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Vassilis Zannis

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Co-Publications
Name
31
Kardassis, Dimitris
19
Kan, Horng-Yuan
17
Kypreos, Kyriakos
16
Chroni, Angeliki
16
Hadzopoulou-Cladaras, Margarita
9
Talianidis, Iannis
8
Chambaz, Jean
8
Liu, Tong
7
Krieger, Monty
7
Havekes, Louis
7
Willems van Dijk, Ko
6
Gorshkova, Irina
6
Cardot, Philippe
5
Atkinson, David
5
Koukos, Georgios

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Publications

TOP 3
Gorshkova Irina N; Kypreos Kyriakos E; Gantz Donald L; Zannis Vassilis I; Atkinson David
Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.
Chroni Angeliki; Pyrpassopoulos Serapion; Thanassoulas Angelos; Nounesis George; Zannis Vassilis I; Stratikos Efstratios
Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties.
Zannis Vassilis I; Koukos Georgios; Drosatos Konstantinos; Vezeridis Alexander; Zanni Eleni E; Kypreos Kyriakos E; Chroni Angeliki
Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.

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All Publications

2008: Gorshkova Irina N; Kypreos Kyriakos E; Gantz Donald L; Zannis Vassilis I; Atkinson David
Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.
Biochemistry 2008;47(47):12644-54.
2008: Chroni Angeliki; Pyrpassopoulos Serapion; Thanassoulas Angelos; Nounesis George; Zannis Vassilis I; Stratikos Efstratios
Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties.
Biochemistry 2008;47(35):9071-80.
2008: Zannis Vassilis I; Koukos Georgios; Drosatos Konstantinos; Vezeridis Alexander; Zanni Eleni E; Kypreos Kyriakos E; Chroni Angeliki
Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.
Annals of medicine 2008;40 Suppl 1():14-28.
2008: Nieland Thomas J F; Shaw Jared T; Jaipuri Firoz A; Duffner Jay L; Koehler Angela N; Banakos Sotirios; Zannis Vassilis I; Kirchhausen Tomas; Krieger Monty
Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Biochemistry 2008;47(1):460-72.
2007: Thymiakou Efstathia; Zannis Vassilis I; Kardassis Dimitris
Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.
Biochemistry 2007;46(41):11473-83.
2007: Koukos Georgios; Chroni Angeliki; Duka Adelina; Kardassis Dimitris; Zannis Vassilis I
LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
Biochemistry 2007;46(37):10713-21.
2007: Drosatos Konstantinos; Kypreos Kyriakos E; Zannis Vassilis I
Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.
Biochemistry 2007;46(33):9645-53.
2007: Koukos Georgios; Chroni Angeliki; Duka Adelina; Kardassis Dimitris; Zannis Vassilis I
Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.
The Biochemical journal 2007;406(1):167-74.
2007: Gafencu Anca V; Robciuc Marius R; Fuior Elena; Zannis Vassilis I; Kardassis Dimitris; Simionescu Maya
Inflammatory signaling pathways regulating ApoE gene expression in macrophages.
The Journal of biological chemistry 2007;282(30):21776-85.
2007: Drosatos Konstantinos; Sanoudou Despina; Kypreos Kyriakos E; Kardassis Dimitris; Zannis Vassilis I
A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice.
The Journal of biological chemistry 2007;282(27):19556-64.
2007: Chroni Angeliki; Koukos Georgios; Duka Adelina; Zannis Vassilis I
The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.
Biochemistry 2007;46(19):5697-708.
2007: Kypreos Kyriakos E; Zannis Vassilis I
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
The Biochemical journal 2007;403(2):359-67.
2006: Nikolaidou-Neokosmidou Varvara; Zannis Vassilis I; Kardassis Dimitris
Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway.
The Biochemical journal 2006;398(3):439-50.
2006: Singaraja Roshni R; Visscher Henk; James Erick R; Chroni Angeliki; Coutinho Jonathan M; Brunham Liam R; Kang Martin H; Zannis Vassilis I; Chimini Giovanna; Hayden Michael R
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
Circulation research 2006;99(4):389-97.
