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Jian Yu

Research Profile

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Publications

TOP 3
W Qiu; A Sebastini; Qinmiao Sun; H Wang; Huaitian Liu; Lin Zhang; Jian Yu
An apoptosis-independent role of SMAC in tumor suppression.
R Peng; J-S Tong; Jian Yu; B Yue; H Li; F Zou; Lin Zhang
Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.
Crissy Dudgeon; R Peng; A Sebastiani; Ping Wang; Jian Yu; Lin Zhang
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth.

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All Publications

2013: W Qiu; A Sebastini; Qinmiao Sun; H Wang; Huaitian Liu; Lin Zhang; Jian Yu
An apoptosis-independent role of SMAC in tumor suppression.
Oncogene 2013;32(19):2380-9.
2013: R Peng; J-S Tong; Jian Yu; B Yue; H Li; F Zou; Lin Zhang
Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.
Cell death and differentiation 2013;20(5):744-54.
2012: Crissy Dudgeon; R Peng; A Sebastiani; Ping Wang; Jian Yu; Lin Zhang
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth.
Oncogene 2012;31(46):4848-58.
2012: Rajan K Bista; Randall E Brand; Douglas J Hartman; Wei Qiu; Shikhar Uttam; Jian Yu; Lin Zhang; Yang Liu
Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.
Journal of biomedical optics 2012;17(6):066014.
2012: Jing Sun; Quanhong Sun; Xiang Xu; Matthew F Brown; Julie Chandler; Crissy Dudgeon; Yongqian Shu; Lin Zhang; Jian Yu
The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.
PloS one 2012;7(8):e43158.
2011: Wei Qiu; Xinwei Wang; Wancai Yang; Brian Leibowitz; Lin Zhang; Jian Yu
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.
Hepatology (Baltimore, Md.) 2011;54(4):1249-58.
2011: Hua Li; Peng Wang; Jian Yu; Lin Zhang
Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis.
Autophagy 2011;7(10):1239-41.
2011: Hua Li; Peng Wang; Quanhong Sun; Wen-Xing Ding; Xiao-Ming Yin; Robert W Sobol; Donna B Stolz; Jian Yu; Lin Zhang
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.
Cancer research 2011;71(10):3625-34.
2011: Quanhong Sun; Xingnan Zheng; Lin Zhang; Jian Yu
Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2361-72.
2011: Gabriela Mustata; Mei Li; Nicki Zevola; Ahmet Bakan; Lin Zhang; Michael Epperly; Joel S Greenberger; Jian Yu; Ivet Bahar
Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death.
Current topics in medicinal chemistry 2011;11(3):281-90.
2010: Wei Qiu; Xinwei Wang; Brian Leibowitz; Hongtao Liu; Nick Barker; Hitoshi Okada; Naohide Oue; Wataru Yasui; Hans Clevers; Robert E Schoen; Jian Yu; Lin Zhang
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20027-32.
2010: Crissy Dudgeon; Peng Wang; Xiameng Sun; Rui Peng; Quanhong Sun; Jian Yu; Lin Zhang
PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.
Molecular cancer therapeutics 2010;9(11):2893-902.
2010: Hui Yu; Hongmei Shen; Youzhong Yuan; Richard XuFeng; Xiaoxia Hu; Sean P Garrison; Lin Zhang; Jian Yu; Gerard P Zambetti; Tao Cheng
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.
Blood 2010;115(17):3472-80.
2010: W Qiu; B Leibowitz; Lin Zhang; Jian Yu
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.
Oncogene 2010;29(11):1622-32.
2010: Brian Leibowitz; Jian Yu
Mitochondrial signaling in cell death via the Bcl-2 family.
Cancer biology & therapy 2010;9(6):417-22.
2009: Ping Wang; W Qiu; Crissy Dudgeon; Huaitian Liu; C Huang; Gerard P Zambetti; Jian Yu; Lin Zhang
PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis.
