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Timothy Zacharewski

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TOP 3
Agnes L Forgacs; Michelle M Angrish; Edward Dere; Timothy R Zacharewski
Comparative Analysis of Temporal and Dose-Dependent TCDD-Elicited Gene Expression in Human, Mouse, and Rat Primary Hepatocytes.
Rance Nault; Suntae Kim; Timothy R Zacharewski
Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice.
Michelle Manente Angrish; Claudia Yvette Dominici; Timothy R Zacharewski
TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice.

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All Publications

2013: Agnes L Forgacs; Michelle M Angrish; Edward Dere; Timothy R Zacharewski
Comparative Analysis of Temporal and Dose-Dependent TCDD-Elicited Gene Expression in Human, Mouse, and Rat Primary Hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2013;133(1):54-66.
2013: Rance Nault; Suntae Kim; Timothy R Zacharewski
Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice.
Toxicology and applied pharmacology 2013;267(2):184-91.
2013: Michelle Manente Angrish; Claudia Yvette Dominici; Timothy R Zacharewski
TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(1):108-15.
2012: Michelle Manente Angrish; Arthur Daniel Jones; Bryan David Mets; Timothy R Zacharewski
Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(2):377-86.
2012: Anna K Kopec; Chad M Thompson; Agnes L Forgacs; Suntae Kim; Timothy R Zacharewski
Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.
Toxicology and applied pharmacology 2012;262(2):124-38.
2012: Agnes L Forgacs; Ilpo T Huhtaniemi; Rosemary G Jaremba; Nafis A Rahman; Qi Ding; Timothy R Zacharewski
BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):391-402.
2012: Anna K Kopec; Deborah M Proctor; Timothy R Zacharewski; Agnes L Forgacs; Mark A Harris; Laurie C Haws; Suntae Kim; Chad M Thompson
Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.
Toxicology and applied pharmacology 2012;259(1):13-26.
2012: Agnes L Forgacs; Bryan Mets; Gary L Jahns; Meghan K Makley; Michael N Kent; Timothy R Zacharewski; Nicholas DelRaso; Lyle D Burgoon; Nicholas V Reo
Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(1):41-55.
2011: Michelle M Angrish; Jack R Harkema; A D Jones; Timothy R Zacharewski
Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(2):299-310.
2011: Raymond Lo; Laura MacPherson; Timothy R Zacharewski; T Celius; Edward Dere; Agnes L Forgacs; Patricia Harper; Jason Matthews
Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2011;257(1):38-47.
2011: Anna K Kopec; Bryan D Mets; Dave Potter; Sarah E Reese; Bonnie Sharratt; Colleen Tashiro; Kellie J Archer; Lyle Burgoon; Michelle L D'Souza; Jack R Harkema; Timothy R Zacharewski
Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.
Toxicology and applied pharmacology 2011;256(2):154-67.
2011: Chad M Thompson; Timothy R Zacharewski; Sheila D Grimes; Laurie C Haws; Charles D Hébert; J Gregory Hixon; Anna K Kopec; Deborah M Proctor; Howard G Shertzer; Mark A Harris
Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(1):58-70.
2011: Edward Dere; Agnes L Forgacs; Timothy R Zacharewski; Lyle Burgoon
Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes.
Chemical research in toxicology 2011;24(4):494-504.
2011: Edward Dere; Raymond Lo; J Matthews; T Celius; Timothy R Zacharewski
Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver.
BMC genomics 2011;12():365.
2011: Edward Dere; Andrea W Lee; Lyle Burgoon; Timothy R Zacharewski
Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells.
BMC genomics 2011;12():193.
2010: Anna K Kopec; Lyle Burgoon; Daher Ibrahim-Aibo; Ashley R Burg; Andrea W Lee; Colleen Tashiro; Dave Potter; Bonnie Sharratt; Jack R Harkema; Craig Rowlands; Robert A Budinsky; Timothy R Zacharewski
Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):286-97.
2010: Cora J Fong; Lyle Burgoon; Kurt J Williams; A Daniel Jones; Agnes L Forgacs; Timothy R Zacharewski
Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice.
Journal of molecular endocrinology 2010;45(3):161-73.
2010: Agnes L Forgacs; Lyle Burgoon; Scott G Lynn; John J LaPres; Timothy R Zacharewski
Effects of TCDD on the expression of nuclear encoded mitochondrial genes.
Toxicology and applied pharmacology 2010;246(1-2):58-65.
