stantchev; Christopher C Broder; Victoria R Polonis; Gregory A Prince
Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection.
Virology journal 2009;6():57.
2009: Yee Peng Chan; Lianying Yan; Yan-Ru Feng; Christopher C Broder
Preparation of recombinant viral glycoproteins for novel and therapeutic antibody discovery.
Methods in molecular biology (Clifton, N.J.) 2009;525():31-58, xiii.
2009: Dimana Dimitrova; Vidita Choudhry; Christopher C Broder
Antibody fragment expression and purification.
Methods in molecular biology (Clifton, N.J.) 2009;525():491-8, xiii.
2008: Kimberly A Bishop; Andrew C Hickey; Dimple Khetawat; Jared R Patch; Katharine N Bossart; Zhongyu Zhu; Lin-Fa Wang; Dimiter S Dimitrov; Christopher C Broder
Residues in the stalk domain of the hendra virus g glycoprotein modulate conformational changes associated with receptor binding.
Journal of virology 2008;82(22):11398-409.
2008: Julie A Pavlin; Andrew C Hickey; Nancy D Ulbrandt; Yee Peng Chan; Timothy Endy; Marina S Boukhvalova; Supamit Chunsuttiwat; Ananda Nisalak; Daniel H Libraty; Sharone Green; Alan L Rothman; Irene Bosch; Rick G Jarman; Robert V Gibbons; Christopher C Broder
Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein.
The Journal of infectious diseases 2008;198(6):836-42.
2008: Jennifer McEachern; John Bingham; Gary Crameri; Diane J Green; Tim J Hancock; Deborah Middleton; Yan-Ru Feng; Christopher C Broder; Lin-Fa Wang; Katharine N Bossart
A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats.
Vaccine 2008;26(31):3842-52.
2008: Katharine N Bossart; Mary Tachedjian; Jennifer McEachern; Gary Crameri; Zhongyu Zhu; Dimiter S Dimitrov; Christopher C Broder; Lin-Fa Wang
Functional studies of host-specific ephrin-B ligands as Henipavirus receptors.
Virology 2008;372(2):357-71.
2008: Jared R Patch; Ziying Han; Sarah E McCarthy; Lianying Yan; Lin-Fa Wang; Ronald N Harty; Christopher C Broder
The YPLGVG sequence of the Nipah virus matrix protein is required for budding.
Virology journal 2008;5():137.
2007: Bruce A Mungall; Deborah Middleton; Gary Crameri; Kim Halpin; John Bingham; Bryan T Eaton; Christopher C Broder
Vertical transmission and fetal replication of Nipah virus in an experimentally infected cat.
The Journal of infectious diseases 2007;196(6):812-6.
2007: Vidita Choudhry; Mei-Yun Zhang; Igor A Sidorov; John M Louis; Ilia Harris; Antony S Dimitrov; Peter Bouma; Fatim Cham; Anil Choudhary; Susanna M Rybak; Timothy R Fouts; David C Montefiori; Christopher C Broder; Gerald V Quinnan; Dimiter S Dimitrov
Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies.
Virology 2007;363(1):79-90.
2007: Peng Fei Zhang; Fatim Cham; Ming Dong; Anil Choudhary; Peter Bouma; Zhiqiang Zhang; Yiming Shao; Yan-Ru Feng; Lemin Wang; Nathalie Mathy; Gerald Voss; Christopher C Broder; Gerald V Quinnan
Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10193-8.
2007: Kimberly A Bishop; Tzanko S Stantchev; Andrew C Hickey; Dimple Khetawat; Katharine N Bossart; Valery Krasnoperov; Parkash Gill; Yan-Ru Feng; Lemin Wang; Bryan T Eaton; Lin-Fa Wang; Christopher C Broder
Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.
Journal of virology 2007;81(11):5893-901.
2007: Tzanko S Stantchev; Ingrid Markovic; William G Telford; Kathleen A Clouse; Christopher C Broder
The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages.
Virus research 2007;123(2):178-89.
2007: Jared R Patch; Gary Crameri; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein.
Virology journal 2007;4():1.
2006: Mei-Yun Zhang; Vidita Choudhry; Igor A Sidorov; Vladimir Tenev; Bang K Vu; Anil Choudhary; Hong Lu; Gabriela Stiegler; Hermann Katinger; Shibo Jiang; Christopher C Broder; Dimiter S Dimitrov
Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning.
Journal of immunological methods 2006;317(1-2):21-30.
2006: Bruce A Mungall; Deborah Middleton; Gary Crameri; John Bingham; Kim Halpin; Gail Russell; Diane Green; Jennifer McEachern; L Ian Pritchard; Bryan T Eaton; Lin-Fa Wang; Katharine N Bossart; Christopher C Broder
Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine.
Journal of virology 2006;80(24):12293-302.
