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Karl Broman

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Antonella Galvan; Mariateresa Mancuso; Giacomo Manenti; Sara Noci; Simonetta Pazzaglia; Anna Saran; Karl W Broman; Francesca Colombo; Tommaso A Dragani
The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse.
Karl W Broman; Sungjin Kim; Cécile Ané; Saunak Sen; Bret Payseur
Mapping quantitative trait loci onto a phylogenetic tree.
Elias Chaibub Neto; Alan D Attie; Andrew F Broman; Karl W Broman; Ritsert C Jansen; Mark P Keller; Brian S Yandell
Quantile-based permutation thresholds for quantitative trait loci hotspots.

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2012: Antonella Galvan; Mariateresa Mancuso; Giacomo Manenti; Sara Noci; Simonetta Pazzaglia; Anna Saran; Karl W Broman; Francesca Colombo; Tommaso A Dragani
The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse.
G3 (Bethesda, Md.) 2012;2(9):1041-6.
2012: Karl W Broman; Sungjin Kim; Cécile Ané; Saunak Sen; Bret Payseur
Mapping quantitative trait loci onto a phylogenetic tree.
Genetics 2012;192(1):267-79.
2012: Elias Chaibub Neto; Alan D Attie; Andrew F Broman; Karl W Broman; Ritsert C Jansen; Mark P Keller; Brian S Yandell
Quantile-based permutation thresholds for quantitative trait loci hotspots.
Genetics 2012;191(4):1355-65.
2012: Chen-Yu Wang; Brian S Yandell; Karl W Broman; Mark P Keller; Christina Kendziorski; Angie T Oler; Mary E Rabaglia; Eric E Schadt; Kathryn L Schueler; Donald S Stapleton; Alan D Attie
Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis.
Journal of lipid research 2012;53(8):1493-501.
2012: Elizabeth G King; Anthony D Long; Karl W Broman; Steven R Hoofer; Casey L McNeil; Chris M Merkes; Saunak Sen; Stuart J Macdonald
Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.
Genome research 2012;22(8):1558-66.
2012: Danny Arends; Karl W Broman; Ritsert C Jansen; Steffen Möller; Pjotr Prins; K Joeri van der Velde; Morris A Swertz
xQTL workbench: a scalable web environment for multi-level QTL analysis.
Bioinformatics (Oxford, England) 2012;28(7):1042-4.
2012: Jessica Amlin-Van Schaick; Karl W Broman; Sungjin Kim; Karlyne M Reilly
Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.
Mammalian genome : official journal of the International Mammalian Genome Society 2012;23(3-4):277-85.
2012: Karl W Broman
Haplotype probabilities in advanced intercross populations.
G3 (Bethesda, Md.) 2012;2(2):199-202.
2012: Karl W Broman
Genotype probabilities at intermediate generations in the construction of recombinant inbred lines.
Genetics 2012;190(2):403-12.
2012: Jessica C Amlin-Van Schaick; Karl W Broman; Christina DiFabio; Sungjin Kim; Min-Hyung Lee; Karlyne M Reilly
Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.
Neuro-oncology 2012;14(2):160-74.
2012: Richard C Davis; Karl W Broman; Lawrence W Castellani; Miklós Péterfy; Hongxiu Qi; Melenie Rosales; Eric E Schadt; Atila Van Nas; Pingzi Wen; Suzanne Yu; Yi Zhao; Zhiqiang Zhou; Aldons J Lusis
Systems genetics of susceptibility to obesity-induced diabetes in mice.
Physiological genomics 2012;44(1):1-13.
2012: C A Rice; Jessica Riehl; Jason W Soukup; Karl W Broman; William R Gengler
Comparing the degree of exothermic polymerization in commonly used acrylic and provisional composite resins for intraoral appliances.
Journal of veterinary dentistry 2012;29(2):78-83.
2012: Justin M Greene; Paul J Hines; Jennifer J Lhost; Jennifer E Nelson; Karl W Broman; Melisa L Budde; Benjamin J Burwitz; Emily N Chin; Thomas C Friedrich; David O'Connor
Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.
PloS one 2012;7(8):e43690.
