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Jason X-J Yuan

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Dustin R Fraidenburg; Jason X-J Yuan
Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension.
Amy L Firth; Jason X-J Yuan
Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells".
Aya Yamamura; Hisao Yamamura; Amy Zeifman; Adriana M Zimnicka; Qiang Guo; Eun A Ko; Ayako Makino; Nicole M Pohl; Kimberly A Smith; Shanshan Song; Jun Wan; Jason X-J Yuan
Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells.

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2013: Dustin R Fraidenburg; Jason X-J Yuan
Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension.
Circulation research 2013;112(8):1091-3.
2013: Amy L Firth; Jason X-J Yuan
Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells".
American journal of physiology. Cell physiology 2013;304(4):C287-8.
2013: Aya Yamamura; Hisao Yamamura; Amy Zeifman; Adriana M Zimnicka; Qiang Guo; Eun A Ko; Ayako Makino; Nicole M Pohl; Kimberly A Smith; Shanshan Song; Jun Wan; Jason X-J Yuan
Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells.
Circulation research 2013;112(4):640-50.
2013: Irene M Lang; Raffaele Pesavento; Diana Bonderman; Jason X-J Yuan
Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2013;41(2):462-8.
2013: Jason X-J Yuan; Christina Holt; Nicholas W Morrell; Ghazwan Butrous
Readership: The heart of Pulmonary Circulation.
Pulmonary circulation 2013;3(1):1-2.
2012: Kimberly A Smith; Jason X-J Yuan
H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on "Endogenous H2S is required for hypoxic sensing by carotid body glomus cells".
American journal of physiology. Cell physiology 2012;303(9):C911-2.
2012: Irene A Estrada; Wenlong Han; Patryk Debski; Reshma Donthamsetty; Jason X-J Yuan; Shenyuan L Zhang; Meng-Hua Zhou; Ayako Makino
STIM1 restores coronary endothelial function in type 1 diabetic mice.
Circulation research 2012;111(9):1166-75.
2012: Ankit A Desai; Joe G. N. Garcia; Victor Roland Gordeuk; Yong Huang; Gregory Kato ; Roberto M Lang; Homaa Ahmad; Nicole Artz; Wenbo Mu; Amit R Patel; Marlene H Peters-Lawrence; Nalini Raghavachari; Tejas Thiruvoipati; Sharon Trevino; Kristin Turner; Michael S Wade; Jason X-J Yuan; Wei Zhang; Tong Zhou; Roberto Machado
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.
American journal of respiratory and critical care medicine 2012;186(4):359-68.
2012: Aya Yamamura; Hisao Yamamura; Amy Zeifman; Adriana M Zimnicka; Hui Dong; Ruby A Fernandez; Qiang Guo; Ayako Makino; Nicole M Pohl; Kimberly A Smith; Jason X-J Yuan
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Circulation research 2012;111(4):469-81.
2012: Amy L Firth; Jason X-J Yuan
"Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cells. Focus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel".
American journal of physiology. Cell physiology 2012;303(2):C113-4.
2012: Premanand C Sundivakkam; Ankit A Desai; Kimberly A Smith; Jason X-J Yuan
Are men at risk? The role of testosterone in cardiovascular morbidity.
Pulmonary circulation 2012;2(3):275-7.
2012: Kimberly A Smith; Jason X-J Yuan
CRACing the cluster: functionally active Orai1 channels in the absence of clustering with STIM1.
Circulation research 2012;111(1):9-11.
2012: Yidan D Zhao; Lei Cai; Dave L Geenen; Franz Hofmann; Xiaojia Huang; Muhammad Kamran Mirza; Jason X-J Yuan; Youyang Zhao
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.
The American journal of pathology 2012;180(6):2268-75.
2012: Ayako Makino; Brian T Scott; Hong Wang; Jason X-J Yuan; Wolfgang H Dillmann
Thyroid hormone receptor-α and vascular function.
American journal of physiology. Cell physiology 2012;302(9):C1346-52.
2012: Frank K Kuhr; Irena Levitan; Kimberly A Smith; Michael Y Song; Jason X-J Yuan
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling.
American journal of physiology. Heart and circulatory physiology 2012;302(8):H1546-62.
