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Luigi Zecca

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Parkinson's Disease

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Brain Chemistry

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Electrochemistry

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TOP 3
Kazumasa Wakamatsu; Luigi Zecca; Fabio A Zucca; Takaya Murase; Shosuke Ito
Biosynthetic pathway to neuromelanin and its aging process.
Mireille Engelen; Shosuke Ito; Enrico Monzani; Renzo Vanna; Kazumasa Wakamatsu; Chiara Bellei; Luigi Casella; Fabio A Zucca; Luigi Zecca
Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure.
Pier Raimondo Crippa; Melvin Eisner; Silvia Morante; Francesco Stellato; Flavio C Vicentin; Luigi Zecca
An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.

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All Publications

2012: Kazumasa Wakamatsu; Luigi Zecca; Fabio A Zucca; Takaya Murase; Shosuke Ito
Biosynthetic pathway to neuromelanin and its aging process.
Pigment cell & melanoma research 2012;25(6):792-803.
2012: Mireille Engelen; Shosuke Ito; Enrico Monzani; Renzo Vanna; Kazumasa Wakamatsu; Chiara Bellei; Luigi Casella; Fabio A Zucca; Luigi Zecca
Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure.
PloS one 2012;7(11):e48490.
2010: Pier Raimondo Crippa; Melvin Eisner; Silvia Morante; Francesco Stellato; Flavio C Vicentin; Luigi Zecca
An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.
European biophysics journal : EBJ 2010;39(6):959-70.
2009: Weslyn C Ward; Fabio A Zucca; Chiara Bellei; Luigi Zecca; John D Simon
Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids.
Archives of biochemistry and biophysics 2009;484(1):94-9.
2009: Muralidhar Hegde; P Bharathi; Anitha Suram; Chitra Venugopal; Ramya Jagannathan; Pankaj Poddar; Pullabhatla Srinivas; Kumar Sambamurti; Kosagisharaf Jagannatha Rao; Janez Scancar; Luigi Messori; Luigi Zecca; Paolo Zatta
Challenges associated with metal chelation therapy in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;17(3):457-68.
2009: William D Bush; Jacob Garguilo; Fabio A Zucca; Chiara Bellei; Robert J Nemanich; Glenn S Edwards; Luigi Zecca; John D Simon
Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold.
Photochemistry and photobiology 2009;85(1):387-90.
2008: Luigi Zecca; Chiara Bellei; Patrizia Costi; Alberto Albertini; Enrico Monzani; Luigi Casella; Mario Gallorini; Luigi Bergamaschi; Alberto Moscatelli; Nicholas J Turro; Melvin Eisner; Pier Raimondo Crippa; Shosuke Ito; Kazumasa Wakamatsu; William D Bush; Weslyn C Ward; John D Simon; Fabio A Zucca
New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17567-72.
2008: David Sulzer; Eugene V Mosharov; Zsolt Talloczy; Fabio A Zucca; John D Simon; Luigi Zecca
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.
Journal of neurochemistry 2008;106(1):24-36.
2007: Weslyn C Ward; Ziqiang Guan; Fabio A Zucca; Ruggero G Fariello; Reza Kordestani; Luigi Zecca; Christian R H Raetz; John D Simon
Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain.
Journal of lipid research 2007;48(7):1457-62.
2007: Henrik Wilms; Luigi Zecca; Philip Rosenstiel; Jobst Sievers; Günther Deuschl; Ralph Lucius
Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications.
Current pharmaceutical design 2007;13(18):1925-8.
2006: Luigi Zecca; Fabio A Zucca; Alberto Albertini; Enrico Rizzio; Ruggero G Fariello
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
Neurology 2006;67(7 Suppl 2):S8-11.
2006: William D Bush; Jacob Garguilo; Fabio A Zucca; Alberto Albertini; Luigi Zecca; Glenn S Edwards; Robert J Nemanich; John D Simon
The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14785-9.
2006: Fabio A Zucca; C Bellei; S Giannelli; Maria Rosa Terreni; Mario Gallorini; Enrico Rizzio; Gianni Pezzoli; Alberto Albertini; Luigi Zecca
Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(6):757-67.
2006: K S J Rao; Muralidhar Hegde; Suram Anitha; Massimo Musicco; Fabio A Zucca; Nicholas J Turro; Luigi Zecca
Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.
