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Angela Brodie

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Gauri Sabnis; Preeti Shah; Olga Golubeva; Armina Kazi; Angela Brodie
Effect of selumetinib on the growth of anastrozole-resistant tumors.
Amanda J Schech; Brandon E Nemieboka; Angela Brodie
Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction.
Rabia A Gilani; Anil K Jaiswal; Armina A Kazi; Gauri Sabnis; Amanda J Schech; Preeti Shah; Saranya Chumsri; Angela Brodie
The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer.

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All Publications

2013: Gauri Sabnis; Preeti Shah; Olga Golubeva; Armina Kazi; Angela Brodie
Effect of selumetinib on the growth of anastrozole-resistant tumors.
Breast cancer research and treatment 2013;138(3):699-708.
2012: Amanda J Schech; Brandon E Nemieboka; Angela Brodie
Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction.
The Journal of steroid biochemistry and molecular biology 2012;132(3-5):195-202.
2012: Rabia A Gilani; Anil K Jaiswal; Armina A Kazi; Gauri Sabnis; Amanda J Schech; Preeti Shah; Saranya Chumsri; Angela Brodie
The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer.
Breast cancer research and treatment 2012;135(3):681-92.
2012: Lisa A Tobin; Alan E Tomkinson; William S Twaddell; Carine Robert; Angela Brodie; Saranya Chumsri; George E Greco; Olga B Ioffe; Pratik Nagaria; Feyruz V Rassool
Targeting abnormal DNA repair in therapy-resistant breast cancers.
Molecular cancer research : MCR 2012;10(1):96-107.
2011: Xiaonan Hou; Angela Brodie; Marco M Gottardis; Ann Greer; Luciana F Macedo; Fei Huang; Karen A Reeves; Joan M Carboni; Friedrich Graf Finckenstein; Sean C Harrington; Paul Haluska
Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
Cancer research 2011;71(24):7597-607.
2011: Robert D Bruno; Lalji Gediya; Abhijit M Godbole; Zeynep Ates-Alagoz; Angela Brodie; Puranik Purushottamachar; Tadas S Vasaitis; Vincent Njar
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
Steroids 2011;76(12):1268-79.
2011: Xi Yang; Alan Alfano; Angela Brodie; Hegang Chen; Mingyuan Chen; Zhiyong Guo; Wei Li; Hermela Shimelis; Feng Sun; Timothy D Veenstra; Zhen Xiao; Yun Qiu
Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells.
The Journal of biological chemistry 2011;286(41):36152-60.
2011: Gauri Sabnis; Angela Brodie
Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance.
Molecular and cellular endocrinology 2011;340(2):142-7.
2011: Saranya Chumsri; Timothy Howes; Gauri Sabnis; Angela Brodie
Aromatase inhibitors and xenograft studies.
Steroids 2011;76(8):730-5.
2011: Angela Brodie; Gauri Sabnis
Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(13):4208-13.
2011: Saranya Chumsri; Timothy Howes; Ting Bao; Gauri Sabnis; Angela Brodie
Aromatase, aromatase inhibitors, and breast cancer.
The Journal of steroid biochemistry and molecular biology 2011;125(1-2):13-22.
2011: Gauri Sabnis; Olga Goloubeva; Saranya Chumsri; Nguyen Nguyen; Saraswati Sukumar; Angela Brodie
Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole.
Cancer research 2011;71(5):1893-903.
2011: Tesfom Abrhale; Angela Brodie; Luciana Macedo; Gauri Sabnis; Changsheng Tian; Binbin Yue; Ginette Serrero
GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells.
BMC cancer 2011;11():231.
2010: Yuan Yao; Angela Brodie; Nancy E Davidson; Thomas W Kensler; Qun Zhou
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.
Breast cancer research and treatment 2010;124(2):585-91.
2010: Scott Burks; Luciana F Macedo; Eugene D Barth; Katherine Tkaczuk; Stuart S Martin; Gerald M. Rosen; Howard J Halpern; Angela Brodie; Joseph Kao
Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells.
Breast cancer research and treatment 2010;124(1):121-31.
2010: A Schayowitz; Gauri Sabnis; Olga Goloubeva; Vincent Njar; Angela Brodie
Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR.
British journal of cancer 2010;103(7):1001-7.
2010: Martin Smollich; Martin Götte; Jeanett Fischgräbe; Luciana F Macedo; Angela Brodie; Shiuan Chen; Isabel Radke; Ludwig Kiesel; Pia Wülfing
ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole.
Breast cancer research and treatment 2010;123(2):345-57.
2010: M B Lodish; L A Gartner; P Albini; Gauri Sabnis; Angela Brodie; Jeanne M Meck; Aurelia Meloni-Ehrig; S Hill; Ekaterini T Tsilou; V A Valera; B A Walter; Maria J Merino; Constantine Straturis
Intrauterine growth retardation associated with precocious puberty and sertoli cell hyperplasia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2010;42(9):682-8.
2010: T Nakanishi; Saranya Chumsri; Nazanin Khakpour; Angela Brodie; Brian Leyland-Jones; Anne W Hamburger; Douglas Ross; Angelika Burger
Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling.
British journal of cancer 2010;102(5):815-26.
2010: Angela Brodie; Luciana Macedo; Gauri Sabnis
Aromatase resistance mechanisms in model systems in vivo.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):283-7.
2010: Gauri Sabnis; Angela Brodie
Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention.