2006: Zannis Vassilis I; Chroni Angeliki; Krieger Monty
Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.
Journal of molecular medicine (Berlin, Germany) 2006;84(4):276-94.
2006: Kypreos Kyriakos E; Zannis Vassilis I
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice.
Journal of lipid research 2006;47(3):521-9.
2006: Gorshkova Irina N; Liu Tong; Kan Horng-Yuan; Chroni Angeliki; Zannis Vassilis I; Atkinson David
Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation.
Biochemistry 2006;45(4):1242-54.
2005: Chroni Angeliki; Duka Adelina; Kan Horng-Yuan; Liu Tong; Zannis Vassilis I
Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Biochemistry 2005;44(43):14353-66.
2005: Chroni Angeliki; Nieland Thomas J F; Kypreos Kyriakos E; Krieger Monty; Zannis Vassilis I
SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.
Biochemistry 2005;44(39):13132-43.
2005: Gerritsen Gery; Rensen Patrick C N; Kypreos Kyriakos E; Zannis Vassilis I; Havekes Louis M; Willems van Dijk Ko
ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
Journal of lipid research 2005;46(7):1466-73.
2005: Chroni Angeliki; Kan Horng-Yuan; Shkodrani Adelina; Liu Tong; Zannis Vassilis I
Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.
Biochemistry 2005;44(10):4108-17.
2005: Kypreos Kyriakos E; van Dijk Ko W; Havekes Louis M; Zannis Vassilis I
Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia.
The Journal of biological chemistry 2005;280(8):6276-84.
2004: Chroni Angeliki; Kan Horng-Yuan; Kypreos Kyriakos E; Gorshkova Irina N; Shkodrani Adelina; Zannis Vassilis I
Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.
Biochemistry 2004;43(32):10442-57.
2004: Nieland Thomas J F; Chroni Angeliki; Fitzgerald Michael L; Maliga Zoltan; Zannis Vassilis I; Kirchhausen Tomas; Krieger Monty
Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.
Journal of lipid research 2004;45(7):1256-65.
2004: Kan Horng-Yuan; Georgopoulos Spiros; Zanni Markella; Shkodrani Adelina; Tzatsos Alexandros; Xie Hou Xiang; Zannis Vassilis I
Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice.
Biochemistry 2004;43(17):5084-93.
2004: Zannis Vassilis I; Chroni Angeliki; Kypreos Kyriakos E; Kan Horng-Yuan; Cesar Thais Borges; Zanni Eleni E; Kardassis Dimitris
Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.
Current opinion in lipidology 2004;15(2):151-66.
2004: Chroni Angeliki; Liu Tong; Fitzgerald Michael L; Freeman Mason W; Zannis Vassilis I
Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.
Biochemistry 2004;43(7):2126-39.
2004: Fitzgerald M L; Morris A L; Chroni A; Mendez A J; Zannis V I; Freeman M W
ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.
Journal of lipid research 2004;45(2):287-94.
2003: Hatzivassiliou Eudoxia; Koukos George; Ribeiro Agnes; Zannis Vassilis; Kardassis Dimitris
Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta and upstream stimulatory factor 2a.
The Biochemical journal 2003;376(Pt 2):423-31.
2003: Li Xiaoping; Kypreos Kyriakos; Zanni Eleni E; Zannis Vassilis
Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.
Biochemistry 2003;42(35):10406-17.
2003: Kypreos Kyriakos E; Li Xiaoping; van Dijk Ko Willems; Havekes Louis M; Zannis Vassilis I
Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.
Biochemistry 2003;42(33):9841-53.
2003: Kardassis Dimitris; Roussou Anastasia; Papakosta Paraskevi; Boulias Konstantinos; Talianidis Iannis; Zannis Vassilis I
Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids.
The Biochemical journal 2003;372(Pt 2):291-304.
2003: Zannis Vassilis I; Liu Tong; Zanni Markella; Kan Horng-Yuan; Kardassis Dimitris
Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(4):411-24.
2003: Chou Wan-Chih; Prokova Vassiliki; Shiraishi Keiko; Valcourt Ulrich; Moustakas Aristidis; Hadzopoulou-Cladaras Margarita; Zannis Vassilis I; Kardassis Dimitris
Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4.
