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Stuart Yuspa

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Megan R Ansbro; Suneet Shukla; Stuart H Yuspa; Suresh V Ambudkar; Luowei Li
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
Junko Okano; Yasuo Sakai; Hong-Wei Sun; Stuart H Yuspa; Clara Levy; Ulrike Lichti; Maria I Morasso
Cutaneous retinoic acid levels determine hair follicle development and downgrowth.
Huei-Chen Lao; Stuart H Yuspa; Jacqueline K Akunda; Kyung-Soo Chun; Gordon P Flake; Robert Langenbach
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.

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2013: Megan R Ansbro; Suneet Shukla; Stuart H Yuspa; Suresh V Ambudkar; Luowei Li
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
PloS one 2013;8(4):e60334.
2012: Junko Okano; Yasuo Sakai; Hong-Wei Sun; Stuart H Yuspa; Clara Levy; Ulrike Lichti; Maria I Morasso
Cutaneous retinoic acid levels determine hair follicle development and downgrowth.
The Journal of biological chemistry 2012;287(47):39304-15.
2012: Huei-Chen Lao; Stuart H Yuspa; Jacqueline K Akunda; Kyung-Soo Chun; Gordon P Flake; Robert Langenbach
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
Carcinogenesis 2012;33(11):2293-300.
2012: V C Padmakumar; Sonali Pal-Ghosh; Andrew Ryscavage; Kelsey Speer; Mary Ann Stepp; Lino Tessarollo; Vincenzo Coppola; Samuel L Dengler; John C Edwards; Shelly Hwang; Katelyn E Masiuk; Stuart H Yuspa
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.
The American journal of pathology 2012;181(1):74-84.
2012: Stuart H Yuspa; Andrzej Dlugosz; Kenneth H Kraemer; Molly Kulesz-Martin; Dennis R Roop; Jackie R Bickenbach
Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.
The Journal of investigative dermatology 2012;132(5):1317-20.
2012: K Stephen Suh; Joshua D Webster; Lisa Wright; John M Crutchley; Rebecca A Dumont; Ester Fernandez-Salas; Kasey Jividen; Mariam Malik; Andrew Ryscavage; Anjali Shukla; R Mark Simpson; Stuart H Yuspa
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.
Carcinogenesis 2012;33(5):986-95.
2012: Mariam Malik; V C Padmakumar; Christophe Cataisson; O M Zack Howard; Kasey Jividen; Jessica Lee; Luowei Li; Stuart H Yuspa
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6130-5.
2012: Junko Okano; Yasuo Sakai; Stuart H Yuspa; Guofeng Zhang; Maria Aronova; Hiroshi Hamada; Ulrike Lichti; Satoru Mamiya; Maria I Morasso
Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development.
Journal of cell science 2012;125(Pt 7):1827-36.
2012: Francesca Mascia; Mitchell F Denning; Raphael Kopan; Stuart H Yuspa
The black box illuminated: signals and signaling.
The Journal of investigative dermatology 2012;132(3 Pt 2):811-9.
2012: Mohd W Nasser; Catherine A Powell; Zahida Qamri; Janani Ravi; Reto A Schwendener; Konstantin Shilo; Prashant Trikha; Ronald Wolf; Stuart H Yuspa; Xianghong Zou; Xue-Feng Bai; Yadwinder S Deol; Gustavo Leone; Ramesh K Ganju
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
Cancer research 2012;72(3):604-15.
2011: Ronald Wolf; Thomas Ruzicka; Stuart H Yuspa
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Amino acids 2011;41(4):789-96.
2010: Ronald Wolf; Francesca Mascia; Alif Dharamsi; O M Zack Howard; Christophe Cataisson; Val Bliskovski; Jason Winston; Lionel Feigenbaum; Ulrike Lichti; Thomas Ruzicka; Triantafyllos Chavakis; Stuart H Yuspa
Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Science translational medicine 2010;2(61):61ra90.
2010: Dazhi Yang; Noemi Kedei; Luowei Li; Juan Tao; Julia F Velasquez; Aleksandra M Michalowski; Balázs Istvan Tóth; Rita Marincsák; Attila Varga; Tamás Bíró; Stuart H Yuspa; Peter M Blumberg
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.
Cancer research 2010;70(20):7905-17.
2010: Mariam Malik; Anjali Shukla; Palak Amin; Wendy Niedelman; Jessica Lee; Kasey Jividen; Juanita M Phang; Jinhui Ding; Kwang S Suh; Paul M G Curmi; Stuart H Yuspa
S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.
The Journal of biological chemistry 2010;285(31):23818-28.
2010: Luowei Li; Suneet Shukla; Andrew Lee; Susan H Garfield; David J Maloney; Suresh V Ambudkar; Stuart H Yuspa
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Cancer research 2010;70(11):4509-19.
2010: Rolando Pérez-Lorenzo; Lauren Mordasky Markell; Kelly A Hogan; Stuart H Yuspa; Adam B Glick
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.
Carcinogenesis 2010;31(6):1116-23.
2010: Mary Ann Stepp; Sonali Pal-Ghosh; Gauri Tadvalkar; Lamise Rajjoub; Rosalyn A Jurjus; Michael Gerdes; Andrew Ryscavage; Christophe Cataisson; Anjali Shukla; Stuart H Yuspa
Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis.
Molecular carcinogenesis 2010;49(4):363-73.
2010: Anjali Shukla; Stuart H Yuspa
CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease.
Nucleus (Austin, Tex.) 2010;1(2):144-9.
2010: Francesca Mascia; Christophe Cataisson; Tang-Cheng Lee; David Threadgill; Valentina Mariani; Paolo Amerio; Chinmayi Chandrasekhara; Gema Souto Adeva; Giampiero Girolomoni; Stuart H Yuspa; Saveria Pastore
EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo.
The Journal of investigative dermatology 2010;130(3):682-93.
2010: Aniruddha Sengupta; Ulrike F Lichti; Bradley A Carlson; Andrew O Ryscavage; Vadim N Gladyshev; Stuart H Yuspa; Dolph L Hatfield
Selenoproteins are essential for proper keratinocyte function and skin development.
PloS one 2010;5(8):e12249.
2009: Victoria Virador; Rafael E Flores-Obando; Adam Berry; Rinal Patel; Julia Zakhari; Yu-Chien Lo; Kathryn Strain; Joanna Anders; Christophe Cataisson; Laura A Hansen; Stuart H Yuspa
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis.
Molecular carcinogenesis 2009;48(7):599-609.
2009: Anjali Shukla; Mariam Malik; Christophe Cataisson; Yan Ho; Travis Friesen; Kwang S Suh; Stuart H Yuspa
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.
