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Shuangxing Yu

Research Profile

Chemicals & Drugs

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Physiology

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Publications

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Han Liang; Chang-Gong Liu; Xiuping Liu; Karen H Lu; Yiling Lu; Steven E Scherer; Kenneth L Scott; Katherine Stemke-Hale; Roeland G W Verhaak; Shannon N Westin; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Hannah Carter; Lydia W T Cheung; Turgut Dogruluk; Mary D Dyer; Chao Gu; Wei Guo; Bryan T Hennessy; Zhenlin Ju; Rachel Karchin; Jie Li; Gordon B Mills
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Sofie Claerhout; Jennifer Dennison; Bhaskar Dutta; Yiling Lu; Catherine Nguyen-Charles; Qinghua Yu; Shuangxing Yu; Fan Zhang; Gábor Balázsi; Wouter Bossuyt; Gordon B Mills
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
Lydia W T Cheung; Bojana Djordjevic; Mary D Dyer; Bryan T Hennessy; Zhenlin Ju; Jie Li; Han Liang; Karen H Lu; Yiling Lu; Andrea P Myers; Steven E Scherer; Katherine Stemke-Hale; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Lewis C Cantley; Gordon B Mills
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.

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All Publications

2012: Han Liang; Chang-Gong Liu; Xiuping Liu; Karen H Lu; Yiling Lu; Steven E Scherer; Kenneth L Scott; Katherine Stemke-Hale; Roeland G W Verhaak; Shannon N Westin; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Hannah Carter; Lydia W T Cheung; Turgut Dogruluk; Mary D Dyer; Chao Gu; Wei Guo; Bryan T Hennessy; Zhenlin Ju; Rachel Karchin; Jie Li; Gordon B Mills
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Genome research 2012;22(11):2120-9.
2012: Sofie Claerhout; Jennifer Dennison; Bhaskar Dutta; Yiling Lu; Catherine Nguyen-Charles; Qinghua Yu; Shuangxing Yu; Fan Zhang; Gábor Balázsi; Wouter Bossuyt; Gordon B Mills
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
PloS one 2012;7(6):e39400.
2011: Lydia W T Cheung; Bojana Djordjevic; Mary D Dyer; Bryan T Hennessy; Zhenlin Ju; Jie Li; Han Liang; Karen H Lu; Yiling Lu; Andrea P Myers; Steven E Scherer; Katherine Stemke-Hale; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Lewis C Cantley; Gordon B Mills
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Cancer discovery 2011;1(2):170-85.
2010: Molly K Altman; Vashisht Gopal; Wei Jia; Shuangxing Yu; Hassan Hall; Gordon B Mills; A Cary McGinnis; Michael G Bartlett; Guowei Jiang; Damian Madan; Glenn D Prestwich; Yong Xu; Michael A Davies; Mandi M Murph
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Molecular cancer 2010;9():140.
2009: Shuying Liu; Makiko Umezu-Goto; Mandi Murph; Yiling Lu; Wenbin Liu; Fan Zhang; Shuangxing Yu; L Clifton Stephens; Xiaojiang Cui; George Murrow; Kevin Coombes; William Muller; Mien-Chie Hung; Charles M Perou; Adrian V Lee; Xianjun Fang; Gordon B Mills
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2009: Mandi Murph; Wenbin Liu; Shuangxing Yu; Yiling Lu; Hassan Hall; Bryan T. J. Hennessy; John Lahad; Marci Schaner; Aslaug Helland; Gunnar Kristensen; Anne-Lise Børresen-Dale; Gordon B Mills
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
PloS one 2009;4(5):e5583.
2008: Shuangxing Yu; Mandi Murph; Yiling Lu; Shuying Liu; Hassan S Hall; Jinsong Liu; Clifton Stephens; Xianjun Fang; Gordon B Mills
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Journal of the National Cancer Institute 2008;100(22):1630-42.
