Angela Brodie

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

Living Beings

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Guo Zhiyong; Yang Xi; Sun Feng; Jiang Richeng; Linn Douglas E; Chen Hege; Chen Hegang; Kong Xiangtian; Melamed Jonathan; Tepper Clifford G; Kung Hsing-Jien; Brodie Angela M H; Edwards Joanne; Qiu Yun
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Macedo Luciana Furtado; Sabnis Gauri; Brodie Angela
Aromatase inhibitors and breast cancer.
Sabnis Gauri; Schayowitz Adam; Goloubeva Olga; Macedo Luciana; Brodie Angela
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Angela Brodie (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Guo Zhiyong; Yang Xi; Sun Feng; Jiang Richeng; Linn Douglas E; Chen Hege; Chen Hegang; Kong Xiangtian; Melamed Jonathan; Tepper Clifford G; Kung Hsing-Jien; Brodie Angela M H; Edwards Joanne; Qiu Yun
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Cancer research 2009;69(6):2305-13.
2009: Macedo Luciana Furtado; Sabnis Gauri; Brodie Angela
Aromatase inhibitors and breast cancer.
Annals of the New York Academy of Sciences 2009;1155():162-73.
2009: Sabnis Gauri; Schayowitz Adam; Goloubeva Olga; Macedo Luciana; Brodie Angela
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.
Cancer research 2009;69(4):1416-28.
2009: Brodie Angela; Njar Vincent; Macedo Luciana Furtado; Vasaitis T Sean; Sabnis Gauri
The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer.
Urologic oncology 2009;27(1):53-63.
2008: Bruno Robert D; Gover Tony D; Burger Angelika M; Brodie Angela M; Njar Vincent C O
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.
Molecular cancer therapeutics 2008;7(9):2828-36.
2008: Vasaitis Tadas; Belosay Aashvini; Schayowitz Adam; Khandelwal Aakanksha; Chopra Pankaj; Gediya Lalji K; Guo Zhiyong; Fang Hong-Bin; Njar Vincent C O; Brodie Angela M H
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.
Molecular cancer therapeutics 2008;7(8):2348-57.
2008: Miller William R; Bartlett John; Brodie Angela M H; Brueggemeier Robert W; di Salle Enrico; Lønning Per Eystein; Llombart Antonio; Maass Nicolai; Maudelonde Thierry; Sasano Hironobu; Goss Paul E
Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
The oncologist 2008;13(8):829-37.
2008: Sabnis Gauri J; Macedo Luciana F; Goloubeva Olga; Schayowitz Adam; Brodie Angela M H
Stopping treatment can reverse acquired resistance to letrozole.
Cancer research 2008;68(12):4518-24.
2008: Macedo Luciana F; Sabnis Gauri J; Goloubeva Olga G; Brodie Angela
Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.
Cancer research 2008;68(9):3516-22.
2008: Macedo Luciana F; Sabnis Gauri; Brodie Angela
Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors.
Cancer 2008;112(3 Suppl):679-88.
2008: Come Steven E; Buzdar Aman U; Ingle James N; Johnston Stephen R D; Brodie Angela M; Coombes R Charles; Miller William R; Pritchard Kathleen I; Winer Eric P; Zujewski Jo Anne; Goss Paul E
Endocrine and targeted manipulation of breast cancer: summary statement for the Sixth Cambridge Conference.
Cancer 2008;112(3 Suppl):673-8.
2008: Schayowitz Adam; Sabnis Gauri; Njar Vincent C O; Brodie Angela M H
Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.
Molecular cancer therapeutics 2008;7(1):121-32.
2008: Sabnis Gauri J; Macedo Luciana; Goloubeva Olga; Schayowitz Adam; Zhu Yue; Brodie Angela
Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model.
The Journal of steroid biochemistry and molecular biology 2008;108(1-2):1-7.
2007: Brodie A; Sabnis G; Macedo L
Xenograft models for aromatase inhibitor studies.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):119-24.
2007: Sabnis Gauri; Goloubeva Olga; Jelovac Danijela; Schayowitz Adam; Brodie Angela
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2751-7.
2007: Patel J B; Mehta J; Belosay A; Sabnis G; Khandelwal A; Brodie A M H; Soprano D R; Njar V C O
Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.
British journal of cancer 2007;96(8):1204-15.
2007: Jordan V Craig; Brodie Angela M H
Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer.
Steroids 2007;72(1):7-25.
2006: Belosay Aashvini; Brodie Angela M H; Njar Vincent C O
Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells.
Cancer research 2006;66(23):11485-93.