Clinical breast cancer 2010;10(1):E6-E15.
2010: Gauri Sabnis; Olga Goloubeva; Rabia Gilani; Luciana Macedo; Angela Brodie
Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment.
Molecular cancer therapeutics 2010;9(1):46-56.
2009: Richard J Santen; H Brodie; E R Simpson; P K Siiteri; Angela Brodie
History of aromatase: saga of an important biological mediator and therapeutic target.
Endocrine reviews 2009;30(4):343-75.
2009: Zhiyong Guo; Xi Yang; Feng Sun; Richeng Jiang; Douglas E Linn; Hegang Chen; He-Ge Chen; Xiangtian Kong; Jonathan Melamed; Clifford G Tepper; Hsing-Jien Kung; Angela Brodie; Joanne Edwards; Yun Qiu
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Cancer research 2009;69(6):2305-13.
2009: Gauri Sabnis; Adam Schayowitz; Olga Goloubeva; Luciana Macedo; Angela Brodie
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.
Cancer research 2009;69(4):1416-28.
2009: Luciana Macedo; Gauri Sabnis; Angela Brodie
Aromatase inhibitors and breast cancer.
Annals of the New York Academy of Sciences 2009;1155():162-73.
2009: Angela Brodie; Vincent Njar; Luciana Macedo; Tadas S Vasaitis; Gauri Sabnis
The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer.
Urologic oncology 2009;27(1):53-63.
2008: Robert D Bruno; tony gover; Angelika Burger; Angela Brodie; Vincent Njar
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.
Molecular cancer therapeutics 2008;7(9):2828-36.
2008: Tadas S Vasaitis; Aashvini Belosay; Adam Schayowitz; Aakanksha Khandelwal; Pankaj Chopra; Lalji Gediya; Zhiyong Guo; Hongbin Fang; Vincent Njar; Angela Brodie
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.
Molecular cancer therapeutics 2008;7(8):2348-57.
2008: William R Miller; John Bartlett; Angela Brodie; Robert W Brueggemeier; Enrico di Salle; Per Eystein Lønning; Antonio Llombart; Nicolai Maass; Thierry Maudelonde; Hironobu Sasano; Paul E Goss
Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
The oncologist 2008;13(8):829-37.
2008: Gauri Sabnis; Luciana Macedo; Olga Goloubeva; Adam Schayowitz; Angela Brodie
Stopping treatment can reverse acquired resistance to letrozole.
Cancer research 2008;68(12):4518-24.
2008: Luciana Macedo; Gauri Sabnis; Olga Goloubeva; Angela Brodie
Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.
Cancer research 2008;68(9):3516-22.
2008: Luciana Macedo; Gauri Sabnis; Angela Brodie
Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors.
Cancer 2008;112(3 Suppl):679-88.
2008: Steven E Come; Aman U Buzdar; James N Ingle; Stephen R D Johnston; Angela Brodie; R Charles Coombes; William R Miller; Kathleen I Pritchard; Eric P Winer; Jo Anne Zujewski; Paul E Goss
Endocrine and targeted manipulation of breast cancer: summary statement for the Sixth Cambridge Conference.
Cancer 2008;112(3 Suppl):673-8.
2008: Adam Schayowitz; Gauri Sabnis; Vincent Njar; Angela Brodie
Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.
Molecular cancer therapeutics 2008;7(1):121-32.
2008: Gauri Sabnis; Luciana Macedo; Olga Goloubeva; Adam Schayowitz; Yue Zhu; Angela Brodie
Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model.
The Journal of steroid biochemistry and molecular biology 2008;108(1-2):1-7.
2007: Angela Brodie; Gauri Sabnis; Luciana Macedo
Xenograft models for aromatase inhibitor studies.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):119-24.
2007: Gauri Sabnis; Olga Goloubeva; Danijela Jelovac; Adam Schayowitz; Angela Brodie
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2751-7.
2007: Jyoti B Patel; J Mehta; Aashvini Belosay; Gauri Sabnis; Aakanksha Khandelwal; Angela Brodie; Dianne Robert Soprano; Vincent Njar
Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.
British journal of cancer 2007;96(8):1204-15.
2007: V Craig Jordan; Angela Brodie
Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer.
Steroids 2007;72(1):7-25.
2006: Aashvini Belosay; Angela Brodie; Vincent Njar
Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells.
Cancer research 2006;66(23):11485-93.
2006: Angela Brodie; Gauri Sabnis; Danijela Jelovac
Aromatase and breast cancer.
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):97-102.
2006: Zhiyong Guo; Bojie Dai; Tianyun Jiang; Kexin Xu; Yingqiu Xie; Oekyung Kim; Issa Nesheiwat; Xiangtian Kong; Jonathan Melamed; Venkatesh D Handratta; Vincent Njar; Angela Brodie; Li-Rong Yu; Timothy D Veenstra; Hegang Chen; Yun Qiu
Regulation of androgen receptor activity by tyrosine phosphorylation.
Cancer cell 2006;10(4):309-19.
2006: X Tao; Angela Brodie; Ivo P Nnane
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.
Biopharmaceutics & drug disposition 2006;27(7):335-44.
2006: Bojie Dai; Oekyung Kim; Yingqiu Xie; Zhiyong Guo; Kexin Xu; Bin Wang; Xiangtian Kong; Jonathan Melamed; Hegang Chen; Charles J Bieberich; Alexander D Borowsky; Hsing-Jien Kung; Guo Wei; Michael C Ostrowski; Angela Brodie; Yun Qiu
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.
