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Eyal Zcharia

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Eyal Zcharia; Ruth Atzmon; Adi Nagler; Tamar Peretz; Avichai Shimoni; Israel Vlodavsky; Arnon Nagler
Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor.
Xiao Zhang; Feng Gong; Elina Hjertström; Juan Jia; Lars Lannfelt; Ulf Lindahl; Lars N G Nilsson; Paul O'Callaghan; Israel Vlodavsky; Bo Wang; Eyal Zcharia; Jin-Ping Li
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.
Aaron B Baker; William J Gibson; Mordechai Golomb; Laura Indolfi; Vijaya Kolachalama; Christopher Spruell; Israel Vlodavsky; Eyal Zcharia; Elazer R Edelman
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance.

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2012: Eyal Zcharia; Ruth Atzmon; Adi Nagler; Tamar Peretz; Avichai Shimoni; Israel Vlodavsky; Arnon Nagler
Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor.
Anti-cancer drugs 2012;23(10):1022-31.
2012: Xiao Zhang; Feng Gong; Elina Hjertström; Juan Jia; Lars Lannfelt; Ulf Lindahl; Lars N G Nilsson; Paul O'Callaghan; Israel Vlodavsky; Bo Wang; Eyal Zcharia; Jin-Ping Li
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.
Acta neuropathologica 2012;124(4):465-78.
2012: Aaron B Baker; William J Gibson; Mordechai Golomb; Laura Indolfi; Vijaya Kolachalama; Christopher Spruell; Israel Vlodavsky; Eyal Zcharia; Elazer R Edelman
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance.
Journal of the American College of Cardiology 2012;59(17):1551-60.
2012: Sandrine Benhamron; Amir Grau; Inna Reiner; Israel Vlodavsky; Eyal Zcharia; Mizhir Atallah; Dror Mevorach
Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.
PloS one 2012;7(5):e35602.
2011: Bo Wang; Eyal Zcharia; Xiao Zhang; Juan Jia; Gunnar Pejler; Israel Vlodavsky; Jin-Ping Li
Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin.
The Journal of allergy and clinical immunology 2011;128(6):1310-1317.e8.
2011: Immanuel Lerner; Esther Hermano; Eyal Zcharia; Dina Rodkin; Raanan Bulvik; Victoria Doviner; Ariel M Rubinstein; Rivka Ishai-Michaeli; Ruth Atzmon; Yoav Sherman; Amichay Meirovitz; Tamar Peretz; Israel Vlodavsky; Michael Elkin
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
The Journal of clinical investigation 2011;121(5):1709-21.
2011: Shay Sela; Shira Natanson-Yaron; Eyal Zcharia; Israel Vlodavsky; Simcha Yagel; Eli Keshet
Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase.
Circulation research 2011;108(9):1063-70.
2011: Amichay Meirovitz; Esther Hermano; Immanuel Lerner; Eyal Zcharia; Claudio Pisano; Tamar Peretz; Michael Elkin
Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinoma.
Cancer research 2011;71(7):2772-80.
2011: David Planer; Shula Metzger; Eyal Zcharia; Isaiah D Wexler; Israel Vlodavsky; Tova Chajek-Shaul
Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice.
PloS one 2011;6(4):e18370.
2010: Yona Nadir; Yael Kenig; Arie Drugan; Eyal Zcharia; Benjamin Brenner
Involvement of heparanase in vaginal and cesarean section deliveries.
Thrombosis research 2010;126(6):e444-50.
2010: Sara Massena; Gustaf Christoffersson; Elina Hjertström; Eyal Zcharia; Israel Vlodavsky; Nora Ausmees; Charlotte Rolny; Jin-Ping Li; Mia Phillipson
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
Blood 2010;116(11):1924-31.
2010: Menachem Bitan; Lola Weiss; Israel Reibstein; Michael Zeira; Yakov Fellig; Shimon Slavin; Eyal Zcharia; Arnon Nagler; Israel Vlodavsky
Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.
Molecular immunology 2010;47(10):1890-8.
2010: Ida Waern; Juan Jia; Gunnar Pejler; Eyal Zcharia; Israel Vlodavsky; Jin-Ping Li; Sara Wernersson
Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase.
Molecular immunology 2010;47(7-8):1467-75.
2010: Menachem Bitan; Lola Weiss; Michael Zeira; Eyal Zcharia; Shimon Slavin; Arnon Nagler; Israel Vlodavsky
Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantation.
PloS one 2010;5(4):e10135.
2009: Nicola J Nasser; Aaron Avivi; Itay Shafat; Evgeny Edovitsky; Eyal Zcharia; Neta Ilan; Israel Vlodavsky; Eviatar Nevo
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2253-8.
