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Manuela Zaccolo

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TOP 3
Stefania Monterisi; Valeria Casavola; Manuela Zaccolo
Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
Anna Terrin; Anna Zoccarato; Niove E Jordanides; Andreas Koschinski; Marco Mongillo; Stefania Monterisi; joanne mountford; Akira Sawa; Alessandra Stangherlin; Nicoletta Concetta Surdo; Manuela Zaccolo
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
Euan Parnell; Brian O Smith; Anna Terrin; Timothy Palmer; Manuela Zaccolo; Stephen J Yarwood
Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

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All Publications

2013: Stefania Monterisi; Valeria Casavola; Manuela Zaccolo
Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
British journal of pharmacology 2013;169(1):1-9.
2012: Anna Terrin; Anna Zoccarato; Niove E Jordanides; Andreas Koschinski; Marco Mongillo; Stefania Monterisi; joanne mountford; Akira Sawa; Alessandra Stangherlin; Nicoletta Concetta Surdo; Manuela Zaccolo
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
The Journal of cell biology 2012;198(4):607-21.
2012: Euan Parnell; Brian O Smith; Anna Terrin; Timothy Palmer; Manuela Zaccolo; Stephen J Yarwood
Regulation of the inflammatory response of vascular endothelial cells by EPAC1.
British journal of pharmacology 2012;166(2):434-46.
2012: Stefania Monterisi; Stephan J Reshkin; Rosa A Cardone; Valeria Casavola; Maria Favia; Lorenzo Guerra; Domenico Marzulli; Manuela Zaccolo
CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.
Journal of cell science 2012;125(Pt 5):1106-17.
2012: Kyeong-Rok Choi; Mathias Hafner; Yvonne Petersen; Markus Reischl; Ira V Röder; Marina Albrizio; Marco Berrera; Siegfried Strack; Anika Wagner; Manuela Zaccolo; Ruediger Rudolf
Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.
Journal of cell science 2012;125(Pt 3):714-23.
2012: Alessandra Stangherlin; Manuela Zaccolo
cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.
Biochemical Society transactions 2012;40(1):11-4.
2012: Ira Verena Röder; Siegfried Strack; Manuela Zaccolo; Oliver Dahley; Olivier Kassel; Muzamil Majid Khan; Markus Reischl; Ruediger Rudolf
Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.
PloS one 2012;7(7):e40860.
2011: Tamer M A Mohamed; Delvac Oceandy; Sukhpal Prehar; Celine Schelcher; Mohamed A Shaheen; Yanwen Wang; Manuela Zaccolo; Min Zi; Riham Abou-Leisa; Nasser Alatwi; Florence Baudoin; Elizabeth J Cartwright; Giulietta Di Benedetto; Michael Emerson; Zeinab Hegab; Ming Lei; Mamas A Mamas; Ludwig Neyses
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
The Journal of biological chemistry 2011;286(48):41520-9.
2011: Manuela Zaccolo
Spatial control of cAMP signalling in health and disease.
Current opinion in pharmacology 2011;11(6):649-55.
2011: Clint L Miller; Masayoshi Oikawa; Tamlyn Thomas; Yujun Cai; Wolfgang R Dostmann; Keigi Fujiwara; Manuela Zaccolo; Chen Yan
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
Basic research in cardiology 2011;106(6):1023-39.
2011: Alessandra Stangherlin; Manuela Zaccolo
Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases.
Journal of cardiovascular pharmacology 2011;58(4):345-53.
2011: Lindsay S Wilson; George S Baillie; Lisa M Pritchard; Bibiana Umana; Anna Terrin; Manuela Zaccolo; Miles D Houslay; Donald H Maurice
A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
The Journal of biological chemistry 2011;286(18):16285-96.
2011: Y Y Sin; H V Edwards; Xiang Li; Jonathan P Day; F Christian; Allan J Dunlop; David R Adams; Manuela Zaccolo; Miles D Houslay; George S Baillie
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Journal of molecular and cellular cardiology 2011;50(5):872-83.
2011: Alessandra Stangherlin; Frank Gesellchen; Anna Zoccarato; Anna Terrin; Laura Ashley Fields; Marco Berrera; Nicoletta Concetta Surdo; Margaret Anne Craig; Godfrey Smith; Graham Hamilton; Manuela Zaccolo
cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
Circulation research 2011;108(8):929-39.
2011: Frank Gesellchen; Alessandra Stangherlin; Nicoletta Surdo; Anna Terrin; Anna Zoccarato; Manuela Zaccolo
Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors.
