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Margherita Zanetti

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Francesca D'Este; Barbara Skerlavaj; Linda Tomasinsig; Margherita Zanetti
Modulation of cytokine gene expression by cathelicidin BMAP-28 in LPS-stimulated and -unstimulated macrophages.
Linda Tomasinsig; Alessandro Tossi; Filomena Guida; Renata Piccinini; Michele Scarsini; Barbara Skerlavaj; Margherita Zanetti
Comparative activity and mechanism of action of three types of bovine antimicrobial peptides against pathogenic Prototheca spp.
Linda Tomasinsig; Gennyfer De Conti; Barbara Skerlavaj; Renata Piccinini; Maria Mazzilli; Francesca D'Este; Alessandro Tossi; Margherita Zanetti
Broad-spectrum activity against bacterial mastitis pathogens and activation of mammary epithelial cells support a protective role of neutrophil cathelicidins in bovine mastitis.

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All Publications

2012: Francesca D'Este; Barbara Skerlavaj; Linda Tomasinsig; Margherita Zanetti
Modulation of cytokine gene expression by cathelicidin BMAP-28 in LPS-stimulated and -unstimulated macrophages.
Immunobiology 2012;217(10):962-71.
2012: Linda Tomasinsig; Alessandro Tossi; Filomena Guida; Renata Piccinini; Michele Scarsini; Barbara Skerlavaj; Margherita Zanetti
Comparative activity and mechanism of action of three types of bovine antimicrobial peptides against pathogenic Prototheca spp.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(2):105-13.
2010: Linda Tomasinsig; Gennyfer De Conti; Barbara Skerlavaj; Renata Piccinini; Maria Mazzilli; Francesca D'Este; Alessandro Tossi; Margherita Zanetti
Broad-spectrum activity against bacterial mastitis pathogens and activation of mammary epithelial cells support a protective role of neutrophil cathelicidins in bovine mastitis.
Infection and immunity 2010;78(4):1781-8.
2009: Linda Tomasinsig; Francesca Morgera; Nikolinka Antcheva; Sabrina Pacor; Barbara Skerlavaj; Margherita Zanetti; Alessandro Tossi
Structure dependence of biological activities for primate cathelicidins.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(9):576-82.
2008: Linda Tomasinsig; Cinzia Pizzirani; Barbara Skerlavaj; Patrizia Pellegatti; Sara Gulinelli; Alessandro Tossi; Francesco Di Virgilio; Margherita Zanetti
The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.
The Journal of biological chemistry 2008;283(45):30471-81.
2008: Oscar Cirioni; Roberto Ghiselli; Linda Tomasinsig; Fiorenza Orlando; Carmela Silvestri; Barbara Skerlavaj; Alessandra Riva; Marco Rocchi; Vittorio Saba; Margherita Zanetti; Giorgio Scalise; Andrea Giacometti
Efficacy of LL-37 and granulocyte colony-stimulating factor in a neutropenic murine sepsis due to Pseudomonas aeruginosa.
Shock (Augusta, Ga.) 2008;30(4):443-8.
2008: Fiorenza Orlando; Roberto Ghiselli; Oscar Cirioni; Daniele Minardi; Linda Tomasinsig; Federico Mocchegiani; Carmela Silvestri; Barbara Skerlavaj; Alessandra Riva; Giovanni Muzzonigro; Vittorio Saba; Giorgio Scalise; Margherita Zanetti; Andrea Giacometti
BMAP-28 improves the efficacy of vancomycin in rat models of gram-positive cocci ureteral stent infection.
Peptides 2008;29(7):1118-23.
2006: Roberto Ghiselli; Oscar Cirioni; Andrea Giacometti; Federico Mocchegiani; Fiorenza Orlando; Cristina Bergnach; Barbara Skerlavaj; Carmela Silvestri; Agnese Della Vittoria; Margherita Zanetti; Marco Rocchi; Giorgio Scalise; Vittorio Saba
Effects of the antimicrobial peptide BMAP-27 in a mouse model of obstructive jaundice stimulated by lipopolysaccharide.
Peptides 2006;27(11):2592-9.
2006: Roberto Ghiselli; Andrea Giacometti; Oscar Cirioni; Giorgio Dell'Acqua; Cristina Bergnach; Fiorenza Orlando; Federico Mocchegiani; Carmela Silvestri; Barbara Skerlavaj; Alberto Licci; Naomi Balaban; Margherita Zanetti; Giorgio Scalise; Vittorio Saba
RNAIII-inhibiting peptide in combination with the cathelicidin BMAP-28 reduces lethality in mouse models of staphylococcal sepsis.
Shock (Augusta, Ga.) 2006;26(3):296-301.