2006: Zhongyu Zhu; Antony S Dimitrov; Samitabh Chakraborti; Dimana Dimitrova; Xiaodong Xiao; Christopher C Broder; Dimiter S Dimitrov
Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses.
Expert review of anti-infective therapy 2006;4(1):57-66.
2006: Katharine N Bossart; Christopher C Broder
Developments towards effective treatments for Nipah and Hendra virus infection.
Expert review of anti-infective therapy 2006;4(1):43-55.
2006: Zhongyu Zhu; Antony S Dimitrov; Katharine N Bossart; Gary Crameri; Kimberly A Bishop; Vidita Choudhry; Bruce A Mungall; Yan-Ru Feng; Anil Choudhary; Mei-Yun Zhang; Yang Feng; Lin-Fa Wang; Xiaodong Xiao; Bryan T Eaton; Christopher C Broder; Dimiter S Dimitrov
Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies.
Journal of virology 2006;80(2):891-9.
2006: Bryan Eaton; Christopher C Broder; Deborah Middleton; Lin-Fa Wang
Hendra and Nipah viruses: different and dangerous.
Nature reviews. Microbiology 2006;4(1):23-35.
2005: Bryan Eaton; Christopher C Broder; Lin-Fa Wang
Hendra and Nipah viruses: pathogenesis and therapeutics.
Current molecular medicine 2005;5(8):805-16.
2005: Matthew I Bonaparte; Antony S Dimitrov; Katharine N Bossart; Gary Crameri; Bruce A Mungall; Kimberly A Bishop; Vidita Choudhry; Dimiter S Dimitrov; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10652-7.
2005: Katharine N Bossart; Gary Crameri; Antony S Dimitrov; Bruce A Mungall; Yan-Ru Feng; Jared R Patch; Anil Choudhary; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus.
Journal of virology 2005;79(11):6690-702.
2005: Gerald V Quinnan; XIAOFANG YU; Mark G Lewis; Peng Fei Zhang; Gerd Sutter; Peter Silvera; Ming Dong; Anil Choudhary; Phuong Thi Nguyen Sarkis; Peter Bouma; Zhiqiang Zhang; David C Montefiori; Thomas C VanCott; Christopher C Broder
Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells.
Journal of virology 2005;79(6):3358-69.
2005: Katharine N Bossart; Bruce A Mungall; Gary Crameri; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein.
Virology journal 2005;2():57.
2004: Mei-Yun Zhang; Xiaodong Xiao; Igor A Sidorov; Vidita Choudhry; Fatim Cham; Peng Fei Zhang; Peter Bouma; Michael B Zwick; Anil Choudhary; David C Montefiori; Christopher C Broder; Dennis R Burton; Gerald V Quinnan; Dimiter S Dimitrov
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Journal of virology 2004;78(17):9233-42.
2004: Ingrid Markovic; Tzanko S Stantchev; Karen H Fields; Linda J Tiffany; Melanija Tomiç; Carol D Weiss; Christopher C Broder; Klaus Strebel; Kathleen A Clouse
Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.
Blood 2004;103(5):1586-94.
2004: Bryan T Eaton; P J Wright; Lin-Fa Wang; O Sergeyev; Wojtek P Michalski; Katharine N Bossart; Christopher C Broder
Henipaviruses: recent observations on regulation of transcription and the nature of the cell receptor.
Archives of virology. Supplementum 2004;(18):122-31.
2004: Katharine N Bossart; Christopher C Broder
Viral glycoprotein-mediated cell fusion assays using vaccinia virus vectors.
Methods in molecular biology (Clifton, N.J.) 2004;269():309-32.
2003: Mei-Yun Zhang; Yuuei Shu; Sanjay Phogat; Xiaodong Xiao; Fatim Cham; Peter Bouma; Anil Choudhary; Yan-Ru Feng; Inaki Sanz; Susanna M Rybak; Christopher C Broder; Gerald V Quinnan; Thomas Evans; Dimiter S Dimitrov
Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library.
Journal of immunological methods 2003;283(1-2):17-25.
2003: Xiaodong Xiao; Sanjay Phogat; Yuuei Shu; Adhuna Phogat; Yen-Hung Chow; Olivia L Wei; Harris Goldstein; Christopher C Broder; Dimiter S Dimitrov
Purified complexes of HIV-1 envelope glycoproteins with CD4 and CCR5(CXCR4): production, characterization and immunogenicity.
Vaccine 2003;21(27-30):4275-84.
2003: Diana I Albu; Agnes Jones-Trower; Amy M Woron; Kathleen A Stellrecht; Christopher C Broder; Dennis W Metzger
Intranasal vaccination using interleukin-12 and cholera toxin subunit B as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins.
Journal of virology 2003;77(10):5589-97.
