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Yinhua Yu

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Genes, Tumor Suppressor

Disorders

Physiology

Anatomy

Living Beings

Procedures

Reverse Transcriptase Polymerase Chain Reaction

Phenomena

Acetylation

Co-author Network

Publications

TOP 3
Min-Yu Chen; Violeta Hennessey; Warren S-L Liao; Zhen Lu; Gary Rosner; Michele N Washington; Yinhua Yu; Ahmed Ashour Ahmed; William G Bornmann; Robert C Bast
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Shaoyi Huang; In Soon Chang; Wenbo Lin; Wenduo Ye; Robert Z Luo; Zhen Lu; Yiling Lu; Ke Zhang; Warren S-L Liao; Tao Tao; Robert C Bast; Xiaomin Chen; Yinhua Yu
ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins.
Weiwei Feng; Rebecca T Marquez; Zhen Lu; Jinsong Liu; Karen H Lu; Jean-Pierre J Issa; David M Fishman; Yinhua Yu; Robert C Bast
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.

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All Publications

2011: Min-Yu Chen; Violeta Hennessey; Warren S-L Liao; Zhen Lu; Gary Rosner; Michele N Washington; Yinhua Yu; Ahmed Ashour Ahmed; William G Bornmann; Robert C Bast
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Cancer 2011;117(19):4424-38.
2010: Shaoyi Huang; In Soon Chang; Wenbo Lin; Wenduo Ye; Robert Z Luo; Zhen Lu; Yiling Lu; Ke Zhang; Warren S-L Liao; Tao Tao; Robert C Bast; Xiaomin Chen; Yinhua Yu
ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins.
Bioscience reports 2010;30(3):159-68.
2008: Weiwei Feng; Rebecca T Marquez; Zhen Lu; Jinsong Liu; Karen H Lu; Jean-Pierre J Issa; David M Fishman; Yinhua Yu; Robert C Bast
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.
Cancer 2008;112(7):1489-502.
2007: Weiwei Feng; Zhen Lu; Robert Z Luo; Xiaohong Zhang; Edward Seto; Warren S-L Liao; Yinhua Yu
Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer.
International journal of cancer. Journal international du cancer 2007;120(8):1664-8.
2007: Weiwei Feng; Lanlan Shen; Sijin Wen; Daniel G Rosen; Jaroslav Jelinek; Xin Hu; Shaoyi Huan; Miao Huang; Jinsong Liu; Aysegul A Sahin; Kelly K Hunt; Robert C Bast; Yu Shen; Jean-Pierre J Issa; Yinhua Yu
Correlation between CpG methylation profiles and hormone receptor status in breast cancers.
Breast cancer research : BCR 2007;9(4):R57.
2007: Robert C Bast; Molly Brewer; Changping Zou; Mary A Hernandez; Mary Daley; Robert F Ozols; Karen Lu; Zhen Lu; Donna Badgwell; Gordon B Mills; Steven J Skates; Zhen Zhang; Dan Chan; Anna Lokshin; Yinhua Yu
Prevention and early detection of ovarian cancer: mission impossible?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():91-100.
2006: Zhen Lu; Robert Z Luo; Hongqi Peng; Daniel G Rosen; E Neely Atkinson; Carla L Warneke; Maosheng Huang; Arata Nishmoto; Jinsong Liu; Warren S-L Liao; Yinhua Yu; Robert C Bast
Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2404-13.
2006: Zhen Lu; Robert Z Luo; Hua Peng; Maosheng Huang; A Nishmoto; Kelly K Hunt; K Helin; Warren S-L Liao; Yinhua Yu
E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer.
Oncogene 2006;25(2):230-9.
2005: Daniel G Rosen; Lin Wang; J Neeley Atkinson; Yinhua Yu; Karen H Lu; Eleftherios P Diamandis; Ingegerd Hellstrom; Samuel C Mok; Jinsong Liu; Robert C Bast
Potential markers that complement expression of CA125 in epithelial ovarian cancer.
Gynecologic oncology 2005;99(2):267-77.
2005: Arata Nishimoto; Yinhua Yu; Zhen Lu; Xiang Mao; Zhiyong Ren; Stephanie S Watowich; Gordon B Mills; Warren S-L Liao; Xiaomin Chen; Robert C Bast; Robert Z Luo
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
Cancer research 2005;65(15):6701-10.
2004: Daniel G Rosen; Lin Wang; Ajay N Jain; Karen H Lu; Robert Z Luo; Yinhua Yu; Jinsong Liu; Robert C Bast
Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6559-66.
2004: Jinsong Liu; Gong Yang; Jennifer A Thompson-Lanza; Armand B. Glassman; Kimberly Hayes; Andrea Patterson; Rebecca T Marquez; Nelly Auersperg; Yinhua Yu; William C Hahn; Gordon B Mills; Robert C Bast