2006: Oscar Cirioni; Andrea Giacometti; Roberto Ghiselli; Cristina Bergnach; Fiorenza Orlando; Federico Mocchegiani; Carmela Silvestri; Alberto Licci; Barbara Skerlavaj; Margherita Zanetti; Vittorio Saba; Giorgio Scalise
Pre-treatment of central venous catheters with the cathelicidin BMAP-28 enhances the efficacy of antistaphylococcal agents in the treatment of experimental catheter-related infection.
Peptides 2006;27(9):2104-10.
2006: Oscar Cirioni; Andrea Giacometti; Roberto Ghiselli; Cristina Bergnach; Fiorenza Orlando; Carmela Silvestri; Federico Mocchegiani; Alberto Licci; Barbara Skerlavaj; Marco Rocchi; Vittorio Saba; Margherita Zanetti; Giorgio Scalise
LL-37 protects rats against lethal sepsis caused by gram-negative bacteria.
Antimicrobial agents and chemotherapy 2006;50(5):1672-9.
2006: Linda Tomasinsig; Barbara Skerlavaj; niv papo; Barbara Giabbai; Yechiel Shai; Margherita Zanetti
Mechanistic and functional studies of the interaction of a proline-rich antimicrobial peptide with mammalian cells.
The Journal of biological chemistry 2006;281(1):383-91.
2005: Margherita Zanetti
The role of cathelicidins in the innate host defenses of mammals.
Current issues in molecular biology 2005;7(2):179-96.
2005: Linda Tomasinsig; Margherita Zanetti
The cathelicidins--structure, function and evolution.
Current protein & peptide science 2005;6(1):23-34.
2004: Andrea Giacometti; Oscar Cirioni; Roberto Ghiselli; Cristina Bergnach; Fiorenza Orlando; Giuseppina D'Amato; Federico Mocchegiani; Carmela Silvestri; Maria Simona Del Prete; Barbara Skerlavaj; Vittorio Saba; Margherita Zanetti; Giorgio Scalise
The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis.
Critical care medicine 2004;32(12):2485-90.
2004: Linda Tomasinsig; Marco Scocchi; Romina Mettulio; Margherita Zanetti
Genome-wide transcriptional profiling of the Escherichia coli response to a proline-rich antimicrobial peptide.
Antimicrobial agents and chemotherapy 2004;48(9):3260-7.
2004: Andrea Giacometti; Oscar Cirioni; Roberto Ghiselli; Federico Mocchegiani; Giuseppina D'Amato; Raffaella Circo; Fiorenza Orlando; Barbara Skerlavaj; Carmela Silvestri; Vittorio Saba; Margherita Zanetti; Giorgio Scalise
Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock.
American journal of respiratory and critical care medicine 2004;169(2):187-94.
2004: Margherita Zanetti
Cathelicidins, multifunctional peptides of the innate immunity.
Journal of leukocyte biology 2004;75(1):39-48.
2003: Monica Benincasa; Barbara Skerlavaj; Renato Gennaro; Antonio Pellegrini; Margherita Zanetti
In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs.
Peptides 2003;24(11):1723-31.
2003: Alessandra Arzese; Barbara Skerlavaj; Linda Tomasinsig; Renato Gennaro; Margherita Zanetti
Antimicrobial activity of SMAP-29 against the Bacteroides fragilis group and clostridia.
The Journal of antimicrobial chemotherapy 2003;52(3):375-81.
2003: Roberto Ghiselli; Andrea Giacometti; Oscar Cirioni; Raffaella Circo; Federico Mocchegiani; Barbara Skerlavaj; Giuseppina D'Amato; Giorgio Scalise; Margherita Zanetti; Vittorio Saba
Neutralization of endotoxin in vitro and in vivo by Bac7(1-35), a proline-rich antibacterial peptide.
Shock (Augusta, Ga.) 2003;19(6):577-81.
2003: Andrea Giacometti; Oscar Cirioni; Maria Simona Del Prete; Barbara Skerlavaj; Raffaella Circo; Margherita Zanetti; Giorgio Scalise
In vitro effect on Cryptosporidium parvum of short-term exposure to cathelicidin peptides.
The Journal of antimicrobial chemotherapy 2003;51(4):843-7.
2002: Linda Tomasinsig; Marco Scocchi; Carla Di Loreto; Daria Artico; Margherita Zanetti
Inducible expression of an antimicrobial peptide of the innate immunity in polymorphonuclear leukocytes.
Journal of leukocyte biology 2002;72(5):1003-10.
2002: Raffaella Circo; Barbara Skerlavaj; Renato Gennaro; Antonio Amoroso; Margherita Zanetti
Structural and functional characterization of hBD-1(Ser35), a peptide deduced from a DEFB1 polymorphism.
Biochemical and biophysical research communications 2002;293(1):586-92.
2002: Angela Risso; Enrico Braidot; Maria Concetta Sordano; Angelo Vianello; Francesco Macrì; Barbara Skerlavaj; Margherita Zanetti; Renato Gennaro; Paolo Bernardi
BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore.
Molecular and cellular biology 2002;22(6):1926-35.