2011: Jason T Weinfurter; Yoshihiro Kawaoka; Chengjun Li; Karl W Broman; Kevin Brunner; Saverio Capuano; Thomas C Friedrich
Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates.
PLoS pathogens 2011;7(11):e1002381.
2011: David L Aylor; Ralph S Baric; Timothy A Bell; Lisa A Branstetter; Karl W Broman; Ryan J Buus; Elissa J Chesler; Francis S Collins; John D Didion; Caroline Durrant; Martin T Ferris; Wendy Foulds-Mathes; Jeff A Frelinger; Matthew Frieman; Lisa E Gralinski; Mark Heise; Kunjie Hua; Fuad A Iraqi; Samir N P Kelada; Ron Korstanje; Eric Yi Liu; Leonard McMillan; Darla R Miller; Richard Mott; Derrick L Nehrenberg; Daniel Pomp; Christine L Powell; Abhishek Sarkar; David A Schwartz; Jason Spence; Jill Steigerwalt; David Threadgill; William Valdar; Ricardo A Verdugo; Jeremy Wang; Wei Wang; Yuying Xie; Ivana V Yang; Qi Zhang; Fernando Pardo-Manuel de Villena; Gary A Churchill
Genetic analysis of complex traits in the emerging Collaborative Cross.
Genome research 2011;21(8):1213-22.
2011: Nicolas Svetec; Annegret Werzner; Ricardo Wilches; Pavlos Pavlidis; José M Álvarez-Castro; Karl W Broman; Dirk Metzler; Wolfgang Stephan
Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis.
Molecular ecology 2011;20(3):530-44.
2011: Justin M Greene; Oriana E Hawkins; William H Hildebrand; Julie A Karl; Kevin J Kunstman; Simon M Lank; Jennifer J Lhost; Benjamin N Bimber; Karl W Broman; Benjamin J Burwitz; Roger W Wiseman; Steven M Wolinsky; David O'Connor
Differential MHC class I expression in distinct leukocyte subsets.
BMC immunology 2011;12():39.
2011: Anna J Moreland; David O'Connor; Peter Parham; R Keith Reeves; Karl W Broman; Lisbeth A Guethlein; R Paul Johnson; Benjamin N Bimber
Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.
BMC genomics 2011;12():295.
2010: Brenda Murdoch; Nichole Owen; Sofia Shirley; Sara Crumb; Karl W Broman; Terry Hassold
Multiple loci contribute to genome-wide recombination levels in male mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2010;21(11-12):550-5.
2010: Danny Arends; Pjotr Prins; Ritsert C Jansen; Karl W Broman
R/qtl: high-throughput multiple QTL mapping.
Bioinformatics (Oxford, England) 2010;26(23):2990-2.
2010: G Jurisic; J P Sundberg; A Bleich; E H Leiter; Karl W Broman; G Buechler; L Alley; D Vestweber; M Detmar
Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.
Genes and immunity 2010;11(3):219-31.
2010: Lindsay C Burrage; Annie E Baskin-Hill; David S Sinasac; Jonathan Singer; Colleen Croniger; Andrew Kirby; E J Kulbokas; Mark J Daly; Eric S Lander; Karl W Broman; Joseph H Nadeau
Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2010;21(3-4):115-29.
2010: Justin M Greene; Jennifer J Lhost; Benjamin J Burwitz; Melisa L Budde; Caitlin E Macnair; Madelyn K Weiker; Emma Gostick; Thomas C Friedrich; Karl W Broman; David A Price; Shelby L O'Connor; David O'Connor
Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.
Journal of virology 2010;84(7):3362-72.
2010: Aaron K Wong; Alison L Ruhe; Beth L Dumont; Kathryn R Robertson; Giovanna Guerrero; Sheila M Shull; Janet S Ziegle; Lee V Millon; Karl W Broman; Bret Payseur; Mark Neff
A comprehensive linkage map of the dog genome.
Genetics 2010;184(2):595-605.
2010: Timothy Billings; Evelyn E Sargent; Jin P Szatkiewicz; Nicole Leahy; Il-Youp Kwak; Nazira Bektassova; Michael Walker; Terry Hassold; Joel H Graber; Karl W Broman; Petko M Petkov
Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.