Cell death and differentiation 2009;16(9):1192-202.
2009: Wen Yue; Quanhong Sun; Rodney Landreneau; Chuanyue Wu; Jill M Siegfried; Jian Yu; Lin Zhang
Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.
Cancer research 2009;69(15):6339-46.
2009: Qinmiao Sun; L Ming; Sufi Thomas; Y Wang; Zhuo Georgia Chen; Robert L Ferris; Jennifer Rubin Grandis; Lin Zhang; Jian Yu
PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells.
Oncogene 2009;28(24):2348-57.
2009: Wei Qiu; Eleanor B Carson-Walter; Shih-Fan Kuan; Lin Zhang; Jian Yu
PUMA suppresses intestinal tumorigenesis in mice.
Cancer research 2009;69(12):4999-5006.
2008: Jian Yu; Lin Zhang
PUMA, a potent killer with or without p53.
Oncogene 2008;27 Suppl 1():S71-83.
2008: Lihua Ming; Tsukasa Sakaida; Wen Yue; Anupma Jha; Lin Zhang; Jian Yu
Sp1 and p73 activate PUMA following serum starvation.
Carcinogenesis 2008;29(10):1878-84.
2008: Wei Qiu; Eleanor B Carson-Walter; Hongtao Liu; Michael W Epperly; Joel S Greenberger; Gerard P Zambetti; Lin Zhang; Jian Yu
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome.
Cell stem cell 2008;2(6):576-83.
2008: Crissy Dudgeon; Jian Yu
Green tea and PUMA: a deadly combination?
Cancer biology & therapy 2008;7(6):909-10.
2008: Alexander Bank; Jian Yu; Lin Zhang
NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells.
Nutrition and cancer 2008;60 Suppl 1():98-103.
2008: Alexander Bank; Peng Wang; Chunying Du; Jian Yu; Lin Zhang
SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release.
Cancer research 2008;68(1):276-84.
2007: Quanhong Sun; Tsukasa Sakaida; Wen Yue; Susanne M Gollin; Jian Yu
Chemosensitization of head and neck cancer cells by PUMA.
Molecular cancer therapeutics 2007;6(12 Pt 1):3180-8.
2007: Lin Zhang; Lihua Ming; Jian Yu
BH3 mimetics to improve cancer therapy; mechanisms and examples.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2007;10(6):207-17.
2007: Wen Yue; Sanja Dacic; Quanhong Sun; Rodney J Landreneau; Mingzhou Guo; Wei Zhou; Jill M Siegfried; Jian Yu; Lin Zhang
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4336-44.
2007: Jian Yu; Peng Wang; L Ming; M A Wood; Lin Zhang
SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
Oncogene 2007;26(29):4189-98.
2007: Bin Wu; Wei Qiu; Peng Wang; Hui Yu; Tao Cheng; Gerard P Zambetti; Lin Zhang; Jian Yu
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion.
Gut 2007;56(5):645-54.
2007: Peng Wang; Jian Yu; Lin Zhang
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4054-9.
2007: Wen-Xing Ding; Hong-Min Ni; Xiaoyun Chen; Jian Yu; Lin Zhang; Xiao-Ming Yin
A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells.
Molecular cancer therapeutics 2007;6(3):1062-9.
2006: Lihua Ming; Peng Wang; Alexander Bank; Jian Yu; Lin Zhang
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells.
The Journal of biological chemistry 2006;281(23):16034-42.
2006: Jian Yu; Wen Yue; Bin Wu; Lin Zhang
PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2928-36.
2005: Jian Yu; Lin Zhang
The transcriptional targets of p53 in apoptosis control.
Biochemical and biophysical research communications 2005;331(3):851-8.
2004: Jian Yu; Lin Zhang
Apoptosis in human cancer cells.
Current opinion in oncology 2004;16(1):19-24.
2003: Jian Yu; Sagarika Tiwari; Philipp Steiner; Lin Zhang
Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells.
Cancer biology & therapy 2003;2(6):694-9.
2003: Jian Yu; Lin Zhang
No PUMA, no death: implications for p53-dependent apoptosis.
Cancer cell 2003;4(4):248-9.