2009: Aaron B Baker; Adam Groothuis; Michael Jonas; David Ettenson; Tarek Shazly; Eyal Zcharia; Israel Vlodavsky; Philip Seifert; Elazer R Edelman
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice.
Circulation research 2009;104(3):380-7.
2009: Eyal Zcharia; Juan Jia; Xiao Zhang; Lea Baraz; Ulf Lindahl; Tamar Peretz; Israel Vlodavsky; Jin-Ping Li
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.
PloS one 2009;4(4):e5181.
2008: Asaf Spiegel; Eyal Zcharia; Yaron Vagima; Tomer Itkin; Alexander Kalinkovich; Ayelet Dar; Orit Kollet; Neta Netzer; Karin Golan; Itay Shafat; Neta Ilan; Arnon Nagler; Israel Vlodavsky; Tsvee Lapidot
Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.
Blood 2008;111(10):4934-43.
2008: Yona Nadir; Benjamin Brenner; Svetlana Gingis-Velitski; Flonia Levy-Adam; Neta Ilan; Eyal Zcharia; Erez Nadir; Israel Vlodavsky
Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
Thrombosis and haemostasis 2008;99(1):133-41.
2007: Martha L Escobar Galvis; Juan Jia; Xiao Zhang; Nadja Jastrebova; Dorothe Spillmann; Eva Gottfridsson; Toin H van Kuppevelt; Eyal Zcharia; Israel Vlodavsky; Ulf Lindahl; Jin-Ping Li
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate.
Nature chemical biology 2007;3(12):773-8.
2007: Irit Cohen; Bella Maly; Itamar Simon; Amichay Meirovitz; Eli Pikarsky; Eyal Zcharia; Tamar Peretz; Israel Vlodavsky; Michael Elkin
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4069-77.
2007: Yang Yang; Veronica MacLeod; Hua-Quan Miao; Allison Theus; Fenghuang Zhan; John D Shaughnessy; Jeffrey Sawyer; Jin-Ping Li; Eyal Zcharia; Israel Vlodavsky; Ralph D Sanderson
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
The Journal of biological chemistry 2007;282(18):13326-33.
2006: Yona Nadir; Benjamin Brenner; Anna Zetser; Neta Ilan; Itay Shafat; Eyal Zcharia; Orit Goldshmidt; Israel Vlodavsky
Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
Journal of thrombosis and haemostasis : JTH 2006;4(11):2443-51.
2006: Sandrine Benhamron; hovav nechushtan; Inna Verbovetski; Alon Krispin; Ghada Abboud-Jarrous; Eyal Zcharia; Evgeny Edovitsky; Efrat Nahari; Tamar Peretz; Israel Vlodavsky; Dror Mevorach
Translocation of active heparanase to cell surface regulates degradation of extracellular matrix heparan sulfate upon transmigration of mature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6417-24.
2006: Vardit Kram; Eyal Zcharia; Oron Yacoby-Zeevi; Shula Metzger; Tova Chajek-Shaul; Yankel Gabet; Ralph Müller; Israel Vlodavsky; Itai Bab
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.
Journal of cellular physiology 2006;207(3):784-92.
2006: Evgeny Edovitsky; Immanuel Lerner; Eyal Zcharia; Tamar Peretz; Israel Vlodavsky; Michael Elkin
Role of endothelial heparanase in delayed-type hypersensitivity.
Blood 2006;107(9):3609-16.
2006: Itay Shafat; Eyal Zcharia; Benjamin Nisman; Yona Nadir; Farid Nakhoul; Israel Vlodavsky; Neta Ilan
An ELISA method for the detection and quantification of human heparanase.
Biochemical and biophysical research communications 2006;341(4):958-63.
2006: N J Nasser; G Sarig; Benjamin Brenner; Erez Nevo; Orit Goldshmidt; Eyal Zcharia; J P Li; Israel Vlodavsky
Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.
Journal of thrombosis and haemostasis : JTH 2006;4(3):560-5.
2005: Ronit Haimov-Kochman; Diana Prus; Eyal Zcharia; Debra Goldman-Wohl; Shira Natanson-Yaron; Caryn Greenfield; Eyal Y Anteby; Reuven Reich; Joseph Orly; Alex Tsafriri; Arye Hurwitz; Israel Vlodavsky; Simcha Yagel
Spatiotemporal expression of heparanase during human and rodent ovarian folliculogenesis.
Biology of reproduction 2005;73(1):20-8.
2005: Jin-Ping Li; Martha L Escobar Galvis; Feng Gong; Xiao Zhang; Eyal Zcharia; Shula Metzger; Israel Vlodavsky; Robert Kisilevsky; Ulf Lindahl
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6473-7.
2005: Eyal Zcharia; Deborah Philp; Evgeny Edovitsky; Helena Aingorn; Shula Metzger; Hynda K Kleinman; Israel Vlodavsky; Michael Elkin
Heparanase regulates murine hair growth.
