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Alexander Zaika

Research Profile

Chemicals & Drugs

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Physiology

Genes & Molecular Sequences

Genes, Tumor Suppressor

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Reverse Transcriptase Polymerase Chain Reaction

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Publications

TOP 3
Vikas Sehdev; Alexander Zaika; Abbes Belkhiri; Jeffrey Ecsedy; Ahmed Katsha; Wael El-Rifai
The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas.
Alexander Zaika; Jinxiong Wei; Jennifer Noto; Richard Peek
Regulation of the p53 by Helicobacter pylori.
Jinxiong Wei; Elena Zaika; Pelayo Correa; Wael El-Rifai; Jennifer Noto; Richard M Peek; Judith Romero-Gallo; Alexander Zaika
Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses.

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All Publications

2013: Vikas Sehdev; Alexander Zaika; Abbes Belkhiri; Jeffrey Ecsedy; Ahmed Katsha; Wael El-Rifai
The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas.
Cancer 2013;119(4):904-14.
2012: Alexander Zaika; Jinxiong Wei; Jennifer Noto; Richard Peek
Regulation of the p53 by Helicobacter pylori.
Oncotarget 2012;3(10):1057-8.
2012: Jinxiong Wei; Elena Zaika; Pelayo Correa; Wael El-Rifai; Jennifer Noto; Richard M Peek; Judith Romero-Gallo; Alexander Zaika
Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):E2543-50.
2012: Dunfa Peng; Keith T Wilson; Alexander Zaika; Tianling Hu; Mohammad Asim; Abbes Belkhiri; Rupesh Chaturvedi; Wael El-Rifai
Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.
Gut 2012;61(9):1250-60.
2012: Vikas Sehdev; mohammed Soutto; M Kay Washington; Alexander Zaika; Dunfa Peng; Tilman T Rau; Frank Revetta; Regine Schneider-Stock; Abbes Belkhiri; Jeffrey Ecsedy; Wael El-Rifai
The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.
Molecular cancer therapeutics 2012;11(3):763-74.
2012: Jinxiong Wei; Elena Zaika; Alexander Zaika
p53 Family: Role of Protein Isoforms in Human Cancer.
Journal of nucleic acids 2012;2012():687359.
2011: Elena Zaika; Claudia Andl; Wael El-Rifai; Ute Moll; Jinxiong Wei; Dengping Yin; Alexander Zaika
p73 protein regulates DNA damage repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4406-14.
2010: Jinxiong Wei; Toni A Nagy; Anna Vilgelm; Elena Zaika; Seth R Ogden; Judith Romero-Gallo; M Blanca Piazuelo; Pelayo Correa; M Kay Washington; Wa'el El-Rifai; Richard M Peek; Alexander Zaika
Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells.
Gastroenterology 2010;139(4):1333-43.
2008: Altaf A Dar; Abbes Belkhiri; Jeffrey Ecsedy; Alexander Zaika; Wa'el El-Rifai
Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells.
Cancer research 2008;68(21):8998-9004.
2008: Anna Vilgelm; Wa'el El-Rifai; Alexander Zaika
Therapeutic prospects for p73 and p63: rising from the shadow of p53.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2008;11(4-5):152-63.
2008: Jinxiong Wei; Daniel O'Brien; Anna Vilgelm; Maria B Piazuelo; Pelayo Correa; M Kay Washington; Wa'el El-Rifai; Richard M Peek; Alexander Zaika
Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family.
Gastroenterology 2008;134(5):1412-23.
2008: Altaf A Dar; Alexander Zaika; Maria B Piazuelo; Pelayo Correa; Tatsuki Koyama; Abbes Belkhiri; Kay Washington; Antoni Castells; Manuel Pera; Wa'el El-Rifai
Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions.
Cancer 2008;112(8):1688-98.
2008: A Vilgelm; J X Wei; M Blanca Piazuelo; M K Washington; V Prassolov; Wa'el El-Rifai; Alexander Zaika
DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.
Oncogene 2008;27(15):2170-6.
2008: Abbes Belkhiri; Altaf A Dar; Alexander Zaika; Mark Kelley; Wa'el El-Rifai
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism.
Cancer research 2008;68(2):395-403.
2007: Seung-Mo Hong; Hyungjun Cho; Christopher A Moskaluk; Eunsil Yu; Alexander Zaika
p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.
Journal of molecular histology 2007;38(3):167-75.
2006: K Tomkova; Wa'el El-Rifai; A Vilgelm; M C Kelly; Timothy C Wang; Alexander Zaika
The gastrin gene promoter is regulated by p73 isoforms in tumor cells.
Oncogene 2006;25(44):6032-6.
2006: Alexander Zaika; Wa'el El-Rifai
The role of p53 protein family in gastrointestinal malignancies.
Cell death and differentiation 2006;13(6):935-40.
2006: Patricia McChesney; Sarah E Aiyar; Ok-Jae Lee; Alexander Zaika; Christopher A Moskaluk; Rong Li; Wa'el El-Rifai
Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas.
Cancer research 2006;66(3):1346-53.
2005: Abbes Belkhiri; Alexander Zaika; Nataliya Pidkovka; Sakari Knuutila; Christopher A Moskaluk; Wa'el El-Rifai
Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas.
Cancer research 2005;65(15):6583-92.
2005: Adam H Johnson; Henry F Frierson; Alexander Zaika; Steven M Powell; James Roche; Sheila Crowe; Christopher A Moskaluk; Wa'el El-Rifai
Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis.
The American journal of pathology 2005;167(2):577-84.
2004: Katarina Tomkova; Abbes Belkhiri; Wa'el El-Rifai; Alexander Zaika
p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells.
Cancer research 2004;64(18):6390-3.
2004: Asta Varis; Alexander Zaika; Pauli Puolakkainen; Balint Nagy; Irene Madrigal; Arto Kokkola; Aki Väyrynen; Päivi Kärkkäinen; Christopher A Moskaluk; Wa'el El-Rifai; Sakari Knuutila
Coamplified and overexpressed genes at ERBB2 locus in gastric cancer.
International journal of cancer. Journal international du cancer 2004;109(4):548-53.
2004: Natalie Koon; Alexander Zaika; Christopher A Moskaluk; Henry F Frierson; Sakari Knuutila; Steven M Powell; Wa'el El-Rifai
Clustering of molecular alterations in gastroesophageal carcinomas.
Neoplasia (New York, N.Y.) 2004;6(2):143-9.
2004: Neda Slade; Alexander Zaika; susan erster; Ute M Moll
DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation.
Cell death and differentiation 2004;11(3):357-60.
2004: Natalie Koon; R Schneider-Stock; Maarit Sarlomo-Rikala; J Lasota; Mark E Smolkin; Gina R Petroni; Alexander Zaika; C Boltze; F Meyer; L Andersson; Sakari Knuutila; M Miettinen; Wa'el El-Rifai
Molecular targets for tumour progression in gastrointestinal stromal tumours.
Gut 2004;53(2):235-40.
2003: Andy Beckler; Christopher A Moskaluk; Alexander Zaika; Garret M Hampton; Steven M Powell; Henry F Frierson; Wa'el El-Rifai
Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas.
Cancer 2003;98(7):1547-51.
2003: Troy W Joseph; Alexander Zaika; Ute M Moll
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1622-30.
2003: Oleksi Petrenko; Alexander Zaika; Ute M Moll
deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.
Molecular and cellular biology 2003;23(16):5540-55.
2003: Motohiro Mihara; susan erster; Alexander Zaika; Oleksi Petrenko; Thomas Chittenden; Petr Pancoska; Ute M Moll
p53 has a direct apoptogenic role at the mitochondria.
Molecular cell 2003;11(3):577-90.
2002: Alexander Zaika; Neda Slade; susan erster; Christine Sansome; Troy W Joseph; Michael L Pearl; Eva Chalas; Ute M Moll
DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.
The Journal of experimental medicine 2002;196(6):765-80.
2002: Troy R Shirangi; Alexander Zaika; Ute M Moll
Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):420-2.
2001: Ute M Moll; susan erster; Alexander Zaika
p53, p63 and p73--solos, alliances and feuds among family members.
Biochimica et biophysica acta 2001;1552(2):47-59.
2001: Alexander Zaika; M Irwin; Christine Sansome; Ute M Moll
Oncogenes induce and activate endogenous p73 protein.
The Journal of biological chemistry 2001;276(14):11310-6.
2001: Ute M Moll; Alexander Zaika
Nuclear and mitochondrial apoptotic pathways of p53.
FEBS letters 2001;493(2-3):65-9.
2001: Christine Sansome; Alexander Zaika; Natasha D Marchenko; Ute M Moll
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells.
FEBS letters 2001;488(3):110-5.
2000: Natasha D Marchenko; Alexander Zaika; Ute M Moll
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling.
The Journal of biological chemistry 2000;275(21):16202-12.
2000: Sergey Kovalev; A Mateen; Alexander Zaika; B J O'Hea; Ute M Moll
Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines.
International journal of oncology 2000;16(4):825-31.
1999: Alexander Zaika; Natasha D Marchenko; Ute M Moll
Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation.
The Journal of biological chemistry 1999;274(39):27474-80.
1999: Alexander Zaika; Sergey Kovalev; Natasha D Marchenko; Ute M Moll
Overexpression of the wild type p73 gene in breast cancer tissues and cell lines.
Cancer research 1999;59(13):3257-63.
1999: Alexander Zaika; Dmitry Ju Mozzherin; Cheng-Keat Tan; Kathleen M Downey; Paul A Fisher
A two-dimensional support for selective binding of polyhistidine-tagged proteins: identification of a proliferating cell nuclear antigen point mutant with altered function in vitro.
Analytical biochemistry 1999;268(2):193-200.