2006: Brodie A; Sabnis G; Jelovac D
Aromatase and breast cancer.
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):97-102.
2006: Guo Zhiyong; Dai Bojie; Jiang Tianyun; Xu Kexin; Xie Yingqiu; Kim Oekyung; Nesheiwat Issa; Kong Xiangtian; Melamed Jonathan; Handratta Venkatesh D; Njar Vincent C O; Brodie Angela M H; Yu Li-Rong; Veenstra Timothy D; Chen Hegang; Qiu Yun
Regulation of androgen receptor activity by tyrosine phosphorylation.
Cancer cell 2006;10(4):309-19.
2006: Tao X; Brodie A M H; Nnane I P
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.
Biopharmaceutics & drug disposition 2006;27(7):335-44.
2006: Dai Bojie; Kim Oekyung; Xie Yingqiu; Guo Zhiyong; Xu Kexin; Wang Bin; Kong Xiangtian; Melamed Jonathan; Chen Hegang; Bieberich Charles J; Borowsky Alexander D; Kung Hsing-Jien; Wei Guo; Ostrowski Michael C; Brodie Angela; Qiu Yun
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.
Cancer research 2006;66(16):8058-64.
2006: Macedo Luciana F; Guo Zhiyong; Tilghman Syreeta L; Sabnis Gauri J; Qiu Yun; Brodie Angela
Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
Cancer research 2006;66(15):7775-82.
2006: Chao Jianping; Ling Yangzhi; Liu Xiaofeng; Luo Xuande; Brodie A M H
A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids.
Steroids 2006;71(7):585-90.
2006: Huynh C K; Brodie A M H; Njar V C O
Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice.
British journal of cancer 2006;94(4):513-23.
2006: Tang Yao; Khan Mohammad A; Goloubeva Olga; Lee Dong I; Jelovac Danijela; Brodie Angela M; Hussain Arif
Docetaxel followed by castration improves outcomes in LNCaP prostate cancer-bearing severe combined immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):169-74.
2006: Brodie Angela
David Kupfer and the metabolism connection: on aromatase inhibitors and tamoxifen.
Drug metabolism reviews 2006;38(1-2):129-37.
2005: Zhang Yuexing; Wang Xin-Wei; Jelovac Danijela; Nakanishi Takeo; Yu Myoung-Hee; Akinmade Damilola; Goloubeva Olga; Ross Douglas D; Brodie Angela; Hamburger Anne W
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9890-5.
2005: Jelovac Danijela; Macedo Luciana; Goloubeva Olga G; Handratta Venkatesh; Brodie Angela M H
Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.
Cancer research 2005;65(12):5439-44.
2005: Jelovac Danijela; Sabnis Gauri; Long Brian J; Macedo Luciana; Goloubeva Olga G; Brodie Angela M H
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole.
Cancer research 2005;65(12):5380-9.
2005: Brodie Angela; Jelovac Danijela; Sabnis Gauri; Long Brian; Macedo Luciana; Goloubeva Olga
Model systems: mechanisms involved in the loss of sensitivity to letrozole.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):41-8.
2005: Sabnis Gauri J; Jelovac Danijela; Long Brian; Brodie Angela
The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation.
Cancer research 2005;65(9):3903-10.
2005: Handratta Venkatesh D; Vasaitis Tadas S; Njar Vincent C O; Gediya Lalji K; Kataria Ritesh; Chopra Pankaj; Newman Donnell; Farquhar Rena; Guo Zhiyong; Qiu Yun; Brodie Angela M H
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Journal of medicinal chemistry 2005;48(8):2972-84.
2005: Brodie Angela; Jelovac Danijela; Macedo Luciana; Sabnis Gauri; Tilghman Syreeta; Goloubeva Olga
Therapeutic observations in MCF-7 aromatase xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):884s-8s.
2005: Come Steven E; Buzdar Aman U; Ingle James N; Arteaga Carlos L; Brodie Angela M; Colditz Graham A; Johnston Stephen R D; Kristensen Vessela N; Lønning Per E; McDonnell Donald P; Osborne C Kent; Russo Jose; Santen Richard J; Yee Douglas; Hart Carol S
Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):861s-4s.
2004: Patel Jyoti B; Huynh Carlic K; Handratta Venkatesh D; Gediya Lalji K; Brodie Angela M H; Goloubeva Olga G; Clement Omoshile O; Nanne Ivo P; Soprano Dianne Robert; Njar Vincent C O
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Journal of medicinal chemistry 2004;47(27):6716-29.