2003: Ming Dong; Peng Fei Zhang; Franziska Grieder; James Lee; Govindaraj Krishnamurthy; Thomas C VanCott; Christopher C Broder; Victoria R Polonis; XIAOFANG YU; Yiming Shao; Dennis Faix; Patricia Valente; Gerald V Quinnan
Induction of primary virus-cross-reactive human immunodeficiency virus type 1-neutralizing antibodies in small animals by using an alphavirus-derived in vivo expression system.
Journal of virology 2003;77(5):3119-30.
2002: Katharine N Bossart; Lin-Fa Wang; Michael N Flora; Kaw Bing Chua; Sai Kit Lam; Bryan T Eaton; Christopher C Broder
Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins.
Journal of virology 2002;76(22):11186-98.
2002: Yen-Hung Chow; Olivia L Wei; Sanjay Phogat; Igor A Sidorov; Timothy R Fouts; Christopher C Broder; Dimiter S Dimitrov
Conserved structures exposed in HIV-1 envelope glycoproteins stabilized by flexible linkers as potent entry inhibitors and potential immunogens.
Biochemistry 2002;41(22):7176-82.
2002: Maxime Moulard; Sanjay Phogat; Yuuei Shu; Aran F Labrijn; Xiaodong Xiao; James M Binley; Mei-Yun Zhang; Igor A Sidorov; Christopher C Broder; James Robinson; Paul W H I Parren; Dennis R Burton; Dimiter S Dimitrov
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6913-8.
2001: Katharine N Bossart; Lin-Fa Wang; Bryan T Eaton; Christopher C Broder
Functional expression and membrane fusion tropism of the envelope glycoproteins of Hendra virus.
Virology 2001;290(1):121-35.
2001: Tzanko S Stantchev; Christopher C Broder
Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors.
Cytokine & growth factor reviews 2001;12(2-3):219-43.
2001: Patricia L Earl; Wataru Sugiura; D C Montefiori; Christopher C Broder; S A Lee; C Wild; J Lifson; Bernard Moss
Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140.
Journal of virology 2001;75(2):645-53.
2000: DJ Chabot; Christopher C Broder
Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry.
The Journal of biological chemistry 2000;275(31):23774-82.
2000: Tzanko S Stantchev; Christopher C Broder
Consistent and significant inhibition of human immunodeficiency virus type 1 envelope-mediated membrane fusion by beta-chemokines (RANTES) in primary human macrophages.
The Journal of infectious diseases 2000;182(1):68-78.
2000: Xiaodong Xiao; D Norwood; Yan-Ru Feng; M Moriuchi; Agnes Jones-Trower; Tzanko S Stantchev; H Moriuchi; Christopher C Broder; Dimiter S Dimitrov
Inefficient formation of a complex among CXCR4, CD4 and gp120 in U937 clones resistant to X4 gp120-gp41-mediated fusion.
Experimental and molecular pathology 2000;68(3):139-46.
2000: Xiaodong Xiao; A Kinter; Christopher C Broder; Dimiter S Dimitrov
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Experimental and molecular pathology 2000;68(3):133-8.
2000: Sherwin Lee; Cheryl K Lapham; H Chen; L King; Jody Manischewitz; Tatiana Romantseva; Howard Mostowski; Tzanko S Stantchev; Christopher C Broder; Hana Golding
Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1.
Journal of virology 2000;74(11):5016-23.
2000: DJ Chabot; H Chen; Dimiter S Dimitrov; Christopher C Broder
N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.
Journal of virology 2000;74(9):4404-13.
1999: Christopher C Broder; Patricia L Earl
Recombinant vaccinia viruses. Design, generation, and isolation.
Molecular biotechnology 1999;13(3):223-45.
1999: DJ Chabot; Peng Fei Zhang; Gerald V Quinnan; Christopher C Broder
Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates.
Journal of virology 1999;73(8):6598-609.
1999: Xiaodong Xiao; L Wu; Tzanko S Stantchev; Yan-Ru Feng; S Ugolini; H Chen; Z Shen; James L Riley; Christopher C Broder; Quentin J Sattentau; Dimiter S Dimitrov
Constitutive cell surface association between CD4 and CCR5.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7496-501.
1999: Dimiter S Dimitrov; D Norwood; Tzanko S Stantchev; Y Feng; Xiaodong Xiao; Christopher C Broder
A mechanism of resistance to HIV-1 entry: inefficient interactions of CXCR4 with CD4 and gp120 in macrophages.
Virology 1999;259(1):1-6.
1999: Wataru Sugiura; Christopher C Broder; Bernard Moss; Patricia L Earl
Characterization of conformation-dependent anti-gp120 murine monoclonal antibodies produced by immunization with monomeric and oligomeric human immunodeficiency virus type 1 envelope proteins.
Virology 1999;254(2):257-67.