2002: Margherita Zanetti; Renato Gennaro; Barbara Skerlavaj; Linda Tomasinsig; Raffaella Circo
Cathelicidin peptides as candidates for a novel class of antimicrobials.
Current pharmaceutical design 2002;8(9):779-93.
2002: Renato Gennaro; Margherita Zanetti; Monica Benincasa; Elena Podda; Monica Miani
Pro-rich antimicrobial peptides from animals: structure, biological functions and mechanism of action.
Current pharmaceutical design 2002;8(9):763-78.
2001: Barbara Skerlavaj; Marco Scocchi; Renato Gennaro; Angela Risso; Margherita Zanetti
Structural and functional analysis of horse cathelicidin peptides.
Antimicrobial agents and chemotherapy 2001;45(3):715-22.
2000: Renato Gennaro; Margherita Zanetti
Structural features and biological activities of the cathelicidin-derived antimicrobial peptides.
Biopolymers 2000;55(1):31-49.
2000: Margherita Zanetti; Renato Gennaro; Marco Scocchi; Barbara Skerlavaj
Structure and biology of cathelicidins.
Advances in experimental medicine and biology 2000;479():203-18.
1999: Barbara Skerlavaj; Monica Benincasa; Angela Risso; Margherita Zanetti; Renato Gennaro
SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes.
FEBS letters 1999;463(1-2):58-62.
1999: Marco Scocchi; D Bontempo; Sabrina Boscolo; Linda Tomasinsig; E Giulotto; Margherita Zanetti
Novel cathelicidins in horse leukocytes(1).
FEBS letters 1999;457(3):459-64.
1998: Angela Risso; Margherita Zanetti; Renato Gennaro
Cytotoxicity and apoptosis mediated by two peptides of innate immunity.
Cellular immunology 1998;189(2):107-15.
1998: Renato Gennaro; Marco Scocchi; L Merluzzi; Margherita Zanetti
Biological characterization of a novel mammalian antimicrobial peptide.
Biochimica et biophysica acta 1998;1425(2):361-8.
1998: Marco Scocchi; S Wang; Renato Gennaro; Margherita Zanetti
Cloning and analysis of a transcript derived from two contiguous genes of the cathelicidin family.
Biochimica et biophysica acta 1998;1398(3):393-6.
1997: Margherita Zanetti; Renato Gennaro; Domenico Romeo
The cathelicidin family of antimicrobial peptide precursors: a component of the oxygen-independent defense mechanisms of neutrophils.
Annals of the New York Academy of Sciences 1997;832():147-62.
1997: Marco Scocchi; S Wang; Margherita Zanetti
Structural organization of the bovine cathelicidin gene family and identification of a novel member.
FEBS letters 1997;417(3):311-5.
1997: Alessandro Tossi; Marco Scocchi; Margherita Zanetti; Renato Gennaro; P Storici; Domenico Romeo
An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides.
Methods in molecular biology (Clifton, N.J.) 1997;78():133-50.
1996: B Skerlavaj; Renato Gennaro; L Bagella; L Merluzzi; Angela Risso; Margherita Zanetti
Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
The Journal of biological chemistry 1996;271(45):28375-81.
1995: L Bagella; Marco Scocchi; Margherita Zanetti
cDNA sequences of three sheep myeloid cathelicidins.
FEBS letters 1995;376(3):225-8.
1995: Margherita Zanetti; Renato Gennaro; Domenico Romeo
Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain.
FEBS letters 1995;374(1):1-5.
1995: Alessandro Tossi; Marco Scocchi; Margherita Zanetti; P Storici; Renato Gennaro
PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.
European journal of biochemistry / FEBS 1995;228(3):941-6.
1994: Marco Scocchi; Domenico Romeo; Margherita Zanetti
Molecular cloning of Bac7, a proline- and arginine-rich antimicrobial peptide from bovine neutrophils.
FEBS letters 1994;352(2):197-200.
1994: Margherita Zanetti; P Storici; Alessandro Tossi; Marco Scocchi; Renato Gennaro
Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.
The Journal of biological chemistry 1994;269(11):7855-8.
1994: P Storici; Marco Scocchi; Alessandro Tossi; Renato Gennaro; Margherita Zanetti
Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA.
FEBS letters 1994;337(3):303-7.
1993: D Verbanac; Margherita Zanetti; Domenico Romeo
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors.
FEBS letters 1993;317(3):255-8.
1993: Margherita Zanetti; G Del Sal; P Storici; C Schneider; Domenico Romeo
The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.
The Journal of biological chemistry 1993;268(1):522-6.
1992: P Storici; G Del Sal; C Schneider; Margherita Zanetti
cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils.
FEBS letters 1992;314(2):187-90.
1992: G Del Sal; P Storici; C Schneider; Domenico Romeo; Margherita Zanetti
cDNA cloning of the neutrophil bactericidal peptide indolicidin.
Biochemical and biophysical research communications 1992;187(1):467-72.