Methods in molecular biology (Clifton, N.J.) 2011;746():297-316.
2010: Mandy Diskar; Hans-Michael Zenn; Alexandra Kaupisch; Melanie Kaufholz; Stefanie Brockmeyer; Daniel Sohmen; Marco Berrera; Manuela Zaccolo; Michael Boshart; Friedrich W Herberg; Anke Prinz
Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.
The Journal of biological chemistry 2010;285(46):35910-8.
2010: Angela Vaasa; Marje Lust; Anna Terrin; Asko Uri; Manuela Zaccolo
Small-molecule FRET probes for protein kinase activity monitoring in living cells.
Biochemical and biophysical research communications 2010;397(4):750-5.
2010: Ira V Röder; Kyeong-Rock Choi; Markus Reischl; Yvonne Petersen; Markus E Diefenbacher; Manuela Zaccolo; Tullio Pozzan; Ruediger Rudolf
Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2031-6.
2010: Rodrigo F Oliveira; Anna Terrin; Giulietta Di Benedetto; Robert C Cannon; Wonryull Koh; Myungsook Kim; Manuela Zaccolo; Kim T Blackwell
The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.
PloS one 2010;5(7):e11725.
2009: Manuela Zaccolo
cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.
British journal of pharmacology 2009;158(1):50-60.
2009: Ira Verena Röder; Valentina Lissandron; Jessica Martin; Yvonne Petersen; Giulietta Di Benedetto; Manuela Zaccolo; Ruediger Rudolf
PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo.
Cellular signalling 2009;21(5):819-26.
2009: Micol Maritan; Giovanni Monaco; Ilaria Zamparo; Manuela Zaccolo; Tullio Pozzan; Claudia Lodovichi
Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3537-42.
2008: Federica Dal Molin; Irene Zornetta; Andrea Puhar; Fiorella Tonello; Manuela Zaccolo; Cesare Montecucco
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin.
Biochemical and biophysical research communications 2008;376(2):429-33.
2008: Giulietta Di Benedetto; Anna Zoccarato; Valentina Lissandron; Anna Terrin; Xiang Li; Miles D Houslay; George S Baillie; Manuela Zaccolo
Protein kinase A type I and type II define distinct intracellular signaling compartments.
Circulation research 2008;103(8):836-44.
2008: Teresa Fanelli; Rosa Angela Cardone; Maria Favia; Lorenzo Guerra; Manuela Zaccolo; Stefania Monterisi; Teresa De Santis; Stefania Maria Riccardi; Stephan Joel Reshkin; Valeria Casavola
Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.
Biology of the cell / under the auspices of the European Cell Biology Organization 2008;100(7):399-412.
2008: S Vassanelli; L Bandiera; M Borgo; G Cellere; L Santoni; C Bersani; Michela Salamon; Manuela Zaccolo; L Lorenzelli; S Girardi; M Maschietto; M Dal Maschio; A Paccagnella
Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray.
New biotechnology 2008;25(1):55-67.
2008: Alberto Ferlin; Anastasia Pepe; Lisa Gianesello; Andrea Garolla; Shu Feng; Sandro Giannini; Manuela Zaccolo; Arianna Facciolli; Roy Morello; Alexander I Agoulnik; Carlo Foresta
Mutations in the insulin-like factor 3 receptor are associated with osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(5):683-93.
2008: Rachel J Webb; Lorna Tinworth; Geraint M H Thomas; Manuela Zaccolo; John Carroll
Developmentally acquired PKA localisation in mouse oocytes and embryos.
Developmental biology 2008;317(1):36-45.
2008: Daniela Moll; Anke Prinz; Cornelia M Brendel; Marco Berrera; Katrin Guske; Manuela Zaccolo; Hans-Gottfried Genieser; Friedrich W Herberg
Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog.
BMC biochemistry 2008;9():18.
2007: Chunying Li; Partha Krishnamurthy; Himabindu Penmatsa; Kevin L Marrs; XueQing Wang; Manuela Zaccolo; Kees Jalink; Min Li; Deborah J Nelson; John D Schuetz; Anjaparavanda P Naren
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.
Cell 2007;131(5):940-51.
2007: Birgitte Lygren; Cathrine R Carlson; Katja Santamaria; Valentina Lissandron; Theresa McSorley; Jessica Litzenberg; Dorothea Lorenz; Burkhard Wiesner; Walter Rosenthal; Manuela Zaccolo; Kjetil Taskén; Enno Klussmann
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
EMBO reports 2007;8(11):1061-7.
2007: Valentina Lissandron; Maria Giovanna Rossetto; Karen Erbguth; André Fiala; Andrea Daga; Manuela Zaccolo
Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics.