Cancer research 2006;66(16):8058-64.
2006: Luciana Macedo; Zhiyong Guo; Syreeta Latatia Tilghman; Gauri Sabnis; Yun Qiu; Angela Brodie
Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
Cancer research 2006;66(15):7775-82.
2006: Jianping Chao; Yangzhi Ling; Xiaofeng Liu; Xuande Luo; Angela Brodie
A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids.
Steroids 2006;71(7):585-90.
2006: Carlic K Huynh; Angela Brodie; Vincent Njar
Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice.
British journal of cancer 2006;94(4):513-23.
2006: Angela Brodie
David Kupfer and the metabolism connection: on aromatase inhibitors and tamoxifen.
Drug metabolism reviews 2006;38(1-2):129-37.
2006: Yao Tang; Mohammad A Khan; Olga Goloubeva; Dong I Lee; Danijela Jelovac; Angela Brodie; Arif Hussain
Docetaxel followed by castration improves outcomes in LNCaP prostate cancer-bearing severe combined immunodeficient mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):169-74.
2005: Yuexing Zhang; Xin-Wei Wang; Danijela Jelovac; Takeo Nakanishi; Myoung-Hee Yu; Damilola Akinmade; Olga Goloubeva; Douglas Ross; Angela Brodie; Anne W Hamburger
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9890-5.
2005: Danijela Jelovac; Luciana Macedo; Olga Goloubeva; Venkatesh D Handratta; Angela Brodie
Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.
Cancer research 2005;65(12):5439-44.
2005: Danijela Jelovac; Gauri Sabnis; Brian Long; Luciana Macedo; Olga Goloubeva; Angela Brodie
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole.
Cancer research 2005;65(12):5380-9.
2005: Angela Brodie; Danijela Jelovac; Gauri Sabnis; Brian Long; Luciana Macedo; Olga Goloubeva
Model systems: mechanisms involved in the loss of sensitivity to letrozole.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):41-8.
2005: Gauri Sabnis; Danijela Jelovac; Brian Long; Angela Brodie
The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation.
Cancer research 2005;65(9):3903-10.
2005: Venkatesh D Handratta; Tadas S Vasaitis; Vincent Njar; Lalji Gediya; Ritesh Kataria; Pankaj Chopra; Donnell Newman; Rena Farquhar; Zhiyong Guo; Yun Qiu; Angela Brodie
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Journal of medicinal chemistry 2005;48(8):2972-84.
2005: Angela Brodie; Danijela Jelovac; Luciana Macedo; Gauri Sabnis; Syreeta Latatia Tilghman; Olga Goloubeva
Therapeutic observations in MCF-7 aromatase xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):884s-8s.
2005: Steven E Come; Aman U Buzdar; James N Ingle; Carlos L Arteaga; Angela Brodie; GRaham Colditz; Stephen R D Johnston; Vessela N Kristensen; Per Eystein Lønning; Donald P McDonnell; C Kent Osborne; Jose Russo; Richard J Santen; Douglas Yee; Carol S Hart
Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 2):861s-4s.
2004: Jyoti B Patel; Carlic K Huynh; Venkatesh D Handratta; Lalji Gediya; Angela Brodie; Olga Goloubeva; Omoshile O Clement; Ivo P Nanne; Dianne Robert Soprano; Vincent Njar
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Journal of medicinal chemistry 2004;47(27):6716-29.
2004: Constantine Straturis; Dalia Batista; Gauri Sabnis; Angela Brodie
Prepubertal gynaecomastia caused by medication or the aromatase excess syndrome.
Clinical endocrinology 2004;61(6):779-80.
2004: Danijela Jelovac; Luciana Macedo; Venkatesh D Handratta; Brian Long; Olga Goloubeva; James N Ingle; Angela Brodie
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7375-81.
2004: Chunyu Wu; Vincent Njar; Angela Brodie; Michael R Borenstein; Ivo P Nnane
Quantification of a novel retinoic acid metabolism inhibitor, 4-(1H-imidazol-1-yl)retinoic acid (VN/14-1RA) and other retinoids in rat plasma by liquid chromatography with diode-array detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;810(2):203-8.
2004: Venkatesh D Handratta; Danijela Jelovac; Brian Long; Ritesh Kataria; Ivo P Nnane; Vincent Njar; Angela Brodie
Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.
The Journal of steroid biochemistry and molecular biology 2004;92(3):155-65.
2004: Nomelí P Núñez; Danijela Jelovac; Luciana Macedo; David Berrigan; Susan N Perkins; Stephen D Hursting; J Carl Barrett; Angela Brodie
Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(16):5375-80.
2004: Qianben Wang; TS Udayakumar; Tadas S Vasaitis; Angela Brodie; Joseph D Fondell
Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells.
The Journal of biological chemistry 2004;279(17):17319-28.
2004: Brian Long; Danijela Jelovac; Venkatesh D Handratta; Apinya Thiantanawat; Nicol MacPherson; Joseph Ragaz; Olga Goloubeva; Angela Brodie
Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
Journal of the National Cancer Institute 2004;96(6):456-65.
2004: Leigh Samsel; Grazyna Zaidel; Honesty M Drumgoole; Danijela Jelovac; Cinthia Drachenberg; Juong G Rhee; Angela Brodie; Alicja Bielawska; Mary J Miriam Smyth
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
The Prostate 2004;58(4):382-93.