Molecular biology of the cell 2003;14(3):1279-94.
2003: Gerritsen Gery; Kypreos Kyriakos E; van der Zee André; Teusink Bas; Zannis Vassilis I; Havekes Louis M; van Dijk Ko Willems
Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.
Journal of lipid research 2003;44(2):408-14.
2003: Chroni Angeliki; Liu Tong; Gorshkova Irina; Kan Horng-Yuan; Uehara Yoshinari; Von Eckardstein Arnold; Zannis Vassilis I
The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.
The Journal of biological chemistry 2003;278(9):6719-30.
2002: Gorshkova Irina N; Liu Tong; Zannis Vassilis I; Atkinson David
Lipid-free structure and stability of apolipoprotein A-I: probing the central region by mutation.
Biochemistry 2002;41(33):10529-39.
2002: Georgopoulos Spiros; McKee Ann; Kan Horng-Yuan; Zannis Vassilis I
Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells.
Biochemistry 2002;41(30):9293-301.
2002: Liu Tong; Krieger Monty; Kan Horng-Yuan; Zannis Vassilis I
The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport.
The Journal of biological chemistry 2002;277(24):21576-84.
2002: Li Xiaoping; Kan Horng-Yuan; Lavrentiadou Sophia; Krieger Monty; Zannis Vassilis
Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.
The Journal of biological chemistry 2002;277(24):21149-57.
2002: Kardassis Dimitris; Falvey Eileen; Tsantili Panayota; Hadzopoulou-Cladaras Margarita; Zannis Vassilis
Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.
Biochemistry 2002;41(4):1217-28.
2001: Reardon C A; Kan H Y; Cabana V; Blachowicz L; Lukens J R; Wu Q; Liadaki K; Getz G S; Zannis V I
In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice.
Biochemistry 2001;40(45):13670-80.
2001: Kypreos K E; Teusink B; Van Dijk K W; Havekes L M; Zannis V I
Analysis of the structure and function relationship of the human apolipoprotein E in vivo, using adenovirus-mediated gene transfer.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1598-600.
2001: Kypreos K E; van Dijk K W; van Der Zee A; Havekes L M; Zannis V I
Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.
The Journal of biological chemistry 2001;276(23):19778-86.
2001: Kypreos K E; Morani P; van Dijk K W; Havekes L M; Zannis V I
The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.
Biochemistry 2001;40(20):6027-35.
2001: Zannis V I; Kan H Y; Kritis A; Zanni E E; Kardassis D
Transcriptional regulatory mechanisms of the human apolipoprotein genes in vitro and in vivo.
Current opinion in lipidology 2001;12(2):181-207.
2001: Zannis V I; Kan H Y; Kritis A; Zanni E; Kardassis D
Transcriptional regulation of the human apolipoprotein genes.
Frontiers in bioscience : a journal and virtual library 2001;6():D456-504.
2001: Herscovitz H; Derksen A; Walsh M T; McKnight C J; Gantz D L; Hadzopoulou-Cladaras M; Zannis V; Curry C; Small D M
The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins.
Journal of lipid research 2001;42(1):51-9.
2000: Gorshkova I N; Liadaki K; Gursky O; Atkinson D; Zannis V I
Probing the lipid-free structure and stability of apolipoprotein A-I by mutation.
Biochemistry 2000;39(51):15910-9.
2000: Georgopoulos S; Kan H Y; Reardon-Alulis C; Zannis V
The SP1 sites of the human apoCIII enhancer are essential for the expression of the apoCIII gene and contribute to the hepatic and intestinal expression of the apoA-I gene in transgenic mice.
Nucleic acids research 2000;28(24):4919-29.
2000: Kardassis D; Pardali K; Zannis V I
SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4.
The Journal of biological chemistry 2000;275(52):41405-14.
2000: Kan H Y; Georgopoulos S; Zannis V
A hormone response element in the human apolipoprotein CIII (ApoCIII) enhancer is essential for intestinal expression of the ApoA-I and ApoCIII genes and contributes to the hepatic expression of the two linked genes in transgenic mice.