PloS one 2010;5(12):e15340.
2010: Hannah L Bader; Alison L Ruhe; Lauren W Wang; Aaron K Wong; Kari F Walsh; Rebecca A Packer; Jonathan Mitelman; Kathryn R Robertson; Dennis P O'Brien; Karl W Broman; G Diane Shelton; Suneel S Apte; Mark Neff
An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures.
PloS one 2010;5(9):.
2009: Jordan A Shavit; Ani Manichaikul; Heidi L Lemmerhirt; Karl W Broman; David Ginsburg
Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.
Blood 2009;114(26):5368-74.
2009: Edith Y Cheng; Patricia A Hunt; Theresa A Naluai-Cecchini; Corrine L Fligner; Victor Y Fujimoto; Tanya L Pasternack; Jackie M Schwartz; Jody E Steinauer; Tracey J Woodruff; Sheila Cherry; Terah A Hansen; Rhea Vallente; Karl W Broman; Terry J Hassold
Meiotic recombination in human oocytes.
PLoS genetics 2009;5(9):e1000661.
2009: Adi Fledel-Alon; Daniel J Wilson; Karl W Broman; Xiaoquan Wen; Carole Ober; Graham Coop; Molly Przeworski
Broad-scale recombination patterns underlying proper disjunction in humans.
PLoS genetics 2009;5(9):e1000658.
2009: Beth L Dumont; Karl W Broman; Bret Payseur
Variation in genomic recombination rates among heterogeneous stock mice.
Genetics 2009;182(4):1345-9.
2009: Allison Cox; Cheryl L Ackert-Bicknell; Beth L Dumont; Yueming Ding; Jordana Tzenova Bell; Gudrun A Brockmann; Jon E Wergedal; Carol Bult; Beverly Paigen; Jonathan Flint; Shirng-Wern Tsaih; Gary Churchill; Karl W Broman
A new standard genetic map for the laboratory mouse.
Genetics 2009;182(4):1335-44.
2009: Meera Venkatesan; Karl W Broman; M Sellers; Jason Rasgon
An initial linkage map of the West Nile Virus vector Culex tarsalis.
Insect molecular biology 2009;18(4):453-63.
2009: Ani Manichaikul; Karl W Broman
Binary trait mapping in experimental crosses with selective genotyping.
Genetics 2009;182(3):863-74.
2009: Saunak Sen; Frank Johannes; Karl W Broman
Selective genotyping and phenotyping strategies in a complex trait context.
Genetics 2009;181(4):1613-26.
2009: Ani Manichaikul; Jee Young Moon; Saunak Sen; Brian S Yandell; Karl W Broman
A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis.
Genetics 2009;181(3):1077-86.
2009: Oscar Gonzalez-Recio; Evangelina López de Maturana; Andrés T Vega; Corinne D Engelman; Karl W Broman
Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model.
BMC proceedings 2009;3 Suppl 7():S63.
2008: Haifeng Shao; Lindsay C Burrage; David S Sinasac; Annie E Hill; Sheila R Ernest; William O'Brien; Hayden-William Courtland; Karl Jepsen; Andrew Kirby; E J Kulbokas; Mark J Daly; Karl W Broman; Eric S Lander; Joseph H Nadeau
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(50):19910-4.
2008: Matthew M Hill; Karl W Broman; Elia Stupka; William C Smith; Di Jiang; Arend Sidow
The C. savignyi genetic map and its integration with the reference sequence facilitates insights into chordate genome evolution.
Genome research 2008;18(8):1369-79.
2008: Isabella Lupi; Karl W Broman; Shey-Cherng Tzou; Angelika Gutenberg; Enio Martino; Patrizio Caturegli
Novel autoantigens in autoimmune hypophysitis.
Clinical endocrinology 2008;69(2):269-78.
2008: Kenneth Paigen; Jin P Szatkiewicz; Kathryn Sawyer; Nicole Leahy; Emil D Parvanov; Siemon H S Ng; Joel H Graber; Karl W Broman; Petko M Petkov
The recombinational anatomy of a mouse chromosome.