2012: Jason X-J Yuan; S Harikrishnan; Nicholas W Morrell; Ghazwan Butrous
Science is an endless frontier: Encouraging translational research in pulmonary vascular disease.
Pulmonary circulation 2012;2(2):137-8.
2012: Aiko Ogawa; Mary V Maliakal; Kimberly A Smith; Amy L Firth; Jason X-J Yuan
PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.
American journal of physiology. Cell physiology 2012;302(2):C405-11.
2012: Ruby A Fernandez; Kimberly A Smith; Premanand Sundivakkam; Abigail R Drennan; Amy S Zeifman; Jason X-J Yuan
Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.
Journal of signal transduction 2012;2012():951497.
2012: Amy L Firth; Jason X-J Yuan
Identification of functional progenitor cells in the pulmonary vasculature.
Pulmonary circulation 2012;2(1):84-100.
2012: Jason X-J Yuan; S Harikrishnan; Nicholas W Morrell; Ghazwan Butrous
A one-year-old baby… into the Year of the Dragon.
Pulmonary circulation 2012;2(1):1-2.
2011: Qiang Guo; Jiwan Chen; Jun Jin; Bo Shen; Jason X-J Yuan; Amy Zeifman; Jianan Huang
VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury.
Biochemical and biophysical research communications 2011;413(4):630-6.
2011: Michael Y Song; Ayako Makino; Jason X-J Yuan
Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels.
Antioxidants & redox signaling 2011;15(6):1549-65.
2011: Annarosa Arcangeli; Jason X-J Yuan
American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer.
American journal of physiology. Cell physiology 2011;301(2):C253-4.
2011: Weijuan Yao; Jason X-J Yuan; Amy Zeifman; Joe G. N. Garcia; Michelle Lofti; Ayako Makino; Wenbo Mu; David L Perkins; Carmelle V Remillard; Wei Zhang
Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells.
Pulmonary circulation 2011;1(3):405-18.
2011: Jason X-J Yuan; S Harikrishnan; Nicholas W Morrell; Ghazwan Butrous
The world of pulmonary vascular disease.
Pulmonary circulation 2011;1(3):303-4.
2011: Tong Tang; H Kirk Hammond; Amy Firth; Yuan Yang; Mei Hua Gao; Jason X-J Yuan; N Chin Lai
Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts.
Journal of the American College of Cardiology 2011;57(18):1846-55.
2011: Aya Yamamura; Hisao Yamamura; Amy Zeifman; Jason X-J Yuan
Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells.
Pulmonary circulation 2011;1(2):269-79.
2011: Jason X-J Yuan; S Harikrishnan; Nicholas W Morrell; Ghazwan Butrous
Our journey continues.
Pulmonary circulation 2011;1(2):133.
2011: Mei Hua Gao; Tong Tang; Ngai Chin Lai; Atsushi Miyanohara; Tracy Guo; Rouying Tang; Amy L Firth; Jason X-J Yuan; H Kirk Hammond
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
Molecular pharmacology 2011;79(3):381-8.
2011: Yasuo Sugano; N Chin Lai; Mei Hua Gao; Amy L Firth; Jason X-J Yuan; Wilbur Y W Lew; H Kirk Hammond
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
Biochemical and biophysical research communications 2011;405(3):349-55.
2011: Tuguang Kuang; Baosen Pang; Elyssa D Burg; Xiuxia Huang; Jun Wang; Jason X-J Yuan; Amy Zeifman; Chen Wang
Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension.
Pulmonary circulation 2011;1(1):111-4.
2011: Jason X-J Yuan; S Harikrishnan; Nicholas W Morrell; Ghazwan Butrous
Pulmonary Circulation : A new venue for communicating your findings, ideas and perspectives.
Pulmonary circulation 2011;1(1):1-2.
2010: Tuguang Kuang; Jun Wang; Baosen Pang; Xiuxia Huang; Elyssa D Burg; Jason X-J Yuan; Chen Wang
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
Pulmonary pharmacology & therapeutics 2010;23(5):456-64.
2010: Eun A Ko; Won Sun Park; Amy L Firth; Nari Kim; Jason X-J Yuan; Jin Han
Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases.