2003: Apinya Thiantanawat; Brian Long; Angela Brodie
Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens.
Cancer research 2003;63(22):8037-50.
2003: Paul Chr De Jong; Marinus A Blankenstein; J W R Nortier; Peter Slee; Joost van de Ven; Joost M H H van Gorp; Johannes R J Elbers; Margriet E I Schipper; Geert H Blijham; Jos H H Thijssen; Qing Lu; Danijela Jelovac; Angela Brodie
The relationship between aromatase in primary breast tumors and response to treatment with aromatase inhibitors in advanced disease.
The Journal of steroid biochemistry and molecular biology 2003;87(2-3):149-55.
2003: Angela Brodie; Danijela Jelovac; Brian Long
The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):283-8.
2003: Na Zhu; Yangzhi Ling; Xiaoping Lei; Venkatesh D Handratta; Angela Brodie
Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives.
Steroids 2003;68(7-8):603-11.
2003: Henning T Mouridsen; Carsten Rose; Angela Brodie; Ian E Smith
Challenges in the endocrine management of breast cancer.
Breast (Edinburgh, Scotland) 2003;12 Suppl 2():S2-19.
2003: Angela Brodie
Aromatase inhibitor development and hormone therapy: a perspective.
Seminars in oncology 2003;30(4 Suppl 14):12-22.
2003: Angela Brodie; Henning T Mouridsen
Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.
American journal of clinical oncology 2003;26(4):S17-26.
2003: C Jo Corbin; Francisco M Moran; Justin D Vidal; J Joe Ford; T Wise; Samantha Mapes; Vincent Njar; Angela Brodie; Alan J Conley
Biochemical assessment of limits to estrogen synthesis in porcine follicles.
Biology of reproduction 2003;69(2):390-7.
2003: Omoshile O Clement; Clive M Freeman; Rolf W Hartmann; Venkatesh D Handratta; Tadas S Vasaitis; Angela Brodie; Vincent Njar
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
Journal of medicinal chemistry 2003;46(12):2345-51.
2003: Ivo P Nnane; Vincent Njar; Angela Brodie
Pharmacokinetics of novel inhibitors of androgen synthesis after intravenous administration in mice.
Cancer chemotherapy and pharmacology 2003;51(6):519-24.
2003: Angela Brodie; Danijela Jelovac; Brian Long
Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):455S-9S.
2003: Steven E Come; Aman U Buzdar; Carlos L Arteaga; Angela Brodie; Nancy E Davidson; Mitch Dowsett; James N Ingle; Stephen R D Johnston; Adrian V Lee; C Kent Osborne; Kathleen I Pritchard; Victor G Vogel; Eric P Winer; Carol S Hart
Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1 Pt 2):443S-6S.
2002: Francisco M Moran; J Joe Ford; C Jo Corbin; Samantha Mapes; Vincent Njar; Angela Brodie; Alan J Conley
Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig.
Endocrinology 2002;143(9):3361-9.
2002: Brian Long; Danijela Jelovac; Apinya Thiantanawat; Angela Brodie
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2378-88.
2002: Angela Brodie
Aromatase inhibitors in breast cancer.
Trends in endocrinology and metabolism: TEM 2002;13(2):61-5.
2001: Angela Brodie; Brian Long
Aromatase inhibition and inactivation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12 Suppl):4343s-4349s; discussion 4411s-4412s.
2001: Aman U Buzdar; Steven E Come; Angela Brodie; M Ellis; P E Goss; James N Ingle; Stephen R D Johnston; Adrian V Lee; C Kent Osborne; V G Vogel; Carol S Hart
Proceedings of the First International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: summary consensus statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12 Suppl):4335s-4337s; discussion 4411s-4412s.
2001: Angela Brodie; Qing Lu; Brian Long; Amy M Fulton; T Chen; N Macpherson; P C DeJong; Marinus A Blankenstein; J W R Nortier; Peter Slee; Joost van de Ven; Joost M H H van Gorp; Johannes R J Elbers; M E Schipper; Geert H Blijham; Jos H H Thijssen
Aromatase and COX-2 expression in human breast cancers.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):41-7.
2001: Ivo P Nnane; Vincent Njar; Angela Brodie
Pharmacokinetic profile of 3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1), a potent androgen synthesis inhibitor, in mice.
The Journal of steroid biochemistry and molecular biology 2001;78(3):241-6.
2001: Angela Brodie; S Inkster; W Yue
Aromatase expression in the human male.
Molecular and cellular endocrinology 2001;178(1-2):23-8.
2001: A S Bhatnagar; Angela Brodie; Brian Long; D B Evans; W R Miller
Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):199-202.
2000: Dmitry N Grigoryev; Brian Long; Vincent Njar; Angela Brodie
Pregnenolone stimulates LNCaP prostate cancer cell growth via the mutated androgen receptor.
The Journal of steroid biochemistry and molecular biology 2000;75(1):1-10.
2000: Brian Long; Dmitry N Grigoryev; Ivo P Nnane; Y Liu; YZ Ling; Angela Brodie
Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer.
Cancer research 2000;60(23):6630-40.
2000: Vincent Njar; Ivo P Nnane; Angela Brodie
Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.
Bioorganic & medicinal chemistry letters 2000;10(17):1905-8.
2000: Ivo P Nnane; Brian Long; YZ Ling; Dmitry N Grigoryev; Angela Brodie
Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis.
British journal of cancer 2000;83(1):74-82.
