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Jonathan Brody

Research Profile

Disorders

Anatomy

Chemicals & Drugs

Physiology

Gene Expression Regulation, Neoplastic

Procedures

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Publications

TOP 3
Wan-chi Lin; Chengbao Liu; John P Morris; Rene Opavsky; Nirakar Rajbhandari; Hallgeir Rui; Kazuhito Sakamoto; Aleata A Triplett; Surinder K Batra; Jonathan R Brody; Dominick J DiMaio; Dean W Felsher; Matthias Hebrok; Michael A Hollingsworth; Agnieszka K Witkiewicz; Qian Zhang; Kay-Uwe Wagner
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
Jordan M Winter; Charles J Yeo; Jonathan R Brody
Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer.
Matthew J Schiewer; Wayne D Tilley; Fengzhi Liu; Peter McCue; John M Pascal; Jamie L Planck; Ganesh V Raj; Preethi Ravindranathan; Michael A Augello; J Chad Brenner; Jonathan R Brody; Lisa M Butler; Margaret M Centenera; Arul M Chinnaiyan; Jeffry L Dean; Adam P Dicker; Felix Y Feng; Leonard G Gomella; Jonathan F Goodwin; Sumin Han; Karen E Knudsen
Dual roles of PARP-1 promote cancer growth and progression.