2004: Stratakis Constantine A; Batista Dalia; Sabnis Gauri; Brodie Angela
Prepubertal gynaecomastia caused by medication or the aromatase excess syndrome.
Clinical endocrinology 2004;61(6):779-80.
2004: Jelovac Danijela; Macedo Luciana; Handratta Venkatesh; Long Brian J; Goloubeva Olga G; Ingle James N; Brodie Angela M H
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7375-81.
2004: Handratta Venkatesh D; Jelovac Danijela; Long Brian J; Kataria Ritesh; Nnane Ivo P; Njar Vincent C O; Brodie Angela M H
Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.
The Journal of steroid biochemistry and molecular biology 2004;92(3):155-65.
2004: Wu Chunyu; Njar Vincent; Brodie Angela; Borenstein Michael; Nnane Ivo
Quantification of a novel retinoic acid metabolism inhibitor, 4-(1H-imidazol-1-yl)retinoic acid (VN/14-1RA) and other retinoids in rat plasma by liquid chromatography with diode-array detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;810(2):203-8.
2004: Núñez Nomelí P; Jelovac Danijela; Macedo Luciana; Berrigan David; Perkins Susan N; Hursting Stephen D; Barrett J Carl; Brodie Angela
Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5375-80.
2004: Wang Qianben; Udayakumar T S; Vasaitis Tadas S; Brodie Angela M; Fondell Joseph D
Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells.
The Journal of biological chemistry 2004;279(17):17319-28.
2004: Long Brian J; Jelovac Danijela; Handratta Venkatesh; Thiantanawat Apinya; MacPherson Nicol; Ragaz Joseph; Goloubeva Olga G; Brodie Angela M
Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
Journal of the National Cancer Institute 2004;96(6):456-65.
2004: Samsel Leigh; Zaidel Grazyna; Drumgoole Honesty M; Jelovac Danijela; Drachenberg Cinthia; Rhee Juong G; Brodie Angela M H; Bielawska Alicja; Smyth Miriam J
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
The Prostate 2004;58(4):382-93.
2003: de Jong Paul Chr; Blankenstein Marinus A; Nortier Johannes W R; Slee Peter H Th J; van de Ven Joost; van Gorp Joost M H H; Elbers Johannes R J; Schipper Margriet E I; Blijham Geert H; Thijssen Jos H H; Lu Qing; Jelovac Danijela; Brodie Angela M
The relationship between aromatase in primary breast tumors and response to treatment with aromatase inhibitors in advanced disease.
The Journal of steroid biochemistry and molecular biology 2003;87(2-3):149-55.
2003: Thiantanawat Apinya; Long Brian J; Brodie Angela M
Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens.
Cancer research 2003;63(22):8037-50.
2003: Brodie Angela H; Jelovac Danijela; Long Brian
The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):283-8.
2003: Zhu Na; Ling Yangzhi; Lei Xiaoping; Handratta Venkatesh; Brodie Angela M H
Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives.
Steroids 2003;68(7-8):603-11.
2003: Mouridsen Henning T; Rose Carsten; Brodie Angela H; Smith Ian E
Challenges in the endocrine management of breast cancer.
Breast (Edinburgh, Scotland) 2003;12 Suppl 2():S2-19.
2003: Brodie Angela
Aromatase inhibitor development and hormone therapy: a perspective.
Seminars in oncology 2003;30(4 Suppl 14):12-22.
2003: Brodie Angela H; Mouridsen Henning T
Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.
American journal of clinical oncology 2003;26(4):S17-26.
2003: Corbin C J; Moran F M; Vidal J D; Ford J J; Wise T; Mapes S M; Njar V C; Brodie A M; Conley A J
Biochemical assessment of limits to estrogen synthesis in porcine follicles.
Biology of reproduction 2003;69(2):390-7.
2003: Clement Omoshile O; Freeman Clive M; Hartmann Rolf W; Handratta Venkatesh D; Vasaitis Tadas S; Brodie Angela M H; Njar Vincent C O
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
Journal of medicinal chemistry 2003;46(12):2345-51.
2003: Nnane Ivo P; Njar Vincent C O; Brodie Angela M H
Pharmacokinetics of novel inhibitors of androgen synthesis after intravenous administration in mice.
Cancer chemotherapy and pharmacology 2003;51(6):519-24.
2003: Brodie Angela; Jelovac Danijela; Long Brian J
Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):455S-9S.