2000: Angela Brodie; Vincent Njar
Aromatase inhibitors and their application in breast cancer treatment*.
Steroids 2000;65(4):171-9.
1999: Ivo P Nnane; Vincent Njar; Y Liu; Qing Lu; Angela Brodie
Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo.
The Journal of steroid biochemistry and molecular biology 1999;71(3-4):145-52.
1999: Dmitry N Grigoryev; Brian Long; Ivo P Nnane; Vincent Njar; Y Liu; Angela Brodie
Effects of new 17alpha-hydroxylase/C(17,20)-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo.
British journal of cancer 1999;81(4):622-30.
1999: Qing Lu; Y Liu; Brian Long; Dmitry N Grigoryev; M Gimbel; Angela Brodie
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
Breast cancer research and treatment 1999;57(2):183-92.
1999: Vincent Njar; Angela Brodie
Comprehensive pharmacology and clinical efficacy of aromatase inhibitors.
Drugs 1999;58(2):233-55.
1999: Angela Brodie; Qing Lu; Y Liu; Brian Long
Aromatase inhibitors and their antitumor effects in model systems.
Endocrine-related cancer 1999;6(2):205-10.
1999: Ivo P Nnane; K Kato; Y Liu; Brian Long; Qing Lu; X Wang; YZ Ling; Angela Brodie
Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds.
Endocrinology 1999;140(6):2891-7.
1999: Angela Brodie; Qing Lu; Brian Long
Aromatase and its inhibitors.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):205-10.
1999: J Nakamura; Qing Lu; Graham W Aberdeen; Eugene D Albrecht; Angela Brodie
The effect of estrogen on aromatase and vascular endothelial growth factor messenger ribonucleic acid in the normal nonhuman primate mammary gland.
The Journal of clinical endocrinology and metabolism 1999;84(4):1432-7.
1999: Vincent Njar; Angela Brodie
Inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17): potential agents for the treatment of prostate cancer.
Current pharmaceutical design 1999;5(3):163-80.
1999: Shangara S Dehal; Angela Brodie; David Kupfer
The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):389-94.
1999: Dmitry N Grigoryev; K Kato; Vincent Njar; Brian Long; YZ Ling; X Wang; J Mohler; Angela Brodie
Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17alpha-hydroxylase-C17,20-lyase inhibitors.
Analytical biochemistry 1999;267(2):319-30.
1998: Brian Long; Syreeta Latatia Tilghman; W Yue; Apinya Thiantanawat; Dmitry N Grigoryev; Angela Brodie
The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity.
The Journal of steroid biochemistry and molecular biology 1998;67(4):293-304.
1998: YZ Ling; J S Li; K Kato; Y Liu; X Wang; GT Klus; K Marat; Ivo P Nnane; Angela Brodie
Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase.
Bioorganic & medicinal chemistry 1998;6(10):1683-93.
1998: S Li; Edward J Parish; C Rodriguez-Valenzuela; Angela Brodie
Synthesis of new steroidal isoxazoles: inhibitors of estrogen synthase.
Bioorganic & medicinal chemistry 1998;6(9):1525-9.
1998: Ivo P Nnane; K Kato; Y Liu; Qing Lu; X Wang; YZ Ling; Angela Brodie
Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
Cancer research 1998;58(17):3826-32.
1998: Qing Lu; W Yue; J Wang; Y Liu; Brian Long; Angela Brodie
The effects of aromatase inhibitors and antiestrogens in the nude mouse model.
Breast cancer research and treatment 1998;50(1):63-71.
1998: Angela Brodie; Vincent Njar
Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications.
The Journal of steroid biochemistry and molecular biology 1998;66(1-2):1-10.
1998: Constantine Straturis; Alessandra Vottero; Angela Brodie; Lawrence S Kirschner; D DeAtkine; Qing Lu; W Yue; C S Mitsiades; A W Flor; George Chrousos
The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.
The Journal of clinical endocrinology and metabolism 1998;83(4):1348-57.
1998: Vincent Njar; K Kato; Ivo P Nnane; Dmitry N Grigoryev; Brian Long; Angela Brodie
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
Journal of medicinal chemistry 1998;41(6):902-12.
1998: Alessandra Vottero; Lawrence S Kirschner; W Yue; Angela Brodie; Constantine Straturis
P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for exon-1 after Epstein-Barr virus transformation.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):245-50.
1998: Angela Brodie; Qing Lu; Y Liu; Brian Long; J P Wang; W Yue
Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer.
Oncology (Williston Park, N.Y.) 1998;12(3 Suppl 5):36-40.
1998: K C Shenton; M Dowsett; Qing Lu; Angela Brodie; H Sasano; N P Sacks; M G Rowlands
Comparison of biochemical aromatase activity with aromatase immunohistochemistry in human breast carcinomas.
Breast cancer research and treatment 1998;49 Suppl 1():S101-7; discussion S109-19.
1998: Angela Brodie; Brian Long; Qing Lu
Aromatase expression in the human breast.
Breast cancer research and treatment 1998;49 Suppl 1():S85-91; discussion S109-19.
1998: Angela Brodie; Qing Lu; W Yue; J Wang; Y Liu
Intratumoral aromatase model: the effects of letrozole (CGS 20267).
Breast cancer research and treatment 1998;49 Suppl 1():S23-6; discussion S33-7.
1997: W Yue; Angela Brodie
Mechanisms of the actions of aromatase inhibitors 4-hydroxyandrostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):317-28.