The Journal of biological chemistry 2000;275(39):30423-31.
2000: Segrest J P; Harvey S C; Zannis V
Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.
Trends in cardiovascular medicine 2000;10(6):246-52.
2000: Carraway M; Herscovitz H; Zannis V; Small D M
Specificity of lipid incorporation is determined by sequences in the N-terminal 37 of apoB.
Biochemistry 2000;39(32):9737-45.
2000: Liadaki K N; Liu T; Xu S; Ishida B Y; Duchateaux P N; Krieger J P; Kane J; Krieger M; Zannis V I
Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding.
The Journal of biological chemistry 2000;275(28):21262-71.
2000: Segrest J P; Li L; Anantharamaiah G M; Harvey S C; Liadaki K N; Zannis V
Structure and function of apolipoprotein A-I and high-density lipoprotein.
Current opinion in lipidology 2000;11(2):105-15.
2000: Zannis V I; Cohen J
Old and new players in the lipoprotein system.
Current opinion in lipidology 2000;11(2):101-3.
1999: Aleshkov S B; Li X; Lavrentiadou S N; Zannis V I
Contribution of cysteine 158, the glycosylation site threonine 194, the amino- and carboxy-terminal domains of apolipoprotein E in the binding to amyloid peptide beta (1-40).
Biochemistry 1999;38(28):8918-25.
1999: Pissios P; Kan H Y; Nagaoka S; Zannis V I
SREBP-1 binds to multiple sites and transactivates the human ApoA-II promoter in vitro : SREBP-1 mutants defective in DNA binding or transcriptional activation repress ApoA-II promoter activity.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(6):1456-69.
1999: Le Beyec J; Chauffeton V; Kan H Y; Janvier P L; Cywiner-Golenzer C; Chatelet F P; Kalopissis A D; Zannis V; Chambaz J; Pinçon-Raymond M; Cardot P
The -700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene.
The Journal of biological chemistry 1999;274(8):4954-61.
1999: Kan H Y; Pissios P; Chambaz J; Zannis V I
DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter.
Nucleic acids research 1999;27(4):1104-17.
1999: Lavrentiadou S N; Hadzopoulou-Cladaras M; Kardassis D; Zannis V I
Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors.
Biochemistry 1999;38(3):964-75.
1998: Hadzopoulou-Cladaras M; Lavrentiadou S N; Zannis V I; Kardassis D
Transactivation of the ApoCIII promoter by ATF-2 and repression by members of the Jun family.
Biochemistry 1998;37(40):14078-87.
1998: Kardassis D; Sacharidou E; Zannis V I
Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.
The Journal of biological chemistry 1998;273(28):17810-6.
1998: Vorgia P; Zannis V I; Kardassis D
A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2.
The Journal of biological chemistry 1998;273(7):4188-96.
1997: Lacorte J M; Ktistaki E; Beigneux A; Zannis V I; Chambaz J; Talianidis I
Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression.
The Journal of biological chemistry 1997;272(38):23578-84.
1997: Aleshkov S; Abraham C R; Zannis V I
Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.
Biochemistry 1997;36(34):10571-80.
1997: Xu S; Laccotripe M; Huang X; Rigotti A; Zannis V I; Krieger M
Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake.
Journal of lipid research 1997;38(7):1289-98.
1997: Hatzivassiliou E; Cardot P; Zannis V I; Mitsialis S A
Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter.
Biochemistry 1997;36(30):9221-31.
1997: Laccotripe M; Makrides S C; Jonas A; Zannis V I
The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein.
The Journal of biological chemistry 1997;272(28):17511-22.
1997: Kardassis D; Tzameli I; Hadzopoulou-Cladaras M; Talianidis I; Zannis V
Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal enhancer sites.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(1):222-32.
1996: Kritis A A; Argyrokastritis A; Moschonas N K; Power S; Katrakili N; Zannis V I; Cereghini S; Talianidis I
Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4.
Gene 1996;173(2):275-80.
1996: Tzameli I; Zannis V I
Binding specificity and modulation of the ApoA-I promoter activity by homo- and heterodimers of nuclear receptors.