2003: Come Steven E; Buzdar Aman U; Arteaga Carlos L; Brodie Angela M; Davidson Nancy E; Dowsett Mitch; Ingle James N; Johnston Stephen R D; Lee Adrian V; Osborne C Kent; Pritchard Kathleen I; Vogel Victor G; Winer Eric P; Hart Carol S
Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):443S-6S.
2002: Moran F M; Ford J J; Corbin C J; Mapes S M; Njar V C; Brodie A M; Conley A J
Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig.
Endocrinology 2002;143(9):3361-9.
2002: Long Brian J; Jelovac Danijela; Thiantanawat Apinya; Brodie Angela M
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2378-88.
2002: Brodie Angela
Aromatase inhibitors in breast cancer.
Trends in endocrinology and metabolism: TEM 2002;13(2):61-5.
2001: Brodie A; Long B
Aromatase inhibition and inactivation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12 Suppl):4343s-4349s; discussion 4411s-4412s.
2001: Buzdar A U; Come S E; Brodie A; Ellis M; Goss P E; Ingle J N; Johnston S R; Lee A V; Osborne C K; Vogel V G; Hart C S
Proceedings of the First International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: summary consensus statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12 Suppl):4335s-4337s; discussion 4411s-4412s.
2001: Brodie A M; Lu Q; Long B J; Fulton A; Chen T; Macpherson N; DeJong P C; Blankenstein M A; Nortier J W; Slee P H; van de Ven J; van Gorp J M; Elbers J R; Schipper M E; Blijham G H; Thijssen J H
Aromatase and COX-2 expression in human breast cancers.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):41-7.
2001: Brodie A; Inkster S; Yue W
Aromatase expression in the human male.
Molecular and cellular endocrinology 2001;178(1-2):23-8.
2001: Bhatnagar A S; Brodie A M; Long B J; Evans D B; Miller W R
Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):199-202.
2000: Grigoryev D N; Long B J; Njar V C; Brodie A H
Pregnenolone stimulates LNCaP prostate cancer cell growth via the mutated androgen receptor.
The Journal of steroid biochemistry and molecular biology 2000;75(1):1-10.
2000: Long B J; Grigoryev D N; Nnane I P; Liu Y; Ling Y Z; Brodie A M
Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.
Cancer research 2000;60(23):6630-40.
2000: Njar V C; Nnane I P; Brodie A M
Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.
Bioorganic & medicinal chemistry letters 2000;10(17):1905-8.
2000: Nnane I P; Long B J; Ling Y Z; Grigoryev D N; Brodie A M
Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis.
British journal of cancer 2000;83(1):74-82.
2000: Brodie A M; Njar V C
Aromatase inhibitors and their application in breast cancer treatment*.
Steroids 2000;65(4):171-9.
1999: Nnane I P; Njar V C; Liu Y; Lu Q; Brodie A M
Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo.
The Journal of steroid biochemistry and molecular biology 1999;71(3-4):145-52.
1999: Grigoryev D N; Long B J; Nnane I P; Njar V C; Liu Y; Brodie A M
Effects of new 17alpha-hydroxylase/C(17,20)-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo.
British journal of cancer 1999;81(4):622-30.
1999: Lu Q; Liu Y; Long B J; Grigoryev D; Gimbel M; Brodie A
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
Breast cancer research and treatment 1999;57(2):183-92.
1999: Njar V C; Brodie A M
Comprehensive pharmacology and clinical efficacy of aromatase inhibitors.
Drugs 1999;58(2):233-55.
1999: Brodie A; Lu Q; Liu Y; Long B
Aromatase inhibitors and their antitumor effects in model systems.
Endocrine-related cancer 1999;6(2):205-10.
1999: Nnane I P; Kato K; Liu Y; Long B J; Lu Q; Wang X; Ling Y Z; Brodie A
Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds.
Endocrinology 1999;140(6):2891-7.
1999: Brodie A; Lu Q; Long B
Aromatase and its inhibitors.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):205-10.
1999: Nakamura J; Lu Q; Aberdeen G; Albrecht E; Brodie A
The effect of estrogen on aromatase and vascular endothelial growth factor messenger ribonucleic acid in the normal nonhuman primate mammary gland.
The Journal of clinical endocrinology and metabolism 1999;84(4):1432-7.
1999: Njar V C; Brodie A M
Inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17): potential agents for the treatment of prostate cancer.
Current pharmaceutical design 1999;5(3):163-80.
1999: Dehal S S; Brodie A M; Kupfer D
The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):389-94.
1999: Grigoryev D N; Kato K; Njar V C; Long B J; Ling Y Z; Wang X; Mohler J; Brodie A M
Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17alpha-hydroxylase-C17,20-lyase inhibitors.