Progress in neurobiology 2006;78(6):364-73.
2005: Luigi Zecca; Daniela Berg; Thomas Arzberger; Petra Ruprecht; Wolf D Rausch; Massimo Musicco; Davide Tampellini; Peter Riederer; Manfred Gerlach; Georg Becker
In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage.
Movement disorders : official journal of the Movement Disorder Society 2005;20(10):1278-85.
2005: Veer Bala Gupta; Suram Anitha; Muralidhar Hegde; Luigi Zecca; R M Garruto; Rivka Ravid; S K Shankar; Reuven Stein; Ponnuswamy Shanmugavelu; Kosagi S Jagannatha Rao
Aluminium in Alzheimer's disease: are we still at a crossroad?
Cellular and molecular life sciences : CMLS 2005;62(2):143-58.
2004: Fabio A Zucca; Giuseppe Giaveri; Mario Gallorini; Alberto Albertini; Marco Toscani; Gianni Pezzoli; Ralph Lucius; Henrik Wilms; David Sulzer; Shosuke Ito; Kazumasa Wakamatsu; Luigi Zecca
The neuromelanin of human substantia nigra: physiological and pathogenic aspects.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(6):610-7.
2004: Luigi Zecca; Moussa B H Youdim; Peter Riederer; James Connor; Robert R Crichton
Iron, brain ageing and neurodegenerative disorders.
Nature reviews. Neuroscience 2004;5(11):863-73.
2004: Masayo Shamoto-Nagai; Wakako Maruyama; Yukihiro Akao; Toshihiko Osawa; F Tribl; Manfred Gerlach; Fabio A Zucca; Luigi Zecca; Peter Riederer; Makoto Naoi
Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(10-11):1253-65.
2004: Luigi Zecca; Antonella Stroppolo; Alberto Gatti; Davide Tampellini; Marco Toscani; Mario Gallorini; Giuseppe Giaveri; paolo arosio; Paolo Santambrogio; Ruggero G Fariello; Erdem Karatekin; Mark H Kleinman; Nicholas J Turro; Oleh Hornykiewicz; Fabio A Zucca
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9843-8.
2003: Luigi Zecca; Fabio A Zucca; Henrik Wilms; David Sulzer
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics.
Trends in neurosciences 2003;26(11):578-80.
2003: Kay L Double; Manfred Gerlach; Volker Schünemann; Alfred X Trautwein; Luigi Zecca; Mario Gallorini; Moussa B H Youdim; Peter Riederer; Dorit Ben-Shachar
Iron-binding characteristics of neuromelanin of the human substantia nigra.
Biochemical pharmacology 2003;66(3):489-94.
2003: Kazumasa Wakamatsu; Kenichi Fujikawa; Fabio A Zucca; Luigi Zecca; Shosuke Ito
The structure of neuromelanin as studied by chemical degradative methods.
Journal of neurochemistry 2003;86(4):1015-23.
2003: Margherita Canesi; Luigi Perbellini; L Maestri; A Silvani; Luigi Zecca; L Bet; Gianni Pezzoli
Poor metabolization of n-hexane in Parkinson's disease.
Journal of neurology 2003;250(5):556-60.
2003: Henrik Wilms; Philip Rosenstiel; Jobst Sievers; Günther Deuschl; Luigi Zecca; Ralph Lucius
Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):500-2.
2003: Luigi Zecca; Fabio A Zucca; P Costi; Davide Tampellini; Alberto Gatti; Manfred Gerlach; Peter Riederer; Ruggero G Fariello; Shosuke Ito; Mario Gallorini; David Sulzer
The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour.
Journal of neural transmission. Supplementum 2003;(65):145-55.
2003: Manfred Gerlach; Kay L Double; Dorit Ben-Shachar; Luigi Zecca; Moussa B H Youdim; Peter Riederer
Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease.
Neurotoxicity research 2003;5(1-2):35-44.
2002: Kay L Double; Dorit Ben-Shachar; Moussa B H Youdim; Luigi Zecca; Peter Riederer; Manfred Gerlach
Influence of neuromelanin on oxidative pathways within the human substantia nigra.
Neurotoxicology and teratology 2002;24(5):621-8.
2002: Luigi Zecca; Davide Tampellini; Alberto Gatti; R Crippa; M Eisner; David Sulzer; Shosuke Ito; Ruggero G Fariello; Mario Gallorini
The neuromelanin of human substantia nigra and its interaction with metals.
