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Junying Yuan

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
20
Degterev, Alexei
12
Boyce, Michael
11
hongwen, zhu
11
Moskowitz, Michael
9
Friedlander, Robert
7
Gagliardini, Valeria
7
Bergeron, L
7
Wagner, Gerhard
6
Cuny, Gregory
6
Lipinski, Marta
5
Ma, Dawei
5
Gozani, Or
4
Fink, K
4
Endres, Matthias
4
Cryns, Vincent

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Publications

TOP 3
Py Bénédicte F; Boyce Michael; Yuan Junying
A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.
Yuan Junying
Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke.
Yi Caroline H; Yuan Junying
The Jekyll and Hyde functions of caspases.

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All Publications

2009: Py Bénédicte F; Boyce Michael; Yuan Junying
A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.
Autophagy 2009;5(3):393-6.
2009: Yuan Junying
Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke.
Apoptosis : an international journal on programmed cell death 2009;14(4):469-77.
2009: Yi Caroline H; Yuan Junying
The Jekyll and Hyde functions of caspases.
Developmental cell 2009;16(1):21-34.
2008: Hitomi Junichi; Christofferson Dana E; Ng Aylwin; Yao Jianhua; Degterev Alexei; Xavier Ramnik J; Yuan Junying
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.
Cell 2008;135(7):1311-23.
2008: Pan Heling; Yu Jia; Zhang Lihong; Carpenter Anne; Zhu Hong; Li Li; Ma Dawei; Yuan Junying
A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking.
The Journal of biological chemistry 2008;283(45):31087-96.
2008: Li J; Yuan J
Caspases in apoptosis and beyond.
Oncogene 2008;27(48):6194-206.
2008: Zheng Weihong; Degterev Alexei; Hsu Emily; Yuan Junying; Yuan Chengye
Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.
Bioorganic & medicinal chemistry letters 2008;18(18):4932-5.
2008: Bryant Kevin F; Macari Elizabeth R; Malik Natasha; Boyce Michael; Yuan Junying; Coen Donald M
ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Virology 2008;379(2):197-204.
2008: Sanchez-Olea Roberto; Ortiz Sara; Barreto Odmara; Yang Qing; Xu Chi-jie; Zhu Hong; Yuan Junying
Parcs is a dual regulator of cell proliferation and apaf-1 function.
The Journal of biological chemistry 2008;283(36):24400-5.
2008: You Zerong; Savitz Sean I; Yang Jinsheng; Degterev Alexei; Yuan Junying; Cuny Gregory D; Moskowitz Michael A; Whalen Michael J
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(9):1564-73.
2008: Teng Xin; Keys Heather; Yuan Junying; Degterev Alexei; Cuny Gregory D
Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(11):3219-23.
2008: Zhu Jidong; Blenis John; Yuan Junying
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6584-9.
2008: Li Juying; Yin Helen L; Yuan Junying
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
The Journal of cell biology 2008;181(2):321-33.
2008: Boyce M; Py B F; Ryazanov A G; Minden J S; Long K; Ma D; Yuan J
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.
Cell death and differentiation 2008;15(3):589-99.
2008: Yuan Junying
Inducing autophagy harmlessly.
Autophagy 2008;4(2):249-50.
2007: Xu Lei; Zhu Jidong; Hu Xiaofang; Zhu Hong; Kim Hyoung Tae; LaBaer Joshua; Goldberg Alfred; Yuan Junying
c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.
Molecular cell 2007;28(5):914-22.
2007: Teng Xin; Keys Heather; Jeevanandam Arumugasamy; Porco John A; Degterev Alexei; Yuan Junying; Cuny Gregory D
Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(24):6836-40.
2007: Sanchez-Olea Roberto; Yuan Junying
To kill or to arrest: that is the new question for Apaf-1.
Molecular cell 2007;28(4):520-1.
2007: Zhang Lihong; Yu Jia; Pan Heling; Hu Ping; Hao Yan; Cai Wenqing; Zhu Hong; Yu Albert D; Xie Xin; Ma Dawei; Yuan Junying
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19023-8.
2007: Yi Caroline H; Sogah Dodzie K; Boyce Michael; Degterev Alexei; Christofferson Dana E; Yuan Junying
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
The Journal of cell biology 2007;179(4):619-26.
2007: Zhang Yong; Zhou Xiaobo; Degterev Alexei; Lipinski Marta; Adjeroh Donald; Yuan Junying; Wong Stephen T C
Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays.
NeuroImage 2007;35(4):1502-15.