Nature cell biology 2009;11(6):777-84.
2009: Ronald Wolf; Christopher Voscopoulos; Jason Winston; Alif Dharamsi; Paul Goldsmith; Michele Gunsior; Barbara K Vonderhaar; Melanie Olson; Peter H Watson; Stuart H Yuspa
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.
Cancer letters 2009;277(1):101-7.
2009: Jung-Eun Park; Luowei Li; Joobae Park; Rainald Knecht; Klaus Strebhardt; Stuart H Yuspa; Kyung S Lee
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1725-30.
2009: Christophe Cataisson; Rebecca Ohman; Gopal Patel; Andrea Pearson; Margaret Tsien; Steve Jay; Lisa Wright; Henry Hennings; Stuart H Yuspa
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.
Cancer research 2009;69(1):319-28.
2008: Ronald Wolf; O M Zack Howard; Hui-Fang Dong; Christopher Voscopoulos; Karen Boeshans; Jason Winston; Rao Divi; Michele Gunsior; Paul Goldsmith; Bijan Ahvazi; Triantafyllos Chavakis; Joost J Oppenheim; Stuart H Yuspa
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1499-506.
2008: Marzia Scortegagna; Christophe Cataisson; Rebecca J Martin; Daniel J Hicklin; Robert D Schreiber; Stuart H Yuspa; Jeffrey M Arbeit
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling.
Blood 2008;111(7):3343-54.
2008: Ulrike Lichti; Joanna Anders; Stuart H Yuspa
Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice.
Nature protocols 2008;3(5):799-810.
2007: Nadine Darwiche; Andrew Ryscavage; Rolando Perez-Lorenzo; L Wright; D-S Bae; Henry Hennings; Stuart H Yuspa; Adam Glick
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.
Oncogene 2007;26(48):6885-95.
2007: Mary Ann Stepp; Yueyuan Liu; Sonali Pal-Ghosh; Rosalyn A Jurjus; Gauri Tadvalkar; Adith Sekaran; Kristen Losicco; Li Jiang; Melinda Larsen; Luowei Li; Stuart H Yuspa
Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1.
Journal of cell science 2007;120(Pt 16):2851-63.
2007: Kwang S Suh; Michihiro Mutoh; Tomoko Mutoh; Luowei Li; Andrew Ryscavage; John M Crutchley; Rebecca A Dumont; Christina Cheng; Stuart H Yuspa
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation.
Journal of cell science 2007;120(Pt 15):2631-40.
2007: Adam Glick; Andrew Ryscavage; Rolando Perez-Lorenzo; Henry Hennings; Stuart H Yuspa; Nadine Darwiche
The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer.
Molecular carcinogenesis 2007;46(8):605-10.
2007: Kwang S Suh; Mariam Malik; Anjali Shukla; Stuart H Yuspa
CLIC4, skin homeostasis and cutaneous cancer: surprising connections.
Molecular carcinogenesis 2007;46(8):599-604.
2007: Kwang S Suh; John M Crutchley; Arash Koochek; Andrew Ryscavage; Kiran Bhat; Takemi Tanaka; Akira Oshima; Peter Fitzgerald; Stuart H Yuspa
Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):121-31.
2006: Christophe Cataisson; Andrea J Pearson; Margaret Z Tsien; Francesca Mascia; Ji-Liang Gao; Saveria Pastore; Stuart H Yuspa
CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation.
The Journal of clinical investigation 2006;116(10):2757-66.
2006: Michael J Gerdes; Max Myakishev-Rempel; Nicholas A Frost; Vikas Rishi; Jaideep Moitra; Asha Acharya; Michelle R Levy; Sang-won Park; Adam Glick; Stuart H Yuspa; Charles Vinson
Activator protein-1 activity regulates epithelial tumor cell identity.
Cancer research 2006;66(15):7578-88.
2006: Ronald Wolf; Christopher J Voscopoulos; Peter C FitzGerald; Paul Goldsmith; Christophe Cataisson; Michele Gunsior; Markus Walz; Thomas Ruzicka; Stuart H Yuspa
The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation.
The Journal of investigative dermatology 2006;126(7):1600-8.
2006: Karen M Boeshans; Ronald Wolf; Christopher Voscopoulos; William K Gillette; Dominic Esposito; Timothy C Mueser; Stuart H Yuspa; Bijan Ahvazi
Purification, crystallization and preliminary X-ray diffraction of human S100A15.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 5):467-70.
2006: Luowei Li; Keeran Sampat; Nancy Hu; Julia Zakari; Stuart H Yuspa
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes.
The Journal of biological chemistry 2006;281(6):3237-43.
2006: Yuzuru Shiio; Kwang S Suh; Hookeun Lee; Stuart H Yuspa; Robert N Eisenman; Ruedi Aebersold
Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4.
The Journal of biological chemistry 2006;281(5):2750-6.
2005: Svante Bohman; Taro Matsumoto; Kwang Suh; Anna Dimberg; Lars Jakobsson; Stuart H Yuspa; Lena Claesson-Welsh
Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis.
The Journal of biological chemistry 2005;280(51):42397-404.
2005: Kwang S Suh; Michihiro Mutoh; Michael J Gerdes; Stuart H Yuspa
CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2005;10(2):105-9.
2005: Adam Glick; Stuart H Yuspa
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers.
Seminars in cancer biology 2005;15(2):75-83.
2005: Stuart H Yuspa; Ervin H Epstein
Cancer. An anchor for tumor cell invasion.
Science (New York, N.Y.) 2005;307(5716):1727-8.
2005: Christophe Cataisson; Andrea J Pearson; Sara Torgerson; Sergei A Nedospasov; Stuart H Yuspa
Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1686-92.
2005: Kwang S Suh; Michihiro Mutoh; Michael J Gerdes; John M Crutchley; Tomoko Mutoh; Lindsay E Edwards; Rebecca A Dumont; Pooja Sodha; Christina Cheng; Adam Glick; Stuart H Yuspa
Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth.
Cancer research 2005;65(2):562-71.
2005: Michael J Gerdes; Stuart H Yuspa
The contribution of epidermal stem cells to skin cancer.
Stem cell reviews 2005;1(3):225-31.
2005: Kwang S Suh; Stuart H Yuspa
Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy.
Current pharmaceutical design 2005;11(21):2753-64.
2004: Susan Repertinger; Erica Campagnaro; Jill Fuhrman; Taghrid B El-Abaseri; Stuart H Yuspa; Laura A Hansen
EGFR enhances early healing after cutaneous incisional wounding.
The Journal of investigative dermatology 2004;123(5):982-9.
2004: Craig D Woodworth; Evan Michael; Laura Smith; Kinnimulki Vijayachandra; Adam Glick; Henry Hennings; Stuart H Yuspa
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte.
