Herbert Brok

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Kap Yolanda S; van Meurs Marjan; van Driel Nikki; Koopman Gerrit; Melief Marie-Jose; Brok Herbert P M; Laman Jon D; 't Hart Bert A
A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
Bajramovic Jeffrey J; Brok Herbert P M; Ouwerling Boudewijn; Jagessar S Anwar; van Straalen Linda; Kondova Ivanela; Bauer Jan; Amor Sandra; 't Hart Bert A; Ben-Nun Avraham
Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve.
Kap Yolanda S; Smith Paul; Jagessar S Anwar; Remarque Ed; Blezer Erwin; Strijkers Gustav J; Laman Jon D; Hintzen Rogier Q; Bauer Jan; Brok Herbert P M; 't Hart Bert A
Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells.

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2009: Kap Yolanda S; van Meurs Marjan; van Driel Nikki; Koopman Gerrit; Melief Marie-Jose; Brok Herbert P M; Laman Jon D; 't Hart Bert A
A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(12):1159-67.
2008: Bajramovic Jeffrey J; Brok Herbert P M; Ouwerling Boudewijn; Jagessar S Anwar; van Straalen Linda; Kondova Ivanela; Bauer Jan; Amor Sandra; 't Hart Bert A; Ben-Nun Avraham
Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve.
European journal of immunology 2008;38(5):1452-64.
2008: Kap Yolanda S; Smith Paul; Jagessar S Anwar; Remarque Ed; Blezer Erwin; Strijkers Gustav J; Laman Jon D; Hintzen Rogier Q; Bauer Jan; Brok Herbert P M; 't Hart Bert A
Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1326-37.
2007: Blezer Erwin L A; Bauer Jan; Brok Herbert P M; Nicolay Klaas; 't Hart Bert A
Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis.
NMR in biomedicine 2007;20(2):90-103.
2007: Bessis Natacha; Lemeiter Delphine; Laroche Liliane; Fournier Catherine; Huizinga Tom; Brok Herbert; 't Hart Bert; Boissier Marie-Christophe
Engraftment of cutaneous fibroblasts within synovial membrane in a nonhuman primate: short-term results.
Joint, bone, spine : revue du rhumatisme 2007;74(1):48-51.
2007: Brok Herbert P M; Boven Leonie; van Meurs Marjan; Kerlero de Rosbo Nicole; Celebi-Paul Liesbeth; Kap Yolanda S; Jagessar Anwar; Hintzen Rogier Q; Keir Geoff; Bajramovic Jeffrey; Ben-Nun Avraham; Bauer Jan; Laman Jon D; Amor Sandra; 't Hart Bert A
The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.
Journal of neuroimmunology 2007;182(1-2):135-52.
2006: Doxiadis Gaby G M; van der Wiel Marit K H; Brok Herbert P M; de Groot Natasja G; Otting Nel; 't Hart Bert A; van Rood Jon J; Bontrop Ronald E
Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5864-8.
2005: 't Hart Bert A; Bauer Jan; Brok Herbert P M; Amor Sandra
Non-human primate models of experimental autoimmune encephalomyelitis: Variations on a theme.
Journal of neuroimmunology 2005;168(1-2):1-12.
2005: 't Hart Bert A; Brok Herbert P M; Remarque Ed; Benson Jacqueline; Treacy George; Amor Sandra; Hintzen Rogier Q; Laman Jon D; Bauer Jan; Blezer Erwin L A
Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4761-8.
2005: 't Hart Bert A; Blezer Erwin L A; Brok Herbert P M; Boon Louis; de Boer Mark; Bauer Jan; Laman Jon D
Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE.
Journal of neuroimmunology 2005;163(1-2):31-9.
2005: De Vos Alex F; van Riel Debby A J; van Meurs Marjan; Brok Herbert P M; Boon Louis; Hintzen Rogier Q; Claassen Eric; 't Hart Bert A; Laman Jon D
Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE).
Journal of neuroimmunology 2005;161(1-2):29-39.
2005: van Beek Johan; van Meurs Marjan; 't Hart Bert A; Brok Herbert P M; Neal Jim W; Chatagner Alexandra; Harris Claire L; Omidvar Nader; Morgan B Paul; Laman Jon D; Gasque Philippe
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2353-65.
2004: 't Hart Bert A; Vogels Jack; Bauer Jan; Brok Herbert P M; Blezer Erwin
Non-invasive measurement of brain damage in a primate model of multiple sclerosis.
Trends in molecular medicine 2004;10(2):85-91.
2003: 't Hart Bert A; Vogels Jack T W E; Spijksma Gerwin; Brok Herbert P M; Polman Chris; van der Greef Jan
1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urines of MS patients and non-human primates with MS-like disease.
Journal of the neurological sciences 2003;212(1-2):21-30.
2002: Brok Herbert P M; van Meurs Marjan; Blezer Erwin; Schantz Allen; Peritt David; Treacy George; Laman Jon D; Bauer Jan; 't Hart Bert A
Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6554-63.
2002: de Vos Alex F; van Meurs Marjan; Brok Herbert P; Boven Leonie A; Hintzen Rogier Q; van der Valk Paul; Ravid Rivka; Rensing Susanne; Boon Louis; 't Hart Bert A; Laman Jon D
Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5415-23.