2008: Yutaka Hasegawa; Mandi Murph; Shuangxing Yu; Gabor Tigyi; Gordon B Mills
Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
Molecular oncology 2008;2(1):54-69.
2008: Shuying Liu; Xianjun Fang; Hassan Hall; Shuangxing Yu; Debra Smith; Zhimin Lu; Dexing Fang; Jinsong Liu; L Clifton Stephens; James R Woodgett; Gordon B Mills
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
2007: Bryan T. J. Hennessy; Yiling Lu; Enrique Poradosu; Qianghua Yu; Shuangxing Yu; Hassan Hall; Mark S Carey; Murali Ravoori; Ana M Gonzalez-Angulo; Robert Birch; I Craig Henderson; Vikas Kundra; Gordon B Mills
Pharmacodynamic markers of perifosine efficacy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(24):7421-31.
2006: Lian Qian; Yong Xu; Ted Simper; Guowei Jiang; Junken Aoki; Makiko Umezu-Goto; Hiroyuki Arai; Shuangxing Yu; Gordon B Mills; Ryoko Tsukahara; Natalia Makarova; Yuko Fujiwara; Gabor Tigyi; Glenn D Prestwich
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
2006: Barbara Visentin; John A Vekich; Bradley J Sibbald; Amy L Cavalli; Kelli M Moreno; Rosalia G Matteo; William A Garland; Yiling Lu; Shuangxing Yu; Hassan S Hall; Vikas Kundra; Gordon B Mills; Roger A Sabbadini
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages.
Cancer cell 2006;9(3):225-38.
2006: Zendra Lee; Ramona F Swaby; Yuewei Liang; Shuangxing Yu; Shuying Liu; Karen H Lu; Robert C Bast; Gordon B Mills; Xianjun Fang
Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Cancer research 2006;66(5):2740-8.
2005: Yong Xu; Junken Aoki; Kumiko Shimizu; Makiko Umezu-Goto; Kotaro Hama; Yasukazu Takanezawa; Shuangxing Yu; Gordon B Mills; Hiroyuki Arai; Lian Qian; Glenn D Prestwich
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
2004: Shuying Liu; Shuangxing Yu; Yutaka Hasegawa; Ruth Lapushin; Hong-Ji Xu; James R Woodgett; Gordon B Mills; Xianjun Fang
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
2004: Makiko Umezu-Goto; Janos L Tanyi; John Lahad; Shuying Liu; Shuangxing Yu; Ruth Lapushin; Yutaka Hasegawa; Yiling Lu; Rosanne Trost; Therese Bevers; Eric Jonasch; Kenneth Aldape; Jinsong Liu; Robyn D James; Colin G Ferguson; Yong Xu; Glenn D Prestwich; Gordon B Mills
Lysophosphatidic acid production and action: validated targets in cancer?
Journal of cellular biochemistry 2004;92(6):1115-40.
2004: Xianjun Fang; Shuangxing Yu; Robert C Bast; Shuying Liu; Hong-Ji Xu; Shi-Xue Hu; Ruth Lapushin; Francois Claret; Bharat B Aggarwal; Yiling Lu; Gordon B Mills
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2004: Elise C Kohn; Yiling Lu; Hongwei Wang; Qinghua Yu; Shuangxing Yu; Hassan Hall; Debra L Smith; Funda Meric-Bernstam; Gabriel N Hortobagyi; Gordon B Mills
Molecular therapeutics: promise and challenges.
Seminars in oncology 2004;31(1 Suppl 3):39-53.
2003: Yutaka Hasegawa; James R Erickson; Graham J Goddard; Shuangxing Yu; Shuying Liu; Kwai Wa Cheng; Astrid Eder; Koji Bandoh; Junken Aoki; Renata Jarosz; Andrew D Schrier; Kevin R Lynch; Gordon B Mills; Xianjun Fang
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
2002: Xianjun Fang; Michel Schummer; Muling Mao; Shuangxing Yu; Fazal H Tabassam; Ramona Swaby; Yutaka Hasegawa; Janos L Tanyi; Ruth Lapushin; Astrid Eder; Robert Jaffe; Jim Erickson; Gordon B Mills
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
2002: Xianjun Fang; Shuangxing Yu; Janos L Tanyi; Yiling Lu; James R Woodgett; Gordon B Mills
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology 2002;22(7):2099-110.