Carcinogenesis 2004;25(9):1771-8.
2004: Kwang S Suh; Michihiro Mutoh; Kunio Nagashima; Ester Fernandez-Salas; Lindsay E Edwards; Daniel D Hayes; John M Crutchley; Keith G Marin; Rebecca A Dumont; Joshua M Levy; Christina Cheng; Susan H Garfield; Stuart H Yuspa
The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis.
The Journal of biological chemistry 2004;279(6):4632-41.
2003: Yeon-Sun Seong; Changhee Min; Luowei Li; Jae Young Yang; Soo-Yeon Kim; Xiaodong Cao; Keetae Kim; Stuart H Yuspa; Hyun-Ho Chung; Kyung S Lee
Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026.
Cancer research 2003;63(21):7384-91.
2003: Laura A Hansen; Diane Brown; Victoria Virador; Takemi Tanaka; Fausto Andreola; Kathryn Strain; Barbara Dancheck; Rebeccah Riley; Jeffrey M Arbeit; LUIGI DE LUCA; Scott Kogan; Stuart H Yuspa
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.
Cancer research 2003;63(17):5257-65.
2003: Christophe Cataisson; Elizabeth Joseloff; Rodolfo Murillas; Alice Wang; Coralyn Atwell; Sara Torgerson; Michael J Gerdes; Jeffrey Subleski; Ji-Liang Gao; Philip M Murphy; Robert Wiltrout; Charles Vinson; Stuart H Yuspa
Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2703-13.
2003: Kwang S Suh; Tamara T Tatunchak; John M Crutchley; Lindsay E Edwards; Keith G Marin; Stuart H Yuspa
Genomic structure and promoter analysis of PKC-delta.
Genomics 2003;82(1):57-67.
2002: Andrzej Dlugosz; Glenn Merlino; Stuart H Yuspa
Progress in cutaneous cancer research.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2002;7(1):17-26.
2002: Ester Fernández-Salas; Kwang S Suh; Vladislav V Speransky; Wendy L Bowers; Joshua M Levy; Tracey Adams; Kamal R Pathak; Lindsay E Edwards; Daniel D Hayes; Christina Cheng; Alasdair C Steven; Wendy C Weinberg; Stuart H Yuspa
mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53.
Molecular and cellular biology 2002;22(11):3610-20.
2002: Elizabeth Joseloff; Christophe Cataisson; Heather Aamodt; Henrietta Ocheni; Peter M Blumberg; Alan J Kraker; Stuart H Yuspa
Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.
The Journal of biological chemistry 2002;277(14):12318-23.
2001: Asma Hatoum; Marwan E El Sabban; J Khoury; Stuart H Yuspa; Nadine Darwiche
Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.
Carcinogenesis 2001;22(12):1955-63.
2001: Addy Alt-Holland; Motoi Ohba; L Li; Marina Gartsbein; A Belanger; Mitchell F Denning; Toshio Kuroki; Stuart H Yuspa; Tamar Tennenbaum
Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment.
Cancer research 2001;61(11):4591-8.
2000: Susan Rutberg; T L Adams; Adam Glick; Maria Bonovich; Charles Vinson; Stuart H Yuspa
Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes.
Cancer research 2000;60(22):6332-8.
2000: Laura A Hansen; R L Woodson; S Holbus; K Strain; Y C Lo; Stuart H Yuspa
The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors.
Cancer research 2000;60(13):3328-32.
2000: Mitchell F Denning; Andrzej Dlugosz; Christina Cheng; Peter J Dempsey; R J Coffey; David Threadgill; Terry Magnuson; Stuart H Yuspa
Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes.
Experimental dermatology 2000;9(3):192-9.
2000: Peter Acs; M Beheshti; Z Szállási; Luowei Li; Stuart H Yuspa; Peter M Blumberg
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.
Carcinogenesis 2000;21(5):887-91.
2000: Ishtiaq Rehman; DT Lowry; C Adams; R Abdel-Fattah; A Holly; Stuart H Yuspa; Henry Hennings
Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein.
Molecular carcinogenesis 2000;27(4):298-307.
2000: Stuart H Yuspa
Overview of carcinogenesis: past, present and future.
Carcinogenesis 2000;21(3):341-4.
2000: Stuart H Yuspa; L Hansen; L Li; Elizabeth Joseloff; Wendy C Weinberg; Ester Fernandez-Salas
Interacting signaling pathways in the pathogenesis of squamous cell carcinoma.
Medicina 2000;60(5 Pt 2):689-92.
1999: Adam Glick; Nicholas C Popescu; V Alexander; H Ueno; Erwin P Bottinger; Stuart H Yuspa
Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14949-54.
1999: E Fernández-Salas; M Sagar; Christina Cheng; Stuart H Yuspa; Wendy C Weinberg
p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein.
The Journal of biological chemistry 1999;274(51):36488-97.
1999: Luowei Li; Patricia S Lorenzo; K Bogi; Peter M Blumberg; Stuart H Yuspa
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector.
Molecular and cellular biology 1999;19(12):8547-58.
1999: Diane R Bielenberg; Marya F McCarty; Corazon D Bucana; Stuart H Yuspa; D Morgan; J M Arbeit; Lee M Ellis; Karen R Cleary; Isaiah J Fidler
Expression of interferon-beta is associated with growth arrest of murine and human epidermal cells.
The Journal of investigative dermatology 1999;112(5):802-9.
1999: Wendy C Weinberg; Ester Fernandez-Salas; DL Morgan; A Shalizi; E Mirosh; E Stanulis; Chuxia Deng; Henry Hennings; Stuart H Yuspa
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
Cancer research 1999;59(9):2050-4.
1999: Susan Rutberg; T L Adams; M Olive; N Alexander; Charles Vinson; Stuart H Yuspa
CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes.
Oncogene 1999;18(8):1569-79.
1998: Y S Lee; Stuart H Yuspa; Andrzej Dlugosz
Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C signaling pathway.
The Journal of investigative dermatology 1998;111(5):762-6.
1998: Z Zhang; Bhalchandra A Diwan; Lucy M Anderson; Daniel Logsdon; Ofelia A Olivero; Diana C Haines; Jerry M Rice; Stuart H Yuspa; Miriam C Poirier
Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3'-azido-2',3'-dideoxythymidine.
Molecular carcinogenesis 1998;23(1):45-51.
1998: B A Mock; DT Lowry; Ishtiaq Rehman; C Padlan; Stuart H Yuspa; Henry Hennings
Multigenic control of skin tumor susceptibility in SENCARA/Pt mice.
Carcinogenesis 1998;19(6):1109-15.