Progress in biophysics and molecular biology 2010;103(1):95-101.
2010: Zhenguo Zhai; Jun Wang; Lan Zhao; Jason X-J Yuan; Chen Wang
Pulmonary hypertension in China: pulmonary vascular disease: the global perspective.
Chest 2010;137(6 Suppl):69S-77S.
2010: Amy L Firth; Jess Mandel; Jason X-J Yuan
Idiopathic pulmonary arterial hypertension.
Disease models & mechanisms 2010;3(5-6):268-73.
2010: Muhammad Kamran Mirza; Jason X-J Yuan; Xiao-Pei Gao; Sean Garrean; Viktor Brovkovych; Asrar B Malik; Chinnaswamy Tiruppathi; Youyang Zhao
Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation.
The American journal of pathology 2010;176(5):2344-51.
2010: Amy L Firth; Weijuan Yao; Aiko Ogawa; Michael M Madani; Grace Y Lin; Jason X-J Yuan
Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension.
American journal of physiology. Cell physiology 2010;298(5):C1217-25.
2010: Amy L Firth; Weijuan Yao; Carmelle V Remillard; Aiko Ogawa; Jason X-J Yuan
Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology 2010;298(4):L548-57.
2010: Elyssa D Burg; Oleksandr Platoshyn; Igor F Tsigelny; Beatriz Lozano-Ruiz; Brinda K Rana; Jason X-J Yuan
Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns.
American journal of physiology. Cell physiology 2010;298(3):C496-509.
2010: Michael Y Song; Jason X-J Yuan
Introduction to TRP channels: structure, function, and regulation.
Advances in experimental medicine and biology 2010;661():99-108.
2009: Xiaodong Li; Xiaoxue Zhang; Robin Leathers; Ayako Makino; Chengqun Huang; Pouria Parsa; Jesus Macias; Jason X-J Yuan; Stuart W Jamieson; Patricia A Thistlethwaite
Notch3 signaling promotes the development of pulmonary arterial hypertension.
Nature medicine 2009;15(11):1289-97.
2009: Amy L Firth; Oleksandr Platoshyn; Elena E Brevnova; Elyssa D Burg; Frank Powell; Gabriel H Haddad; Jason X-J Yuan
Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.
Annals of the New York Academy of Sciences 2009;1177():101-11.
2009: Aiko Ogawa; Amy L Firth; Weijuan Yao; Michael M Madani; Kim M Kerr; William R Auger; Stuart W Jamieson; Patricia A Thistlethwaite; Jason X-J Yuan
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L666-76.
2009: Youyang Zhao; Yidan D Zhao; Muhammad Kamran Mirza; Julia H Huang; Hari-Hara S K Potula; Stephen M Vogel; Viktor Brovkovych; Jason X-J Yuan; John Wharton; Asrar B Malik
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.
The Journal of clinical investigation 2009;119(7):2009-18.
2009: Nicholas W Morrell; Serge Adnot; Stephen L Archer; Jocelyn Dupuis; Peter Lloyd Jones; Margaret R MacLean; Ivan F McMurtry; Kurt R Stenmark; Patricia A Thistlethwaite; Norbert Weissmann; Jason X-J Yuan; E Kenneth Weir
Cellular and molecular basis of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S20-31.
2009: Paul M Hassoun; Luc Mouthon; Joan A Barberà; Saadia Eddahibi; Sonia C Flores; Friedrich Grimminger; Peter Lloyd Jones; Michael L Maitland; Evangelos D Michelakis; Nicholas W Morrell; John H Newman; Marlene Rabinovitch; Ralph Schermuly; Kurt R Stenmark; Norbert F Voelkel; Jason X-J Yuan; Marc Humbert
Inflammation, growth factors, and pulmonary vascular remodeling.
Journal of the American College of Cardiology 2009;54(1 Suppl):S10-9.
2009: Amy L Firth; Jocelyn Yau; Amanda White; Peter G Chiles; James J Marsh; Timothy A Morris; Jason X-J Yuan
Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2009;296(6):L979-86.