2010: Anna K Kopec; Lyle Burgoon; Daher Ibrahim-Aibo; Bryan D Mets; Colleen Tashiro; Dave Potter; Bonnie Sharratt; Jack R Harkema; Timothy R Zacharewski
PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.
Toxicology and applied pharmacology 2010;243(3):359-71.
2009: Suntae Kim; Edward Dere; Lyle Burgoon; Chia-Cheng Chang; Timothy R Zacharewski
Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):229-44.
2009: Lyle Burgoon; Qi Ding; Alhaji N'jai; Edward Dere; Ashley R Burg; Craig Rowlands; Robert A Budinsky; Kenneth E Stebbins; Timothy R Zacharewski
Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):221-8.
2009: Joshua C Kwekel; Agnes L Forgacs; Lyle Burgoon; Kurt J Williams; Timothy R Zacharewski
Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program.
BMC medical genomics 2009;2():19.
2008: Markus Frericks; Lyle Burgoon; Timothy R Zacharewski; Charlotte Esser
Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response.
Toxicology and applied pharmacology 2008;232(2):268-79.
2008: Lyle Burgoon; Timothy R Zacharewski
Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):412-8.
2008: Alhaji N'Jai; Darrell R Boverhof; Edward Dere; Lyle Burgoon; Ying S Tan; Craig Rowlands; Robert A Budinsky; Kenneth E Stebbins; Timothy R Zacharewski
Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(2):285-97.
2008: Anna K Kopec; Darrell R Boverhof; Lyle Burgoon; Daher Ibrahim-Aibo; Jack R Harkema; Colleen Tashiro; Brock Chittim; Timothy R Zacharewski
Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(1):61-75.
2008: Naoki Kiyosawa; Joshua C Kwekel; Lyle Burgoon; Kurt J Williams; Colleen Tashiro; Brock Chittim; Timothy R Zacharewski
o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(2):350-63.
2008: Naoki Kiyosawa; Joshua C Kwekel; Lyle Burgoon; Edward Dere; Kurt J Williams; Colleen Tashiro; Brock Chittim; Timothy R Zacharewski
Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.
BMC genomics 2008;9():487.
2008: Lyle Burgoon; Timothy R Zacharewski
Bioinformatics: databasing and gene annotation.
Methods in molecular biology (Clifton, N.J.) 2008;460():145-57.
2008: Darrell R Boverhof; Lyle Burgoon; Kurt J Williams; Timothy R Zacharewski
Inhibition of estrogen-mediated uterine gene expression responses by dioxin.
Molecular pharmacology 2008;73(1):82-93.
2007: Lyle Burgoon; Timothy R Zacharewski
dbZach toxicogenomic information management system.
Pharmacogenomics 2007;8(3):287-91.
2007: Grantley D Charles; Chris Gennings; Belen Tornesi; H Lynn Kan; Timothy R Zacharewski; B Bhaskar Gollapudi; Edward W Carney
Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison.
Toxicology and applied pharmacology 2007;218(3):280-8.
2007: Cora J Fong; Lyle Burgoon; Kurt J Williams; Agnes L Forgacs; Timothy R Zacharewski
Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice.
BMC genomics 2007;8():151.
2006: Darrell R Boverhof; Lyle Burgoon; Colleen Tashiro; Bonnie Sharratt; Brock Chittim; Jack R Harkema; Donna L Mendrick; Timothy R Zacharewski
Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):398-416.
2006: KangAe Lee; Lyle Burgoon; Laura Lamb; Edward Dere; Timothy R Zacharewski; John B Hogenesch; John J LaPres
Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades.
Chemical research in toxicology 2006;19(10):1284-93.
2006: Cora J Fong; Lyle Burgoon; Timothy R Zacharewski
Effects of culture conditions on estrogen-mediated hepatic in vitro gene expression and correlation to in vivo responses.
Toxicology and applied pharmacology 2006;215(1):37-50.
2006: Darrell R Boverhof; Joshua C Kwekel; Daryl G Humes; Lyle Burgoon; Timothy R Zacharewski
Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus.
Molecular pharmacology 2006;69(5):1599-606.
2006: Lyle Burgoon; Paul C Boutros; Edward Dere; Timothy R Zacharewski
dbZach: A MIAME-compliant toxicogenomic supportive relational database.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(2):558-68.
2006: Darrell R Boverhof; Timothy R Zacharewski
Toxicogenomics in risk assessment: applications and needs.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(2):352-60.
