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Heinz Zeichhardt

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Virus Replication

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RNA Interference

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Eliza Wyszko; Heinz Zeichhardt; Jan Barciszewski; Florian Müller; Maciej Szymański; Volker A Erdmann
Spiegelzymes: sequence specific hydrolysis of L-RNA with mirror image hammerhead ribozymes and DNAzymes.
Sandra Pinkert; O Brad Spiller; Heinz Zeichhardt; Andrea Dörner; Karin Klingel; Vanessa Lindig; Henry Fechner
Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line.
Tanja Pozzuto; Kristina von Kietzell; Thomas Bock; Caroline Schmidt-Lucke; Wolfgang Poller; Thomas Zobel; Dirk Lassner; Heinz Zeichhardt; Stefan Weger; Henry Fechner
Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions.

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All Publications

2013: Eliza Wyszko; Heinz Zeichhardt; Jan Barciszewski; Florian Müller; Maciej Szymański; Volker A Erdmann
Spiegelzymes: sequence specific hydrolysis of L-RNA with mirror image hammerhead ribozymes and DNAzymes.
PloS one 2013;8(1):e54741.
2011: Sandra Pinkert; O Brad Spiller; Heinz Zeichhardt; Andrea Dörner; Karin Klingel; Vanessa Lindig; Henry Fechner
Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line.
Journal of virology 2011;85(24):13409-19.
2011: Tanja Pozzuto; Kristina von Kietzell; Thomas Bock; Caroline Schmidt-Lucke; Wolfgang Poller; Thomas Zobel; Dirk Lassner; Heinz Zeichhardt; Stefan Weger; Henry Fechner
Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions.
Virology 2011;411(1):50-64.
2010: Diana Rothe; Gisela Wajant; Hans-Peter Grunert; Heinz Zeichhardt; Henry Fechner; Jens Kurreck
Rapid construction of adeno-associated virus vectors expressing multiple short hairpin RNAs with high antiviral activity against echovirus 30.
Oligonucleotides 2010;20(4):191-8.
2010: Susanne Rutschow; Sebastian Leschka; Dirk Westermann; Kerstin Puhl; Anneke Weitz; Leonid Ladyszenskij; Sebastian Jaeger; Heinz Zeichhardt; Michel Noutsias; Heinz-Peter Schultheiss; Carsten Tschope; Matthias Pauschinger
Left ventricular enlargement in coxsackievirus-B3 induced chronic myocarditis--ongoing inflammation and an imbalance of the matrix degrading system.
European journal of pharmacology 2010;630(1-3):145-51.
2010: Denise Werk; Jesper Wengel; Suzy L Wengel; Hans-Peter Grunert; Heinz Zeichhardt; Jens Kurreck
Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3.
FEBS letters 2010;584(3):591-8.
2009: Sandra Pinkert; Dirk Westermann; Xiaomin Wang; Karin Klingel; Andrea Dörner; Konstantinos Savvatis; Tobias Grössl; Stefanie Krohn; Carsten Tschöpe; Heinz Zeichhardt; Katja Kotsch; Kerstin Weitmann; Wolfgang Hoffmann; Heinz-Peter Schultheiss; O Brad Spiller; Wolfgang Poller; Henry Fechner
Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor.
Circulation 2009;120(23):2358-66.
2009: Denise Werk; Sandra Pinkert; Albert Heim; Heinz Zeichhardt; Hans-Peter Grunert; Wolfgang Poller; Volker A Erdmann; Henry Fechner; Jens Kurreck
Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3.
Antiviral research 2009;83(3):298-306.
2009: Linda Ebermann; Cornelia Piper; Uwe Kühl; Karin Klingel; Uwe Schlattner; Nikias Siafarikas; Heinz Zeichhardt; Heinz-Peter Schultheiss; Andrea Dörner
Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression.
Basic research in cardiology 2009;104(3):247-57.
2009: Diana Rothe; Denise Werk; Sonja Niedrig; Daniel Horbelt; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
Antiviral activity of highly potent siRNAs against echovirus 30 and its receptor.
Journal of virological methods 2009;157(2):211-8.
2008: Mariola Dutkiewicz; Hans-Peter Grunert; Heinz Zeichhardt; Suzy W Lena; Jesper Wengel; Jens Kurreck
Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.
FEBS letters 2008;582(20):3061-6.
2008: Henry Fechner; Isaac Sipo; Dirk Westermann; Sandra Pinkert; Xiaomin Wang; Lennart Suckau; Jens Kurreck; Heinz Zeichhardt; Oliver Müller; Roland Vetter; Volker A Erdmann; Carsten Tschope; Wolfgang Poller
Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) 2008;86(9):987-97.