2009: Weijuan Yao; Amy L Firth; Richard S Sacks; Aiko Ogawa; William R Auger; Peter F Fedullo; Michael M Madani; Grace Y Lin; Naohide Sakakibara; Patricia A Thistlethwaite; Stuart W Jamieson; Lewis J Rubin; Jason X-J Yuan
Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2009;296(6):L870-8.
2009: Ying Yu; Steve H Keller; Carmelle V Remillard; Olga Safrina; Ann Nicholson; Shenyuan L Zhang; Weihua Jiang; Nivruthi Vangala; Judd W Landsberg; Jian-Ying Wang; Patricia A Thistlethwaite; Richard N Channick; Ivan M Robbins; James E Loyd; Hossein A Ghofrani; Friedrich Grimminger; Ralph T Schermuly; Michael D Cahalan; Lewis J Rubin; Jason X-J Yuan
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.
Circulation 2009;119(17):2313-22.
2008: Amy L Firth; Jason X-J Yuan
Bringing down the ROS: a new therapeutic approach for PPHN.
American journal of physiology. Lung cellular and molecular physiology 2008;295(6):L976-8.
2008: Rao Jaladanki; Stephen V Liu; Tongtong Zou; Lan Liu; Lan Xiao; Xian Zhang; Emily Bellavance; Jason X-J Yuan; Jian-Ying Wang
Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding.
American journal of physiology. Cell physiology 2008;295(6):C1499-509.
2008: Richard S Sacks; Amy L Firth; Carmelle V Remillard; Negin Agange; Jocelyn Yau; Eun A Ko; Jason X-J Yuan
Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;295(6):L1048-55.
2008: Aiko Ogawa; Amy L Firth; Weijuan Yao; Lewis J Rubin; Jason X-J Yuan
Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2008;295(4):L648-57.
2008: Minlin Xu; Carmelle V Remillard; Benjamin D Sachs; Ayako Makino; Oleksandr Platoshyn; Weijuan Yao; Wolfgang H Dillmann; Katerina Akassoglou; Jason X-J Yuan
p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1529-38.
2008: Ayako Makino; Oleksandr Platoshyn; Jorge Suarez; Jason X-J Yuan; Wolfgang H Dillmann
Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice.
American journal of physiology. Cell physiology 2008;295(1):C221-30.
2008: Christian Schach; Amy L Firth; Minlin Xu; Carmelle V Remillard; Hemal H Patel; Paul Insel; Jason X-J Yuan
Regulation of pulmonary vasoconstriction by agonists and caveolae.
Experimental lung research 2008;34(4):195-208.
2008: Elyssa D Burg; Carmelle V Remillard; Jason X-J Yuan
Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications.
British journal of pharmacology 2008;153 Suppl 1():S99-S111.
2008: Igor Tsigelny; Leslie Crews; Paula Desplats; Gideon M Shaked; Yuriy Sharikov; Hideya Mizuno; Brian Spencer; Edward Rockenstein; Margarita Trejo; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.
PloS one 2008;3(9):e3135.
2008: Tong Tang; Mei Hua Gao; N Chin Lai; Amy L Firth; Toshiyuki Takahashi; Tracy Guo; Jason X-J Yuan; David M Roth; H Kirk Hammond
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.
Circulation 2008;117(1):61-9.
2008: Minlin Xu; Oleksandr Platoshyn; Ayako Makino; Wolfgang H Dillmann; Katerina Akassoglou; Carmelle V Remillard; Jason X-J Yuan
Characterization of agonist-induced vasoconstriction in mouse pulmonary artery.
American journal of physiology. Heart and circulatory physiology 2008;294(1):H220-8.
2007: Winnie Wu; Oleksandr Platoshyn; Amy L Firth; Jason X-J Yuan
Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2007;293(4):L952-9.
2007: Eun A Ko; Elyssa D Burg; Oleksandr Platoshyn; Joseph Msefya; Amy L Firth; Jason X-J Yuan
Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology 2007;293(3):C928-37.
2007: Hemal H Patel; Shen Zhang; Fiona Murray; Ryan Y S Suda; Brian P Head; Utako Yokoyama; James S Swaney; Ingrid R Niesman; Ralph Theo Schermuly; Soni Pullamsetti; Patricia A Thistlethwaite; Atsushi Miyanohara; Marilyn G Farquhar; Jason X-J Yuan; Paul Insel
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2970-9.