2006: Edward Dere; Darrell R Boverhof; Lyle Burgoon; Timothy R Zacharewski
In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue.
BMC genomics 2006;7():80.
2005: Joshua C Kwekel; Lyle Burgoon; Jeremy W Burt; Jack R Harkema; Timothy R Zacharewski
A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.
Physiological genomics 2005;23(3):327-42.
2005: Yue-wern Huang; Jason B Matthews; Kirsten C Fertuck; Timothy R Zacharewski
Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians.
Environmental toxicology and chemistry / SETAC 2005;24(8):2002-9.
2005: Cora J Fong; Lyle Burgoon; Timothy R Zacharewski
Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):342-53.
2005: Darrell R Boverhof; Lyle Burgoon; Colleen Tashiro; Brock Chittim; Jack R Harkema; Donald B Jump; Timothy R Zacharewski
Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(2):1048-63.
2005: JE Eckel; Chris Gennings; Terry M Therneau; Lyle Burgoon; Darrell R Boverhof; Timothy R Zacharewski
Normalization of two-channel microarray experiments: a semiparametric approach.
Bioinformatics (Oxford, England) 2005;21(7):1078-83.
2005: Lyle Burgoon; J E Eckel-Passow; Chris Gennings; Darrell R Boverhof; J W Burt; Cora J Fong; Timothy R Zacharewski
Protocols for the assurance of microarray data quality and process control.
Nucleic acids research 2005;33(19):e172.
2004: Darrell R Boverhof; Elaine Tam; Allison S Harney; Robert B Crawford; Norbert E Kaminski; Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells.
Molecular pharmacology 2004;66(6):1662-70.
2004: J E Eckel; Chris Gennings; Vernon M Chinchilli; Lyle Burgoon; Timothy R Zacharewski
Empirical bayes gene screening tool for time-course or dose-response microarray data.
Journal of biopharmaceutical statistics 2004;14(3):647-70.
2004: James P Luyendyk; William Mattes; Lyle Burgoon; Timothy R Zacharewski; Jane F Maddox; Gregory N Cosma; Patricia E Ganey; Robert A Roth
Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):203-13.
2004: Darrell R Boverhof; Kirsten C Fertuck; Lyle Burgoon; JE Eckel; Chris Gennings; Timothy R Zacharewski
Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol.
Carcinogenesis 2004;25(7):1277-91.
2004: Byung S Yoo; Darrell R Boverhof; Dina Shnaider; Robert B Crawford; Timothy R Zacharewski; Norbert E Kaminski
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the regulation of Pax5 in lipopolysaccharide-activated B cells.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):272-9.
2004: Y V Sun; Darrell R Boverhof; Lyle Burgoon; Mark R Fielden; Timothy R Zacharewski
Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.
Nucleic acids research 2004;32(15):4512-23.
2003: Kirsten C Fertuck; JE Eckel; Chris Gennings; Timothy R Zacharewski
Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol.
Physiological genomics 2003;15(2):127-41.
2003: Michael L Cunningham; Matthew S Bogdanffy; Timothy R Zacharewski; Ronald Hines
Workshop overview: use of genomic data in risk assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):209-15.
2003: Lawrence H Lash; Ronald Hines; Frank J Gonzalez; Timothy R Zacharewski; Mark A Rothstein
Genetics and susceptibility to toxic chemicals: do you (or should you) know your genetic profile?
The Journal of pharmacology and experimental therapeutics 2003;305(2):403-9.
2003: Mark R Fielden; S M Samy; K C Chou; Timothy R Zacharewski
Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(4):447-54.
2002: Jason B Matthews; Kirsten C Fertuck; T Celius; Yue-wern Huang; Cora J Fong; Timothy R Zacharewski
Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species.
The Journal of steroid biochemistry and molecular biology 2002;82(2-3):181-94.
2002: Mette G Goodin; Kirsten C Fertuck; Timothy R Zacharewski; Rhonda J Rosengren
Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(2):354-61.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):721-34.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):709-19.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):679-708.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):655-78.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):529-653.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):489-527.
2002: Robert Kavlock; Kim Boekelheide; Robert Chapin; Michael Cunningham; Elaine Faustman; Paul Foster; Mari Golub; Rogene Henderson; Irwin Hinberg; Ruth Little; Jennifer Seed; Katherine Shea; Sonia Tabacova; Rochelle Tyl; Paige Williams; Timothy R Zacharewski
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(5):453-87.