PLoS genetics 2008;4(7):e1000119.
2008: Hans T Bjornsson; Thomas J Albert; Christine M Ladd-Acosta; Roland D Green; Michael A Rongione; Christina M Middle; Rafael A Irizarry; Karl W Broman; Andrew P Feinberg
SNP-specific array-based allele-specific expression analysis.
Genome research 2008;18(5):771-9.
2008: Jeremy Peirce; Karl W Broman; Lu Lu; Elissa J Chesler; G Zhou; David C Airey; Amanda E Birmingham; Robert Williams
Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis.
PloS one 2008;3(4):e1977.
2008: Marie-Hélène Roy-Gagnon; Rasika A Mathias; MARGARET D FALLIN; S H Jee; Karl W Broman; Alexander F Wilson
An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method.
Annals of human genetics 2008;72(Pt 1):115-25.
2008: Debasish Sinha; Andrew Klise; Yuri V Sergeev; Stacey Hose; Imran A Bhutto; Laszlo Hackler; Tanya Malpic-Llanos; Sonia Samtani; Rhonda Grebe; Morton F Goldberg; J Fielding Hejtmancik; Avindra Nath; Donald J Zack; Robert Fariss; D Scott McLeod; Olof H Sundin; Karl W Broman; Gerard A Lutty; J. SAMUEL ZIGLER
betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development.
Molecular and cellular neurosciences 2008;37(1):85-95.
2007: Satish K Rajagopal; Qing Ma; Dita Obler; Jie Shen; Ani Manichaikul; Aoy Tomita-Mitchell; Kari Boardman; Christine Briggs; Vidu Garg; Deepak Srivastava; Elizabeth Goldmuntz; Karl W Broman; D Woodrow Benson; Leslie B Smoot; William T Pu
Spectrum of heart disease associated with murine and human GATA4 mutation.
Journal of molecular and cellular cardiology 2007;43(6):677-85.
2007: Petko M Petkov; Karl W Broman; Jin P Szatkiewicz; Kenneth Paigen
Crossover interference underlies sex differences in recombination rates.
Trends in genetics : TIG 2007;23(11):539-42.
2007: Ani Manichaikul; Abraham A Palmer; Saunak Sen; Karl W Broman
Significance thresholds for quantitative trait locus mapping under selective genotyping.
Genetics 2007;177(3):1963-6.
2007: Friedrich Teuscher; Karl W Broman
Haplotype probabilities for multiple-strain recombinant inbred lines.
Genetics 2007;175(3):1267-74.
2007: Saunak Sen; Jaya M Satagopan; Karl W Broman; Gary Churchill
R/qtlDesign: inbred line cross experimental design.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(2):87-93.
2007: H L Lemmerhirt; Karl W Broman; Jordan A Shavit; David Ginsburg
Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model.
Journal of thrombosis and haemostasis : JTH 2007;5(2):329-35.
2007: Jeremy Peirce; Karl W Broman; Lu Lu; Robert Williams
A simple method for combining genetic mapping data from multiple crosses and experimental designs.
PloS one 2007;2(10):e1036.
2007: Krista M Nichols; Karl W Broman; Kyle Sundin; Jennifer M Young; Paul A Wheeler; Gary H Thorgaard
Quantitative trait loci x maternal cytoplasmic environment interaction for development rate in Oncorhynchus mykiss.
Genetics 2007;175(1):335-47.
2006: Karl W Broman; Saunak Sen; Sarah E Owens; Ani Manichaikul; E Michelle Southard-Smith; Gary Churchill
The X chromosome in quantitative trait locus mapping.
Genetics 2006;174(4):2151-8.
2006: Sadeep Shrestha; Michael W Smith; Karl W Broman; Homayoon Farzadegan; David Vlahov; Steffanie A Strathdee
Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysis.
Journal of acquired immune deficiency syndromes (1999) 2006;43(3):335-43.