The Journal of biological chemistry 1996;271(14):8402-15.
1996: Kardassis D; Laccotripe M; Talianidis I; Zannis V
Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene regulation.
Hypertension 1996;27(4):980-1008.
1995: Talianidis I; Tambakaki A; Toursounova J; Zannis V I
Complex interactions between SP1 bound to multiple distal regulatory sites and HNF-4 bound to the proximal promoter lead to transcriptional activation of liver-specific human APOCIII gene.
Biochemistry 1995;34(32):10298-309.
1995: Herscovitz H; Kritis A; Talianidis I; Zanni E; Zannis V; Small D M
Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):659-63.
1994: Ktistaki E; Lacorte J M; Katrakili N; Zannis V I; Talianidis I
Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene.
Nucleic acids research 1994;22(22):4689-96.
1994: Cardot P; Pastier D; Lacorte J M; Mangeney M; Zannis V I; Chambaz J
Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.
Biochemistry 1994;33(40):12139-48.
1994: Lopez J; Roghani A; Bertrand J; Zanni E; Kalopissis A; Zannis V I; Chambaz J
Intracellular early and late modifications of human apolipoprotein A-II. Effect of glutamine- +1 to leucine substitution.
Biochemistry 1994;33(13):4056-64.
1993: Kritis A A; Ktistaki E; Barda D; Zannis V I; Talianidis I
An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.
Nucleic acids research 1993;21(25):5882-9.
1993: Cardot P; Chambaz J; Kardassis D; Cladaras C; Zannis V I
Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription.
Biochemistry 1993;32(35):9080-93.
1993: Zannis V I; Kardassis D; Zanni E E
Genetic mutations affecting human lipoproteins, their receptors, and their enzymes.
Advances in human genetics 1993;21():145-319.
1992: Minnich A; Collet X; Roghani A; Cladaras C; Hamilton R L; Fielding C J; Zannis V I
Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding.
The Journal of biological chemistry 1992;267(23):16553-60.
1992: Ladias J A; Hadzopoulou-Cladaras M; Kardassis D; Cardot P; Cheng J; Zannis V; Cladaras C
Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.
The Journal of biological chemistry 1992;267(22):15849-60.
1992: Herscovitz H; Gantz D; Tercyak A M; Zannis V I; Small D M
Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs.
Journal of lipid research 1992;33(6):791-803.
1992: Kardassis D; Zannis V I; Cladaras C
Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene.
The Journal of biological chemistry 1992;267(11):7956.
1992: Kardassis D; Zannis V I; Cladaras C
Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene.
The Journal of biological chemistry 1992;267(4):2622-32.
1991: Cardot P; Chambaz J; Cladaras C; Zannis V I
Regulation of the human ApoA-II gene by the synergistic action of factors binding to the proximal and distal regulatory elements.
The Journal of biological chemistry 1991;266(36):24460-70.
1991: Herscovitz H; Hadzopoulou-Cladaras M; Walsh M T; Cladaras C; Zannis V I; Small D M
Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7313-7.
1991: Chambaz J; Cardot P; Pastier D; Zannis V I; Cladaras C
Promoter elements and factors required for hepatic transcription of the human ApoA-II gene.
The Journal of biological chemistry 1991;266(18):11676-85.
1991: Ogami K; Kardassis D; Cladaras C; Zannis V I
Purification and characterization of a heat stable nuclear factor CIIIB1 involved in the regulation of the human ApoC-III gene.
The Journal of biological chemistry 1991;266(15):9640-6.
1991: Hussain M M; Roghani A; Cladaras C; Zanni E E; Zannis V I
Secretion of lipid-poor nascent human apolipoprotein apoAI, apoCIII, and apoE by cell clones expressing the corresponding genes.
Electrophoresis 1991;12(4):273-83.
1991: Lenich C M; Chobanian A V; Brecher P; Zannis V I
Effect of dietary cholesterol and alloxan-diabetes on tissue cholesterol and apolipoprotein E mRNA levels in the rabbit.
Journal of lipid research 1991;32(3):431-8.