2002: Grantley D Charles; Chris Gennings; Timothy R Zacharewski; B Bhaskar Gollapudi; Edward W Carney
An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: a pilot study.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):349-60.
2002: Mark R Fielden; Robert G Halgren; Cora J Fong; Christophe Staub; Larry Johnson; Karen Chou; Timothy R Zacharewski
Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression.
Endocrinology 2002;143(8):3044-59.
2002: Mark R Fielden; Cora J Fong; Sandra Z Haslam; Timothy R Zacharewski
Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure.
Toxicology letters 2002;133(2-3):181-91.
2002: Mark R Fielden; Robert G Halgren; Edward Dere; Timothy R Zacharewski
GP3: GenePix post-processing program for automated analysis of raw microarray data.
Bioinformatics (Oxford, England) 2002;18(5):771-3.
2002: Grantley D Charles; Chris Gennings; Timothy R Zacharewski; B Bhaskar Gollapudi; Edward W Carney
Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay.
Toxicology and applied pharmacology 2002;180(1):11-21.
2002: Mark R Fielden; Jason B Matthews; Kirsten C Fertuck; Robert G Halgren; Timothy R Zacharewski
In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists.
Critical reviews in toxicology 2002;32(2):67-112.
2002: G Rosen; Erin L O'Bryant; J Matthews; Timothy R Zacharewski; Juli Wade
Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard.
Journal of neuroendocrinology 2002;14(1):19-28.
2001: Jason B Matthews; JH Clemons; Timothy R Zacharewski
Reciprocal mutagenesis between human alpha(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures.
Molecular and cellular endocrinology 2001;183(1-2):127-39.
2001: Kirsten C Fertuck; S Kumar; H C Sikka; Jason B Matthews; Timothy R Zacharewski
Interaction of PAH-related compounds with the alpha and beta isoforms of the estrogen receptor.
Toxicology letters 2001;121(3):167-77.
2001: Mark R Fielden; Robert G Halgren; Colleen Tashiro; Brian Yeo; Brock Chittim; Karen Chou; Timothy R Zacharewski
Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice.
Reproductive toxicology (Elmsford, N.Y.) 2001;15(3):281-92.
2001: Mark R Fielden; Timothy R Zacharewski
Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):6-10.
2001: Jason B Matthews; K Twomey; Timothy R Zacharewski
In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.
Chemical research in toxicology 2001;14(2):149-57.
2001: Kirsten C Fertuck; Jason B Matthews; Timothy R Zacharewski
Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(2):231-40.
2001: Robert G Halgren; Mark R Fielden; Cora J Fong; Timothy R Zacharewski
Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones.
Nucleic acids research 2001;29(2):582-8.
2000: H Hodgert Jury; Timothy R Zacharewski; Geoffrey L Hammond
Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands.
The Journal of steroid biochemistry and molecular biology 2000;75(2-3):167-76.
2000: T Celius; Jason B Matthews; John P Giesy; Timothy R Zacharewski
Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol.
The Journal of steroid biochemistry and molecular biology 2000;75(2-3):109-19.
2000: J Matthews; T Celius; Robert G Halgren; Timothy R Zacharewski
Differential estrogen receptor binding of estrogenic substances: a species comparison.
The Journal of steroid biochemistry and molecular biology 2000;74(4):223-34.
2000: Grantley D Charles; Chris Gennings; JH Clemons; Timothy R Zacharewski; B Bhaskar Gollapudi; Edward W Carney
Optimization of an estrogen receptor-alpha transcriptional activation assay for testing a diverse spectrum of chemicals.
Journal of applied toxicology : JAT 2000;20(6):449-54.
2000: Grantley D Charles; Michael J Bartels; Timothy R Zacharewski; B Bhaskar Gollapudi; NL Freshour; Edward W Carney
Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor-alpha reporter gene assay.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(2):320-6.
2000: Grantley D Charles; Michael J Bartels; Chris Gennings; Timothy R Zacharewski; NL Freshour; B Bhaskar Gollapudi; Edward W Carney
Incorporation of S-9 activation into an ER-alpha transactivation assay.
Reproductive toxicology (Elmsford, N.Y.) 2000;14(3):207-16.
2000: J Matthews; Timothy R Zacharewski
Differential binding affinities of PCBs, HO-PCBs, and aroclors with recombinant human, rainbow trout (Onchorhynkiss mykiss), and green anole (Anolis carolinensis) estrogen receptors, using a semi-high throughput competitive binding assay.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):326-39.