Journal of neural transmission (Vienna, Austria : 1996) 2002;109(5-6):663-72.
2002: Luigi Zecca; Ruggero G Fariello; Peter Riederer; David Sulzer; Alberto Gatti; Davide Tampellini
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease.
FEBS letters 2002;510(3):216-20.
2001: Luigi Zecca; Davide Tampellini; Manfred Gerlach; Peter Riederer; Ruggero G Fariello; David Sulzer
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.
Molecular pathology : MP 2001;54(6):414-8.
2001: Daniela Berg; Manfred Gerlach; Moussa B H Youdim; Kay L Double; Luigi Zecca; Peter Riederer; G Becker
Brain iron pathways and their relevance to Parkinson's disease.
Journal of neurochemistry 2001;79(2):225-36.
2001: Andreas Reif; Luigi Zecca; Peter Riederer; M Feelisch; Harald Schmidt
Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner.
Free radical biology & medicine 2001;30(7):803-8.
2001: Luigi Zecca; Mario Gallorini; Volker Schünemann; Alfred X Trautwein; Manfred Gerlach; Peter Riederer; Paolo Vezzoni; Davide Tampellini
Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes.
Journal of neurochemistry 2001;76(6):1766-73.
2000: Kay L Double; Luigi Zecca; P Costi; M Mauer; C Griesinger; Shosuke Ito; Dorit Ben-Shachar; G Bringmann; Ruggero G Fariello; Peter Riederer; Manfred Gerlach
Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins.
Journal of neurochemistry 2000;75(6):2583-9.
2000: David Sulzer; J Bogulavsky; Kristin Larsen; GG Behr; E Karatekin; Mark H Kleinman; Nicholas J Turro; D Krantz; Robert H Edwards; Lloyd A Greene; Luigi Zecca
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11869-74.
2000: Maria Grazia Sacco; M Ungari; Enrica Mira Catò; Anna Villa; D Strina; Luigi D Notarangelo; J Jonkers; Luigi Zecca; Fabio Facchetti; Paolo Vezzoni
Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome.
Cancer gene therapy 2000;7(10):1299-306.
2000: Annalisa Frattini; Paul J Orchard; Cristina Sobacchi; Silvia Giliani; Mario Abinun; JP Mattsson; DJ Keeling; A K Andersson; Pia Wallbrandt; Luigi Zecca; Luigi D Notarangelo; Paolo Vezzoni; Anna Villa
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.
Nature genetics 2000;25(3):343-6.
2000: Maria Grazia Sacco; Mario Caniatti; Enrica Mira Catò; Annalisa Frattini; Giulia Chiesa; Roberta Ceruti; F Adorni; Luigi Zecca; Eugenio Scanziani; Paolo Vezzoni
Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer.
Cancer research 2000;60(10):2660-5.
2000: Luigi Zecca; P Costi; C Mecacci; Shosuke Ito; Maria Rosa Terreni; Sandro Sonnino
Interaction of human substantia nigra neuromelanin with lipids and peptides.
Journal of neurochemistry 2000;74(4):1758-65.
2000: David Sulzer; Luigi Zecca
Intraneuronal dopamine-quinone synthesis: a review.
Neurotoxicity research 2000;1(3):181-95.
1999: Maria Grazia Bridelli; Davide Tampellini; Luigi Zecca
The structure of neuromelanin and its iron binding site studied by infrared spectroscopy.
FEBS letters 1999;457(1):18-22.
1998: A J Kropf; Bruce A Bunker; M Eisner; S C Moss; Luigi Zecca; Antonella Stroppolo; P R Crippa
X-ray absorption fine-structure spectroscopy studies of Fe sites in natural human neuromelanin and synthetic analogues.
Biophysical journal 1998;75(6):3135-42.
1998: Luigi Zecca; M Rosati; R Renella; M Galimberti; A Ambrosini; Ruggero G Fariello
Nitrite and nitrate levels in cerebrospinal fluid of normal subjects.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(6-7):627-33.
1998: Luigi Zecca; C Mantegazza; V Margonato; Paolo Cerretelli; Mario Caniatti; Flavio Piva; Donatella Dondi; N Hagino
Biological effects of prolonged exposure to ELF electromagnetic fields in rats: III. 50 Hz electromagnetic fields.