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All Publications

2013: Wan-chi Lin; Chengbao Liu; John P Morris; Rene Opavsky; Nirakar Rajbhandari; Hallgeir Rui; Kazuhito Sakamoto; Aleata A Triplett; Surinder K Batra; Jonathan R Brody; Dominick J DiMaio; Dean W Felsher; Matthias Hebrok; Michael A Hollingsworth; Agnieszka K Witkiewicz; Qian Zhang; Kay-Uwe Wagner
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
Cancer research 2013;73(6):1821-30.
2013: Jordan M Winter; Charles J Yeo; Jonathan R Brody
Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer.
Journal of surgical oncology 2013;107(1):15-22.
2012: Matthew J Schiewer; Wayne D Tilley; Fengzhi Liu; Peter McCue; John M Pascal; Jamie L Planck; Ganesh V Raj; Preethi Ravindranathan; Michael A Augello; J Chad Brenner; Jonathan R Brody; Lisa M Butler; Margaret M Centenera; Arul M Chinnaiyan; Jeffry L Dean; Adam P Dicker; Felix Y Feng; Leonard G Gomella; Jonathan F Goodwin; Sumin Han; Karen E Knudsen
Dual roles of PARP-1 promote cancer growth and progression.
Cancer discovery 2012;2(12):1134-49.
2012: Renee Tholey; Janet A Sawicki; Jonathan R Brody
Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box".
Cancer journal (Sudbury, Mass.) 2012;18(6):665-73.
2012: Danielle M Pineda; Isidore Rigoutsos; David W Rittenhouse; Jonathan N Sachs; Christopher C Valley; Matthew C Weber; Jordan M Winter; Agnieska K Witkiewicz; Charles J Yeo; Richard A Burkhart; Joseph A Cozzitorto; Myriam Gorospe; Benjamin Leiby; Eric R Londin; Jonathan R Brody
HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.
Cancer biology & therapy 2012;13(10):946-55.
2012: Matias E Valsecchi; Charles J Yeo; Jonathan R Brody; Boris Freydin; Terry Hyslop; Mary McDonald; Stephen C Peiper; Charalambos Solomides; Agnieszka K Witkiewicz
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma.
Cancer 2012;118(14):3484-93.
2012: Vanessa A Talbott; Jonathan R Brody; Charles J Yeo; Agnieszka K Witkiewicz
Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient.
The Journal of surgical research 2012;176(1):154-8.
2012: Jordan M Winter; Murray F Brennan; Jonathan R Brody; Michael I D'Angelica; Ronald P DeMatteo; Yuman Fong; William R Jarnagin; Xiaoyu Jia; David S Klimstra; Eileen M O'Reilly; Li-Xuan Qin; Flavio G Rocha; Laura H Tang; Peter J Allen
A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers.
PloS one 2012;7(7):e40157.
2012: Matias E Valsecchi; Charles J Yeo; Jonathan R Brody; Thomas Holdbrook; Benjamin E Leiby; Susan J Littman; Ed Pequignot; Agnieszka Witkiewicz
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
BMC cancer 2012;12():104.
2011: Karen N Wu; Jonathan R Brody; Michael P Lisanti; Magdalena B Potoczek; Maria Queenan; Federica Sotgia; Agnieszka Witkiewicz
Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival.
Cell cycle (Georgetown, Tex.) 2011;10(24):4250-5.
2011: David W Rittenhouse; Vanessa A Talbott; Agnieszka Witkiewicz; Zafia Anklesaria; Jonathan R Brody; Charles J Yeo
Subject review: pancreatic ductal adenocarcinoma in the setting of mutations in the cystic fibrosis transmembrane conductance regulator gene: case report and review of the literature.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2011;15(12):2284-90.
2011: Agnieszka Witkiewicz; Erhan Bilal; Jonathan R Brody; Adam Ertel; Jessica Kline; Stephanos Pavlides; Maria Queenan; Federica Sotgia; Aristotelis Tsirigos; Michael P Lisanti
Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.
Cell cycle (Georgetown, Tex.) 2011;10(11):1794-809.
2011: Jonathan R Brody; Gregory E Gonye
HuR's role in gemcitabine efficacy: an exception or opportunity?
Wiley interdisciplinary reviews. RNA 2011;2(3):435-44.
2011: Jonathan R Brody; Agnieszka K Witkiewicz; Charles J Yeo
The past, present, and future of biomarkers: a need for molecular beacons for the clinical management of pancreatic cancer.
Advances in surgery 2011;45():301-21.
2010: Yu-Hung Huang; Joseph A Cozzitorto; Nathan G Richards; Ahmed A Eltoukhy; Charles J Yeo; Robert Langer; Daniel G Anderson; Jonathan R Brody; Janet A Sawicki
CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy.
Cancer biology & therapy 2010;10(9):878-84.
2010: Jonathan R Brody; Agnieszka Witkiewicz
CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers.
Cancer biology & therapy 2010;10(6):615-6.
2010: Nathan G Richards; David W Rittenhouse; Boris Freydin; Joseph A Cozzitorto; Dane Grenda; Hallgeir Rui; Greg Gonye; Eugene P Kennedy; Charles J Yeo; Jonathan R Brody; Agnieszka Witkiewicz
HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients.
Annals of surgery 2010;252(3):499-505; discussion 505-6.