2006: Daniel Kess; Anna-Karin B Lindqvist; Thorsten Peters; Honglin Wang; Jan Zamek; Roswitha Nischt; Karl W Broman; Robert Blakytny; Thomas Krieg; Rikard Holmdahl; Karin Scharffetter-Kochanek
Identification of susceptibility loci for skin disease in a murine psoriasis model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4612-9.
2006: Olof H Sundin; Karl W Broman; Howard H Chang; Elizabeth C L Vito; Walter J Stark; John D Gottsch
A common locus for late-onset Fuchs corneal dystrophy maps to 18q21.2-q21.32.
Investigative ophthalmology & visual science 2006;47(9):3919-26.
2006: Ani Manichaikul; Josée Dupuis; Saunak Sen; Karl W Broman
Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus.
Genetics 2006;174(1):481-9.
2006: Bjarke Feenstra; Ib M Skovgaard; Karl W Broman
Mapping quantitative trait loci by an extension of the Haley-Knott regression method using estimating equations.
Genetics 2006;173(4):2269-82.
2006: Lisa Helbling Chadwick; Lisa M Pertz; Karl W Broman; Marisa S Bartolomei; Huntington F Willard
Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.
Genetics 2006;173(4):2103-10.
2006: Gemma R Grant; Susan W Robinson; Richard E Edwards; Bruce Clothier; Reginald Davies; David J Judah; Karl W Broman; Andrew G Smith
Multiple polymorphic loci determine basal hepatic and splenic iron status in mice.
Hepatology (Baltimore, Md.) 2006;44(1):174-85.
2006: Virginie Orgogozo; Karl W Broman; David L Stern
High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species.
Genetics 2006;173(1):197-205.
2006: Sadeep Shrestha; Steffanie A Strathdee; Karl W Broman; Michael W Smith
Unknown biological mixtures evaluation using STR analytical quantification.
Electrophoresis 2006;27(2):409-15.
2006: Karlyne M Reilly; Karl W Broman; Roderick T Bronson; Shirley Tsang; Dagan A Loisel; Emily S Christy; Zhonghe Sun; John Diehl; David J Munroe; Robert G Tuskan
An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.
Cancer research 2006;66(1):62-8.
2006: Olof H Sundin; Albert S Jun; Karl W Broman; Sammy H Liu; Siobhan E Sheehan; Elizabeth C L Vito; Walter J Stark; John D Gottsch
Linkage of late-onset Fuchs corneal dystrophy to a novel locus at 13pTel-13q12.13.
Investigative ophthalmology & visual science 2006;47(1):140-5.
2005: Olof H Sundin; Gregory S Leppert; Eduardo D Silva; Jun-Ming Yang; Sharola Dharmaraj; Irene H Maumenee; Luisa Coutinho Santos; Cameron F Parsa; Elias Traboulsi; Karl W Broman; Cathy DiBernardo; Janet S Sunness; Jeffrey Toy; Ethan M Weinberg
Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9553-8.
2005: John D Gottsch; Olof H Sundin; Sammy H Liu; Albert S Jun; Karl W Broman; Walter J Stark; Elizabeth C L Vito; Amol K Narang; John M Thompson; Malcolm Magovern
Inheritance of a novel COL8A2 mutation defines a distinct early-onset subtype of fuchs corneal dystrophy.
Investigative ophthalmology & visual science 2005;46(6):1934-9.
2005: Sarah E Owens; Karl W Broman; Timothy Wiltshire; J Bradford Elmore; Kevin M Bradley; Jeffrey R Smith; E Michelle Southard-Smith
Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease.
Human molecular genetics 2005;14(11):1549-58.
2005: Karl W Broman
Mapping expression in randomized rodent genomes.
Nature genetics 2005;37(3):209-10.
2005: Mehmet L Guler; Davinna L Ligons; Yan Wang; Michael Bianco; Karl W Broman; Noel R Rose
Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2167-73.
2005: Karl W Broman
The genomes of recombinant inbred lines.
Genetics 2005;169(2):1133-46.
2005: Nathan G Congdon; Karl W Broman; Hong Lai; Beatriz Munoz; Heidi Bowie; Donna Gilbert; Robert Wojciechowski; Sheila K West
Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors.