Bioelectromagnetics 1998;19(1):57-66.
1997: Maria Grazia Sacco; Luigi Zecca; L Bagnasco; Giulia Chiesa; Cinzia Parolini; P Bromley; Enrica Mira Catò; R Roncucci; L A Clerici; Paolo Vezzoni
A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds.
Nature biotechnology 1997;15(13):1392-7.
1997: Luigi Zecca; Ruggero G Fariello; M Galimberti; G Racagni; A Ambrosini
Changes in nitric oxide metabolite levels in stimulated substantia nigra neurons.
Neuroreport 1997;8(9-10):2121-5.
1997: T Shima; T Sarna; Harold M Swartz; Antonella Stroppolo; R Gerbasi; Luigi Zecca
Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study.
Free radical biology & medicine 1997;23(1):110-9.
1996: Luigi Zecca; T Shima; A Stroppolo; C Goj; G A Battiston; R Gerbasi; Tadeusz Sarna; Harold M Swartz
Interaction of neuromelanin and iron in substantia nigra and other areas of human brain.
Neuroscience 1996;73(2):407-15.
1995: S Colombo; Gabriele Toietta; Luigi Zecca; Marco Vanoni; paolo tortora
Molecular cloning, nucleotide sequence, and expression of a carboxypeptidase-encoding gene from the archaebacterium Sulfolobus solfataricus.
Journal of bacteriology 1995;177(19):5561-6.
1995: M Zareba; A Bober; Witold Korytowski; Luigi Zecca; Tadeusz Sarna
The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems.
Biochimica et biophysica acta 1995;1271(2-3):343-8.
1995: K Kolasa; S Consolo; P Costi; Zdzislaw Kleinrok; Luigi Zecca
Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat.
Pharmacology, biochemistry, and behavior 1995;51(1):29-35.
1995: V Margonato; P Nicolini; R Conti; Luigi Zecca; Arsenio Veicsteinas; Paolo Cerretelli
Biologic effects of prolonged exposure to ELF electromagnetic fields in rats: II. 50 Hz magnetic fields.
Bioelectromagnetics 1995;16(6):343-55.
1994: G S Roi; U Garagiola; P Verza; G Spadari; D Radice; Luigi Zecca; Paolo Cerretelli
Aspirin does not affect exercise performance.
International journal of sports medicine 1994;15(5):224-7.
1994: Luigi Zecca; R Pietra; C Goj; C Mecacci; D Radice; E Sabbioni
Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain.
Journal of neurochemistry 1994;62(3):1097-101.
1994: W S Enochs; Tadeusz Sarna; Luigi Zecca; P A Riley; Harold M Swartz
The roles of neuromelanin, binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis.
Journal of neural transmission. Parkinson's disease and dementia section 1994;7(2):83-100.
1993: A Villa; Luigi Zecca; Paola Fusi; S Colombo; Gabriella Tedeschi; paolo tortora
Structural features responsible for kinetic thermal stability of a carboxypeptidase from the archaebacterium Sulfolobus solfataricus.
The Biochemical journal 1993;295 ( Pt 3)():827-31.
1993: E Cazzola; N Lattuada; Luigi Zecca; D Radice; M Luzzana; BP Imbimbo; A Auteri; Andrea Mosca
Rapid potentiometric determination of cholinesterases in plasma and red cells: application to eptastigmine monitoring.
Chemico-biological interactions 1993;87(1-3):265-8.
1993: Andrea Mosca; Renata Paleari; Federico Maria Rubino; Luigi Zecca; De Bellis Gianluca; S Debernardi; F Baudo; D Cappellini; Gemino Fiorelli
Hb Abruzzo [beta 143(H21)His-->Arg] identified by mass spectrometry and DNA analysis.
Hemoglobin 1993;17(3):261-8.
1993: Luigi Zecca; D Radice; Andrea Mosca; P G Pagella
Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography 1993;615(1):169-73.
1993: Luigi Zecca; H M Swartz
Total and paramagnetic metals in human substantia nigra and its neuromelanin.
Journal of neural transmission. Parkinson's disease and dementia section 1993;5(3):203-13.
1993: A Auteri; Andrea Mosca; N Lattuada; M Luzzana; Luigi Zecca; D Radice; BP Imbimbo
Pharmacodynamics and pharmacokinetics of eptastigmine in elderly subjects.