1999: B E Gillesby; Timothy R Zacharewski
pS2 (TFF1) levels in human breast cancer tumor samples: correlation with clinical and histological prognostic markers.
Breast cancer research and treatment 1999;56(3):253-65.
1998: Timothy R Zacharewski; M D Meek; JH Clemons; Z F Wu; Mark R Fielden; Jason B Matthews
Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(2):282-93.
1998: M J Twiner; Maurice Hirst; A Valenciano; Timothy R Zacharewski; S Jeffrey Dixon
N,N-Dimethylformamide modulates acid extrusion from murine hepatoma cells.
Toxicology and applied pharmacology 1998;153(2):143-51.
1998: Martin van den Berg; Linda S Birnbaum; Albertus T C Bosveld; B Brunström; P Cook; Mark Feeley; John P Giesy; Annika Hanberg; R Hasegawa; SW Kennedy; T Kubiak; JC Larsen; FX van Leeuwen; A K Liem; C Nolt; Richard E Peterson; Lorenz Poellinger; Stephen Safe; Dieter Schrenk; Donald E Tillitt; Mats Tysklind; M Younes; F Waern; Timothy R Zacharewski
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.
Environmental health perspectives 1998;106(12):775-92.
1998: D Desaulniers; K Leingartner; Timothy R Zacharewski; W G Foster
Optimization of an MCF7-E3 Cell Proliferation Assay and Effects of Environmental Pollutants and Industrial Chemicals.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(4):409-22.
1998: J C Gould; LS Leonard; SC Maness; BL Wagner; K Conner; Timothy R Zacharewski; Stephen Safe; Donald P McDonnell; Kevin W Gaido
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Molecular and cellular endocrinology 1998;142(1-2):203-14.
1998: Timothy R Zacharewski
Identification and assessment of endocrine disruptors: limitations of in vivo and in vitro assays.
Environmental health perspectives 1998;106 Suppl 2():577-82.
1998: H Spielmann; N P Bochkov; L Costa; Laura Gribaldo; A Guillouzo; J J Heindel; M Karol; Ralph E Parchment; Walter Pfaller; P P Peraita; Timothy R Zacharewski
13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for organ toxicity.
Environmental health perspectives 1998;106 Suppl 2():427-39.
1998: Patricia A Fail; J W Hines; Timothy R Zacharewski; Z F Wu; L Borodinsky
Assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and an in vitro recombinant receptor reporter gene assay.
Drug and chemical toxicology 1998;21 Suppl 1():101-21.
1997: Mark R Fielden; I Chen; Brock Chittim; S H Safe; Timothy R Zacharewski
Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155).
Environmental health perspectives 1997;105(11):1238-48.
1997: L Earl Gray; William R Kelce; T Wiese; Rochelle Tyl; Kevin W Gaido; J Cook; Gary R Klinefelter; D Desaulniers; Elizabeth M Wilson; Timothy R Zacharewski; C Waller; Paul Foster; John Laskey; J Reel; J Giesy; Susan C Laws; J McLachlan; W Breslin; R Cooper; R Di Giulio; R Johnson; R Purdy; E Mihaich; S Safe; Theo Colborn
Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms.
Reproductive toxicology (Elmsford, N.Y.) 1997;11(5):719-50.
1997: K Connor; K Ramamoorthy; M Moore; M Mustain; I Chen; Stephen Safe; Timothy R Zacharewski; B Gillesby; A Joyeux; Patrick Balaguer
Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships.
Toxicology and applied pharmacology 1997;145(1):111-23.
1997: B E Gillesby; M Stanostefano; W Porter; S Safe; Z F Wu; Timothy R Zacharewski
Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression.
Biochemistry 1997;36(20):6080-9.
1997: Stephen H Safe; Timothy R Zacharewski
Organochlorine exposure and risk for breast cancer.
Progress in clinical and biological research 1997;396():133-45.
1997: M Moore; M Mustain; K Daniel; I Chen; Stephen Safe; Timothy R Zacharewski; B Gillesby; A Joyeux; Patrick Balaguer
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.
Toxicology and applied pharmacology 1997;142(1):160-8.
1996: K Connor; J Howell; I Chen; H Liu; K Berhane; C Sciarretta; Stephen Safe; Timothy R Zacharewski
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;30(1):93-101.
1996: Patrick Balaguer; A Joyeux; M S Denison; Renaud Vincent; B E Gillesby; Timothy R Zacharewski
Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays.