2010: Adam D Toll; Abhijit Dasgupta; Magdalena Potoczek; Charles J Yeo; Celina G Kleer; Jonathan R Brody; Agnieszka Witkiewicz
Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma.
Human pathology 2010;41(9):1205-9.
2010: Agnieszka Witkiewicz; Boris Freydin; Inna Chervoneva; Magdalena B Potoczek; Wendy Rizzo; Hallgeir Rui; Jonathan R Brody; Gordon Schwartz; Michael P Lisanti
Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence.
Cancer biology & therapy 2010;10(4):391-6.
2010: Agnieszka Witkiewicz; Abhijit Dasgupta; Sara Sammons; Ozlem Er; Magdalena B Potoczek; Fran Guiles; Federica Sotgia; Jonathan R Brody; Edith P Mitchell; Michael P Lisanti
Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers.
Cancer biology & therapy 2010;10(2):135-43.
2010: Shayna L Showalter; Ziqiu Wang; Christina L Costantino; Agnieszka Witkiewicz; Charles J Yeo; Jonathan R Brody; Brian I Carr
Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.
Journal of gastroenterology and hepatology 2010;25(4):738-44.
2010: Shayna L Showalter; Sarah Charles; Justin Belin; Joseph Cozzitorto; Peter Einstein; Nathan G Richards; Patricia K Sauter; Eugene P Kennedy; Agnieszka Witkiewicz; Jonathan R Brody; Charles J Yeo
Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future.
Expert opinion on drug delivery 2010;7(3):273-84.
2009: Jonathan R Brody; Christina L Costantino; Adam C Berger; Takami Sato; Michael P Lisanti; Charles J Yeo; Robert V Emmons; Agnieszka Witkiewicz
Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.
Cell cycle (Georgetown, Tex.) 2009;8(12):1930-4.
2009: Christina L Costantino; Agnieszka Witkiewicz; Yuki Kuwano; Joseph A Cozzitorto; Eugene P Kennedy; Abhijit Dasgupta; Judith C Keen; Charles J Yeo; Myriam Gorospe; Jonathan R Brody
The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.
Cancer research 2009;69(11):4567-72.
2009: Agnieszka Witkiewicz; Abhijit Dasgupta; Federica Sotgia; Isabelle Mercier; Richard G Pestell; Michael Sabel; Celina G Kleer; Jonathan R Brody; Michael P Lisanti
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.
The American journal of pathology 2009;174(6):2023-34.
2009: Agnieszka Witkiewicz; Christina L Costantino; Richard Metz; Alexander J Muller; George C Prendergast; Charles J Yeo; Jonathan R Brody
Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target.
Journal of the American College of Surgeons 2009;208(5):781-7; discussion 787-9.
2009: Jonathan R Brody; Christina L Costantino; Magdalena Potoczek; Joseph Cozzitorto; Peter McCue; Charles J Yeo; Ralph Hruban; Agnieszka Witkiewicz
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(5):651-9.
2009: Jonathan R Brody; Tomas Hucl; Christina L Costantino; James R Eshleman; Eike Gallmeier; Heng Zhu; Michiel S van der Heijden; Jordan M Winter; Agnieszka K Wikiewicz; Charles J Yeo; Scott E Kern
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Cancer research 2009;69(3):984-91.
2008: Shayna L Showalter; Yu-Hung Huang; Agnieszka Witkiewicz; Christina L Costantino; Charles J Yeo; Jordan Green; Robert Langer; Daniel G Anderson; Janet A Sawicki; Jonathan R Brody
Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.
Cancer biology & therapy 2008;7(10):1584-90.
2008: Agnieszka Witkiewicz; Katherine H Nguyen; Abhijit Dasgupta; Eugene P Kennedy; Charles J Yeo; Michael P Lisanti; Jonathan R Brody
Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.
Cell cycle (Georgetown, Tex.) 2008;7(19):3021-5.
2008: Tomas Hucl; Carlo Rago; Eike Gallmeier; Jonathan R Brody; Myriam Gorospe; Scott E Kern
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Cancer research 2008;68(13):5023-30.
2008: Shayna L Showalter; Timothy N Showalter; Agnes Witkiewicz; Robert Havens; Eugene P Kennedy; Tomas Hucl; Scott E Kern; Charles J Yeo; Jonathan R Brody
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
Cancer biology & therapy 2008;7(7):986-94.
2008: Agnes Witkiewicz; Timothy K Williams; Joseph Cozzitorto; Brandice Durkan; Shayna L Showalter; Charles J Yeo; Jonathan R Brody
Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection.
Journal of the American College of Surgeons 2008;206(5):849-54; discussion 854-6.
2007: Jonathan R Brody; Agnes Witkiewicz; Timothy K Williams; Shrihari S. Kadkol; Joseph Cozzitorto; Brandice Durkan; Gary R Pasternack; Charles J Yeo
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(12):1238-44.
2007: Tomas Hucl; Jonathan R Brody; Eike Gallmeier; Christine A Iacobuzio-Donahue; Iain K G Farrance; Scott E Kern
High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.
Cancer research 2007;67(19):9055-65.
2007: Eike Gallmeier; Tomas Hucl; Eric S Calhoun; Steven C Cunningham; Fred Bunz; Jonathan R Brody; Scott E Kern
Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer.