1991: Papazafiri P; Ogami K; Ramji D P; Nicosia A; Monaci P; Cladaras C; Zannis V I
Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites.
The Journal of biological chemistry 1991;266(9):5790-7.
1991: Flordellis C S; Handy D E; Bresnahan M R; Zannis V I; Gavras H
Cloning and expression of a rat brain alpha 2B-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):1019-23.
1991: Zannis V I; Kardassis D; Ogami K; Hadzopoulou-Cladaras M; Cladaras C
Transcriptional regulation of the human apolipoprotein genes.
Advances in experimental medicine and biology 1991;285():1-23.
1990: Kardassis D; Zannis V I; Cladaras C
Purification and characterization of the nuclear factor BA1. A transcriptional activator of the human apoB gene.
The Journal of biological chemistry 1990;265(35):21733-40.
1990: Kardassis D; Hadzopoulou-Cladaras M; Ramji D P; Cortese R; Zannis V I; Cladaras C
Characterization of the promoter elements required for hepatic and intestinal transcription of the human apoB gene: definition of the DNA-binding site of a tissue-specific transcriptional factor.
Molecular and cellular biology 1990;10(6):2653-9.
1990: Ogami K; Hadzopoulou-Cladaras M; Cladaras C; Zannis V I
Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.
The Journal of biological chemistry 1990;265(17):9808-15.
1990: Flordellis C S; Castellano M; Franco R; Zannis V I; Gavras H
Expression of multiple alpha 2-adrenergic receptor messenger RNA species in rat tissues.
Hypertension 1990;15(6 Pt 2):881-7.
1990: Bresnahan M R; Flordellis C S; Vassilatis D K; Makrides S C; Zannis V I; Gavras H
High level of expression of functional human platelet alpha 2-adrenergic receptors in a stable mouse C127 cell line.
Biochimica et biophysica acta 1990;1052(3):439-45.
1990: Hussain M M; Zannis V I
Intracellular modification of human apolipoprotein AII (apoAII) and sites of apoAII mRNA synthesis: comparison of apoAII with apoCII and apoCIII isoproteins.
Biochemistry 1990;29(1):209-17.
1989: Hussain M M; Zannis V I; Plaitakis A
Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines.
The Journal of biological chemistry 1989;264(34):20730-5.
1989: Zanni E E; Kouvatsi A; Hadzopoulou-Cladaras M; Krieger M; Zannis V I
Expression of ApoE gene in Chinese hamster cells with a reversible defect in O-glycosylation. Glycosylation is not required for apoE secretion.
The Journal of biological chemistry 1989;264(16):9137-40.
1989: Hussain M M; Zanni E E; Kelly M; Zannis V I
Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins.
Biochimica et biophysica acta 1989;1001(1):90-101.
1989: Zannis V I
Molecular biology of human apolipoproteins B and E and associated diseases of lipoprotein metabolism.
Advances in lipid research 1989;23():1-64.
1988: Roghani A; Zannis V I
Mutagenesis of the glycosylation site of human ApoCIII. O-linked glycosylation is not required for ApoCIII secretion and lipid binding.
The Journal of biological chemistry 1988;263(34):17925-32.
1988: Makrides S C; Mulinari R; Zannis V I; Gavras H
Regulation of renin gene expression in hypertensive rats.
Hypertension 1988;12(4):405-10.
1988: Roghani A; Zannis V I
Alterations of the glutamine residues of human apolipoprotein AI propeptide by in vitro mutagenesis. Characterization of the normal and mutant protein forms.
Biochemistry 1988;27(19):7428-35.
1988: Hussain M M; Bucher N L; Faris B; Franzblau C; Zannis V I
Tissue-specific posttranslational modification of rat apoE. Synthesis of sialated apoE forms by neonatal rat aortic smooth muscle cells.
Journal of lipid research 1988;29(7):915-23.
1988: Lenich C; Brecher P; Makrides S; Chobanian A; Zannis V I
Apolipoprotein gene expression in the rabbit: abundance, size, and distribution of apolipoprotein mRNA species in different tissues.
Journal of lipid research 1988;29(6):755-64.
