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Hai Yu

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raghavendra kikkeri; Martijn A Langereis; Vered Padler-Karavani; Hongzhi Cao; Xi Chen; Raoul J de Groot; Sandra Diaz; Andrea Verhagen; Hai Yu; Ajit Varki
Quantum dot nanometal surface energy transfer based biosensing of sialic Acid compositions and linkages in biological samples.
Vered Padler-Karavani; Adriana H Tremoulet; Jane C Burns; Xi Chen; Hai Yu; Ajit Varki
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease.
Zahra Khedri; Yanhong Li; Musleh M Muthana; Jingyao Qu; Hai Yu; Hongzhi Cao; Xi Chen
Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2.

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All Publications

2013: raghavendra kikkeri; Martijn A Langereis; Vered Padler-Karavani; Hongzhi Cao; Xi Chen; Raoul J de Groot; Sandra Diaz; Andrea Verhagen; Hai Yu; Ajit Varki
Quantum dot nanometal surface energy transfer based biosensing of sialic Acid compositions and linkages in biological samples.
Analytical chemistry 2013;85(8):3864-70.
2013: Vered Padler-Karavani; Adriana H Tremoulet; Jane C Burns; Xi Chen; Hai Yu; Ajit Varki
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease.
PloS one 2013;8(3):e58443.
2012: Zahra Khedri; Yanhong Li; Musleh M Muthana; Jingyao Qu; Hai Yu; Hongzhi Cao; Xi Chen
Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2.
Organic & biomolecular chemistry 2012;10(30):6112-20.
2012: Vered Padler-Karavani; Melitta Schachner; Richard Schwab; David Smith; Xuezheng Song; Andrea Verhagen; Hai Yu; Xi Chen; Jiansong Cheng; Harshal A Chokhawala; Richard D Cummings; Raoul J de Groot; Shengshu Huang; Nancy Hurtado-Ziola; Ralf Kleene; Martijn A Langereis; Yi Lasanajak; Haruo Matsuda; Saddam Muthana; Ajit Varki
Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays.
The Journal of biological chemistry 2012;287(27):22593-608.
2012: Vireak Thon; Hai Yu; Kam Lau; Yanhong Li; Xi Chen
PmST3 from Pasteurella multocida encoded by Pm1174 gene is a monofunctional α2-3-sialyltransferase.
Applied microbiology and biotechnology 2012;94(4):977-85.
2012: Zahra Khedri; Yanhong Li; Musleh M Muthana; Saddam M Muthana; Hai Yu; Hongzhi Cao; Xi Chen
Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid.
Chemical communications (Cambridge, England) 2012;48(27):3357-9.
2012: Qiaozhen Lu; Vered Padler-Karavani; Ajit Varki; Shiaw-Lin Wu; Hai Yu; Xi Chen; William S Hancock
LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion.
Analytical chemistry 2012;84(6):2761-8.
2012: Musleh M Muthana; Jingyao Qu; Hai Yu; Lei Zhang; Li Ding; Yanhong Li; Hamed Malekan; Xi Chen
Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP).
Chemical communications (Cambridge, England) 2012;48(21):2728-30.
2012: Yanhong Li; Saddam Muthana; Hai Yu; Hongzhi Cao; Xi Chen
Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity.
Applied microbiology and biotechnology 2012;93(6):2411-23.
2012: Matthew J Linman; Hai Yu; Xi Chen; Quan Cheng
Surface plasmon resonance imaging analysis of protein binding to a sialoside-based carbohydrate microarray.
Methods in molecular biology (Clifton, N.J.) 2012;808():183-94.
2011: Yiyan Fei; Shengshu Huang; James P Landry; Kam Lau; Yanhong Li; Yung-Shin Sun; Hai Yu; Xi Chen; Harshal A Chokhawala; Xiangdong Zhu
Fluorescent labeling agents change binding profiles of glycan-binding proteins.
Molecular bioSystems 2011;7(12):3343-52.
2011: Go Sugiarto; Hai Yu; Zahra Khedri; Kam Lau; Diem-Thuy Le; Yanhong Li; Xi Chen
Decreasing the sialidase activity of multifunctional Pasteurella multocida α2-3-sialyltransferase 1 (PmST1) by site-directed mutagenesis.
Molecular bioSystems 2011;7(11):3021-7.
2011: Yi Chen; Li Ding; Liana Hie; Kam Lau; Yanhong Li; Jingyao Qu; Vireak Thon; Hai Yu; Xi Chen
One-pot three-enzyme synthesis of UDP-GlcNAc derivatives.