A genetically defined model for human ovarian cancer.
Cancer research 2004;64(5):1655-63.
2003: Lin Wang; Ashraful Hoque; Robert Z Luo; Jiuhong Yuan; Zhen Lu; Arata Nishimoto; Jinsong Liu; Aysegul A Sahin; Scott M Lippman; Robert C Bast; Yinhua Yu
Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3660-6.
2003: Satoshi Fujii; Robert Z Luo; Jiuhong Yuan; Mitsutaka Kadota; Mitsuo Oshimura; Sharon R Dent; Yutaka Kondo; Jean-Pierre J Issa; Robert C Bast; Yinhua Yu
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.
Human molecular genetics 2003;12(15):1791-800.
2003: Jiuhong Yuan; Robert Z Luo; Satoshi Fujii; Lin Wang; Wei Hu; Michael Andreeff; Yong Pan; Mitsutaka Kadota; Mitsuo Oshimura; Aysegul A Sahin; Jean-Pierre J Issa; Robert C Bast; Yinhua Yu
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.
Cancer research 2003;63(14):4174-80.
2003: Robert Z Luo; Xianjun Fang; Rebecca T Marquez; Shu-Ying Liu; Gordon B Mills; Warren S-L Liao; Yinhua Yu; Robert C Bast
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Oncogene 2003;22(19):2897-909.
2003: Yinhua Yu; Satoshi Fujii; Jiuhong Yuan; Robert Z Luo; Lin Wang; Jiaju Bao; Mitsutaka Kadota; Mitsuo Oshimura; Sharon R Dent; Jean-Pierre J Issa; Robert C Bast
Epigenetic regulation of ARHI in breast and ovarian cancer cells.
Annals of the New York Academy of Sciences 2003;983():268-77.
2002: Jia-Ju Bao; Xiao-Feng Le; Rui-Yu Wang; Jiuhong Yuan; Lin Wang; E Neely Atkinson; Ruth Lapushin; Michael Andreeff; Bingliang Fang; Yinhua Yu; Robert C Bast
Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway.
Cancer research 2002;62(24):7264-72.
2002: Tongyu Lin; Xuefeng Huang; Jian Gu; Lidong Zhang; Jack A Roth; Momiao Xiong; Steven A Curley; Yinhua Yu; Kelly K Hunt; Bingliang Fang
Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells.
Oncogene 2002;21(52):8020-8.
2002: Xuefeng Huang; Tongyu Lin; Jian Gu; Lidong Zhang; Jack A Roth; L Clifton Stephens; Yinhua Yu; Jinsong Liu; Bingliang Fang
Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft.
Gene therapy 2002;9(20):1379-86.
2001: Michael M Weil; Frances S Kittrell; Yinhua Yu; M McCarthy; R C Zabriskie; Robert L Ullrich
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice.
Oncogene 2001;20(32):4409-11.
2001: Robert Z Luo; Hua Peng; F Xu; J Bao; Y Pang; R Pershad; Jean-Pierre J Issa; Warren S-L Liao; Robert C Bast; Yinhua Yu
Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.
Biochimica et biophysica acta 2001;1519(3):216-22.
2000: F Xu; Weiya Xia; Robert Z Luo; Hua Peng; S Zhao; J Dai; Y Long; L Zou; W Le; Jinsong Liu; A F Parlow; Mien-Chie Hung; Robert C Bast; Yinhua Yu
The human ARHI tumor suppressor gene inhibits lactation and growth in transgenic mice.
Cancer research 2000;60(17):4913-20.
2000: F Xu; Steven A Leadon; Yinhua Yu; CM Boyer; KC O'Briant; K Ward; Amanda McWatters; X Zhao; D S Bae; Karen DeSombre; Michael R Zalutsky; Robert C Bast
Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3334-41.
2000: Hua Peng; F Xu; Rashmi Pershad; Kelly K Hunt; M L Frazier; Andrew Berchuck; Joe Gray; David Hogg; Robert C Bast; Yinhua Yu
ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers.
International journal of cancer. Journal international du cancer 2000;86(5):690-4.
1999: F Xu; Yinhua Yu; Xiao-Feng Le; C Boyer; Gordon B Mills; Robert C Bast
The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3653-60.
1999: Zhen Zhang; SD Barnhill; H Zhang; F Xu; Yinhua Yu; I Jacobs; R P Woolas; Andrew Berchuck; KR Madyastha; Robert C Bast
Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses.
Gynecologic oncology 1999;73(1):56-61.
1999: Yinhua Yu; F Xu; Hua Peng; Xiang Fang; S Zhao; Y Li; Bruce D Cuevas; Wen-Lin Kuo; Joe Gray; M Siciliano; Gordon B Mills; Robert C Bast
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):214-9.
1998: Xiang Fang; X Jin; Hong-Ji Xu; Lieqi Liu; HQ Peng; David Hogg; Jack A Roth; Yinhua Yu; F Xu; Robert C Bast; Gordon B Mills
Expression of p16 induces transcriptional downregulation of the RB gene.
Oncogene 1998;16(1):1-8.