1997: YZ Ling; J S Li; Y Liu; K Kato; GT Klus; Angela Brodie
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Journal of medicinal chemistry 1997;40(20):3297-304.
1997: Vincent Njar; GT Klus; H H Johnson; Angela Brodie
Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17 alpha-hydroxylase/17,20-lyase (17 alpha-lyase).
Steroids 1997;62(6):468-73.
1997: Angela Brodie; Qing Lu; J Nakamura
Aromatase in the normal breast and breast cancer.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):281-6.
1996: J Nakamura; A Savinov; Qing Lu; Angela Brodie
Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.
Endocrinology 1996;137(12):5589-96.
1996: G T Klus; J Nakamura; J S Li; YZ Ling; C Son; J A Kemppainen; Elizabeth M Wilson; Angela Brodie
Growth inhibition of human prostate cells in vitro by novel inhibitors of androgen synthesis.
Cancer research 1996;56(21):4956-64.
1996: J S Li; Y Li; C Son; Angela Brodie
Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
Journal of medicinal chemistry 1996;39(21):4335-9.
1996: Angela Brodie; Vincent Njar
Aromatase inhibitors and breast cancer.
Seminars in oncology 1996;23(4 Suppl 9):10-20.
1996: Qing Lu; J Nakmura; A Savinov; W Yue; Judith Weisz; D J Dabbs; G Wolz; Angela Brodie
Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers.
Endocrinology 1996;137(7):3061-8.
1996: J M Coll; J W Sekowski; Robert Hickey; Lauren Schnaper; W Yue; Angela Brodie; L Uitto; J E Syvaoja; Linda H Malkas
The human breast cell DNA synthesome: its purification from tumor tissue and cell culture.
Oncology research 1996;8(10-11):435-47.
1995: W Yue; J Wang; A Savinov; Angela Brodie
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
Cancer research 1995;55(14):3073-7.
1995: S Inkster; W Yue; Angela Brodie
Human testicular aromatase: immunocytochemical and biochemical studies.
The Journal of clinical endocrinology and metabolism 1995;80(6):1941-7.
1995: J Li; Y Li; C Son; Angela Brodie
Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-one.
The Prostate 1995;26(3):140-50.
1995: J L Zhou; Angela Brodie
The effect of aromatase inhibitor 4-hydroxyandrostenedione on steroid receptors in hormone-dependent tissues of the rat.
The Journal of steroid biochemistry and molecular biology 1995;52(1):71-6.
1994: W Yue; D Zhou; S Chen; Angela Brodie
A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene.
Cancer research 1994;54(19):5092-5.
1994: Angela Brodie
Aromatase inhibitors in the treatment of breast cancer.
The Journal of steroid biochemistry and molecular biology 1994;49(4-6):281-7.
1994: Serdar E Bulun; I M Rosenthal; Angela Brodie; S E Inkster; W P Zeller; A M DiGeorge; S D Frasier; M W Kilgore; Evan R Simpson
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1994;78(2):1616-21.
1994: Angela Brodie; R J Santen
Aromatase and its inhibitors in breast cancer treatment--overview and perspective.
Breast cancer research and treatment 1994;30(1):1-6.
1993: Serdar E Bulun; I M Rosenthal; Angela Brodie; S E Inkster; W P Zeller; A M DiGeorge; S D Frasier; M W Kilgore; Evan R Simpson
Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.
The Journal of clinical endocrinology and metabolism 1993;77(6):1616-21.
1993: Angela Brodie
Aromatase, its inhibitors and their use in breast cancer treatment.
Pharmacology & therapeutics 1993;60(3):501-15.
1993: Robert D Koos; P K Banks; S E Inkster; W Yue; Angela Brodie
Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction.
The Journal of steroid biochemistry and molecular biology 1993;45(4):217-25.
1993: W Yue; Angela Brodie
MCF-7 human breast carcinomas in nude mice as a model for evaluating aromatase inhibitors.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):671-3.
1993: Angela Brodie; S Inkster
Aromatase in the human testis.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):549-55.
1993: L M Berstein; S J Santner; Angela Brodie; Robert D Koos; Frederick Naftolin; R J Santen
Pseudoaromatase in circulating lymphocytes.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):647-9.
1992: J Li; Y Li; C Son; P Banks; Angela Brodie
4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):313-20.
1991: S E Inkster; Angela Brodie
Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study.
The Journal of clinical endocrinology and metabolism 1991;73(4):717-26.
1991: P K Banks; K Meyer; Angela Brodie
Regulation of ovarian steroid biosynthesis by estrogen during proestrus in the rat.
Endocrinology 1991;129(3):1295-304.
1991: S J Zimniski; M E Brandt; Michael Melner; Angela Brodie; J David Puett
Effect of 4-hydroxyandrostenedione on murine Leydig tumor cell steroidogenesis.
Cancer research 1991;51(14):3663-8.
1991: P Coen; Howard E Kulin; T Ballantine; R Zaino; E Frauenhoffer; D Boal; S Inkster; Angela Brodie; Richard J Santen
An aromatase-producing sex-cord tumor resulting in prepubertal gynecomastia.
The New England journal of medicine 1991;324(5):317-22.
1991: Angela Brodie
Aromatase and its inhibitors--an overview.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):255-61.
1990: Angela Brodie; P K Banks; S E Inkster; C Son; Robert D Koos
Aromatase and other inhibitors in breast and prostatic cancer.