Canadian journal of physiology and pharmacology 1996;74(2):216-22.
1995: Mary F Ruh; Timothy R Zacharewski; K Connor; J Howell; I Chen; Stephen Safe
Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity.
Biochemical pharmacology 1995;50(9):1485-93.
1995: Timothy R Zacharewski; K Berhane; B E Gillesby; B K Burnison
Detection of Estrogen- and Dioxin-like Activity in Pulp and Paper Mill Black Liquor and Effluent Using in vitro Recombinant Receptor/Reporter Gene Assays.
Environmental science & technology 1995;29(8):2140-6.
1995: S Safe; K Washburn; Timothy R Zacharewski; T Phillips
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.
Chemosphere 1995;31(4):3017-23.
1994: Timothy R Zacharewski; K L Bondy; P McDonell; Z F Wu
Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.
Cancer research 1994;54(10):2707-13.
1993: K L Bondy; Timothy R Zacharewski
ICI 164,384: a control for investigating estrogen responsive genes.
Nucleic acids research 1993;21(22):5277-8.
1993: D M Heery; Timothy R Zacharewski; Benoit Pierrat; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4281-5.
1993: M Harris; Timothy R Zacharewski; Stephen Safe
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs).
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(4):456-63.
1992: Timothy R Zacharewski; M Harris; L Biegel; V Morrison; M Merchant; Stephen Safe
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Toxicology and applied pharmacology 1992;113(2):311-8.
1991: Stephen Safe; B Astroff; M Harris; Timothy R Zacharewski; R Dickerson; M Romkes; L Biegel
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action.
Pharmacology & toxicology 1991;69(6):400-9.
1991: J Piskorska-Pliszczynska; V Morrison; Timothy R Zacharewski; Stephen Safe
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Archives of biochemistry and biophysics 1991;290(2):362-8.
1991: Timothy R Zacharewski; M Harris; Stephen Safe
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.
Biochemical pharmacology 1991;41(12):1931-9.
1991: J Piskorska-Pliszczynska; B Astroff; Timothy R Zacharewski; M Harris; R Rosengren; V Morrison; L Safe; Stephen Safe
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Archives of biochemistry and biophysics 1991;284(1):193-200.
1991: Stephen Safe; M Harris; Timothy R Zacharewski
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans.
IARC scientific publications 1991;(108):147-59.
1990: M Harris; Timothy R Zacharewski; J Piskorska-Pliszczynska; R Rosengren; Stephen Safe
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.
Toxicology and applied pharmacology 1990;105(2):243-53.
1990: M Harris; Timothy R Zacharewski; Stephen Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.
Cancer research 1990;50(12):3579-84.
1990: Kurt Randerath; K L Putman; E Randerath; Timothy R Zacharewski; M Harris; S Safe
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships.
Toxicology and applied pharmacology 1990;103(2):271-80.
1989: JP Landers; J Piskorska-Pliszczynska; Timothy R Zacharewski; Nigel J Bunce; Stephen Safe
Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
The Journal of biological chemistry 1989;264(31):18463-71.
1989: Stephen Safe; G Mason; T Sawyer; Timothy R Zacharewski; M Harris; C Yao; B Keys; K Farrell; M Holcomb; D Davis
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Toxicology and industrial health 1989;5(5):757-75.
1989: M Harris; J Piskorska-Pliszczynska; Timothy R Zacharewski; M Romkes; Stephen Safe
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Cancer research 1989;49(16):4531-5.
1989: Timothy R Zacharewski; M Harris; Stephen Safe
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Archives of biochemistry and biophysics 1989;272(2):344-55.
1989: M Harris; Timothy R Zacharewski; B Astroff; Stephen Safe
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Molecular pharmacology 1989;35(5):729-35.
1988: Timothy R Zacharewski; M Harris; Stephen Safe; H Thoma; O Hutzinger
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Toxicology 1988;51(2-3):177-89.
1988: B Astroff; Timothy R Zacharewski; Stephen Safe; M P Arlotto; A Parkinson; P Thomas; W Levin
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Molecular pharmacology 1988;33(2):231-6.
1987: R Bannister; D Davis; Timothy R Zacharewski; I Tizard; S Safe
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Toxicology 1987;46(1):29-42.
1987: G Mason; Timothy R Zacharewski; M A Denomme; L Safe; Stephen Safe
Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships.
Toxicology 1987;44(3):245-55.