Cellular signalling 2007;19(11):2296-303.
2007: Manuela Zaccolo; Matthew A Movsesian
cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology.
Circulation research 2007;100(11):1569-78.
2007: Victor H Hernandez; Mario Bortolozzi; Vanessa Pertegato; Martina Beltramello; Michele Giarin; Manuela Zaccolo; Sergio Pantano; Fabio Mammano
Unitary permeability of gap junction channels to second messengers measured by FRET microscopy.
Nature methods 2007;4(4):353-8.
2007: Carlo G Tocchetti; Wang Wang; Jeffrey P Froehlich; Sabine Huke; Miguel A Aon; Gerald M Wilson; Giulietta Di Benedetto; Brian O'Rourke; Wei Dong Gao; David A Wink; John P Toscano; Manuela Zaccolo; Donald M Bers; Hector H Valdivia; Heping Cheng; David A Kass; Nazareno Paolocci
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circulation research 2007;100(1):96-104.
2007: Giorgia Beffagna; Marzia De Bortoli; Andrea Nava; Michela Salamon; Alessandra Lorenzon; Manuela Zaccolo; Luisa Mancuso; Luca Sigalotti; Barbara Bauce; Gianluca Occhi; Cristina Basso; Gerolamo Lanfranchi; Jeffrey A Towbin; Gaetano Thiene; Gian Antonio Danieli; Alessandra Rampazzo
Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro.
BMC medical genetics 2007;8():65.
2006: Timothy A Dunn; Chih-Tien Wang; Michael A Colicos; Manuela Zaccolo; Lisa M DiPilato; Jin Zhang; Roger Y Tsien; Marla B Feller
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(49):12807-15.
2006: Federica Dal Molin; Fiorella Tonello; Daniel Ladant; Irene Zornetta; Ilaria Zamparo; Giulietta Di Benedetto; Manuela Zaccolo; Cesare Montecucco
Cell entry and cAMP imaging of anthrax edema toxin.
The EMBO journal 2006;25(22):5405-13.
2006: Anna Terrin; Giulietta Di Benedetto; Vanessa Pertegato; York-Fong Cheung; George S Baillie; Martin J Lynch; Nicola Elvassore; Anke Prinz; Friedrich W Herberg; Miles D Houslay; Manuela Zaccolo
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
The Journal of cell biology 2006;175(3):441-51.
2006: Andreas Schmid; Ge Bai; Nathalie Schmid; Manuela Zaccolo; Lawrence E Ostrowski; Gregory Conner; Nevis Fregien; Matthias Salathe
Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells.
Journal of cell science 2006;119(Pt 20):4176-86.
2006: Marco Mongillo; Manuela Zaccolo
A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.
Biochemical Society transactions 2006;34(Pt 4):510-1.
2006: Manuela Zaccolo; Giulietta Di Benedetto; Valentina Lissandron; L Mancuso; Anna Terrin; Ilaria Zamparo
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling.
Biochemical Society transactions 2006;34(Pt 4):495-7.
2006: Manuela Zaccolo
Phosphodiesterases and compartmentalized cAMP signalling in the heart.
European journal of cell biology 2006;85(7):693-7.
2006: Marco Mongillo; Carlo G Tocchetti; Anna Terrin; Valentina Lissandron; York-Fong Cheung; Wolfgang R Dostmann; Tullio Pozzan; David A Kass; Nazareno Paolocci; Miles D Houslay; Manuela Zaccolo
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Circulation research 2006;98(2):226-34.
2006: Valentina Lissandron; Manuela Zaccolo
Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.
Journal of muscle research and cell motility 2006;27(5-7):399-403.
2005: Valentina Lissandron; Anna Terrin; Maddalena Collini; Laura D'Alfonso; Giuseppe Chirico; Sergio Pantano; Manuela Zaccolo
Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction.
Journal of molecular biology 2005;354(3):546-55.
2005: Manuela Zaccolo; T Cesetti; Giulietta Di Benedetto; Marco Mongillo; Valentina Lissandron; Anna Terrin; Ilaria Zamparo
Imaging the cAMP-dependent signal transduction pathway.
Biochemical Society transactions 2005;33(Pt 6):1323-6.
2005: Andrea Gerbino; Warren C Ruder; Silvana Curci; Tullio Pozzan; Manuela Zaccolo; Aldebaran M Hofer
Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations.
The Journal of cell biology 2005;171(2):303-12.