Analytical biochemistry 1999;267(2):319-30.
1998: Long B J; Tilghman S L; Yue W; Thiantanawat A; Grigoryev D N; Brodie A M
The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity.
The Journal of steroid biochemistry and molecular biology 1998;67(4):293-304.
1998: Ling Y Z; Li J S; Kato K; Liu Y; Wang X; Klus G T; Marat K; Nnane I P; Brodie A M
Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase.
Bioorganic & medicinal chemistry 1998;6(10):1683-93.
1998: Li S; Parish E J; Rodriguez-Valenzuela C; Brodie A M
Synthesis of new steroidal isoxazoles: inhibitors of estrogen synthase.
Bioorganic & medicinal chemistry 1998;6(9):1525-9.
1998: Nnane I P; Kato K; Liu Y; Lu Q; Wang X; Ling Y Z; Brodie A
Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
Cancer research 1998;58(17):3826-32.
1998: Lu Q; Yue W; Wang J; Liu Y; Long B; Brodie A
The effects of aromatase inhibitors and antiestrogens in the nude mouse model.
Breast cancer research and treatment 1998;50(1):63-71.
1998: Brodie A M; Njar V C
Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications.
The Journal of steroid biochemistry and molecular biology 1998;66(1-2):1-10.
1998: Stratakis C A; Vottero A; Brodie A; Kirschner L S; DeAtkine D; Lu Q; Yue W; Mitsiades C S; Flor A W; Chrousos G P
The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.
The Journal of clinical endocrinology and metabolism 1998;83(4):1348-57.
1998: Vottero A; Kirschner L S; Yue W; Brodie A; Stratakis C A
P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for exon-1 after Epstein-Barr virus transformation.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):245-50.
1998: Brodie A; Lu Q; Liu Y; Long B; Wang J P; Yue W
Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer.
Oncology (Williston Park, N.Y.) 1998;12(3 Suppl 5):36-40.
1998: Njar V C; Kato K; Nnane I P; Grigoryev D N; Long B J; Brodie A M
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
Journal of medicinal chemistry 1998;41(6):902-12.
1998: Shenton K C; Dowsett M; Lu Q; Brodie A; Sasano H; Sacks N P; Rowlands M G
Comparison of biochemical aromatase activity with aromatase immunohistochemistry in human breast carcinomas.
Breast cancer research and treatment 1998;49 Suppl 1():S101-7; discussion S109-19.
1998: Brodie A; Long B; Lu Q
Aromatase expression in the human breast.
Breast cancer research and treatment 1998;49 Suppl 1():S85-91; discussion S109-19.
1998: Brodie A; Lu Q; Yue W; Wang J; Liu Y
Intratumoral aromatase model: the effects of letrozole (CGS 20267).
Breast cancer research and treatment 1998;49 Suppl 1():S23-6; discussion S33-7.
1997: Yue W; Brodie A M
Mechanisms of the actions of aromatase inhibitors 4-hydroxyandrostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):317-28.
1997: Ling Y Z; Li J S; Liu Y; Kato K; Klus G T; Brodie A
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Journal of medicinal chemistry 1997;40(20):3297-304.
1997: Njar V C; Klus G T; Johnson H H; Brodie A M
Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17 alpha-hydroxylase/17,20-lyase (17 alpha-lyase).
Steroids 1997;62(6):468-73.
1997: Brodie A; Lu Q; Nakamura J
Aromatase in the normal breast and breast cancer.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):281-6.
1996: Nakamura J; Savinov A; Lu Q; Brodie A
Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.
Endocrinology 1996;137(12):5589-96.
1996: Klus G T; Nakamura J; Li J S; Ling Y Z; Son C; Kemppainen J A; Wilson E M; Brodie A M
Growth inhibition of human prostate cells in vitro by novel inhibitors of androgen synthesis.
Cancer research 1996;56(21):4956-64.
1996: Li J S; Li Y; Son C; Brodie A M
Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
Journal of medicinal chemistry 1996;39(21):4335-9.
1996: Brodie A M; Njar V C
Aromatase inhibitors and breast cancer.
Seminars in oncology 1996;23(4 Suppl 9):10-20.
1996: Lu Q; Nakmura J; Savinov A; Yue W; Weisz J; Dabbs D J; Wolz G; Brodie A
Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers.
Endocrinology 1996;137(7):3061-8.
1996: Coll J M; Sekowski J W; Hickey R J; Schnaper L; Yue W; Brodie A M; Uitto L; Syvaoja J E; Malkas L H
The human breast cell DNA synthesome: its purification from tumor tissue and cell culture.