European journal of clinical pharmacology 1993;45(4):373-6.
1992: N Zonta; Paolo Ferrario; Anna Maria Di Giulio; Luigi Zecca; Alfredo Gorio; P Mantegazza
Neurochemical changes of long-term adrenalectomy in rat brain: effects on neurotransmitter amino acids.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1992;10(5):439-45.
1992: Federico Maria Rubino; Luigi Zecca
Application of triple quadrupole tandem mass spectrometry to the analysis of pyridine-containing derivatives of long-chain acids and alcohols.
Journal of chromatography 1992;579(1):1-12.
1992: Sandro Sonnino; D Acquotti; G Kirschner; A Uguaglianza; Luigi Zecca; F Rubino; Guido Tettamanti
Preparation of lyso-GM1 (II3Neu5AcGgOse4-long chain bases) by a one-pot reaction.
Journal of lipid research 1992;33(8):1221-6.
1992: S Colombo; Sabato D'Auria; Paola Fusi; Luigi Zecca; Carlo Antonio Raia; paolo tortora
Purification and characterization of a thermostable carboxypeptidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus.
European journal of biochemistry / FEBS 1992;206(2):349-57.
1992: Federico Maria Rubino; Luigi Zecca; F Chillemi
Characterization of putative neurotransmitter N-acetyl-aspartyl-glutamic acid and some related compounds by fast atom bombardment and tandem mass spectrometry.
Biological mass spectrometry 1992;21(2):85-91.
1992: Luigi Zecca; C Mecacci; Roberta Seraglia; E Parati
The chemical characterization of melanin contained in substantia nigra of human brain.
Biochimica et biophysica acta 1992;1138(1):6-10.
1992: Laura Riboni; D Acquotti; R Casellato; R Ghidoni; G Montagnolo; A Benevento; Luigi Zecca; F Rubino; Sandro Sonnino
Changes of the human liver GM3 ganglioside molecular species during aging.
European journal of biochemistry / FEBS 1992;203(1-2):107-13.
1992: K Kolasa; Zdzislaw Kleinrok; S Consolo; Paolo Ferrario; Luigi Zecca
Susceptibility to seizures produced by chemical convulsants and maximal electric shock in rats after electrolytic lesions into the red nucleus.
Pharmacology, biochemistry, and behavior 1992;41(1):99-103.
1992: Harold M Swartz; Tadeusz Sarna; Luigi Zecca
Modulation by neuromelanin of the availability and reactivity of metal ions.
Annals of neurology 1992;32 Suppl():S69-75.
1991: Luigi Zecca; Paolo Ferrario; V Margonato; Paolo Cerretelli; N Zonta
Neurotransmitter amino acid variations in striatum of rats exposed to 50 Hz electric fields.
Biochimica et biophysica acta 1991;1075(1):1-5.
1991: Luigi Zecca; Paolo Ferrario; P Costi
Determination of diclofenac and its metabolites in plasma and cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography 1991;567(2):425-32.
1991: F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; Luigi Zecca; Paolo Ferrario; P Mantegazza
Effects of diazepam on nociception in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(1):84-9.
1990: giovanni lucignani; Carlo Rossetti; Paolo Ferrario; Luigi Zecca; Maria Carla Gilardi; F Zito; D Perani; G L Lenzi; Ferruccio Fazio
In vivo metabolism and kinetics of 99mTc-HMPAO.
European journal of nuclear medicine 1990;16(4-6):249-55.
1989: Bruno Danieli; Federico Maria Rubino; Luigi Zecca
Electron impact mass spectrometry of substituted 1,3,8-triazaspiro[4,5]decan-4-ones.
Biomedical & environmental mass spectrometry 1989;18(11):1000-4.
1989: Luigi Zecca; Paolo Ferrario
Determination of diclofenac in plasma and synovial fluid by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography 1989;495():303-8.
1989: Luigi Zecca; Paolo Ferrario; Rodolfo Pirola; F Zambotti; N Zonta; Franco Fraschini
Analysis of pirprofen in cerebrospinal fluid, plasma, and synovial fluid by high-performance liquid chromatography with electrochemical detection.
Journal of pharmaceutical sciences 1989;78(9):776-9.
1989: Luigi Zecca; Paolo Ferrario; Rodolfo Pirola; L Reina; F Zambotti; N Zonta; A M Lepore; F Scaglione; Franco Fraschini
Pharmacokinetics of buflomedil after various dosage forms.