The Journal of steroid biochemistry and molecular biology 1990;37(6):1043-8.
1990: Angela Brodie; P K Banks; S E Inkster; M Dowsett; R C Coombes
Aromatase inhibitors and hormone-dependent cancers.
The Journal of steroid biochemistry and molecular biology 1990;37(3):327-33.
1990: Angela Brodie
Aromatase inhibitors: introduction and perspective.
Journal of enzyme inhibition 1990;4(2):75-7.
1989: Angela Brodie; C Son; D A King; K M Meyer; S E Inkster
Lack of evidence for aromatase in human prostatic tissues: effects of 4-hydroxyandrostenedione and other inhibitors on androgen metabolism.
Cancer research 1989;49(23):6551-5.
1989: S E Inkster; Angela Brodie
Immunocytochemical studies of aromatase in early and full-term human placental tissues: comparison with biochemical assays.
Biology of reproduction 1989;41(5):889-98.
1989: Angela Brodie; J O Hammond; M Ghosh; K Meyer; Eugene D Albrecht
Effect of treatment with aromatase inhibitor 4-hydroxandrostenedione on the nonhuman primate menstrual cycle.
Cancer research 1989;49(17):4780-4.
1988: L Y Wing; J O Hammond; Angela Brodie
Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.
Endocrinology 1988;122(6):2418-27.
1988: S L Dale; M M Holbrook; Angela Brodie; J C Melby
Effect of 4-hydroxyandrostenedione on 19-hydroxylation of deoxycorticosterone in the golden Syrian hamster.
Steroids 1988;51(1-2):185-93.
1988: G T Griffing; M Holbrook; J C Melby; Angela Brodie
Selective 19-hydroxylase inhibition by an aromatase inhibitor, 4-hydroxyandrostenedione.
Clinical physiology and biochemistry 1988;6(3-4):171-8.
1988: Angela Brodie; M Dowsett; R C Coombes
Aromatase inhibitors as new endocrine therapy for breast cancer.
Cancer treatment and research 1988;39():51-65.
1987: Angela Brodie; L Y Wing
In vitro and in vivo studies with aromatase inhibitor 4-hydroxy-androstenedione.
Steroids 1987;50(1-3):89-103.
1987: R Charles Coombes; P E Goss; M Dowsett; G Hutchinson; D Cunningham; M Jarman; Angela Brodie
4-Hydroxyandrostenedione treatment for postmenopausal patients with advanced breast cancer.
Steroids 1987;50(1-3):245-52.
1987: M Dowsett; P E Goss; T J Powles; G Hutchinson; Angela Brodie; S L Jeffcoate; R C Coombes
Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route.
Cancer research 1987;47(7):1957-61.
1987: A Bartke; William Morgan; R N Clayton; T K Banerji; Angela Brodie; T A Parkening; Thomas J Collins
Neuroendocrine studies in hyperprolactinaemic male mice.
The Journal of endocrinology 1987;112(2):215-20.
1987: Y H Hsiang; Gary D Berkovitz; Terry R Brown; Claude J Migeon; Angela Brodie
The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts.
Journal of steroid biochemistry 1987;26(1):131-5.
1987: D Cunningham; T J Powles; M Dowsett; G Hutchison; Angela Brodie; H T Ford; J C Gazet; R C Coombes
Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer.
Cancer chemotherapy and pharmacology 1987;20(3):253-5.
1987: Angela Brodie; R C Coombes; M Dowsett
Aromatase inhibitors: basic and clinical studies.
Journal of steroid biochemistry 1987;27(4-6):899-903.
1986: Angela Brodie; L Y Wing; P Goss; M Dowsett; R C Coombes
Aromatase inhibitors and their potential clinical significance.
Journal of steroid biochemistry 1986;25(5B):859-65.
1986: M Motta; S Zoppi; Angela Brodie; L Martini
Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate.
Journal of steroid biochemistry 1986;25(4):593-600.
1986: P E Goss; T J Powles; M Dowsett; G Hutchison; Angela Brodie; J C Gazet; R C Coombes
Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4-hydroxyandrostenedione: phase II report.
Cancer research 1986;46(9):4823-6.
1986: Angela Brodie; L Y Wing; P Goss; M Dowsett; R C Coombes
Aromatase inhibitors and the treatment of breast cancer.
Journal of steroid biochemistry 1986;24(1):91-7.
1986: Angela Brodie; R J Santen
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Critical reviews in oncology/hematology 1986;5(4):361-96.
1985: Eli Y Adashi; Carol E Resnick; Angela Brodie; M E Svoboda; Judson Vanwyk
Somatomedin-C-mediated potentiation of follicle-stimulating hormone-induced aromatase activity of cultured rat granulosa cells.
Endocrinology 1985;117(6):2313-20.
1985: Angela Brodie
Aromatase inhibition and its pharmacologic implications.
Biochemical pharmacology 1985;34(18):3213-9.
1985: M Knecht; Angela Brodie; K J Catt
Aromatase inhibitors prevent granulosa cell differentiation: an obligatory role for estrogens in luteinizing hormone receptor expression.
Endocrinology 1985;117(3):1156-61.
1985: D A Marsh; H J Brodie; W Garrett; C H Tsai-Morris; Angela Brodie
Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives.
Journal of medicinal chemistry 1985;28(6):788-95.
1985: L Y Wing; W M Garrett; Angela Brodie
Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.
Cancer research 1985;45(6):2425-8.