1998: Stuart H Yuspa
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis.
Journal of dermatological science 1998;17(1):1-7.
1998: Tamar Tennenbaum; DT Lowry; Nadine Darwiche; DL Morgan; Marina Gartsbein; L Hansen; LUIGI DE LUCA; Henry Hennings; Stuart H Yuspa
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.
Cancer research 1998;58(7):1435-43.
1997: Ofelia A Olivero; Lucy M Anderson; Bhalchandra A Diwan; Diana C Haines; Steven W Harbaugh; T J Moskal; A B Jones; Jerry M Rice; CW Riggs; Daniel Logsdon; Stuart H Yuspa; Miriam C Poirier
Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys.
Journal of the National Cancer Institute 1997;89(21):1602-8.
1997: Wendy C Weinberg; Stuart H Yuspa
An antibody to p53 recognizes soluble keratins in epidermal keratinocyte cultures under differentiating, but not proliferating, conditions.
The Journal of investigative dermatology 1997;109(4):611-2.
1997: Henry Hennings; DT Lowry; Stuart H Yuspa; B Mock; M Potter
New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin.
Molecular carcinogenesis 1997;20(1):143-50.
1997: Susan Rutberg; E J Lee; L H Hansen; Adam Glick; Stuart H Yuspa
Identification of differentially expressed genes in chemically induced skin tumors.
Molecular carcinogenesis 1997;20(1):88-98.
1997: Susan Rutberg; E Saez; S Lo; S I Jang; Nelli G Markova; Bruce M Spiegelman; Stuart H Yuspa
Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.
Oncogene 1997;15(11):1337-46.
1997: Andrzej Dlugosz; L Hansen; Christina Cheng; N Alexander; Mitchell F Denning; David Threadgill; Terry Magnuson; R J Coffey; Stuart H Yuspa
Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras.
Cancer research 1997;57(15):3180-8.
1997: Laura A Hansen; N Alexander; M E Hogan; J P Sundberg; Andrzej Dlugosz; David Threadgill; Terry Magnuson; Stuart H Yuspa
Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.
The American journal of pathology 1997;150(6):1959-75.
1997: Y S Lee; Andrzej Dlugosz; R McKay; Nicholas Dean; Stuart H Yuspa
Definition by specific antisense oligonucleotides of a role for protein kinase C alpha in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes.
Molecular carcinogenesis 1997;18(1):44-53.
1996: N Darwiche; G Scita; C Jones; Susan Rutberg; E Greenwald; Tamar Tennenbaum; S J Collins; LUIGI DE LUCA; Stuart H Yuspa
Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.
Cancer research 1996;56(21):4942-9.
1996: A B Glick; Wendy C Weinberg; I H Wu; W Quan; Stuart H Yuspa
Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.
Cancer research 1996;56(16):3645-50.
1996: C Stanwell; B Ye; Stuart H Yuspa; Terrence R Burke
Cell protein cross-linking by erbstatin and related compounds.
Biochemical pharmacology 1996;52(3):475-80.
1996: Susan Rutberg; E Saez; A Glick; Andrzej Dlugosz; Bruce M Spiegelman; Stuart H Yuspa
Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
Oncogene 1996;13(1):167-76.
1996: C Stanwell; Andrzej Dlugosz; Stuart H Yuspa
Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C.
Carcinogenesis 1996;17(6):1259-65.
1996: Tamar Tennenbaum; L Li; A J Belanger; LUIGI DE LUCA; Stuart H Yuspa
Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(5):615-28.
1996: Tamar Tennenbaum; A J Belanger; V Quaranta; Stuart H Yuspa
Differential regulation of integrins and extracellular matrix binding in epidermal differentiation and squamous tumor progression.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):157-61.
1996: Stuart H Yuspa; Andrzej Dlugosz; Mitchell F Denning; A B Glick
Multistage carcinogenesis in the skin.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):147-50.
1996: Mitchell F Denning; Andrzej Dlugosz; David Threadgill; Terry Magnuson; Stuart H Yuspa
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
The Journal of biological chemistry 1996;271(10):5325-31.
1996: C Stanwell; Mitchell F Denning; Susan Rutberg; C Cheng; Stuart H Yuspa; Andrzej Dlugosz
Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes.
The Journal of investigative dermatology 1996;106(3):482-9.
1996: L Li; Tamar Tennenbaum; Stuart H Yuspa
Suspension-induced murine keratinocyte differentiation is mediated by calcium.
The Journal of investigative dermatology 1996;106(2):254-60.
1995: Mitchell F Denning; Marcelo G Kazanietz; Peter M Blumberg; Stuart H Yuspa
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1619-26.
1995: C Stanwell; Terrence R Burke; Stuart H Yuspa
The erbstatin analogue methyl 2,5-dihydroxycinnamate cross-links proteins and is cytotoxic to normal and neoplastic epithelial cells by a mechanism independent of tyrosine kinase inhibition.
Cancer research 1995;55(21):4950-6.
1995: Z Szallasi; Mitchell F Denning; E Y Chang; Juan Rivera; Stuart H Yuspa; C Lehel; Zoltan Olah; Wayne B Anderson; Peter M Blumberg
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
Biochemical and biophysical research communications 1995;214(3):888-94.
1995: E Saez; Susan Rutberg; Elisabetta Mueller; H Oppenheim; J Smoluk; Stuart H Yuspa; Bruce M Spiegelman
c-fos is required for malignant progression of skin tumors.
Cell 1995;82(5):721-32.
1995: L Li; R W Tucker; Henry Hennings; Stuart H Yuspa
Inhibitors of the intracellular Ca(2+)-ATPase in cultured mouse keratinocytes reveal components of terminal differentiation that are regulated by distinct intracellular Ca2+ compartments.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(9):1171-84.
1995: A B Scandurro; Q Wang; L Goodman; S Ledbetter; T P Dooley; Stuart H Yuspa; U Lichti
Immortalized rat whisker dermal papilla cells cooperate with mouse immature hair follicle buds to activate type IV procollagenases in collagen matrix coculture: correlation with ability to promote hair follicle development in nude mouse grafts.
The Journal of investigative dermatology 1995;105(2):177-83.
1995: Tamar Tennenbaum; A J Belanger; A B Glick; R Tamura; V Quaranta; Stuart H Yuspa
A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7041-5.
1995: N Darwiche; G Celli; Tamar Tennenbaum; A B Glick; Stuart H Yuspa; LUIGI DE LUCA
Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors.
Cancer research 1995;55(13):2774-82.
1995: Wendy C Weinberg; Christopher G Azzoli; K Chapman; Arnold J Levine; Stuart H Yuspa
p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein.
Oncogene 1995;10(12):2271-9.