2007: Jagtap Prakash G; Degterev Alexei; Choi Sungwoon; Keys Heather; Yuan Junying; Cuny Gregory D
Structure-activity relationship study of tricyclic necroptosis inhibitors.
Journal of medicinal chemistry 2007;50(8):1886-95.
2007: Li Juying; Brieher William M; Scimone M Lucila; Kang Shin Jung; Zhu Hong; Yin Helen; von Andrian Ulrich H; Mitchison Timothy; Yuan Junying
Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization.
Nature cell biology 2007;9(3):276-86.
2007: Wang Ke; Li Jinfeng; Degterev Alexei; Hsu Emily; Yuan Junying; Yuan Chengye
Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5.
Bioorganic & medicinal chemistry letters 2007;17(5):1455-65.
2007: Py Bénédicte F; Lipinski Marta M; Yuan Junying
Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection.
Autophagy 2007;3(2):117-25.
2007: Zhang Yong; Zhou Xiaobo; Degterev Alexei; Lipinski Marta; Adjeroh Donald; Yuan Junying; Wong Stephen T C
A novel tracing algorithm for high throughput imaging Screening of neuron-based assays.
Journal of neuroscience methods 2007;160(1):149-62.
2007: Moerke Nathan J; Aktas Huseyin; Chen Han; Cantel Sonia; Reibarkh Mikhail Y; Fahmy Amr; Gross John D; Degterev Alexei; Yuan Junying; Chorev Michael; Halperin Jose A; Wagner Gerhard
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
Cell 2007;128(2):257-67.
2006: Yuan Junying
Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death.
Molecular cell 2006;23(1):1-12.
2006: Matsui Toshifumi; Ramasamy Karunya; Ingelsson Martin; Fukumoto Hiroaki; Conrad Cintia; Frosch Matthew P; Irizarry Michael C; Yuan Junying; Hyman Bradley T
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
Journal of neuropathology and experimental neurology 2006;65(5):508-15.
2006: Shibata Mamoru; Lu Tao; Furuya Tsuyoshi; Degterev Alexei; Mizushima Noboru; Yoshimori Tamotsu; MacDonald Marcy; Yankner Bruce; Yuan Junying
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.
The Journal of biological chemistry 2006;281(20):14474-85.
2006: Boyce M; Yuan J
Cellular response to endoplasmic reticulum stress: a matter of life or death.
Cell death and differentiation 2006;13(3):363-73.
2006: Yoo Lina I; Liu David W; Le Vu Sandrine; Bronson Roderick T; Wu Hong; Yuan Junying
Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.
Cancer research 2006;66(4):1929-39.
2005: Teng Xin; Degterev Alexei; Jagtap Prakash; Xing Xuechao; Choi Sungwoon; Denu Régine; Yuan Junying; Cuny Gregory D
Structure-activity relationship study of novel necroptosis inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(22):5039-44.
2005: Lipinski Marta M; Yuan Junying
A cellular response to an internal energy crisis.
Cell 2005;123(1):3-5.
2005: Long Kai; Boyce Michael; Lin He; Yuan Junying; Ma Dawei
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
Bioorganic & medicinal chemistry letters 2005;15(17):3849-52.
2005: Elkin Sheryl K; Ivanov Dmitri; Ewalt Mark; Ferguson Colin G; Hyberts Sven G; Sun Zhen-Yu J; Prestwich Glenn D; Yuan Junying; Wagner Gerhard; Oettinger Marjorie A; Gozani Or P
A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
The Journal of biological chemistry 2005;280(31):28701-10.
2005: Degterev Alexei; Huang Zhihong; Boyce Michael; Li Yaqiao; Jagtap Prakash; Mizushima Noboru; Cuny Gregory D; Mitchison Timothy J; Moskowitz Michael A; Yuan Junying
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Nature chemical biology 2005;1(2):112-9.
2005: Boyce Michael; Bryant Kevin F; Jousse Céline; Long Kai; Harding Heather P; Scheuner Donalyn; Kaufman Randal J; Ma Dawei; Coen Donald M; Ron David; Yuan Junying
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 2005;307(5711):935-9.
2005: Gozani Or; Field Seth J; Ferguson Colin G; Ewalt Mark; Mahlke Christopher; Cantley Lewis C; Prestwich Glenn D; Yuan Junying
Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.
Advances in enzyme regulation 2005;45():171-85.
2004: Kang Shin-Jung; Popat Rishi; Bragdon Christopher; Odonnell Kathryn; Phelan Sally; Yuan Junying; Sonis Stephen T
Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis.
DNA and cell biology 2004;23(8):490-5.
2004: Terui Yasuhito; Saad Natalie; Jia Shidong; McKeon Frank; Yuan Junying
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.