2007: Oleksandr Platoshyn; Ying Yu; Eun A Ko; Carmelle V Remillard; Jason X-J Yuan
Heterogeneity of hypoxia-mediated decrease in I(K(V)) and increase in [Ca2+](cyt) in pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L402-16.
2007: Amy L Firth; Carmelle V Remillard; Jason X-J Yuan
TRP channels in hypertension.
Biochimica et biophysica acta 2007;1772(8):895-906.
2007: Ying Yu; Oleksandr Platoshyn; Olga Safrina; Igor Tsigelny; Jason X-J Yuan; Steven H Keller
Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
Biology of the cell / under the auspices of the European Cell Biology Organization 2007;99(8):433-44.
2007: Shen Zhang; Hui Dong; Lewis J Rubin; Jason X-J Yuan
Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension.
American journal of physiology. Cell physiology 2007;292(6):C2297-305.
2007: Jason X-J Yuan
Point:Counterpoint "Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction".
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(5):2078; discussion 2080.
2007: Carmelle V Remillard; Jason X-J Yuan
Cardiac L-arginine transport: the CAT is back.
The Journal of physiology 2007;580(Pt.3):699-700.
2007: Carmelle V Remillard; Donna D Tigno; Oleksandr Platoshyn; Elyssa D Burg; Elena E Brevnova; Diane Conger; Ann Nicholson; Brinda K Rana; Richard N Channick; Lewis J Rubin; Daniel O'Connor; Jason X-J Yuan
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.
American journal of physiology. Cell physiology 2007;292(5):C1837-53.
2007: Shen Zhang; Hemal H Patel; Fiona Murray; Carmelle V Remillard; Christian Schach; Patricia A Thistlethwaite; Paul Insel; Jason X-J Yuan
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
American journal of physiology. Lung cellular and molecular physiology 2007;292(5):L1202-10.
2007: Igor Tsigelny; Pazit Bar-On; Yuriy Sharikov; Leslie Crews; Makoto Hashimoto; Mark A Miller; Steven H Keller; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein.
The FEBS journal 2007;274(7):1862-77.
2007: Christian Schach; Minlin Xu; Oleksandr Platoshyn; Steven H Keller; Jason X-J Yuan
Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels.
American journal of physiology. Lung cellular and molecular physiology 2007;292(3):L685-98.
2007: Fiona Murray; Hemal H Patel; Ryan Y S Suda; Shen Zhang; Patricia A Thistlethwaite; Jason X-J Yuan; Paul Insel
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1.
American journal of physiology. Lung cellular and molecular physiology 2007;292(1):L294-303.
2006: Carmelle V Remillard; Jason X-J Yuan
TRP channels, CCE, and the pulmonary vascular smooth muscle.
Microcirculation (New York, N.Y. : 1994) 2006;13(8):671-92.
2006: Ivana Fantozzi; Oleksandr Platoshyn; Ada H Wong; Shen Zhang; Carmelle V Remillard; Manohar R Furtado; Olga V Petrauskene; Jason X-J Yuan
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L993-1004.
2006: Carmelle V Remillard; Jason X-J Yuan
Transient receptor potential channels and caveolin-1: good friends in tight spaces.
Molecular pharmacology 2006;70(4):1151-4.
2006: Fiona Murray; Paul Insel; Jason X-J Yuan
Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema.
Respiratory physiology & neurobiology 2006;151(2-3):192-208.
2006: Rao Jaladanki; Oleksandr Platoshyn; Vera A Golovina; Lan Liu; Tongtong Zou; Bernard S Marasa; Douglas J Turner; Jason X-J Yuan; Jian-Ying Wang
TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G782-92.
2006: Oleksandr Platoshyn; Elena E Brevnova; Elyssa D Burg; Ying Yu; Carmelle V Remillard; Jason X-J Yuan
Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology 2006;290(3):C907-16.
2006: Joseph R H Mauban; Katherine Wilkinson; Christian Schach; Jason X-J Yuan
Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.
American journal of physiology. Cell physiology 2006;290(2):C325-36.