1995: M Ueda; H Kawamura; C Sutter; A Glick; Stuart H Yuspa; J E Strickland
Analysis of v-Ha-ras and v-fos oncogene transduction into a mouse epidermal cell line with "initiated" phenotype in culture but normal skin phenotype in vivo.
Molecular carcinogenesis 1995;13(2):96-103.
1995: U Lichti; A B Scandurro; T Kartasova; Jeffrey S Rubin; WJ LaRochelle; Stuart H Yuspa
Hair follicle development and hair growth from defined cell populations grafted onto nude mice.
The Journal of investigative dermatology 1995;104(5 Suppl):43S-44S.
1995: T Kartasova; A B Scandurro; Mitchell F Denning; P J Wirth; Stuart H Yuspa; U Lichti
Factors mediating the interactions between epidermal and dermal cells in skin grafts that might be important for hair follicle development.
The Journal of investigative dermatology 1995;104(5 Suppl):21S-22S.
1995: Andrzej Dlugosz; C Cheng; E K Williams; N Darwiche; Peter J Dempsey; B Mann; A R Dunn; R J Coffey; Stuart H Yuspa
Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.
Cancer research 1995;55(9):1883-93.
1995: L Li; R W Tucker; Henry Hennings; Stuart H Yuspa
Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro.
Journal of cellular physiology 1995;163(1):105-14.
1995: Z Szallasi; K Kosa; C B Smith; Andrzej Dlugosz; E K Williams; Stuart H Yuspa; Peter M Blumberg
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes.
Molecular pharmacology 1995;47(2):258-65.
1995: Mitchell F Denning; Andrzej Dlugosz; E K Williams; Z Szallasi; Peter M Blumberg; Stuart H Yuspa
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(2):149-57.
1995: Stuart H Yuspa; Henry Hennings; Andrzej Dlugosz; Tamar Tennenbaum; A Glick
The role of growth factors in mouse skin tumor promotion and premalignant progression.
Progress in clinical and biological research 1995;391():39-48.
1995: Andrzej Dlugosz; A B Glick; Tamar Tennenbaum; Wendy C Weinberg; Stuart H Yuspa
Isolation and utilization of epidermal keratinocytes for oncogene research.
Methods in enzymology 1995;254():3-20.
1994: Andrzej Dlugosz; C Cheng; E K Williams; A G Dharia; Mitchell F Denning; Stuart H Yuspa
Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha.
Cancer research 1994;54(24):6413-20.
1994: Andrzej Dlugosz; C Cheng; Mitchell F Denning; Peter J Dempsey; R J Coffey; Stuart H Yuspa
Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(12):1283-92.
1994: Z Szallasi; Mitchell F Denning; C B Smith; Andrzej Dlugosz; Stuart H Yuspa; George R Pettit; Peter M Blumberg
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Molecular pharmacology 1994;46(5):840-50.
1994: Stuart H Yuspa; Andrzej Dlugosz; C K Cheng; Mitchell F Denning; Tamar Tennenbaum; A B Glick; Wendy C Weinberg
Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.
The Journal of investigative dermatology 1994;103(5 Suppl):90S-95S.
1994: Wendy C Weinberg; Christopher G Azzoli; N Kadiwar; Stuart H Yuspa
p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.
Cancer research 1994;54(21):5584-92.
1994: A B Glick; M M Lee; N Darwiche; Ashok Kulkarni; S Karlsson; Stuart H Yuspa
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.
Genes & development 1994;8(20):2429-40.
1994: C Sutter; D A Greenhalgh; M Ueda; S Abhyankar; P Ngai; Henry Hennings; Jürgen Schweizer; Stuart H Yuspa; J E Strickland
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
Carcinogenesis 1994;15(9):1975-8.
1994: K Punnonen; Mitchell F Denning; S G Rhee; Stuart H Yuspa
Differences in the regulation of phosphatidylinositol-specific phospholipase C in normal and neoplastic keratinocytes.
Molecular carcinogenesis 1994;10(4):216-25.
1994: Andrzej Dlugosz; Stuart H Yuspa
Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium.
The Journal of investigative dermatology 1994;102(4):409-14.
1994: Stuart H Yuspa
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.
Cancer research 1994;54(5):1178-89.
1993: Mitchell F Denning; Andrzej Dlugosz; M K Howett; Stuart H Yuspa
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.
The Journal of biological chemistry 1993;268(35):26079-81.
1993: Henry Hennings; A B Glick; DT Lowry; L S Krsmanovic; L M Sly; Stuart H Yuspa
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin.
Carcinogenesis 1993;14(11):2353-8.
1993: K Punnonen; Mitchell F Denning; E Lee; L Li; S G Rhee; Stuart H Yuspa
Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes.
The Journal of investigative dermatology 1993;101(5):719-26.
1993: Tamar Tennenbaum; A K Weiner; A J Belanger; A B Glick; Henry Hennings; Stuart H Yuspa
The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.
Cancer research 1993;53(20):4803-10.
1993: Stuart H Yuspa; Q Wang; Wendy C Weinberg; L Goodman; S Ledbetter; T Dooley; U Lichti
Regulation of hair follicle development: an in vitro model for hair follicle invasion of dermis and associated connective tissue remodeling.
The Journal of investigative dermatology 1993;101(1 Suppl):27S-32S.
1993: U Lichti; Wendy C Weinberg; L Goodman; S Ledbetter; T Dooley; D Morgan; Stuart H Yuspa
In vivo regulation of murine hair growth: insights from grafting defined cell populations onto nude mice.
The Journal of investigative dermatology 1993;101(1 Suppl):124S-129S.
1993: A B Glick; Ashok Kulkarni; Tamar Tennenbaum; Henry Hennings; Kathleen C Flanders; M O'Reilly; Michael B. Sporn; S Karlsson; Stuart H Yuspa
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6076-80.
1993: C Cheng; Tamar Tennenbaum; Peter J Dempsey; R J Coffey; Stuart H Yuspa; Andrzej Dlugosz
Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor alpha mediates the induction of keratin 8 by the v-rasHa oncogene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):317-27.
1993: Wendy C Weinberg; L V Goodman; C George; D L Morgan; S Ledbetter; Stuart H Yuspa; U Lichti
Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells.
The Journal of investigative dermatology 1993;100(3):229-36.
1993: L Li; F H Kruszewski; K Punnonen; R W Tucker; Stuart H Yuspa; Henry Hennings
Strontium induces murine keratinocyte differentiation in vitro in the presence of serum and calcium.
Journal of cellular physiology 1993;154(3):643-53.
1993: T Kartasova; D R Roop; K A Holbrook; Stuart H Yuspa
Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network.
The Journal of cell biology 1993;120(5):1251-61.