The American journal of pathology 2005;166(4):999-1008.
2005: Ariel Revel; Aharon Helman; Moriah Koler; Asher Shushan; Orit Goldshmidt; Eyal Zcharia; Helena Aingorn; Israel Vlodavsky
Heparanase improves mouse embryo implantation.
Fertility and sterility 2005;83(3):580-6.
2005: Eyal Zcharia; Rachel Zilka; Alon Yaar; Oron Yacoby-Zeevi; Anna Zetser; Shula Metzger; Ronit Sarid; Annamaria Naggi; Benito Casu; Neta Ilan; Israel Vlodavsky; Rinat Abramovitch
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):211-21.
2004: Evgeny Edovitsky; Michael Elkin; Eyal Zcharia; Tamar Peretz; Israel Vlodavsky
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
Journal of the National Cancer Institute 2004;96(16):1219-30.
2004: Vladislav Temkin; Helena Aingorn; Ilaria Puxeddu; Orit Goldshmidt; Eyal Zcharia; Gerald J Gleich; Israel Vlodavsky; Francesca Levi-Schaffer
Eosinophil major basic protein: first identified natural heparanase-inhibiting protein.
The Journal of allergy and clinical immunology 2004;113(4):703-9.
2004: Eyal Zcharia; Shula Metzger; Tova Chajek-Shaul; Helena Aingorn; Michael Elkin; Yael Friedmann; Talia Weinstein; Jin-Ping Li; Ulf Lindahl; Israel Vlodavsky
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):252-63.
2004: Ben Davidson; Lina Vintman; Eyal Zcharia; Carlos Bedrossian; Aasmund Berner; Søren Nielsen; Neta Ilan; Israel Vlodavsky; Reuven Reich
Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma.
Clinical & experimental metastasis 2004;21(5):469-76.
2003: Michael Elkin; Irit Cohen; Eyal Zcharia; Adam Orgel; Zehava Guatta-Rangini; Tamar Peretz; Israel Vlodavsky; Hynda K Kleinman
Regulation of heparanase gene expression by estrogen in breast cancer.
Cancer research 2003;63(24):8821-6.
2003: Pesach J Shteper; Eyal Zcharia; Yaqoub Ashhab; Tamar Peretz; Israel Vlodavsky; Dina Ben-Yehuda
Role of promoter methylation in regulation of the mammalian heparanase gene.
Oncogene 2003;22(49):7737-49.
2003: Orit Goldshmidt; Eyal Zcharia; Miriam Cohen; Helena Aingorn; Irit Cohen; Liat Nadav; Ben-Zion Katz; Benjamin Geiger; Israel Vlodavsky
Heparanase mediates cell adhesion independent of its enzymatic activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1015-25.
2003: Israel Vlodavsky; Eyal Zcharia; Orit Goldshmidt; Rinat Eshel; Ben-Zion Katz; Saverio Minucci; O Kovalchuk; Sergio Penco; Claudio Pisano; Annamaria Naggi; Benito Casu
Involvement of heparanase in tumor progression and normal differentiation.
Pathophysiology of haemostasis and thrombosis 2003;33 Suppl 1():59-61.
2002: Orit Goldshmidt; Eyal Zcharia; Rinat Abramovitch; Shula Metzger; Helena Aingorn; Yael Friedmann; Volker Schirrmacher; Eduardo Mitrani; Israel Vlodavsky
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10031-6.
2002: Israel Vlodavsky; Orit Goldshmidt; Eyal Zcharia; Ruth Atzmon; Zehava Rangini-Guatta; Michael Elkin; Tamar Peretz; Yael Friedmann
Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.
Seminars in cancer biology 2002;12(2):121-9.
2001: Orit Goldshmidt; Eyal Zcharia; Helena Aingorn; Zehava Guatta-Rangini; Ruth Atzmon; I Michal; Iris Pecker; E Mitrani; Israel Vlodavsky
Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence.
The Journal of biological chemistry 2001;276(31):29178-87.
2001: Israel Vlodavsky; Orit Goldshmidt; Eyal Zcharia; Shula Metzger; Tova Chajek-Shaul; Ruth Atzmon; Zehava Guatta-Rangini; Yael Friedmann
Molecular properties and involvement of heparanase in cancer progression and normal development.
Biochimie 2001;83(8):831-9.
2001: Eyal Zcharia; Shula Metzger; Tova Chajek-Shaul; Yael Friedmann; Orit Pappo; Ayelet Aviv; Michael Elkin; Iris Pecker; Tamar Peretz; Israel Vlodavsky
Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis.
Journal of mammary gland biology and neoplasia 2001;6(3):311-22.