Arzneimittel-Forschung 1989;39(4):518-9.
1988: Luigi Zecca; M Broggini; Rodolfo Pirola; R Campi; Paolo Ferrario; E Bichisao; V Maresca
The diffusion of pirprofen into the cerebrospinal fluid in man.
European journal of clinical pharmacology 1988;35(1):81-3.
1988: F A Rossi; M Ferrero; G E Balladore; Luigi Zecca; Franco Fraschini; Paolo Ferrario; E Bichisao; G C Monza; V Maresca
Pharmacokinetics of pirprofen and its pyrrol metabolite in elderly patients.
European journal of clinical pharmacology 1988;35(4):379-83.
1988: Silvio R Bareggi; G Truci; S Leva; Luigi Zecca; Rodolfo Pirola; Salvatore Smirne
Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans.
European journal of clinical pharmacology 1988;34(1):109-12.
1988: Luigi Zecca; Paolo Ferrario
Synthesis and biodistribution of an 123I labelled flunitrazepam derivative: a potential in vivo tracer for benzodiazepine receptors.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1988;39(4):353-6.
1987: F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; Paolo Ferrario; Luigi Zecca; P Mantegazza
Zopiclone potentiates the antinociceptive effect of morphine in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1987;336(5):526-9.
1987: Luigi Zecca; Paolo Ferrario; Rodolfo Pirola; Silvio R Bareggi
Analysis of chlorodesmethyldiazepam and its metabolites in plasma and urine.
Journal of chromatography 1987;420(2):417-24.
1987: F Zambotti; N Zonta; B Hafner; Paolo Ferrario; Luigi Zecca; P Mantegazza
Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone.
Naunyn-Schmiedeberg's archives of pharmacology 1987;335(5):547-50.
1986: Silvio R Bareggi; Rodolfo Pirola; S Leva; Luigi Zecca
Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans.
European journal of drug metabolism and pharmacokinetics 1986;11(3):171-4.
1986: Luigi Zecca; Paolo Ferrario; Franco Fraschini; F Zambotti; N Zonta; Rodolfo Pirola
Determination of lormetazepam in plasma by gas chromatography and electron-capture detection.
Journal of chromatography 1986;377():368-72.
1986: F Zambotti; N Zonta; Paolo Ferrario; Luigi Zecca; P Mantegazza
Effects of 2-chloroadenosine on hippocampal GABA content and turnover.
Journal of neural transmission 1986;65(3-4):167-75.
1986: Silvio R Bareggi; N P Nielsen; S Leva; Rodolfo Pirola; Luigi Zecca; M Lorini
Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam).
International journal of clinical pharmacology research 1986;6(4):309-14.
1985: Luigi Zecca; Paolo Ferrario
Determination of neurotransmitter amino acids by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1985;337(2):391-6.
1985: Luigi Zecca; L Reina; F Scaglione; Paolo Ferrario; Rodolfo Pirola; G Ceccarelli; M Ciampini; Franco Fraschini
Relative bioavailability in humans for oral tablets and solutions of lormetazepam.
Arzneimittel-Forschung 1985;35(12):1870-2.
1984: P Mantegazza; R Tammiso; F Zambotti; Luigi Zecca; N Zonta
Purine involvement in morphine antinociception.
British journal of pharmacology 1984;83(4):883-8.
1983: Luigi Zecca; L Bonini; Silvio R Bareggi
Determination of dihydroergocristine and dihydroergotamine in plasma by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1983;272(2):401-5.
1982: Luigi Zecca; F Zambotti; N Zonta; P Mantegazza
Determination of gamma-aminobutyric acid in brain areas by high-performance liquid chromatography of dansyl derivatives with ultraviolet detection.
Journal of chromatography 1982;233():307-12.
1982: Silvio R Bareggi; M Franceschi; L Bonini; Luigi Zecca; S Smirne
Decreased CSF concentrations of homovanillic acid and gamma-aminobutyric acid in Alzheimer's disease. Age- or disease-related modifications?
Archives of neurology 1982;39(11):709-12.
1982: Luigi Zecca; L Guadagni; Silvio R Bareggi
Determination of sodium flavodate in body fluids by high-performance liquid chromatography: application to clinical pharmacokinetic studies.
Journal of chromatography 1982;230(1):168-74.