1993: J E Strickland; Andrzej Dlugosz; Henry Hennings; Stuart H Yuspa
Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
Carcinogenesis 1993;14(2):205-9.
1993: Carol Ann Huff; Stuart H Yuspa; D Rosenthal
Identification of control elements 3' to the human keratin 1 gene that regulate cell type and differentiation-specific expression.
The Journal of biological chemistry 1993;268(1):377-84.
1993: Henry Hennings; A B Glick; D A Greenhalgh; D L Morgan; J E Strickland; Tamar Tennenbaum; Stuart H Yuspa
Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;202(1):1-8.
1993: Stuart H Yuspa; K Punnonen; E Lee; Henry Hennings; J Strickland; C Cheng; A Glick; Andrzej Dlugosz
The in vitro analysis of biochemical changes relevant to skin carcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;128():299-308.
1993: Andrzej Dlugosz; Stuart H Yuspa
Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C.
The Journal of cell biology 1993;120(1):217-25.
1992: E Lee; K Punnonen; C Cheng; A Glick; Andrzej Dlugosz; Stuart H Yuspa
Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype.
Carcinogenesis 1992;13(12):2367-73.
1992: Henry Hennings; DT Lowry; V A Robinson; D L Morgan; H Fujiki; Stuart H Yuspa
Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis.
Carcinogenesis 1992;13(11):2145-51.
1992: K Punnonen; Stuart H Yuspa
Ultraviolet light irradiation increases cellular diacylglycerol and induces translocation of diacylglycerol kinase in murine keratinocytes.
The Journal of investigative dermatology 1992;99(2):221-6.
1992: D Morgan; D Welty; A Glick; D Greenhalgh; Henry Hennings; Stuart H Yuspa
Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells.
Cancer research 1992;52(11):3145-56.
1992: Tamar Tennenbaum; Stuart H Yuspa; A Grover; Vincent Castronovo; M E Sobel; Y Yamada; LUIGI DE LUCA
Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression.
Cancer research 1992;52(10):2966-76.
1992: J E Strickland; M Ueda; Henry Hennings; Stuart H Yuspa
A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice.
Cancer research 1992;52(6):1439-44.
1992: D S Rosenthal; Christopher E M Griffiths; Stuart H Yuspa; D R Roop; John J Voorhees
Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14.
The Journal of investigative dermatology 1992;98(3):343-50.
1992: Stuart H Yuspa; K Punnonen; E Lee; Henry Hennings; J E Strickland; C Cheng; A Glick; Andrzej Dlugosz
Alterations in the biology and biochemistry of keratinocytes induced by the ras oncogene.
Progress in clinical and biological research 1992;376():103-15.
1992: T Kartasova; D R Roop; Stuart H Yuspa
Relationship between the expression of differentiation-specific keratins 1 and 10 and cell proliferation in epidermal tumors.
Molecular carcinogenesis 1992;6(1):18-25.
1992: Andrzej Dlugosz; Mischak Harald; J Frederic Mushinski; Stuart H Yuspa
Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells.
Molecular carcinogenesis 1992;5(4):286-92.
1991: W C Weinberg; P D Brown; William Stetler-Stevenson; Stuart H Yuspa
Modulation of hair follicle cell proliferation and collagenolytic activity by specific growth factors.
Annals of the New York Academy of Sciences 1991;642():281-90.
1991: F H Kruszewski; Henry Hennings; Stuart H Yuspa; R W Tucker
Regulation of intracellular free calcium in normal murine keratinocytes.
The American journal of physiology 1991;261(5 Pt 1):C767-73.
1991: Henry Hennings; V A Robinson; Stuart H Yuspa; D J Welty; D G Greenhalgh
Activation of the rasHa gene in urethane-initiated papillomas induced by protocols with high and low frequencies of malignant conversion.
Cancer communications 1991;3(9):277-81.
1991: E Lee; Stuart H Yuspa
Changes in inositol phosphate metabolism are associated with terminal differentiation and neoplasia in mouse keratinocytes.
Carcinogenesis 1991;12(9):1651-8.
1991: Andrzej Dlugosz; Stuart H Yuspa
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.
Cancer research 1991;51(17):4677-84.
1991: F H Kruszewski; Henry Hennings; R W Tucker; Stuart H Yuspa
Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations.
Cancer research 1991;51(16):4206-12.
1991: E Lee; Stuart H Yuspa
Aluminum fluoride stimulates inositol phosphate metabolism and inhibits expression of differentiation markers in mouse keratinocytes.
Journal of cellular physiology 1991;148(1):106-15.
1991: Wendy C Weinberg; D L Morgan; C George; Stuart H Yuspa
A comparison of interfollicular and hair follicle derived cells as targets for the v-rasHa oncogene in mouse skin carcinogenesis.
Carcinogenesis 1991;12(6):1119-24.
1991: Stuart H Yuspa; A Kilkenny; C Cheng; D Roop; Henry Hennings; F Kruszewski; E Lee; J Strickland; D A Greenhalgh
Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.
Environmental health perspectives 1991;93():3-10.
1991: U Lichti; Wendy C Weinberg; Stuart H Yuspa
Properties of murine pelage hair follicles in monolayer and collagen matrix cultures.
The Journal of investigative dermatology 1991;96(5):81S-82S.
1991: D S Rosenthal; P M Steinert; S Chung; Carol Ann Huff; J Johnson; Stuart H Yuspa; D R Roop
A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(2):107-13.
1991: A B Glick; Michael B. Sporn; Stuart H Yuspa
Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras.
Molecular carcinogenesis 1991;4(3):210-9.
1991: C Sutter; J E Strickland; D J Welty; Stuart H Yuspa; Hermelita Winter; Jürgen Schweizer
v-Ha-ras-induced mouse skin papillomas exhibit aberrant expression of keratin K13 as do their 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate -induced analogues.
Molecular carcinogenesis 1991;4(6):467-76.
1990: W C Weinberg; P D Brown; William Stetler-Stevenson; Stuart H Yuspa
Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination.
Differentiation; research in biological diversity 1990;45(3):168-78.
1990: D S Rosenthal; D R Roop; Carol Ann Huff; J S Weiss; Charles Ellis; T Hamilton; John J Voorhees; Stuart H Yuspa
Changes in photo-aged human skin following topical application of all-trans retinoic acid.
The Journal of investigative dermatology 1990;95(5):510-5.
1990: Stuart H Yuspa; Henry Hennings; D Roop; J Strickland; D A Greenhalgh
The malignant conversion step of mouse skin carcinogenesis.
Environmental health perspectives 1990;88():193-5.
1990: Henry Hennings; V A Robinson; D M Michael; George R Pettit; R Jung; Stuart H Yuspa
Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters.