Oncology research 1996;8(10-11):435-47.
1995: Yue W; Wang J; Savinov A; Brodie A
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
Cancer research 1995;55(14):3073-7.
1995: Inkster S; Yue W; Brodie A
Human testicular aromatase: immunocytochemical and biochemical studies.
The Journal of clinical endocrinology and metabolism 1995;80(6):1941-7.
1995: Li J; Li Y; Son C; Brodie A M
Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-one.
The Prostate 1995;26(3):140-50.
1995: Zhou J L; Brodie A
The effect of aromatase inhibitor 4-hydroxyandrostenedione on steroid receptors in hormone-dependent tissues of the rat.
The Journal of steroid biochemistry and molecular biology 1995;52(1):71-6.
1994: Yue W; Zhou D; Chen S; Brodie A
A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene.
Cancer research 1994;54(19):5092-5.
1994: Brodie A M
Aromatase inhibitors in the treatment of breast cancer.
The Journal of steroid biochemistry and molecular biology 1994;49(4-6):281-7.
1994: Bulun S E; Rosenthal I M; Brodie A M; Inkster S E; Zeller W P; DiGeorge A M; Frasier S D; Kilgore M W; Simpson E R
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1994;78(2):1616-21.
1994: Brodie A M; Santen R J
Aromatase and its inhibitors in breast cancer treatment--overview and perspective.
Breast cancer research and treatment 1994;30(1):1-6.
1993: Bulun S E; Rosenthal I M; Brodie A M; Inkster S E; Zeller W P; DiGeorge A M; Frasier S D; Kilgore M W; Simpson E R
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1993;77(6):1616-21.
1993: Brodie A M
Aromatase, its inhibitors and their use in breast cancer treatment.
Pharmacology & therapeutics 1993;60(3):501-15.
1993: Koos R D; Banks P K; Inkster S E; Yue W; Brodie A M
Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction.
The Journal of steroid biochemistry and molecular biology 1993;45(4):217-25.
1993: Yue W; Brodie A
MCF-7 human breast carcinomas in nude mice as a model for evaluating aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):671-3.
1993: Brodie A; Inkster S
Aromatase in the human testis.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):549-55.
1993: Berstein L M; Santner S J; Brodie A M; Koos R D; Naftolin F; Santen R J
Pseudoaromatase in circulating lymphocytes.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):647-9.
1992: Li J; Li Y; Son C; Banks P; Brodie A
4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):313-20.
1991: Inkster S E; Brodie A M
Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study.
The Journal of clinical endocrinology and metabolism 1991;73(4):717-26.
1991: Banks P K; Meyer K; Brodie A M
Regulation of ovarian steroid biosynthesis by estrogen during proestrus in the rat.
Endocrinology 1991;129(3):1295-304.
1991: Zimniski S J; Brandt M E; Melner M H; Brodie A M; Puett D
Effect of 4-hydroxyandrostenedione on murine Leydig tumor cell steroidogenesis.
Cancer research 1991;51(14):3663-8.
1991: Coen P; Kulin H; Ballantine T; Zaino R; Frauenhoffer E; Boal D; Inkster S; Brodie A; Santen R
An aromatase-producing sex-cord tumor resulting in prepubertal gynecomastia.
The New England journal of medicine 1991;324(5):317-22.
1991: Brodie A
Aromatase and its inhibitors--an overview.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):255-61.
1990: Brodie A M; Banks P K; Inkster S E; Son C; Koos R D
Aromatase and other inhibitors in breast and prostatic cancer.
The Journal of steroid biochemistry and molecular biology 1990;37(6):1043-8.
1990: Brodie A M; Banks P K; Inkster S E; Dowsett M; Coombes R C
Aromatase inhibitors and hormone-dependent cancers.
The Journal of steroid biochemistry and molecular biology 1990;37(3):327-33.
1990: Brodie A
Aromatase inhibitors: introduction and perspective.
Journal of enzyme inhibition 1990;4(2):75-7.
1989: Brodie A M; Son C; King D A; Meyer K M; Inkster S E
Lack of evidence for aromatase in human prostatic tissues: effects of 4-hydroxyandrostenedione and other inhibitors on androgen metabolism.
Cancer research 1989;49(23):6551-5.
1989: Inkster S E; Brodie A M
Immunocytochemical studies of aromatase in early and full-term human placental tissues: comparison with biochemical assays.
Biology of reproduction 1989;41(5):889-98.