Ophthalmology 2005;112(1):73-7.
2005: Wei-Min Chen; Karl W Broman; Kung-Yee Liang
Power and robustness of linkage tests for quantitative traits in general pedigrees.
Genetic epidemiology 2005;28(1):11-23.
2004: Simeon Boyd; Jennifer L Dodson; Cristi L Radford; Gerald H Ashrafi; Terri H beaty; Ranjiv Mathews; Karl W Broman; John P Gearhart
Clinical and molecular characterization of the bladder exstrophy-epispadias complex: analysis of 232 families.
BJU international 2004;94(9):1337-43.
2004: Karl W Broman; Eleanor Feingold
SNPs made routine.
Nature methods 2004;1(2):104-5.
2004: Gary Churchill; David C Airey; Hooman Allayee; Joe M Angel; Alan D Attie; Jackson Beatty; William D Beavis; John K Belknap; Beth Bennett; Wade Berrettini; Andre Bleich; Molly Bogue; Karl W Broman; Kari J Buck; Ed Buckler; Margit Burmeister; Elissa J Chesler; James M Cheverud; Steven Clapcote; Melloni N Cook; Roger D Cox; John C Crabbe; Wim Crusio; Ariel Darvasi; Christian Deschepper; R W Doerge; Charles Farber; Jiri Forejt; Daniel Gaile; Steven J Garlow; Hartmut Geiger; Howard Gershenfeld; Terry Gordon; Jing Gu; Weikuan Gu; Gerald de Haan; Nancy L Hayes; Craig Heller; Heinz Himmelbauer; Robert Hitzemann; Kent Hunter; Hui-Chen Hsu; Fuad A Iraqi; Boris Ivandic; Howard J Jacob; Ritsert C Jansen; Karl Jepsen; Dabney K Johnson; Thomas Johnson; Gerd Kempermann; Christina Kendziorski; Malak Kotb; R Frank Kooy; Bastien Llamas; Frank Lammert; Jean-Michel Lassalle; Pedro R Lowenstein; Lu Lu; Aldons Lusis; Kenneth F Manly; Ralph Marcucio; Doug Matthews; Juan F Medrano; Darla R Miller; Guy Mittleman; Beverly A Mock; Jeffrey S Mogil; Xavier Montagutelli; Grant Morahan; David G Morris; Richard Mott; Joseph H Nadeau; Hiroki Nagase; Richard Nowakowski; Bruce F O'Hara; Alexander V Osadchuk; Grier P Page; Beverly Paigen; Kenneth Paigen; Abraham A Palmer; Huei-Ju Pan; Leena Peltonen-Palotie; Jeremy Peirce; Daniel Pomp; Michal Pravenec; Daniel R Prows; Zhonghua Qi; Roger H Reeves; John Roder; Glenn D Rosen; Eric E Schadt; Leonard C Schalkwyk; Ze'ev Seltzer; Kazuhiro Shimomura; Siming Shou; Mikko J Sillanpää; Linda D Siracusa; Hans-Willem Snoeck; Jimmy Spearow; Karen Svenson; Lisa Tarantino; David Threadgill; Linda A Toth; William Valdar; Fernando Villena; Craig H Warden; Steve Whatley; Robert W Williams; Timothy Wiltshire; Nengjun Yi; Dabao Zhang; Min Zhang; Fei Zou
The Collaborative Cross, a community resource for the genetic analysis of complex traits.
Nature genetics 2004;36(11):1133-7.
2004: Solveig K Sieberts; Karl W Broman; Daniel F Gudbjartsson
"Bias toward the null" means reduced power.
American journal of human genetics 2004;75(4):720-2; author reply 723-7.
2004: Mark Neff; Kathryn R Robertson; Aaron K Wong; Noa Safra; Karl W Broman; Montgomery Slatkin; Katrina L Mealey; Niels C Pedersen
Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11725-30.
2004: Nathan G Congdon; Karl W Broman; Hong Lai; Beatriz Munoz; Heidi Bowie; Donna Gilber; Robert Wojciechowski; Christine Alston; Sheila K West
Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors.