The Journal of biological chemistry 2004;279(27):28257-65.
2004: Lipinski Marta M; Yuan Junying
Mechanisms of cell death in polyglutamine expansion diseases.
Current opinion in pharmacology 2004;4(1):85-90.
2004: Qiu Xiao-Bo; Markant Shirley L; Yuan Junying; Goldberg Alfred L
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.
The EMBO journal 2004;23(4):800-10.
2004: Yuan Junying; Horvitz H Robert
A first insight into the molecular mechanisms of apoptosis.
Cell 2004;116(2 Suppl):S53-6, 1 p following S59.
2004: Boyce M; Degterev A; Yuan J
Caspases: an ancient cellular sword of Damocles.
Cell death and differentiation 2004;11(1):29-37.
2004: Kobori M; Yang Z; Gong D; Heissmeyer V; Zhu H; Jung Y-K; Gakidis M Angelica M; Rao A; Sekine T; Ikegami F; Yuan C; Yuan J
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex.
Cell death and differentiation 2004;11(1):123-30.
2003: Degterev Alexei; Boyce Michael; Yuan Junying
A decade of caspases.
Oncogene 2003;22(53):8543-67.
2003: Yuan Junying; Lipinski Marta; Degterev Alexei
Diversity in the mechanisms of neuronal cell death.
Neuron 2003;40(2):401-13.
2003: Welch Kevin; Yuan Junying
Alpha-synuclein oligomerization: a role for lipids?
Trends in neurosciences 2003;26(10):517-9.
2003: Gozani Or; Karuman Philip; Jones David R; Ivanov Dmitri; Cha James; Lugovskoy Alexey A; Baird Cheryl L; Zhu Hong; Field Seth J; Lessnick Stephen L; Villasenor Jennifer; Mehrotra Bharat; Chen Jian; Rao Vikram R; Brugge Joan S; Ferguson Colin G; Payrastre Bernard; Myszka David G; Cantley Lewis C; Wagner Gerhard; Divecha Nullin; Prestwich Glenn D; Yuan Junying
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Cell 2003;114(1):99-111.
2003: Kang Shin Jung; Sanchez Ivelisse; Jing Naisen; Yuan Junying
Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5455-60.
2003: Sánchez Ivelisse; Mahlke Christian; Yuan Junying
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.
Nature 2003;421(6921):373-9.
2003: Takai Yasushi; Canning Jacqueline; Perez Gloria I; Pru James K; Schlezinger Jennifer J; Sherr David H; Kolesnick Richard N; Yuan Junying; Flavell Richard A; Korsmeyer Stanley J; Tilly Jonathan L
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
Endocrinology 2003;144(1):69-74.
2002: Kang S J; Wang S; Kuida K; Yuan J
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response.
Cell death and differentiation 2002;9(10):1115-25.
2002: Yoo Lina I; Chung Daniel C; Yuan Junying
LKB1--a master tumour suppressor of the small intestine and beyond.
Nature reviews. Cancer 2002;2(7):529-35.
2002: Gozani Or; Boyce Michael; Yoo Lina; Karuman Philip; Yuan Junying
Life and death in paradise.
Nature cell biology 2002;4(6):E159-62.
2002: Qiu Jianhua; Whalen Michael J; Lowenstein Pedro; Fiskum Gary; Fahy Brenda; Darwish Ribal; Aarabi Bizhan; Yuan Junying; Moskowitz Michael A
Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3504-11.
2002: Lugovskoy Alexey A; Degterev Alexei I; Fahmy Amr F; Zhou Pei; Gross John D; Yuan Junying; Wagner Gerhard
A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.
Journal of the American Chemical Society 2002;124(7):1234-40.
2001: Degterev A; Boyce M; Yuan J
The channel of death.
The Journal of cell biology 2001;155(5):695-8.
2001: Morita Y; Maravei D V; Bergeron L; Wang S; Perez G I; Tsutsumi O; Taketani Y; Asano M; Horai R; Korsmeyer S J; Iwakura Y; Yuan J; Tilly J L
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Cell death and differentiation 2001;8(6):614-20.
2001: Karuman P; Gozani O; Odze R D; Zhou X C; Zhu H; Shaw R; Brien T P; Bozzuto C D; Ooi D; Cantley L C; Yuan J
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Molecular cell 2001;7(6):1307-19.
2001: Sánchez I; Yuan J
A convoluted way to die.
Neuron 2001;29(3):563-6.
2001: Dull R O; Yuan J; Chang Y S; Tarbell J; Jain R K; Munn L L
Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.
Microvascular research 2001;61(2):203-10.