Cancer research 1990;50(15):4794-800.
1990: Henry Hennings; R A Shores; Miriam C Poirier; Eddie Reed; Robert E Tarone; Stuart H Yuspa
Enhanced malignant conversion of benign mouse skin tumors by cisplatin.
Journal of the National Cancer Institute 1990;82(10):836-40.
1990: Eddie Reed; Y Ostchega; Seth M Steinberg; Stuart H Yuspa; R C Young; R F Ozols; Miriam C Poirier
Evaluation of platinum-DNA adduct levels relative to known prognostic variables in a cohort of ovarian cancer patients.
Cancer research 1990;50(8):2256-60.
1990: Henry Hennings; R Shores; M Balaschak; Stuart H Yuspa
Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.
Cancer research 1990;50(3):653-7.
1990: A B Glick; David Danielpour; D Morgan; Michael B. Sporn; Stuart H Yuspa
Induction and autocrine receptor binding of transforming growth factor-beta 2 during terminal differentiation of primary mouse keratinocytes.
Molecular endocrinology (Baltimore, Md.) 1990;4(1):46-52.
1990: D A Greenhalgh; D J Welty; A Player; Stuart H Yuspa
Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):643-7.
1990: C Cheng; A E Kilkenny; D Roop; Stuart H Yuspa
The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes.
Molecular carcinogenesis 1990;3(6):363-73.
1989: N A Sharkey; Henry Hennings; Stuart H Yuspa; Peter M Blumberg
Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters.
Carcinogenesis 1989;10(10):1937-41.
1989: Stuart H Yuspa; A E Kilkenny; Peter M Steinert; D R Roop
Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.
The Journal of cell biology 1989;109(3):1207-17.
1989: Henry Hennings; F H Kruszewski; Stuart H Yuspa; R W Tucker
Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes.
Carcinogenesis 1989;10(4):777-80.
1989: Kenneth H Kraemer; M Herlyn; Stuart H Yuspa; Wallace H Clark; G K Townsend; G R Neises; Vincent J Hearing
Reduced DNA repair in cultured melanocytes and nevus cells from a patient with xeroderma pigmentosum.
Archives of dermatology 1989;125(2):263-8.
1989: D A Greenhalgh; D J Welty; J E Strickland; Stuart H Yuspa
Spontaneous Ha-ras gene activation in cultured primary murine keratinocytes: consequences of Ha-ras gene activation in malignant conversion and malignant progression.
Molecular carcinogenesis 1989;2(4):199-207.
1989: Stuart H Yuspa; A E Kilkenny; D R Roop; J E Strickland; R Tucker; Henry Hennings; S Jaken
Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformation.
Progress in clinical and biological research 1989;298():127-35.
1989: Stuart H Yuspa; D A Greenhalgh
Molecular mechanisms of malignant conversion in skin carcinogenesis.
Princess Takamatsu symposia 1989;20():281-8.
1989: D R Roop; T Mehrel; T M Krieg; H Nakazawa; C K Cheng; Stuart H Yuspa
Keratin expression in mouse epidermal tumors.
Carcinogenesis; a comprehensive survey 1989;11():257-71.
1988: George E Rogers; N Martinet; Peter M Steinert; P Wynn; D Roop; A Kilkenny; D Morgan; Stuart H Yuspa
A procedure for the culture of hair follicles as functionally intact organoids.
Clinics in dermatology 1988;6(4):36-41.
1988: Eddie Reed; R F Ozols; Robert E Tarone; Stuart H Yuspa; Miriam C Poirier
The measurement of cisplatin-DNA adduct levels in testicular cancer patients.
Carcinogenesis 1988;9(10):1909-11.
1988: T Sako; A I Tauber; A Y Jeng; Stuart H Yuspa; Peter M Blumberg
Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.
Cancer research 1988;48(16):4646-50.
1988: J R Harper; D A Greenhalgh; Stuart H Yuspa
Expression of transfected DNA by primary murine keratinocytes.
The Journal of investigative dermatology 1988;91(2):150-3.
1988: S Jaken; Stuart H Yuspa
Early signals for keratinocyte differentiation: role of Ca2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells.
Carcinogenesis 1988;9(6):1033-8.
1988: D R Roop; T M Krieg; T Mehrel; C K Cheng; Stuart H Yuspa
Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.
Cancer research 1988;48(11):3245-52.
1988: G Pasti; E Rivedal; Stuart H Yuspa; C L Herald; George R Pettit; Peter M Blumberg
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.
Cancer research 1988;48(2):447-51.
1988: Stuart H Yuspa; M C Poirier
Chemical carcinogenesis: from animal models to molecular models in one decade.
Advances in cancer research 1988;50():25-70.
1988: J E Strickland; D A Greenhalgh; A Koceva-Chyla; Henry Hennings; C Restrepo; M Balaschak; Stuart H Yuspa
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.
Cancer research 1988;48(1):165-9.
1988: R Nischt; D R Roop; T Mehrel; Stuart H Yuspa; M Rentrop; Hermelita Winter; Jürgen Schweizer
Aberrant expression during two-stage mouse skin carcinogenesis of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia.
Molecular carcinogenesis 1988;1(2):96-108.
1988: Miriam C Poirier; Merrill J Egorin; A M Fichtinger-Schepman; Stuart H Yuspa; Eddie Reed
DNA adducts of cisplatin and carboplatin in tissues of cancer patients.
IARC scientific publications 1988;(89):313-20.
1988: U Lichti; Stuart H Yuspa
Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture.
Cancer research 1988;48(1):74-81.
1988: D A Greenhalgh; Stuart H Yuspa
Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene.
Molecular carcinogenesis 1988;1(2):134-43.
1988: E Finzi; A Kilkenny; J E Strickland; M Balaschak; T Bringman; R Derynck; Stuart A Aaronson; Stuart H Yuspa
TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression.
Molecular carcinogenesis 1988;1(1):7-12.
1988: P Hawley-Nelson; D R Roop; C K Cheng; T M Krieg; Stuart H Yuspa
Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis.
Molecular carcinogenesis 1988;1(3):202-11.
1988: Stuart H Yuspa; Henry Hennings; R W Tucker; S Jaken; A E Kilkenny; D R Roop
Signal transduction for proliferation and differentiation in keratinocytes.
Annals of the New York Academy of Sciences 1988;548():191-6.
1988: Stuart H Yuspa; A Kilkenny; D R Roop
Aberrant differentiation in mouse skin carcinogenesis.
IARC scientific publications 1988;(92):3-10.
1987: J R Harper; S H Reynolds; D A Greenhalgh; J E Strickland; J C Lacal; Stuart H Yuspa
Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines.