Investigative ophthalmology & visual science 2004;45(7):2182-6.
2004: Clarke G Tankersley; Karl W Broman
Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(1):77-84.
2004: Clarke G Tankersley; Matthew J Campen; Alexis Bierman; Susan E Flanders; Karl W Broman; Richard Rabold
Particle effects on heart-rate regulation in senescent mice.
Inhalation toxicology 2004;16(6-7):381-90.
2004: Wei-Min Chen; Karl W Broman; Kung-Yee Liang
Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression.
Genetic epidemiology 2004;26(4):265-72.
2004: Sinthuja Sivagnanasundaram; Karl W Broman; Michelle Liu; Arturas Petronis
Quasi-linkage: a confounding factor in linkage analysis of complex diseases?
Human genetics 2004;114(6):588-93.
2004: Tara L Kieffer; Mariel M Finucane; Richard E Nettles; Thomas C Quinn; Karl W Broman; Stuart C Ray; Deborah Persaud; Robert Siliciano
Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads.
The Journal of infectious diseases 2004;189(8):1452-65.
2004: Sining Chen; Wenyi Wang; Karl W Broman; Hormuzd A Katki; Giovanni Parmigiani
BayesMendel: an R environment for Mendelian risk prediction.
Statistical applications in genetics and molecular biology 2004;3():Article21.
2003: Olle Lidman; Maria Swanberg; Linn Horvath; Karl W Broman; Tomas Olsson; Fredrik Piehl
Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(30):9817-23.
2003: Rivka L Glaser; Karl W Broman; Rebecca L Schulman; Brenda Eskenazi; Andrew J Wyrobek; Ethylin Jabs
The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm.
American journal of human genetics 2003;73(4):939-47.
2003: Paul Denny; Elaine Hopes; Neill Gingles; Karl W Broman; William McPheat; John Morten; Janet Alexander; Peter W Andrew; Steve D M Brown
A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(7):448-53.
2003: Gyanu Lamichhane; Matteo Zignol; NATALIE BLADES; Deborah E Geiman; Annette Dougherty; Jacques H Grosset; Karl W Broman; William R Bishai
A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7213-8.
2003: Karl W Broman; Hao Wu; Saunak Sen; Gary Churchill
R/qtl: QTL mapping in experimental crosses.
Bioinformatics (Oxford, England) 2003;19(7):889-90.
2003: Karl W Broman
Mapping quantitative trait loci in the case of a spike in the phenotype distribution.
Genetics 2003;163(3):1169-75.
2003: Karl W Broman; BRIAN CAFFO
Simulation-based P values: response to North et al.
American journal of human genetics 2003;72(2):496.
2003: Kristina Becanovic; Erik Wallstrom; Barbara Kornek; Anna Glaser; Karl W Broman; Ingrid Dahlman; Peter Olofsson; Rikard Holmdahl; Holger Luthman; Hans Lassmann; Tomas Olsson
New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1062-9.
2002: Albert S Jun; Karl W Broman; Diana V Do; Esen Karamursel Akpek; Walter J Stark; John D Gottsch
Endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning (edict) syndrome maps to chromosome 15q22.1-q25.3.
American journal of ophthalmology 2002;134(2):172-6.
2002: Karl W Broman; Lucy B Rowe; Gary Churchill; Kenneth Paigen
Crossover interference in the mouse.
Genetics 2002;160(3):1123-31.
2001: Kent W Hunter; Karl W Broman; T L Voyer; Luanne Lukes; D Cozma; Michael T Debies; Jessica Rouse; Danny R Welch
Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1.
Cancer research 2001;61(24):8866-72.
2001: JD Ravenel; Karl W Broman; Elizabeth J. Perlman; Emily L Niemitz; T M Jayawardena; D W Bell; D A Haber; Hiroshi Uejima; Andrew P Feinberg
Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.
Journal of the National Cancer Institute 2001;93(22):1698-703.
2001: Karl W Broman
Review of statistical methods for QTL mapping in experimental crosses.
Lab animal 2001;30(7):44-52.
2001: Karl W Broman
Estimation of allele frequencies with data on sibships.