1988: Mavrothalassitis G; Tzimagiorgis G; Mitsialis A; Zannis V; Plaitakis A; Papamatheakis J; Moschonas N
Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3494-8.
1988: Makrides S C; Ruiz-Opazo N; Hayden M; Nussbaum A L; Breslow J L; Zannis V I
Sequence and expression of Tangier apoA-I gene.
European journal of biochemistry / FEBS 1988;173(2):465-71.
1988: Ruiz-Opazo N; Zannis V I
Expression of the human apolipoprotein A-I gene in rat myogenic L6E9 cells. DNA methylation and regulation of gene activity.
The Journal of biological chemistry 1988;263(4):1739-44.
1988: Zannis V I; Hussain M M; Hadzopoulou-Cladaras M; Kouvatsi A; Kardassis D; Cladaras C
Molecular biology of human apolipoprotein B and related diseases.
Advances in experimental medicine and biology 1988;243():107-21.
1987: Zanni E E; Zannis V I; Blum C B; Herbert P N; Breslow J L
Effect of egg cholesterol and dietary fats on plasma lipids, lipoproteins, and apoproteins of normal women consuming natural diets.
Journal of lipid research 1987;28(5):518-27.
1987: Cladaras C; Hadzopoulou-Cladaras M; Felber B K; Pavlakis G; Zannis V I
The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene.
The Journal of biological chemistry 1987;262(5):2310-5.
1986: Cladaras C; Hadzopoulou-Cladaras M; Nolte R T; Atkinson D; Zannis V I
The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms.
The EMBO journal 1986;5(13):3495-507.
1986: Zannis V I; vanderSpek J; Silverman D
Intracellular modifications of human apolipoprotein E.
The Journal of biological chemistry 1986;261(29):13415-21.
1986: Zanni E E; Stephan Z F; Zannis V I; Breslow J L; Hayes K C
ApoE distribution among lipoproteins of rhesus monkeys is modulated by dietary fat and cholesterol.
The Journal of nutrition 1986;116(9):1611-9.
1986: Cladaras C; Hadzopoulou-Cladaras M; Avila R; Nussbaum A L; Nicolosi R; Zannis V I
Complementary DNA derived structure of the amino-terminal domain of human apolipoprotein B and size of its messenger RNA transcript.
Biochemistry 1986;25(19):5351-7.
1986: Karathanasis S K; Yunis I; Zannis V I
Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV.
Biochemistry 1986;25(13):3962-70.
1986: Zannis V I
Genetic polymorphism in human apolipoprotein E.
Methods in enzymology 1986;128():823-51.
1986: Karathanasis S K; Zannis V I; Breslow J L
Characterization of the apolipoprotein A-I-C-III gene complex.
Methods in enzymology 1986;128():712-26.
1986: Zannis V I; Karathanasis S K; Forbes G M; Breslow J L
Intra- and extracellular modifications of apolipoproteins.
Methods in enzymology 1986;128():690-712.
1985: Zannis V I; Nicolosi R J; Jensen E; Breslow J L; Hayes K C
Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.
Journal of lipid research 1985;26(12):1421-30.
1985: Zannis V I; Ordovas J M; Cladaras C; Cole F S; Forbes G; Schaefer E J
mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency.
The Journal of biological chemistry 1985;260(24):12891-4.
1985: Zannis V I; Cole F S; Jackson C L; Kurnit D M; Karathanasis S K
Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages.
Biochemistry 1985;24(16):4450-5.
1985: Karathanasis S K; Zannis V I; Breslow J L
Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles.
Journal of lipid research 1985;26(4):451-6.
1985: Zannis V I; Breslow J L
Genetic mutations affecting human lipoprotein metabolism.
Advances in human genetics 1985;14():125-215, 383-6.
1984: Nicolosi R J; Zannis V I
Apolipoprotein A-I of primates.
Journal of lipid research 1984;25(9):879-87.
1984: Zannis V I; McPherson J; Goldberger G; Karathanasis S K; Breslow J L
Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
The Journal of biological chemistry 1984;259(9):5495-9.
1983: Karathanasis S K; Zannis V I; Breslow J L
Isolation and characterization of the human apolipoprotein A-I gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(20):6147-51.