1989: Brodie A M; Hammond J O; Ghosh M; Meyer K; Albrecht E D
Effect of treatment with aromatase inhibitor 4-hydroxandrostenedione on the nonhuman primate menstrual cycle.
Cancer research 1989;49(17):4780-4.
1988: Wing L Y; Hammond J O; Brodie A M
Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.
Endocrinology 1988;122(6):2418-27.
1988: Dale S L; Holbrook M M; Brodie A M; Melby J C
Effect of 4-hydroxyandrostenedione on 19-hydroxylation of deoxycorticosterone in the golden Syrian hamster.
Steroids 1988;51(1-2):185-93.
1988: Brodie A M; Dowsett M; Coombes R C
Aromatase inhibitors as new endocrine therapy for breast cancer.
Cancer treatment and research 1988;39():51-65.
1987: Brodie A M; Wing L Y
In vitro and in vivo studies with aromatase inhibitor 4-hydroxy-androstenedione.
Steroids 1987;50(1-3):89-103.
1987: Coombes R C; Goss P E; Dowsett M; Hutchinson G; Cunningham D; Jarman M; Brodie A M
4-Hydroxyandrostenedione treatment for postmenopausal patients with advanced breast cancer.
Steroids 1987;50(1-3):245-52.
1987: Dowsett M; Goss P E; Powles T J; Hutchinson G; Brodie A M; Jeffcoate S L; Coombes R C
Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route.
Cancer research 1987;47(7):1957-61.
1987: Bartke A; Morgan W W; Clayton R N; Banerji T K; Brodie A M; Parkening T A; Collins T J
Neuroendocrine studies in hyperprolactinaemic male mice.
The Journal of endocrinology 1987;112(2):215-20.
1987: Hsiang Y H; Berkovitz G D; Brown T R; Migeon C J; Brodie A M
The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts.
Journal of steroid biochemistry 1987;26(1):131-5.
1987: Cunningham D; Powles T J; Dowsett M; Hutchison G; Brodie A M; Ford H T; Gazet J C; Coombes R C
Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer.
Cancer chemotherapy and pharmacology 1987;20(3):253-5.
1987: Brodie A M; Coombes R C; Dowsett M
Aromatase inhibitors: basic and clinical studies.
Journal of steroid biochemistry 1987;27(4-6):899-903.
1986: Brodie A M; Wing L Y; Goss P; Dowsett M; Coombes R C
Aromatase inhibitors and their potential clinical significance.
Journal of steroid biochemistry 1986;25(5B):859-65.
1986: Motta M; Zoppi S; Brodie A M; Martini L
Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate.
Journal of steroid biochemistry 1986;25(4):593-600.
1986: Goss P E; Powles T J; Dowsett M; Hutchison G; Brodie A M; Gazet J C; Coombes R C
Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4-hydroxyandrostenedione: phase II report.
Cancer research 1986;46(9):4823-6.
1986: Brodie A M; Wing L Y; Goss P; Dowsett M; Coombes R C
Aromatase inhibitors and the treatment of breast cancer.
Journal of steroid biochemistry 1986;24(1):91-7.
1986: Brodie A M; Santen R J
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Critical reviews in oncology/hematology 1986;5(4):361-96.
1985: Adashi E Y; Resnick C E; Brodie A M; Svoboda M E; Van Wyk J J
Somatomedin-C-mediated potentiation of follicle-stimulating hormone-induced aromatase activity of cultured rat granulosa cells.
Endocrinology 1985;117(6):2313-20.
1985: Brodie A M
Aromatase inhibition and its pharmacologic implications.
Biochemical pharmacology 1985;34(18):3213-9.
1985: Knecht M; Brodie A M; Catt K J
Aromatase inhibitors prevent granulosa cell differentiation: an obligatory role for estrogens in luteinizing hormone receptor expression.
Endocrinology 1985;117(3):1156-61.
1985: Marsh D A; Brodie H J; Garrett W; Tsai-Morris C H; Brodie A M
Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives.
Journal of medicinal chemistry 1985;28(6):788-95.
1985: Wing L Y; Garrett W M; Brodie A M
Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.
Cancer research 1985;45(6):2425-8.
1985: Koos R D; LeMaire W J; Hung T T; Brodie A M
Comparison of the effect of 4-hydroxy-4-androstene-3,17-dione on aromatase activity in granulosa cells from preovulatory follicles of rats, rabbits, and humans.
Steroids 1985;45(2):143-50.
1984: Coombes R C; Goss P; Dowsett M; Gazet J C; Brodie A
4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
Lancet 1984;2(8414):1237-9.