Genetic epidemiology 2001;20(3):307-15.
2001: Sabrina Giglio; Karl W Broman; N Matsumoto; Vladimiro Calvari; Giorgio Gimelli; T Neumann; H Ohashi; L Voullaire; D Larizza; Roberto Giorda; James L Weber; David Ledbetter; Orsetta Zuffardi
Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements.
American journal of human genetics 2001;68(4):874-83.
2001: Victor Boyartchuk; Karl W Broman; R E Mosher; Sarah E F D'Orazio; Michael N Starnbach; William F Dietrich
Multigenic control of Listeria monocytogenes susceptibility in mice.
Nature genetics 2001;27(3):259-60.
2001: A Yu; Chengfeng Zhao; Y Fan; W Jang; Andrew Mungall; P Deloukas; A Olsen; Norman A Doggett; Nader Ghebranious; Karl W Broman; James L Weber
Comparison of human genetic and sequence-based physical maps.
Nature 2001;409(6822):951-3.
2001: U Lichter-Konecki; Karl W Broman; E B Blau; DS Konecki
Genetic and physical mapping of the locus for autosomal dominant renal Fanconi syndrome, on chromosome 15q15.3.
American journal of human genetics 2001;68(1):264-8.
2001: J L Weber; Karl W Broman
Genotyping for human whole-genome scans: past, present, and future.
Advances in genetics 2001;42():77-96.
2000: Ahmed H Kissebah; Gabriele E Sonnenberg; Joel Myklebust; M Goldstein; Karl W Broman; R G James; J A Marks; Glenn R Krakower; Howard J Jacob; J Weber; L Martin; John C Blangero; Anthony G Comuzzie
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14478-83.
2000: John S Witte; Katrina Goddard; David V Conti; Robert C Elston; Jennifer Lin; Brian K Suarez; Karl W Broman; James K Burmester; James L Weber; William J Catalona
Genomewide scan for prostate cancer-aggressiveness loci.
American journal of human genetics 2000;67(1):92-9.
2000: Karl W Broman; J L Weber
Characterization of human crossover interference.
American journal of human genetics 2000;66(6):1911-26.
2000: Brian K Suarez; Jennifer Lin; James K Burmester; Karl W Broman; James L Weber; Tarit K Banerjee; Katrina Goddard; John S Witte; Robert C Elston; William J Catalona
A genome screen of multiplex sibships with prostate cancer.
American journal of human genetics 2000;66(3):933-44.
2000: A S Brown; Eleanor Feingold; Karl W Broman; Stephanie L Sherman
Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21.
Human molecular genetics 2000;9(4):515-23.
1999: Karl W Broman; J L Weber
Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain.
American journal of human genetics 1999;65(6):1493-500.
1999: Mark Neff; Karl W Broman; Cathryn S Mellersh; K Ray; Gregory M Acland; G D Aguirre; J S Ziegle; Elaine A Ostrander; Jasper Rine
A second-generation genetic linkage map of the domestic dog, Canis familiaris.
Genetics 1999;151(2):803-20.
1999: Karl W Broman
Cleaning genotype data.
Genetic epidemiology 1999;17 Suppl 1():S79-83.
1999: Karl W Broman; James L Weber
Method for constructing confidently ordered linkage maps.
Genetic epidemiology 1999;16(4):337-43.
1998: Karl W Broman; J L Weber
Estimation of pairwise relationships in the presence of genotyping errors.
American journal of human genetics 1998;63(5):1563-4.
1998: Karl W Broman; J C Murray; V C Sheffield; Raymond White; J L Weber
Comprehensive human genetic maps: individual and sex-specific variation in recombination.
American journal of human genetics 1998;63(3):861-9.
1996: Karl W Broman; T Speed; M Tigges
Estimation of antigen-responsive T cell frequencies in PBMC from human subjects.
Journal of immunological methods 1996;198(2):119-32.
1996: Abby F Dernburg; Karl W Broman; Jennifer Fung; wallace marshall; J Philips; David A Agard; John W Sedat
Perturbation of nuclear architecture by long-distance chromosome interactions.
Cell 1996;85(5):745-59.