2006: Richard S Sacks; Carmelle V Remillard; Negin Agange; William R Auger; Patricia A Thistlethwaite; Jason X-J Yuan
Molecular biology of chronic thromboembolic pulmonary hypertension.
Seminars in thoracic and cardiovascular surgery 2006;18(3):265-76.
2006: Elyssa D Burg; Carmelle V Remillard; Jason X-J Yuan
K+ channels in apoptosis.
The Journal of membrane biology 2006;209(1):3-20.
2005: Michikado Iwata; Randy T Cowling; Devorah Gurantz; Cristina Moore; Shen Zhang; Jason X-J Yuan; Barry H Greenberg
Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2356-63.
2005: Oleksandr Platoshyn; Carmelle V Remillard; Ivana Fantozzi; Tiffany Sison; Jason X-J Yuan
Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.
Pflügers Archiv : European journal of physiology 2005;451(2):380-7.
2005: Ivana Fantozzi; Wei Huang; Jifeng Zhang; Shen Zhang; Oleksandr Platoshyn; Carmelle V Remillard; Patricia A Thistlethwaite; Jason X-J Yuan
Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension.
Experimental lung research 2005;31(8):783-806.
2005: Carmelle V Remillard; Jason X-J Yuan
PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?
American journal of physiology. Lung cellular and molecular physiology 2005;288(5):L789-92.
2005: Carmelle V Remillard; Jason X-J Yuan
ClC-3: more than just a volume-sensitive Cl- channel.
British journal of pharmacology 2005;145(1):1-2.
2005: Karl-Ludwig Laugwitz; Alessandra Moretti; Jason Lam; Peter J Gruber; Yinhong Chen; Sarah Woodard; Li-Zhu Lin; Chen-Leng Cai; Min Min Lu; Michael Reth; Oleksandr Platoshyn; Jason X-J Yuan; Sylvia Evans; Kenneth R Chien
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.
Nature 2005;433(7026):647-53.
2005: Jason X-J Yuan; Lewis J Rubin
Pathogenesis of pulmonary arterial hypertension: the need for multiple hits.
Circulation 2005;111(5):534-8.
2005: Shen Zhang; Jason X-J Yuan; Kim E Barrett; Hui Dong
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology 2005;288(2):C245-52.
2005: Steven H Keller; Oleksandr Platoshyn; Jason X-J Yuan
Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.
Cell biochemistry and biophysics 2005;43(3):365-77.
2005: Carmelle V Remillard; Jason X-J Yuan
High altitude pulmonary hypertension: role of K+ and Ca2+ channels.
High altitude medicine & biology 2005;6(2):133-46.
2005: Igor Tsigelny; Matthew Hotchko; Jason X-J Yuan; Steven H Keller
Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.
Cell biochemistry and biophysics 2005;42(1):41-53.
2005: Joseph R H Mauban; Carmelle V Remillard; Jason X-J Yuan
Hypoxic pulmonary vasoconstriction: role of ion channels.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):415-20.
2004: Naomi Kunichika; Judd W Landsberg; Ying Yu; Hideki Kunichika; Patricia A Thistlethwaite; Lewis J Rubin; Jason X-J Yuan
Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes.
American journal of respiratory and critical care medicine 2004;170(10):1101-7.
2004: Shen Zhang; Carmelle V Remillard; Ivana Fantozzi; Jason X-J Yuan
ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology 2004;287(5):C1192-201.
2004: Naomi Kunichika; Ying Yu; Carmelle V Remillard; Oleksandr Platoshyn; Shen Zhang; Jason X-J Yuan
Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry.
American journal of physiology. Lung cellular and molecular physiology 2004;287(5):L962-9.
2004: Ying Yu; Ivana Fantozzi; Carmelle V Remillard; Judd W Landsberg; Naomi Kunichika; Oleksandr Platoshyn; Donna D Tigno; Patricia A Thistlethwaite; Lewis J Rubin; Jason X-J Yuan
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13861-6.
2004: Mehran Mandegar; Yuan-Cheng B Fung; Wei Huang; Carmelle V Remillard; Lewis J Rubin; Jason X-J Yuan
Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension.
Microvascular research 2004;68(2):75-103.