2005: Sunita Warrier; Andriy Belevych; Monica Ruse; Richard L Eckert; Manuela Zaccolo; Tullio Pozzan; Robert Harvey
Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.
American journal of physiology. Cell physiology 2005;289(2):C455-61.
2005: Rosa A Cardone; Anna Bagorda; Antonia Bellizzi; Giovanni Busco; Lorenzo Guerra; angelo paradiso; Valeria Casavola; Manuela Zaccolo; Stephan J Reshkin
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Molecular biology of the cell 2005;16(7):3117-27.
2005: Sergio Pantano; Manuela Zaccolo; Paolo Carloni
Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit.
FEBS letters 2005;579(12):2679-85.
2005: Michele Caccia; Elisa Camozzi; Maddalena Collini; Manuela Zaccolo; Giuseppe Chirico
Photon moment analysis in cells in the presence of photo-bleaching.
Applied spectroscopy 2005;59(2):227-36.
2005: Eiki Takimoto; Hunter C Champion; Diego F Belardi; Javid Moslehi; Marco Mongillo; Evanthia Mergia; David C Montrose; Takayoshi Isoda; Kate Aufiero; Manuela Zaccolo; Wolfgang R Dostmann; Carolyn J Smith; David A Kass
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
Circulation research 2005;96(1):100-9.
2005: Marco Mongillo; Anna Terrin; Sandrine Evellin; Valentina Lissandron; Manuela Zaccolo
Study of cyclic adenosine monophosphate microdomains in cells.
Methods in molecular biology (Clifton, N.J.) 2005;307():1-13.
2004: Bas Ponsioen; Jun Zhao; Jurgen Riedl; Fried J T Zwartkruis; Gerard van der Krogt; Manuela Zaccolo; Wouter H Moolenaar; Johannes L Bos; Kees Jalink
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
EMBO reports 2004;5(12):1176-80.
2004: Hilde Abrahamsen; George S Baillie; Jacob Ngai; Torkel Vang; Konstantina Nika; Anja Ruppelt; Tomas Mustelin; Manuela Zaccolo; Miles D Houslay; Kjetil Taskén
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4847-58.
2004: Marco Mongillo; Theresa McSorley; Sandrine Evellin; Arvind Sood; Valentina Lissandron; Anna Terrin; Elaine Huston; Annette Hannawacker; Martin J Lohse; Tullio Pozzan; Miles D Houslay; Manuela Zaccolo
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Circulation research 2004;95(1):67-75.
2004: Manuela Zaccolo
Use of chimeric fluorescent proteins and fluorescence resonance energy transfer to monitor cellular responses.
Circulation research 2004;94(7):866-73.
2004: Sandrine Evellin; Marco Mongillo; Anna Terrin; Valentina Lissandron; Manuela Zaccolo
Measuring dynamic changes in cAMP using fluorescence resonance energy transfer.
Methods in molecular biology (Clifton, N.J.) 2004;284():259-70.
2003: Michela Salamon; Caterina Millino; Anna Raffaello; Marco Mongillo; Claudia Sandri; Camilla Bean; Enrico Negrisolo; Alberto Pallavicini; Giorgio Valle; Manuela Zaccolo; Stefano Schiaffino; Gerolamo Lanfranchi
Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.
Journal of molecular biology 2003;326(1):137-49.
2003: Manuela Zaccolo; Tullio Pozzan
CAMP and Ca2+ interplay: a matter of oscillation patterns.
Trends in neurosciences 2003;26(2):53-5.
2002: Manuela Zaccolo; Paulo J Magalhães; Tullio Pozzan
Compartmentalisation of cAMP and Ca(2+) signals.
Current opinion in cell biology 2002;14(2):160-6.
2002: Manuela Zaccolo; Tullio Pozzan
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Science (New York, N.Y.) 2002;295(5560):1711-5.
2002: Manuela Zaccolo
Selection of functional antibodies on the basis of valency.
Methods in molecular biology (Clifton, N.J.) 2002;178():255-8.
2001: Manuela Zaccolo; Luisa Filippin; Paulo J Magalhães; Tullio Pozzan
Heterogeneity of second messenger levels in living cells.
Novartis Foundation symposium 2001;239():85-93; discussion 93-5, 150-9.
2000: Manuela Zaccolo; T Pozzan
Imaging signal transduction in living cells with GFP-based probes.
IUBMB life 2000;49(5):375-9.
2000: Manuela Zaccolo; F De Giorgi; C Y Cho; L Feng; Tom Knapp; Paul Negulescu; S S Taylor; Roger Y Tsien; Tullio Pozzan
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
Nature cell biology 2000;2(1):25-9.