Cancer biology & therapy 2007;6(5):654-60.
2007: Eike Gallmeier; Tomas Hucl; Jonathan R Brody; David A Dezentje; Khola Tahir; Jana Kasparkova; Viktor Brabec; Kurtis E Bachman; Scott E Kern
High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells.
Cancer research 2007;67(5):2169-77.
2006: Jonathan R Brody; Tomas Hucl; Eike Gallmeier; Jordan M Winter; Scott E Kern; KATHLEEN MURPHY
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.
Cancer research 2006;66(19):9369-73.
2006: Jonathan R Brody; Eike Gallmeier; Kiyoshi Yoshimura; Tomas Hucl; Piotr Kulesza; Marcia Canto; Ralph Hruban; Richard D Schulick; Scott E Kern
A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.
Cancer biology & therapy 2006;5(8):923-7.
2006: Eike Gallmeier; Eric S Calhoun; Carlo Rago; Jonathan R Brody; Steven C Cunningham; Tomas Hucl; Myriam Gorospe; Manu Kohli; Christoph Lengauer; Scott E Kern
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 2006;130(7):2145-54.
2006: Jordan M Winter; Jonathan R Brody; Scott E Kern
Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature.
Cancer biology & therapy 2006;5(4):360-70.
2006: Michiel S van der Heijden; Jonathan R Brody; Elhaam Elghalbzouri-Maghrani; Malgorzata Z Zdzienicka; Scott E Kern
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.
BMC genetics 2006;7():3.
2005: Michiel S van der Heijden; Jonathan R Brody; David A Dezentje; Eike Gallmeier; Steven C Cunningham; Michael J Swartz; Angelo M DeMarzo; G Johan A Offerhaus; William H Isacoff; Ralph Hruban; Scott E Kern
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7508-15.
2004: Jonathan R Brody; Eric S Calhoun; Eike Gallmeier; Talisa D Creavalle; Scott E Kern
Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media.
BioTechniques 2004;37(4):598, 600, 602.
2004: Jonathan R Brody; Scott E Kern
History and principles of conductive media for standard DNA electrophoresis.
Analytical biochemistry 2004;333(1):1-13.
2004: Jonathan R Brody; Scott E Kern
Stagnation and herd mentality in the biomedical sciences.
Cancer biology & therapy 2004;3(9):903-10.
2004: Michiel S van der Heijden; Jonathan R Brody; Eike Gallmeier; Steven C Cunningham; David A Dezentje; Dong Shen; Ralph Hruban; Scott E Kern
Functional defects in the fanconi anemia pathway in pancreatic cancer cells.
The American journal of pathology 2004;165(2):651-7.
2004: G John Kochevar; Jonathan R Brody; Shrihari S. Kadkol; KATHLEEN MURPHY; Gary R Pasternack
Identification of a functional mutation in pp32r1 (ANP32C).
Human mutation 2004;23(6):546-51.
2004: Michiel S van der Heijden; Jonathan R Brody; Scott E Kern
Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot.
Cancer biology & therapy 2004;3(6):534-7.
2004: Jonathan R Brody; Scott E Kern
Sodium boric acid: a Tris-free, cooler conductive medium for DNA electrophoresis.
BioTechniques 2004;36(2):214-6.
2004: Jonathan R Brody; Shrihari S. Kadkol; M Claire Hauer; Fatemeh Rajaii; Jessica Lee; Gary R Pasternack
pp32 reduction induces differentiation of TSU-Pr1 cells.
The American journal of pathology 2004;164(1):273-83.
2001: Shrihari S. Kadkol; G A El Naga; Jonathan R Brody; J Bai; Yuriy Gusev; William C Dooley; Gary R Pasternack
Expression of pp32 gene family members in breast cancer.
Breast cancer research and treatment 2001;68(1):65-73.
2001: J Bai; Jonathan R Brody; Shrihari S. Kadkol; Gary R Pasternack
Tumor suppression and potentiation by manipulation of pp32 expression.
Oncogene 2001;20(17):2153-60.
1999: Zhiping Qian; Barbara A Wasowska; E Behrens; DL Cangello; Jonathan R Brody; Shrihari S. Kadkol; LR Horwitz; Jinsong Liu; Charles J Lowenstein; Allan Hess; Alfred P. Sanfilippo; William M Baldwin
C6 produced by macrophages contributes to cardiac allograft rejection.
The American journal of pathology 1999;155(4):1293-302.
1999: Jonathan R Brody; Shrihari S. Kadkol; M A Mahmoud; J M Rebel; Gary R Pasternack
Identification of sequences required for inhibition of oncogene-mediated transformation by pp32.
The Journal of biological chemistry 1999;274(29):20053-5.
1999: Shrihari S. Kadkol; Jonathan R Brody; Jonathan Pevsner; J Bai; Gary R Pasternack
Modulation of oncogenic potential by alternative gene use in human prostate cancer.
Nature medicine 1999;5(3):275-9.
1998: Shrihari S. Kadkol; Jonathan R Brody; Jonathan I Epstein; Francis P Kuhajda; Gary R Pasternack
Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer.
The Prostate 1998;34(3):231-7.
1996: T H Chen; Jonathan R Brody; F E Romantsev; J G Yu; A E Kayler; E Voneiff; Francis P Kuhajda; Gary R Pasternack
Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci.
Molecular biology of the cell 1996;7(12):2045-56.