2004: Elena E Brevnova; Oleksandr Platoshyn; Shen Zhang; Jason X-J Yuan
Overexpression of human KCNA5 increases IK V and enhances apoptosis.
American journal of physiology. Cell physiology 2004;287(3):C715-22.
2004: Mehran Mandegar; Patricia A Thistlethwaite; Jason X-J Yuan
Molecular biology of primary pulmonary hypertension.
Cardiology clinics 2004;22(3):417-29, vi.
2004: Oleksandr Platoshyn; Carmelle V Remillard; Ivana Fantozzi; Mehran Mandegar; Tiffany T Sison; Shen Zhang; Elyssa D Burg; Jason X-J Yuan
Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2004;287(1):L226-38.
2004: Judd W Landsberg; Jason X-J Yuan
Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2004;19():44-50.
2004: Carmelle V Remillard; Jason X-J Yuan
Activation of K+ channels: an essential pathway in programmed cell death.
American journal of physiology. Lung cellular and molecular physiology 2004;286(1):L49-67.
2003: Ivana Fantozzi; Shen Zhang; Oleksandr Platoshyn; Carmelle V Remillard; Randy T Cowling; Jason X-J Yuan
Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2003;285(6):L1233-45.
2003: Shen Zhang; Ivana Fantozzi; Donna D Tigno; Eunhee S Yi; Oleksandr Platoshyn; Patricia A Thistlethwaite; Jolene M Kriett; Gordon L Yung; Lewis J Rubin; Jason X-J Yuan
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2003;285(3):L740-54.
2003: Daryoush Ekhterae; Oleksandr Platoshyn; Shen Zhang; Carmelle V Remillard; Jason X-J Yuan
Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents.
American journal of physiology. Cell physiology 2003;284(6):C1405-10.
2003: Rao Jaladanki; Xin Guo; Lan Liu; Tongtong Zou; Karnam S Murthy; Jason X-J Yuan; Jian-Ying Wang
Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution.
American journal of physiology. Cell physiology 2003;284(4):C848-59.
2003: Lingling Du; Christopher C Sullivan; Danny Chu; Augustine J Cho; Masakuni Kido; Paul L Wolf; Jason X-J Yuan; Reena Deutsch; Stuart W Jamieson; Patricia A Thistlethwaite
Signaling molecules in nonfamilial pulmonary hypertension.
The New England journal of medicine 2003;348(6):500-9.
2003: Ying Yu; Michele Sweeney; Shen Zhang; Oleksandr Platoshyn; Judd W Landsberg; Abraham Rothman; Jason X-J Yuan
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.
American journal of physiology. Cell physiology 2003;284(2):C316-30.
2002: Oleksandr Platoshyn; Shen Zhang; Sharon McDaniel; Jason X-J Yuan
Cytochrome c activates K+ channels before inducing apoptosis.
American journal of physiology. Cell physiology 2002;283(4):C1298-305.
2002: Mehran Mandegar; Carmelle V Remillard; Jason X-J Yuan
Ion channels in pulmonary arterial hypertension.
Progress in cardiovascular diseases 2002;45(2):81-114.
2002: Michele Sweeney; Ying Yu; Oleksandr Platoshyn; Shen Zhang; Sharon McDaniel; Jason X-J Yuan
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L144-55.
2002: Michele Sweeney; Sharon McDaniel; Oleksandr Platoshyn; Shen Zhang; Ying Yu; Bethany R Lapp; Ying Zhao; Patricia A Thistlethwaite; Jason X-J Yuan
Role of capacitative Ca2+ entry in bronchial contraction and remodeling.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(4):1594-602.
2002: Rao Jaladanki; Oleksandr Platoshyn; Li Li; Xin Guo; Vera A Golovina; Jason X-J Yuan; Jian-Ying Wang
Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.
American journal of physiology. Cell physiology 2002;282(4):C885-98.
2002: Mehran Mandegar; Jason X-J Yuan
Role of K+ channels in pulmonary hypertension.
Vascular pharmacology 2002;38(1):25-33.
2002: Stefanie Krick; Oleksandr Platoshyn; Michele Sweeney; Sharon McDaniel; Shen Zhang; Lewis J Rubin; Jason X-J Yuan
Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2002;282(1):H184-93.