2002: Laman Jon D; 't Hart Bert A; Brok Herbert; Meurs Marjan van; Schellekens Marc M; Kasran Ahmad; Boon Louis; Bauer Jan; Boer Mark de; Ceuppens Jan
Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12).
European journal of immunology 2002;32(8):2218-28.
2001: 't Hart B A; Brok H P; Amor S; Bontrop R E
The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels.
Human immunology 2001;62(12):1371-81.
2001: Brok H P; Hornby R J; Griffiths G D; Scott L A; Hart B A
An extensive monoclonal antibody panel for the phenotyping of leukocyte subsets in the common marmoset and the cotton-top tamarin.
Cytometry 2001;45(4):294-303.
2001: Brok H P; Bauer J; Jonker M; Blezer E; Amor S; Bontrop R E; Laman J D; 't Hart B A
Non-human primate models of multiple sclerosis.
Immunological reviews 2001;183():173-85.
2001: Boon L; Brok H P; Bauer J; Ortiz-Buijsse A; Schellekens M M; Ramdien-Murli S; Blezer E; van Meurs M; Ceuppens J; de Boer M; 't Hart B A; Laman J D
Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2942-9.
2001: Poliani P L; Brok H; Furlan R; Ruffini F; Bergami A; Desina G; Marconi P C; Rovaris M; Uccelli A; Glorioso J C; Penna G; Adorini L; Comi G; 't Hart B; Martino G
Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis.
Human gene therapy 2001;12(8):905-20.
2001: Brok H P; Tekoppele J M; Hakimi J; Kerwin J A; Nijenhuis E M; De Groot C W; Bontrop R E; 't Hart B A
Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys.
Clinical and experimental immunology 2001;124(1):134-41.
2001: Mancardi G; Hart B; Roccatagliata L; Brok H; Giunti D; Bontrop R; Massacesi L; Capello E; Uccelli A
Demyelination and axonal damage in a non-human primate model of multiple sclerosis.
Journal of the neurological sciences 2001;184(1):41-9.
2000: Kerlero de Rosbo N; Brok H P; Bauer J; Kaye J F; 't Hart B A; Ben-Nun A
Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes.
Journal of neuroimmunology 2000;110(1-2):83-96.
2000: Brok H P; Uccelli A; Kerlero De Rosbo N; Bontrop R E; Roccatagliata L; de Groot N G; Capello E; Laman J D; Nicolay K; Mancardi G L; Ben-Nun A; Hart B A
Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):1093-101.
2000: Mancardi G; Hart B A; Capello E; Brok H P; Ben-Nun A; Roccatagliata L; Giunti D; Gazzola P; Dono M; Kerlero de Rosbo N; Colombo M; Uccelli A
Restricted immune responses lead to CNS demyelination and axonal damage.
Journal of neuroimmunology 2000;107(2):178-83.
2000: 't Hart B A; van Meurs M; Brok H P; Massacesi L; Bauer J; Boon L; Bontrop R E; Laman J D
A new primate model for multiple sclerosis in the common marmoset.
Immunology today 2000;21(6):290-7.
1999: Goossens P H; Schouten G J; 't Hart B A; Bout A; Brok H P; Kluin P M; Breedveld F C; Valerio D; Huizinga T W
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys.
Human gene therapy 1999;10(7):1139-49.
1998: Brok H P; Vossen J M; Heidt P J
IFN-gamma-mediated prevention of graft-versus-host disease: pharmacodynamic studies and influence on proliferative capacity of chimeric spleen cells.
Bone marrow transplantation 1998;22(10):1005-10.
1998: Antunes S G; de Groot N G; Brok H; Doxiadis G; Menezes A A; Otting N; Bontrop R E
The common marmoset: a new world primate species with limited Mhc class II variability.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11745-50.
1998: Hart B A; Bauer J; Muller H J; Melchers B; Nicolay K; Brok H; Bontrop R E; Lassmann H; Massacesi L
Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus).
The American journal of pathology 1998;153(2):649-63.
1998: Hart B A; Bank R A; De Roos J A; Brok H; Jonker M; Theuns H M; Hakimi J; Te Koppele J M
Collagen-induced arthritis in rhesus monkeys: evaluation of markers for inflammation and joint degradation.
British journal of rheumatology 1998;37(3):314-23.
1998: Schuuring E; van Damme H; Schuuring-Scholtes E; Verhoeven E; Michalides R; Geelen E; de Boer C; Brok H; van Buuren V; Kluin P
Characterization of the EMS1 gene and its product, human Cortactin.
Cell adhesion and communication 1998;6(2-3):185-209.
1997: Brok H P; Vossen J M; Heidt P J
Interferon-gamma-mediated prevention of graft-versus-host disease: development of immune competent and allo-tolerant T cells in chimeric mice.
Bone marrow transplantation 1997;19(6):601-6.
1997: van Damme H; Brok H; Schuuring-Scholtes E; Schuuring E
The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification.
The Journal of biological chemistry 1997;272(11):7374-80.
1993: Brok H P; Heidt P J; van der Meide P H; Zurcher C; Vossen J M
Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6451-9.

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