2001: Degterev A; Lugovskoy A; Cardone M; Mulley B; Wagner G; Mitchison T; Yuan J
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
Nature cell biology 2001;3(2):173-82.
2000: Ding H F; Lin Y L; McGill G; Juo P; Zhu H; Blenis J; Yuan J; Fisher D E
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53.
The Journal of biological chemistry 2000;275(49):38905-11.
2000: Yuan J; Yankner B A
Apoptosis in the nervous system.
Nature 2000;407(6805):802-9.
2000: Matsushita K; Wu Y; Qiu J; Lang-Lazdunski L; Hirt L; Waeber C; Hyman B T; Yuan J; Moskowitz M A
Fas receptor and neuronal cell death after spinal cord ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6879-87.
2000: Nakagawa T; Yuan J
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis.
The Journal of cell biology 2000;150(4):887-94.
2000: Kang S J; Wang S; Hara H; Peterson E P; Namura S; Amin-Hanjani S; Huang Z; Srinivasan A; Tomaselli K J; Thornberry N A; Moskowitz M A; Yuan J
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
The Journal of cell biology 2000;149(3):613-22.
2000: Melder R J; Yuan J; Munn L L; Jain R K
Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvascular research 2000;59(2):316-22.
2000: Chang Y S; Munn L L; Hillsley M V; Dull R O; Yuan J; Lakshminarayanan S; Gardner T W; Jain R K; Tarbell J M
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvascular research 2000;59(2):265-77.
2000: Nakagawa T; Zhu H; Morishima N; Li E; Xu J; Yankner B A; Yuan J
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.
Nature 2000;403(6765):98-103.
1999: Rao V R; Corradetti M N; Chen J; Peng J; Yuan J; Prestwich G D; Brugge J S
Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
The Journal of biological chemistry 1999;274(53):37893-900.
1999: Zhou P; Chou J; Olea R S; Yuan J; Wagner G
Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11265-70.
1999: Ona V O; Li M; Vonsattel J P; Andrews L J; Khan S Q; Chung W M; Frey A S; Menon A S; Li X J; Stieg P E; Yuan J; Penney J B; Young A B; Cha J H; Friedlander R M
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.
Nature 1999;399(6733):263-7.
1999: Li H; Yuan J
Deciphering the pathways of life and death.
Current opinion in cell biology 1999;11(2):261-6.
1999: Sánchez I; Xu C J; Juo P; Kakizaka A; Blenis J; Yuan J
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
Neuron 1999;22(3):623-33.
1999: Chou J J; Li H; Salvesen G S; Yuan J; Wagner G
Solution structure of BID, an intracellular amplifier of apoptotic signaling.
Cell 1999;96(5):615-24.
1999: Fink K B; Andrews L J; Butler W E; Ona V O; Li M; Bogdanov M; Endres M; Khan S Q; Namura S; Stieg P E; Beal M F; Moskowitz M A; Yuan J; Friedlander R M
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade.
Neuroscience 1999;94(4):1213-8.
1998: Friedlander R M; Yuan J
ICE, neuronal apoptosis and neurodegeneration.
Cell death and differentiation 1998;5(10):823-31.
1998: Fink K; Zhu J; Namura S; Shimizu-Sasamata M; Endres M; Ma J; Dalkara T; Yuan J; Moskowitz M A
Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(10):1071-6.
1998: Juo P; Kuo C J; Yuan J; Blenis J
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.
Current biology : CB 1998;8(18):1001-8.
1998: Li H; Zhu H; Xu C J; Yuan J
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
Cell 1998;94(4):491-501.
1998: Zhou B B; Li H; Yuan J; Kirschner M W
Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6785-90.
1998: Bergeron L; Perez G I; Macdonald G; Shi L; Sun Y; Jurisicova A; Varmuza S; Latham K E; Flaws J A; Salter J C; Hara H; Moskowitz M A; Li E; Greenberg A; Tilly J L; Yuan J
Defects in regulation of apoptosis in caspase-2-deficient mice.
Genes & development 1998;12(9):1304-14.
1998: Namura S; Zhu J; Fink K; Endres M; Srinivasan A; Tomaselli K J; Yuan J; Moskowitz M A
Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(10):3659-68.
1998: Bergeron L; Yuan J
Sealing one's fate: control of cell death in neurons.
Current opinion in neurobiology 1998;8(1):55-63.
1998: Wang S; Miura M; Jung Y K; Zhu H; Li E; Yuan J
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
Cell 1998;92(4):501-9.
1997: Cryns V L; Byun Y; Rana A; Mellor H; Lustig K D; Ghanem L; Parker P J; Kirschner M W; Yuan J
Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.