1984: Berkovitz G D; Fujimoto M; Brown T R; Brodie A M; Migeon C J
Aromatase activity in cultured human genital skin fibroblasts.
The Journal of clinical endocrinology and metabolism 1984;59(4):665-71.
1984: Koos R D; Feiertag M A; Brodie A M; LeMaire W J
Inhibition of estrogen synthesis does not inhibit luteinizing hormone-induced ovulation.
American journal of obstetrics and gynecology 1984;148(7):939-45.
1983: Tsai-Morris C H; Ghosh M; Hirshfield A N; Wise P M; Brodie A M
Inhibition of ovarian aromatase by prolactin in vivo.
Biology of reproduction 1983;29(2):342-6.
1983: Brodie A M; Garrett W M; Hendrickson J R; Tsai-Morris C H; Williams J G
1. Estrogen antagonists. Aromatase inhibitors, their pharmacology and application.
Journal of steroid biochemistry 1983;19(1A):53-8.
1983: Bar-Ami S; Nimrod A; Brodie A M; Tsafriri A
Role of FSH and oestradiol-17 beta in the development of meiotic competence in rat oocytes.
Journal of steroid biochemistry 1983;19(1C):965-71.
1983: Dalterio S; Bartke A; Brodie A; Mayfield D
Effects of testosterone, estradiol, aromatase inhibitor, gonadotropin and prolactin on the response of mouse testes to acute gonadotropin stimulation.
Journal of steroid biochemistry 1983;18(4):391-6.
1982: Brodie A M
Overview of recent development of aromatase inhibitors.
Cancer research 1982;42(8 Suppl):3312s-3314s.
1982: Brodie A M; Garrett W M; Hendrickson J R; Tsai-Morris C H
Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.
Cancer research 1982;42(8 Suppl):3360s-3364s.
1982: Brodie A M; Brodie H J; Garrett W M; Hendrickson J R; Marsh D A; Tsai-Morris C H
Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo.
Biochemical pharmacology 1982;31(11):2017-23.
1982: Marsh D A; Romanoff L; Williams K I; Brodie H J; Brodie A M
Synthesis of deuterium- and tritium-labelled 4-hydroxyandrostene-3,17-dione, an aromatase inhibitor, and its metabolism in vitro and in vivo in the rat.
Biochemical pharmacology 1982;31(5):701-5.
1981: Brodie A M; Garrett W M; Hendrickson J R; Tsai-Morris C H; Marcotte P A; Robinson C H
Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.
Steroids 1981;38(6):693-702.
1981: Evans G; Leung P C; Brodie A M; Armstrong D T
Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
Biology of reproduction 1981;25(2):290-4.
1981: Brodie A M; Romanoff L P; Williams K I
Metabolism of the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione by male rhesus monkeys.
Journal of steroid biochemistry 1981;14(8):693-6.
1981: Brodie A M; Brodie H J; Romanoff L; Williams J G; Williams K I; Wu J T
Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.
Advances in experimental medicine and biology 1981;138():179-90.
1980: Brodie A M; Longcope C
Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy- and 4-acetoxy-androstene-3,17-dione.
Endocrinology 1980;106(1):19-21.
1979: Brodie A M
Recent advances in studies on estrogen biosynthesis.
Journal of endocrinological investigation 1979;2(4):445-60.
1979: Brodie A M; Marsh D A; Wu J T; Brodie H J
Aromatase inhibitors and their use in controlling oestrogen-dependent processes.
Journal of steroid biochemistry 1979;11(1A):107-12.
1979: Brodie A M; Marsh D; Brodie H J
Aromatase inhibitors--IV. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione.
Journal of steroid biochemistry 1979;10(4):423-9.
1979: Brodie A M; Wu J T; Marsh D A; Brodie H J
Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione.
Endocrinology 1979;104(1):118-21.
1978: Brodie A M; Wu J T; Marsh D A; Brodie H J
Aromatase inhibitors III. Studies on the antifertility effect of 4-acetoxy-4-androstene-3,17-dione.
Biology of reproduction 1978;18(3):365-70.
1977: Brodie A M; Schwarzel W C; Shaikh A A; Brodie H J
The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer.
Endocrinology 1977;100(6):1684-95.
1976: Brodie A M; Schwarzel W C; Brodie H J
Studies on the mechanism of estrogen biosynthesis in the rat ovary--I.
Journal of steroid biochemistry 1976;7(10):787-93.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Angela Brodie

Research Profile (preview)

Chemicals & Drugs

Disorders

Living Beings

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Angela Brodie (preview)

All Publications