1983: Karathanasis S K; Zannis V I; Breslow J L
A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis.
Nature 1983;305(5937):823-5.
1983: Fisher E A; Blum C B; Zannis V I; Breslow J L
Independent effects of dietary saturated fat and cholesterol on plasma lipids, lipoproteins, and apolipoprotein E.
Journal of lipid research 1983;24(8):1039-48.
1983: Karathanasis S K; McPherson J; Zannis V I; Breslow J L
Linkage of human apolipoproteins A-I and C-III genes.
Nature 1983;304(5924):371-3.
1983: Zannis V I; Karathanasis S K; Keutmann H T; Goldberger G; Breslow J L
Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2574-8.
1983: Karathanasis S K; Norum R A; Zannis V I; Breslow J L
An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis.
Nature 1983;301(5902):718-20.
1982: Breslow J L; McPherson J; Nussbaum A L; Williams H W; Lofquist-Kahl F; Karathanasis S K; Zannis V I
Identification and DNA sequence of a human apolipoprotein E cDNA clone.
The Journal of biological chemistry 1982;257(24):14639-41.
1982: Breslow J L; Zannis V I; SanGiacomo T R; Third J L; Tracy T; Glueck C J
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2.
Journal of lipid research 1982;23(8):1224-35.
1982: Breslow J L; Ross D; McPherson J; Williams H; Kurnit D; Nussbaum A L; Karathanasis S K; Zannis V I
Isolation and characterization of cDNA clones for human apolipoprotein A-I.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(22):6861-5.
1982: Zannis V I; Breslow J L; Utermann G; Mahley R W; Weisgraber K H; Havel R J; Goldstein J L; Brown M S; Schonfeld G; Hazzard W R; Blum C
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.
Journal of lipid research 1982;23(6):911-4.
1982: Zannis V I; Lees A M; Lees R S; Breslow J L
Abnormal apoprotein A-I isoprotein composition in patients with Tangier disease.
The Journal of biological chemistry 1982;257(9):4978-86.
1982: Zannis V I; Breslow J L
Apolipoprotein E.
Molecular and cellular biochemistry 1982;42(1):3-20.
1982: Zannis V I; Kurnit D M; Breslow J L
Hepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.
The Journal of biological chemistry 1982;257(1):536-44.
1981: Zannis V I; Breslow J L; SanGiacomo T R; Aden D P; Knowles B B
Characterization of the major apolipoproteins secreted by two human hepatoma cell lines.
Biochemistry 1981;20(25):7089-96.
1981: Zannis V I; Breslow J L
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification.
Biochemistry 1981;20(4):1033-41.
1981: Zannis V I; Just P W; Breslow J L
Human apolipoprotein E isoprotein subclasses are genetically determined.
American journal of human genetics 1981;33(1):11-24.
1980: Zannis V I; Breslow J L; Katz A J
Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture.
The Journal of biological chemistry 1980;255(18):8612-7.
1980: Zannis V I; Breslow J L
Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia.
The Journal of biological chemistry 1980;255(5):1759-62.
1980: Zannis V I; Gudas L J; Martin D W
Characterization of the subunit composition of HGPRTase from human erythrocytes and cultured fibroblasts.
Biochemical genetics 1980;18(1-2):1-19.
1979: Zannis V I; Gudas L J; Martin D W
Characterization of the subunits of purine nucleoside phosphorylase from cultured normal human fibroblasts.
Biochemical genetics 1979;17(7-8):621-30.
1978: Gudas L J; Zannis V I; Clift S M; Ammann A J; Staal G E; Martin D W
Characterization of mutant subunits of human purine nucleoside phosphorylase.
The Journal of biological chemistry 1978;253(24):8916-24.
1978: Zannis V I; Kirsch J F
Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism.
Biochemistry 1978;17(13):2669-74.
1977: Zannis V I; Gudas L J; Doyle D; Martin D A
Purification and characterization of hypoxanthine-guanine phosphoribosyl transferase from cultured HTC cells.
Advances in experimental medicine and biology 1977;76A():162-71.

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