The Journal of biological chemistry 1997;272(47):29449-53.
1997: Li H; Bergeron L; Cryns V; Pasternack M S; Zhu H; Shi L; Greenberg A; Yuan J
Activation of caspase-2 in apoptosis.
The Journal of biological chemistry 1997;272(34):21010-7.
1997: Friedlander R M; Brown R H; Gagliardini V; Wang J; Yuan J
Inhibition of ICE slows ALS in mice.
Nature 1997;388(6637):31.
1997: Hara H; Fink K; Endres M; Friedlander R M; Gagliardini V; Yuan J; Moskowitz M A
Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(4):370-5.
1997: Yuan J
Transducing signals of life and death.
Current opinion in cell biology 1997;9(2):247-51.
1997: Jung Y K; Yuan J
Suppression of interleukin-1beta converting enzyme (ICE)-induced apoptosis by SV40 large T antigen.
Oncogene 1997;14(10):1207-14.
1997: Friedlander R M; Gagliardini V; Hara H; Fink K B; Li W; MacDonald G; Fishman M C; Greenberg A H; Moskowitz M A; Yuan J
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury.
The Journal of experimental medicine 1997;185(5):933-40.
1997: Yuan J
Genetic control of cellular suicide.
Reproductive toxicology (Elmsford, N.Y.) 1997;11(2-3):377-84.
1997: Hara H; Friedlander R M; Gagliardini V; Ayata C; Fink K; Huang Z; Shimizu-Sasamata M; Yuan J; Moskowitz M A
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2007-12.
1997: Lustig K D; Stukenberg P T; McGarry T J; King R W; Cryns V L; Mead P E; Zon L I; Yuan J; Kirschner M W
Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development.
Methods in enzymology 1997;283():83-99.
1996: Cryns V L; Bergeron L; Zhu H; Li H; Yuan J
Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.
The Journal of biological chemistry 1996;271(49):31277-82.
1996: Shi L; Chen G; MacDonald G; Bergeron L; Li H; Miura M; Rotello R J; Miller D K; Li P; Seshadri T; Yuan J; Greenberg A H
Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):11002-7.
1996: Friedlander R M; Gagliardini V; Rotello R J; Yuan J
Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.
The Journal of experimental medicine 1996;184(2):717-24.
1996: Wang S; Miura M; Jung Y k; Zhu H; Gagliardini V; Shi L; Greenberg A H; Yuan J
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.
The Journal of biological chemistry 1996;271(34):20580-7.
1996: Jung Y; Miura M; Yuan J
Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor.
The Journal of biological chemistry 1996;271(9):5112-7.
1996: Li W; Fishman M C; Yuan J
Prevention of apoptosis in CNTF-dependent neurons by a mutant ICE and by viral protein CrmA but not by proto-oncogene product Bcl-2.
Cell death and differentiation 1996;3(1):105-12.
1996: Yuan J
Evolutionary conservation of a genetic pathway of programmed cell death.
Journal of cellular biochemistry 1996;60(1):4-11.
1996: Miura M; Yuan J
Regulation of programmed cell death by interleukin-1 beta-converting enzyme family of proteases.
Advances in experimental medicine and biology 1996;389():165-72.
1995: Miura M; Friedlander R M; Yuan J
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8318-22.
1995: Yuan J
Molecular control of life and death.
Current opinion in cell biology 1995;7(2):211-4.
1994: Wang L; Miura M; Bergeron L; Zhu H; Yuan J
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.
Cell 1994;78(5):739-50.
1994: Fernandez P A; Rotello R J; Rangini Z; Doupe A; Drexler H C; Yuan J
Expression of a specific marker of avian programmed cell death in both apoptosis and necrosis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8641-5.
1994: Rotello R J; Fernandez P A; Yuan J
Anti-apogens and anti-engulfens: monoclonal antibodies reveal specific antigens on apoptotic and engulfment cells during chicken embryonic development.
Development (Cambridge, England) 1994;120(6):1421-31.
1994: Gagliardini V; Fernandez P A; Lee R K; Drexler H C; Rotello R J; Fishman M C; Yuan J
Prevention of vertebrate neuronal death by the crmA gene.
Science (New York, N.Y.) 1994;263(5148):826-8.
1993: Miura M; Zhu H; Rotello R; Hartwieg E A; Yuan J
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3.
Cell 1993;75(4):653-60.
1993: Yuan J; Shaham S; Ledoux S; Ellis H M; Horvitz H R
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.
Cell 1993;75(4):641-52.
1992: Yuan J; Horvitz H R
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.
Development (Cambridge, England) 1992;116(2):309-20.

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