Carcinogenesis 1987;8(12):1821-5.
1987: J A Hartley; N W Gibson; A Kilkenny; Stuart H Yuspa
Mouse keratinocytes derived from initiated skin or papillomas are resistant to DNA strand breakage by benzoyl peroxide: a possible mechanism for tumor promotion mediated by benzoyl peroxide.
Carcinogenesis 1987;8(12):1827-30.
1987: T Sako; Stuart H Yuspa; C L Herald; George R Pettit; Peter M Blumberg
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Cancer research 1987;47(20):5445-50.
1987: G Rogers; N Martinet; Peter M Steinert; P Wynn; D Roop; A Kilkenny; D Morgan; Stuart H Yuspa
Cultivation of murine hair follicles as organoids in a collagen matrix.
The Journal of investigative dermatology 1987;89(4):369-79.
1987: Henry Hennings; P M Blumberg; George R Pettit; C L Herald; R Shores; Stuart H Yuspa
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Carcinogenesis 1987;8(9):1343-6.
1987: D R Roop; H Huitfeldt; A Kilkenny; Stuart H Yuspa
Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins.
Differentiation; research in biological diversity 1987;35(2):143-50.
1986: P Hawley-Nelson; D R Roop; C K Cheng; Stuart H Yuspa
Regulated synthesis of low-molecular-weight antigens in keratinocyte cell cultures.
The Journal of investigative dermatology 1986;87(4):454-9.
1986: Henry Hennings; E F Spangler; R Shores; P Mitchell; D Devor; AbulKalam M Shamsuddin; K M Elgjo; Stuart H Yuspa
Malignant conversion and metastasis of mouse skin tumors: a comparison of SENCAR and CD-1 mice.
Environmental health perspectives 1986;68():69-74.
1986: J E Strickland; P T Allen; D N Sauder; H Kawamura; M C Fong; Stuart H Yuspa
In vitro comparisons of SENCAR and BALB/c primary epidermal cells.
Environmental health perspectives 1986;68():39-44.
1986: Stuart H Yuspa; D Morgan; U Lichti; E F Spangler; D Michael; A Kilkenny; Henry Hennings
Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol.
Carcinogenesis 1986;7(6):949-58.
1985: Henry Hennings; R Shores; P Mitchell; E F Spangler; Stuart H Yuspa
Induction of papillomas with a high probability of conversion to malignancy.
Carcinogenesis 1985;6(11):1607-10.
1985: A E Kilkenny; D Morgan; E F Spangler; Stuart H Yuspa
Correlation of initiating potency of skin carcinogens with potency to induce resistance to terminal differentiation in cultured mouse keratinocytes.
Cancer research 1985;45(5):2219-25.
1985: Stuart H Yuspa; A E Kilkenny; J Stanley; U Lichti
Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses.
Nature 1985;314(6010):459-62.
1985: U Lichti; T Ben; Stuart H Yuspa
Retinoic acid-induced transglutaminase in mouse epidermal cells is distinct from epidermal transglutaminase.
The Journal of biological chemistry 1985;260(3):1422-6.
1983: Stuart H Yuspa; T Ben; U Lichti
Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters.
Cancer research 1983;43(12 Pt 1):5707-12.
1983: Stuart H Yuspa; T Ben; Henry Hennings
The induction of epidermal transglutaminase and terminal differentiation by tumor promoters in cultured epidermal cells.
Carcinogenesis 1983;4(11):1413-8.
1983: Henry Hennings; R Shores; M L Wenk; E F Spangler; Robert E Tarone; Stuart H Yuspa
Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters.
Nature 1983;304(5921):67-9.
1983: Stuart H Yuspa; Molly Kulesz-Martin; T Ben; Henry Hennings
Transformation of epidermal cells in culture.
The Journal of investigative dermatology 1983;81(1 Suppl):162s-8s.
1983: D R Roop; P Hawley-Nelson; C K Cheng; Stuart H Yuspa
Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture.
The Journal of investigative dermatology 1983;81(1 Suppl):144s-9s.
1983: D R Roop; P Hawley-Nelson; C K Cheng; Stuart H Yuspa
Keratin gene expression in mouse epidermis and cultured epidermal cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(3):716-20.
1982: Stuart H Yuspa; T Ben; Henry Hennings; U Lichti
Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 1982;42(6):2344-9.
1982: J E Strickland; Henry Hennings; A M Jetten; Stuart H Yuspa; P T Allen; K B Hellmann; A G Strickland
Susceptibility determinants for mouse epidermal carcinogenesis.
IARC scientific publications 1982;(39):259-68.
1982: Stuart H Yuspa; Henry Hennings; Molly Kulesz-Martin; U Lichti
The study of tumor promotion in a cell culture model for mouse skin--a tissue that exhibits multistage carcinogenesis in vivo.
Carcinogenesis; a comprehensive survey 1982;7():217-30.
1981: Henry Hennings; D Devor; M L Wenk; Thomas Slaga; B Former; N H Colburn; George Bowden; K Elgjo; Stuart H Yuspa
Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice.
Cancer research 1981;41(3):773-9.
1981: Stuart H Yuspa; U Lichti; T Ben; Henry Hennings
Modulation of terminal differentiation and responses to tumor promoters by retinoids in mouse epidermal cell cultures.
Annals of the New York Academy of Sciences 1981;359():260-73.
1981: N H Colburn; S Ozanne; U Lichti; T Ben; Stuart H Yuspa; E Wendel; E Jardini; G Abruzzo
Retinoids inhibit promoter-dependent preneoplastic progression in mouse epidermal cell lines.
Annals of the New York Academy of Sciences 1981;359():251-9.
1981: Stuart H Yuspa; B Koehler; Molly Kulesz-Martin; Henry Hennings
Clonal growth of mouse epidermal cells in medium with reduced calcium concentration.
The Journal of investigative dermatology 1981;76(2):144-6.
1980: Stuart H Yuspa; T Ben; Henry Hennings; U Lichti
Phorbol ester tumor promoters induce epidermal transglutaminase activity.
Biochemical and biophysical research communications 1980;97(2):700-8.
1980: Stuart H Yuspa; U Lichti; T Ben
Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5312-6.
1980: U Lichti; George Bowden; E Patterson; T Ben; Stuart H Yuspa
Germicidal ultraviolet light induces ornithine decarboxylase in mouse epidermal cells and modifies the induction caused by phorbol ester tumor promoters.
Photochemistry and photobiology 1980;32(2):177-81.
1980: Molly Kulesz-Martin; B Koehler; Henry Hennings; Stuart H Yuspa
Quantitative assay for carcinogen altered differentiation in mouse epidermal cells.
Carcinogenesis 1980;1(12):995-1006.