1999: Hana Golding; J Ouyang; Marina Zaitseva; Christopher C Broder; Dimiter S Dimitrov; Cheryl K Lapham
Increased association of glycoprotein 120-CD4 with HIV type 1 coreceptors in the presence of complex-enhanced anti-CD4 monoclonal antibodies.
AIDS research and human retroviruses 1999;15(2):149-59.
1998: Dimiter S Dimitrov; X Xiao; DJ Chabot; Christopher C Broder
HIV coreceptors.
The Journal of membrane biology 1998;166(2):75-90.
1998: H A Bazan; Ghalib Alkhatib; Christopher C Broder; Edward A Berger
Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates.
Journal of virology 1998;72(5):4485-91.
1997: Sherwin Lee; Keith W C Peden; Dimiter S Dimitrov; Christopher C Broder; Jody Manischewitz; Galina Denisova; Jonathan M Gershoni; Hana Golding
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.
Journal of virology 1997;71(8):6037-43.
1997: Christopher C Broder; R G Collman
Chemokine receptors and HIV.
Journal of leukocyte biology 1997;62(1):20-9.
1997: Patricia L Earl; Christopher C Broder; R W Doms; Bernard Moss
Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein.
Journal of virology 1997;71(4):2674-84.
1997: Christopher C Broder; Patricia L Earl
Design and construction of recombinant vaccinia viruses.
Methods in molecular biology (Clifton, N.J.) 1997;62():173-97.
1996: J Rucker; M Samson; Benjamin J Doranz; Frédérick Libert; Joanne F Berson; Yanjie Yi; R J Smyth; Ronald G Collman; Christopher C Broder; Gilbert Vassart; Robert W Doms; M Parmentier
Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity.
Cell 1996;87(3):437-46.
1996: Ghalib Alkhatib; Christopher C Broder; Edward A Berger
Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages.
Journal of virology 1996;70(8):5487-94.
1996: Ghalib Alkhatib; Christophe Combadiere; Christopher C Broder; Y Feng; Paul E Kennedy; Philip M Murphy; Edward A Berger
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.
Science (New York, N.Y.) 1996;272(5270):1955-8.
1996: Y Feng; Christopher C Broder; Paul E Kennedy; Edward A Berger
HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
Science (New York, N.Y.) 1996;272(5263):872-7.
1996: T M Richardson; B L Stryjewski; Christopher C Broder; James A Hoxie; J R Mascola; Patricia L Earl; Robert W Doms
Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein.
Journal of virology 1996;70(2):753-62.
1996: Christopher C Broder; Dimiter S Dimitrov
HIV and the 7-transmembrane domain receptors.
Pathobiology : journal of immunopathology, molecular and cellular biology 1996;64(4):171-9.
1995: Hana Golding; Dimiter S Dimitrov; Jody Manischewitz; Christopher C Broder; J Robinson; S Fabian; Dan R Littman; Cheryl K Lapham
Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.
Journal of virology 1995;69(10):6140-8.
1995: Christopher C Broder; Edward A Berger
Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):9004-8.
1995: O Nussbaum; Christopher C Broder; Bernard Moss; L B Stern; S Rozenblatt; Edward A Berger
Functional and structural interactions between measles virus hemagglutinin and CD46.
Journal of virology 1995;69(6):3341-9.
1994: Christopher C Broder; Patricia L Earl; D Long; S T Abedon; Bernard Moss; Robert W Doms
Antigenic implications of human immunodeficiency virus type 1 envelope quaternary structure: oligomer-specific and -sensitive monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11699-703.
1994: O Nussbaum; Christopher C Broder; Edward A Berger
Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation.
Journal of virology 1994;68(9):5411-22.
1994: Christopher C Broder; O Nussbaum; W G Gutheil; W W Bachovchin; Edward A Berger
CD26 antigen and HIV fusion?
Science (New York, N.Y.) 1994;264(5162):1156-9; author reply 1162-5.
1994: Christopher C Broder; Paul E Kennedy; F Michaels; Edward A Berger
Expression of foreign genes in cultured human primary macrophages using recombinant vaccinia virus vectors.
Gene 1994;142(2):167-74.
1994: Patricia L Earl; Christopher C Broder; D Long; S A Lee; J Peterson; S Chakrabarti; Robert W Doms; Bernard Moss
Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities.
Journal of virology 1994;68(5):3015-26.
1993: Christopher C Broder; Dimiter S Dimitrov; R Blumenthal; Edward A Berger
The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s).
Virology 1993;193(1):483-91.
1993: Dimiter S Dimitrov; Christopher C Broder; Edward A Berger; Robert Blumenthal
Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction.
Journal of virology 1993;67(3):1647-52.
1993: Christopher C Broder; Edward A Berger
CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion.
Journal of virology 1993;67(2):913-26.