Chemical communications (Cambridge, England) 2011;47(38):10815-7.
2011: Hai Yu; Hongzhi Cao; Yanhong Li; Vinod Kumar Tiwari; Xi Chen
Chemoenzymatic synthesis of C8-modified sialic acids and related α2-3- and α2-6-linked sialosides.
Bioorganic & medicinal chemistry letters 2011;21(17):5037-40.
2011: Vireak Thon; Bao K Tran; Hai Yu; Kam Lau; Xi Chen
PmST2: a novel Pasteurella multocida glycolipid α2-3-sialyltransferase.
Glycobiology 2011;21(9):1206-16.
2011: Yanhong Li; Hongzhi Cao; Nguyet Dao; Zheng Luo; Hai Yu; Yi Chen; Zheng Xing; Nicole Baumgarth; Carol J Cardona; Xi Chen
High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses.
Virology 2011;415(1):12-9.
2011: Vered Padler-Karavani; Nancy Hurtado-Ziola; Minya Pu; Hai Yu; Shengshu Huang; Saddam Muthana; Harshal A Chokhawala; Hongzhi Cao; Patrick Secrest; Dinorah Friedmann-Morvinski; Oded Singer; Darius Ghaderi; Inder M Verma; Yu-Tsueng Liu; Karen Messer; Xi Chen; Ajit Varki; Richard Schwab
Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer.
Cancer research 2011;71(9):3352-63.
2011: Kam Lau; Hai Yu; Vireak Thon; Zahra Khedri; Meghan E Leon; Bao K Tran; Xi Chen
Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives.
Organic & biomolecular chemistry 2011;9(8):2784-9.
2011: Yanhong Li; Hongzhi Cao; Hai Yu; Yi Chen; Kam Lau; Jingyao Qu; Vireak Thon; Go Sugiarto; Xi Chen
Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies.
Molecular bioSystems 2011;7(4):1060-72.
2011: Go Sugiarto; Kam Lau; Hai Yu; Stephanie Vuong; Vireak Thon; Yanhong Li; Shengshu Huang; Xi Chen
Cloning and characterization of a viral α2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx.
Glycobiology 2011;21(3):387-96.
2011: Yanhong Li; Jingyao Qu; Vireak Thon; Vinod Kumar Tiwari; Peng George Wang; Hai Yu; Li Cai; Hongzhi Cao; Yi Chen; Kam Lau; Xi Chen
Substrate promiscuity of N-acetylhexosamine 1-kinases.
Molecules (Basel, Switzerland) 2011;16(8):6396-407.
2010: Hai Yu; Vireak Thon; Kam Lau; Li Cai; Yi Chen; Shengmao Mu; Yanhong Li; Peng George Wang; Xi Chen
Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides.
Chemical communications (Cambridge, England) 2010;46(40):7507-9.
2010: Kam Lau; Vireak Thon; Hai Yu; Li Ding; Yi Chen; Musleh M Muthana; Denton Wong; Ronald Huang; Xi Chen
Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases.
Chemical communications (Cambridge, England) 2010;46(33):6066-8.
2010: Lei Zhang; Kam Lau; Jiansong Cheng; Hai Yu; Yanhong Li; Go Sugiarto; Shengshu Huang; Li Ding; Vireak Thon; Peng G Wang; Xi Chen
Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family.
Glycobiology 2010;20(9):1077-88.
2010: Rachel E Taylor; Christopher J Gregg; Vered Padler-Karavani; Darius Ghaderi; Hai Yu; Shengshu Huang; Ricardo U Sorensen; Xi Chen; Jaime Inostroza; Victor Nizet; Ajit Varki
Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid.
The Journal of experimental medicine 2010;207(8):1637-46.
2010: Jiansong Cheng; Shengshu Huang; Hai Yu; Yanhong Li; Kam Lau; Xi Chen
Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides.
Glycobiology 2010;20(2):260-8.
2009: Hai Yu; Jiansong Cheng; Li Ding; Zahra Khedri; Yi Chen; Sharlene Chin; Kam Lau; Vinod Kumar Tiwari; Xi Chen
Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids.
Journal of the American Chemical Society 2009;131(51):18467-77.
2009: Hongzhi Cao; Yanhong Li; Kam Lau; Saddam Muthana; Hai Yu; Jiansong Cheng; Harshal A Chokhawala; Go Sugiarto; Lei Zhang; Xi Chen
Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids.
Organic & biomolecular chemistry 2009;7(24):5137-45.
2009: Matthew J Linman; Hai Yu; Xi Chen; Quan Cheng
Fabrication and characterization of a sialoside-based carbohydrate microarray biointerface for protein binding analysis with surface plasmon resonance imaging.