1985: Robert D Koos; W J LeMaire; T T Hung; Angela Brodie
Comparison of the effect of 4-hydroxy-4-androstene-3,17-dione on aromatase activity in granulosa cells from preovulatory follicles of rats, rabbits, and humans.
Steroids 1985;45(2):143-50.
1984: R C Coombes; P Goss; M Dowsett; J C Gazet; Angela Brodie
4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
Lancet 1984;2(8414):1237-9.
1984: Gary D Berkovitz; M Fujimoto; Terry R Brown; Angela Brodie; Claude J Migeon
Aromatase activity in cultured human genital skin fibroblasts.
The Journal of clinical endocrinology and metabolism 1984;59(4):665-71.
1984: Robert D Koos; M A Feiertag; Angela Brodie; W J LeMaire
Inhibition of estrogen synthesis does not inhibit luteinizing hormone-induced ovulation.
American journal of obstetrics and gynecology 1984;148(7):939-45.
1983: C H Tsai-Morris; M Ghosh; AN Hirshfield; Phyllis M Wise; Angela Brodie
Inhibition of ovarian aromatase by prolactin in vivo.
Biology of reproduction 1983;29(2):342-6.
1983: Angela Brodie; W M Garrett; J R Hendrickson; C H Tsai-Morris; J G Williams
1. Estrogen antagonists. Aromatase inhibitors, their pharmacology and application.
Journal of steroid biochemistry 1983;19(1A):53-8.
1983: S Bar-Ami; A Nimrod; Angela Brodie; Alex Tsafriri
Role of FSH and oestradiol-17 beta in the development of meiotic competence in rat oocytes.
Journal of steroid biochemistry 1983;19(1C):965-71.
1983: S Dalterio; A Bartke; Angela Brodie; D Mayfield
Effects of testosterone, estradiol, aromatase inhibitor, gonadotropin and prolactin on the response of mouse testes to acute gonadotropin stimulation.
Journal of steroid biochemistry 1983;18(4):391-6.
1982: Angela Brodie
Overview of recent development of aromatase inhibitors.
Cancer research 1982;42(8 Suppl):3312s-3314s.
1982: Angela Brodie; W M Garrett; J R Hendrickson; C H Tsai-Morris
Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.
Cancer research 1982;42(8 Suppl):3360s-3364s.
1982: Angela Brodie; H J Brodie; W M Garrett; J R Hendrickson; D A Marsh; C H Tsai-Morris
Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo.
Biochemical pharmacology 1982;31(11):2017-23.
1982: D A Marsh; L Romanoff; K I Williams; H J Brodie; Angela Brodie
Synthesis of deuterium- and tritium-labelled 4-hydroxyandrostene-3,17-dione, an aromatase inhibitor, and its metabolism in vitro and in vivo in the rat.
Biochemical pharmacology 1982;31(5):701-5.
1981: Angela Brodie; W M Garrett; J R Hendrickson; C H Tsai-Morris; P A Marcotte; C H Robinson
Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.
Steroids 1981;38(6):693-702.
1981: G Evans; P C Leung; Angela Brodie; D T Armstrong
Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
Biology of reproduction 1981;25(2):290-4.
1981: Angela Brodie; L P Romanoff; K I Williams
Metabolism of the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione by male rhesus monkeys.
Journal of steroid biochemistry 1981;14(8):693-6.
1981: Angela Brodie; H J Brodie; L Romanoff; J G Williams; K I Williams; J T Wu
Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.
Advances in experimental medicine and biology 1981;138():179-90.
1980: Angela Brodie; C Longcope
Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy- and 4-acetoxy-androstene-3,17-dione.
Endocrinology 1980;106(1):19-21.
1979: Angela Brodie
Recent advances in studies on estrogen biosynthesis.
Journal of endocrinological investigation 1979;2(4):445-60.
1979: Angela Brodie; D A Marsh; J T Wu; H J Brodie
Aromatase inhibitors and their use in controlling oestrogen-dependent processes.
Journal of steroid biochemistry 1979;11(1A):107-12.
1979: Angela Brodie; D Marsh; H J Brodie
Aromatase inhibitors--IV. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione.
Journal of steroid biochemistry 1979;10(4):423-9.
1979: Angela Brodie; J T Wu; D A Marsh; H J Brodie
Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione.
Endocrinology 1979;104(1):118-21.
1978: Angela Brodie; J T Wu; D A Marsh; H J Brodie
Aromatase inhibitors III. Studies on the antifertility effect of 4-acetoxy-4-androstene-3,17-dione.
Biology of reproduction 1978;18(3):365-70.
1977: Angela Brodie; W C Schwarzel; A A Shaikh; H J Brodie
The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer.
Endocrinology 1977;100(6):1684-95.
1976: Angela Brodie; W C Schwarzel; H J Brodie
Studies on the mechanism of estrogen biosynthesis in the rat ovary--I.
Journal of steroid biochemistry 1976;7(10):787-93.
1968: H M Balikian; Angela Brodie; S L Dale; J C Melby; J F Tait
Effect of posture on the metabolic clearance rate, plasma concentration and blood production rate of aldosterone in man.
The Journal of clinical endocrinology and metabolism 1968;28(11):1630-40.
1967: Angela Brodie; N Shimizu; S A Tait; J F Tait
A method for the measurement of aldosterone in peripheral plasma using 3H-acetic anhydride.
The Journal of clinical endocrinology and metabolism 1967;27(7):997-1011.