Kuo-Long Yu

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Ny Sin; Brian L Venables; Keith D Combrink; H Belgin Gulgeze; Kuo-Long Yu; Rita L Civiello; Jan Thuring; X Alan Wang; Zheng Yang; Lisa Zadjura; et al.
Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Keith D Combrink; H Belgin Gulgeze; Jan W Thuring; Kuo-Long Yu; Rita L Civiello; Yi Zhang; Bradley C Pearce; Zhiwei Yin; David R Langley; Kathleen F Kadow; et al.
Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.
Xiangdong Alan Wang; Christopher W Cianci; Kuo-Long Yu; Keith D Combrink; Jan W Thuring; Yi Zhang; Rita L Civiello; Kathleen F Kadow; Julia Roach; Zhufang Li; et al.
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.

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All Publications

2009: Ny Sin; Brian L Venables; Keith D Combrink; H Belgin Gulgeze; Kuo-Long Yu; Rita L Civiello; Jan Thuring; X Alan Wang; Zheng Yang; Lisa Zadjura; et al.
Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Bioorganic & medicinal chemistry letters 2009;19(16):4857-62.
2007: Keith D Combrink; H Belgin Gulgeze; Jan W Thuring; Kuo-Long Yu; Rita L Civiello; Yi Zhang; Bradley C Pearce; Zhiwei Yin; David R Langley; Kathleen F Kadow; et al.
Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.
Bioorganic & medicinal chemistry letters 2007;17(17):4784-90.
2007: Xiangdong Alan Wang; Christopher W Cianci; Kuo-Long Yu; Keith D Combrink; Jan W Thuring; Yi Zhang; Rita L Civiello; Kathleen F Kadow; Julia Roach; Zhufang Li; et al.
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.
Bioorganic & medicinal chemistry letters 2007;17(16):4592-8.
2007: Richard Dalterio; Xiaohua Stella Huang; Kuo-Long Yu
Infrared and nuclear magnetic resonance spectroscopic study of secondary amide hydrogen bonding in benzoyl PABA derivatives (retinoids).
Applied spectroscopy 2007;61(6):603-7.
2007: Kuo-Long Yu; Ny Sin; Rita L Civiello; X Alan Wang; Keith D Combrink; H Belgin Gulgeze; Brian L Venables; J J Kim Wright; Richard A Dalterio; Lisa Zadjura; et al.
Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Bioorganic & medicinal chemistry letters 2007;17(4):895-901.
2006: Kuo-Long Yu; Xiangdong Alan Wang; Rita L Civiello; Ashok K Trehan; Bradley C Pearce; Zhiwei Yin; Keith D Combrink; H Belgin Gulgeze; Yi Zhang; Kathleen F Kadow; et al.
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.
Bioorganic & medicinal chemistry letters 2006;16(5):1115-22.
2004: Christopher Cianci; David R Langley; Douglas D Dischino; Yaxiong Sun; Kuo-Long Yu; Anne Stanley; Julia Roach; Zhufang Li; Richard Dalterio; Richard Colonno; et al.
Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15046-51.
2004: Christopher Cianci; Eugene V Genovesi; Lucinda Lamb; Ivette Medina; Zheng Yang; Lisa Zadjura; Hyekyung Yang; Celia D'Arienzo; Ny Sin; Kuo-Long Yu; et al.
Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection.
Antimicrobial agents and chemotherapy 2004;48(7):2448-54.
2004: Kuo-Long Yu; Yi Zhang; Rita L Civiello; Ashok K Trehan; Bradley C Pearce; Zhiwei Yin; Keith D Combrink; H Belgin Gulgeze; Xiangdong Alan Wang; Kathleen F Kadow; et al.
Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.
Bioorganic & medicinal chemistry letters 2004;14(5):1133-7.
2004: Christopher Cianci; Kuo-Long Yu; Keith Combrink; Ny Sin; Bradley Pearce; Alan Wang; Rita Civiello; Stacey Voss; Guangxiang Luo; Kathy Kadow; et al.
Orally active fusion inhibitor of respiratory syncytial virus.
Antimicrobial agents and chemotherapy 2004;48(2):413-22.
2003: Kuo Long Yu; Yi Zhang; Rita L Civiello; Kathleen F Kadow; Christopher Cianci; Mark Krystal; Nicholas A Meanwell
Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor.
Bioorganic & medicinal chemistry letters 2003;13(13):2141-4.
2003: Jeffrey Thomas; Kelli S Bramlett; Chahrzad Montrose; Patricia Foxworthy; Patrick I Eacho; Denis McCann; Guoqing Cao; Anton Kiefer; Jeff McCowan; Kuo-Long Yu; et al.
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
The Journal of biological chemistry 2003;278(4):2403-10.
2002: Kuo Long Yu; Albert F Torri; Guangxiang Luo; Christopher Cianci; Katharine Grant-Young; Stephanie Danetz; Lawrence Tiley; Mark Krystal; Nicholas A Meanwell
Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.
Bioorganic & medicinal chemistry letters 2002;12(23):3379-82.
2001: M S Deshpande; J Wei; G Luo; C Cianci; S Danetz; A Torri; L Tiley; M Krystal; K L Yu; S Huang; et al.
An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology.
Bioorganic & medicinal chemistry letters 2001;11(17):2393-6.
2000: K D Combrink; H B Gulgeze; K L Yu; B C Pearce; A K Trehan; J Wei; M Deshpande; M Krystal; A Torri; G Luo; et al.
Salicylamide inhibitors of influenza virus fusion.
Bioorganic & medicinal chemistry letters 2000;10(15):1649-52.
1999: K L Yu; E Ruediger; G Luo; C Cianci; S Danetz; L Tiley; A K Trehan; I Monkovic; B Pearce; A Martel; et al.
Novel quinolizidine salicylamide influenza fusion inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(15):2177-80.
1999: K L Yu; R Civiello; D G Roberts; S M Seiler; N A Meanwell
Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(5):663-6.
1999: C Cianci; K L Yu; D D Dischino; W Harte; M Deshpande; G Luo; R J Colonno; N A Meanwell; M Krystal
pH-dependent changes in photoaffinity labeling patterns of the H1 influenza virus hemagglutinin by using an inhibitor of viral fusion.
Journal of virology 1999;73(3):1785-94.
1998: J Ostrowski; T Roalsvig; L Hammer; A Marinier; J E Starrett; K L Yu; P R Reczek
Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes.
The Journal of biological chemistry 1998;273(6):3490-5.
1997: G Luo; A Torri; W E Harte; S Danetz; C Cianci; L Tiley; S Day; D Mullaney; K L Yu; C Ouellet; et al.
Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus.
Journal of virology 1997;71(5):4062-70.