2001: Jason X-J Yuan
Oxygen-sensitive K(+) channel(s): where and what?
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1345-9.
2001: Sharon McDaniel; Oleksandr Platoshyn; Ying Yu; Michele Sweeney; V A Miriel; Vera A Golovina; Stefanie Krick; B R Lapp; Jian-Ying Wang; Jason X-J Yuan
Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2322-33.
2001: Stefanie Krick; Oleksandr Platoshyn; Sharon McDaniel; Lewis J Rubin; Jason X-J Yuan
Augmented K(+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L887-94.
2001: Ying Yu; Oleksandr Platoshyn; Jun Zhang; Stefanie Krick; Y Zhao; Lewis J Rubin; Abraham Rothman; Jason X-J Yuan
c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells.
Circulation 2001;104(13):1557-63.
2001: Alisa Limsuwan; Oleksandr Platoshyn; Y Yu; Lewis J Rubin; Abraham Rothman; Jason X-J Yuan
Inhibition of K(+) channel activity in human pulmonary artery smooth muscle cells by serum from patients with pulmonary hypertension secondary to congenital heart disease.
Pediatric research 2001;50(1):23-8.
2001: Daryoush Ekhterae; Oleksandr Platoshyn; Stefanie Krick; Ying Yu; Sharon McDaniel; Jason X-J Yuan
Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells.
American journal of physiology. Cell physiology 2001;281(1):C157-65.
2001: Sharon McDaniel; Oleksandr Platoshyn; Jian Wang; Ying Yu; Michele Sweeney; Stefanie Krick; Lewis J Rubin; Jason X-J Yuan
Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L870-80.
2001: Rao Jaladanki; Li Li; Vera A Golovina; Oleksandr Platoshyn; Eric D Strauch; Jason X-J Yuan; Jian-Ying Wang
Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.
American journal of physiology. Cell physiology 2001;280(4):C993-1007.
2001: Stefanie Krick; Oleksandr Platoshyn; Michele Sweeney; H Kim; Jason X-J Yuan
Activation of K+ channels induces apoptosis in vascular smooth muscle cells.
American journal of physiology. Cell physiology 2001;280(4):C970-9.
2001: Oleksandr Platoshyn; Ying Yu; Vera A Golovina; Sharon McDaniel; Stefanie Krick; Li Li; Jian-Ying Wang; Lewis J Rubin; Jason X-J Yuan
Chronic hypoxia decreases K(V) channel expression and function in pulmonary artery myocytes.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L801-12.
2001: Vera A Golovina; Oleksandr Platoshyn; C L Bailey; Jian-Ying Wang; Alisa Limsuwan; Michele Sweeney; Lewis J Rubin; Jason X-J Yuan
Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H746-55.
2000: Oleksandr Platoshyn; Vera A Golovina; C L Bailey; Alisa Limsuwan; Stefanie Krick; M Juhaszova; J E Seiden; Lewis J Rubin; Jason X-J Yuan
Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation.
American journal of physiology. Cell physiology 2000;279(5):C1540-9.
2000: J E Seiden; Oleksandr Platoshyn; A E Bakst; Sharon McDaniel; Jason X-J Yuan
High K(+)-induced membrane depolarization attenuates endothelium-dependent pulmonary vasodilation.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L261-7.
2000: Jian-Ying Wang; Jian Wang; Vera A Golovina; Li Li; Oleksandr Platoshyn; Jason X-J Yuan
Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration.
American journal of physiology. Cell physiology 2000;278(2):C303-14.
2000: M Sweeney; Jason X-J Yuan
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels.
Respiratory research 2000;1(1):40-8.
1998: Jason X-J Yuan; AM Aldinger; M Juhaszova; Jian-Ying Wang; John V Conte; Sean Gaine; Jonathan B Orens; Lewis J Rubin
Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension.
Circulation 1998;98(14):1400-6.
1998: Jian-Ying Wang; M Juhaszova; John V Conte; Sean Gaine; Lewis J Rubin; Jason X-J Yuan
Action of fenfluramine on voltage-gated K+ channels in human pulmonary-artery smooth-muscle cells.
Lancet 1998;352(9124):290.