ACS applied materials & interfaces 2009;1(8):1755-62.
2009: Saddam Muthana; Hai Yu; Hongzhi Cao; Jiansong Cheng; Xi Chen
Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides.
The Journal of organic chemistry 2009;74(8):2928-36.
2009: Sandra L Diaz; Vered Padler-Karavani; Darius Ghaderi; Nancy Hurtado-Ziola; Hai Yu; Xi Chen; Els C M Brinkman-Van der Linden; Ajit Varki; Nissi M Varki
Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.
PloS one 2009;4(1):e4241.
2008: Harshal A Chokhawala; Shengshu Huang; Kam Lau; Hai Yu; Jiansong Cheng; Vireak Thon; Nancy Hurtado-Ziola; Juan A Guerrero; Ajit Varki; Xi Chen
Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides.
ACS chemical biology 2008;3(9):567-76.
2008: Jiansong Cheng; Hai Yu; Kam Lau; Shengshu Huang; Harshal A Chokhawala; Yanhong Li; Vinod Kumar Tiwari; Xi Chen
Multifunctionality of Campylobacter jejuni sialyltransferase CstII: characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities.
Glycobiology 2008;18(9):686-97.
2008: Yanhong Li; Hai Yu; Hongzhi Cao; Kam Lau; Saddam Muthana; Vinod Kumar Tiwari; Bryan Son; Xi Chen
Pasteurella multocida sialic acid aldolase: a promising biocatalyst.
Applied microbiology and biotechnology 2008;79(6):963-70.
2008: Matthew J Linman; Joseph D Taylor; Hai Yu; Xi Chen; Quan Cheng
Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides.
Analytical chemistry 2008;80(11):4007-13.
2007: Saddam Muthana; Hai Yu; Shengshu Huang; Xi Chen
Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides.
Journal of the American Chemical Society 2007;129(39):11918-9.
2007: Yanhong Li; Mingchi Sun; Shengshu Huang; Hai Yu; Harshal A Chokhawala; Vireak Thon; Xi Chen
The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase.
Biochemical and biophysical research communications 2007;361(2):555-60.
2007: Harshal A Chokhawala; Hongzhi Cao; Hai Yu; Xi Chen
Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases.
Journal of the American Chemical Society 2007;129(35):10630-1.
2007: Hai Yu; Harshal A Chokhawala; Ajit Varki; Xi Chen
Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.
Organic & biomolecular chemistry 2007;5(15):2458-63.
2007: Lisheng Ni; Harshal A Chokhawala; Hongzhi Cao; Ryan Henning; Laura Ng; Shengshu Huang; Hai Yu; Xi Chen; Andrew J Fisher
Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism.
Biochemistry 2007;46(21):6288-98.
2007: Hai Yu; Xi Chen
Carbohydrate post-glycosylational modifications.
Organic & biomolecular chemistry 2007;5(6):865-72.
2007: Harshal A Chokhawala; Hai Yu; Xi Chen
High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries.
Chembiochem : a European journal of chemical biology 2007;8(2):194-201.
2007: Shengshu Huang; Hai Yu; Xi Chen
Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end.
Angewandte Chemie (International ed. in English) 2007;46(13):2249-53.
2006: Hai Yu; Shengshu Huang; Harshal A Chokhawala; Mingchi Sun; Haojie Zheng; Xi Chen
Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity.
Angewandte Chemie (International ed. in English) 2006;45(24):3938-44.
2006: Hai Yu; Xi Chen
Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases.
Organic letters 2006;8(11):2393-6.
2006: Lisheng Ni; Mingchi Sun; Hai Yu; Harshal A Chokhawala; Xi Chen; Andrew J Fisher
Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida.
Biochemistry 2006;45(7):2139-48.
2006: Hai Yu; Harshal A Chokhawala; Shengshu Huang; Xi Chen
One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities.
Nature protocols 2006;1(5):2485-92.
2006: Hui Yu; Wesley Ryan; Hai Yu; Xi Chen
Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae.
Biotechnology letters 2006;28(2):107-13.
2005: Hai Yu; Harshal A Chokhawala; Rebekah Karpel; Hui Yu; Bingyuan Wu; Jianbo Zhang; Yingxin Zhang; Qiang Jia; Xi Chen
A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.
Journal of the American Chemical Society 2005;127(50):17618-9.
2004: Hai Yu; Hui Yu; Rebekah Karpel; Xi Chen
Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases.
Bioorganic & medicinal chemistry 2004;12(24):6427-35.