2008: Diana Rothe; Denise Werk; Mariola Dutkiewicz; Steffen Schubert; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Henry Fechner; Jens Kurreck
Inhibition of picornaviruses by means of RNA interference.
Nucleic acids symposium series (2004) 2008;(52):63-4.
2007: Henry Fechner; Sandra Pinkert; Xiaomin Wang; Isaac Sipo; Lennart Suckau; Jens Kurreck; Andrea Dörner; K Sollerbrant; Heinz Zeichhardt; Hans-Peter Grunert; Roland Vetter; Heinz-Peter Schultheiss; Wolfgang Poller
Coxsackievirus B3 and adenovirus infections of cardiac cells are efficiently inhibited by vector-mediated RNA interference targeting their common receptor.
Gene therapy 2007;14(12):960-71.
2007: Steffen Schubert; Diana Rothe; Denise Werk; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
Strand-specific silencing of a picornavirus by RNA interference: evidence for the superiority of plus-strand specific siRNAs.
Antiviral research 2007;73(3):197-205.
2007: Jun Li; Sebastian Leschka; Susanne Rutschow; Peter L Schwimmbeck; Lars Husmann; Michel Noutsias; Dirk Westermann; Wolfgang Poller; Heinz Zeichhardt; Karin Klingel; Carsten Tschope; Heinz-Peter Schultheiss; Matthias Pauschinger
Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis.
European journal of pharmacology 2007;554(1):60-8.
2006: Andrea Dörner; Hans-Peter Grunert; V Lindig; Kumaran Chandrasekharan; Henry Fechner; Kirk U Knowlton; A Isik; Matthias Pauschinger; Heinz Zeichhardt; Heinz-Peter Schultheiss
Treatment of coxsackievirus-B3-infected BALB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury.
Journal of molecular medicine (Berlin, Germany) 2006;84(10):842-51.
2005: Denise Werk; Steffen Schubert; Vanessa Lindig; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor.
Biological chemistry 2005;386(9):857-63.
2005: Matthias Pauschinger; Susanne Rutschow; Kumaran Chandrasekharan; Dirk Westermann; Anneke Weitz; Lothar Peter Schwimmbeck; Heinz Zeichhardt; Wolfgang Poller; Michel Noutsias; Jun Li; Heinz-Peter Schultheiss; Carsten Tschope
Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response.
European journal of heart failure 2005;7(4):444-52.
2005: Steffen Schubert; Hans-Peter Grunert; Heinz Zeichhardt; Denise Werk; Volker A Erdmann; Jens Kurreck
Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs.
Journal of molecular biology 2005;346(2):457-65.
2004: Steffen Schubert; Jens P Fürste; Denise Werk; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
Gaining target access for deoxyribozymes.
Journal of molecular biology 2004;339(2):355-63.
2003: Steffen Schubert; Deniz C Gül; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
RNA cleaving '10-23' DNAzymes with enhanced stability and activity.
Nucleic acids research 2003;31(20):5982-92.
2002: Jun Li; Peter L Schwimmbeck; Carsten Tschope; Sebastian Leschka; Lars Husmann; Susanne Rutschow; Florian Reichenbach; Michel Noutsias; Ursula Kobalz; Wolfgang Poller; Frank Spillmann; Heinz Zeichhardt; Heinz-Peter Schultheiss; Matthias Pauschinger
Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction.
Cardiovascular research 2002;56(2):235-47.
1999: MA Paulik; PA Grieco; Chinpal Kim; H G Maxeiner; Hans-Peter Grunert; Heinz Zeichhardt; Dorothy M Morré; D James Morré
Drug-antibody conjugates with anti-HIV activity.
Biochemical pharmacology 1999;58(11):1781-90.
1998: D James Morré; Heinz Zeichhardt; H G Maxeiner; H P Grünert; D Sawitzky; PA Grieco
Effect of the quassinoids glaucarubolone and simalikalactone D on growth of cells permanently infected with feline and human immunodeficiency viruses and on viral infections.
Life sciences 1998;62(3):213-9.
1997: Hans-Peter Grunert; K U Wolf; K D Langner; D Sawitzky; K O Habermehl; Heinz Zeichhardt
Internalization of human rhinovirus 14 into HeLa and ICAM-1-transfected BHK cells.
Medical microbiology and immunology 1997;186(1):1-9.
1996: D Sawitzky; A Voigt; Heinz Zeichhardt; K O Habermehl
Glycoprotein B (gB) of pseudorabies virus interacts specifically with the glycosaminoglycan heparin.
Virus research 1996;41(1):101-8.
1995: A Voigt; D Sawitzky; Heinz Zeichhardt; K O Habermehl
Cellular receptor structures for pseudorabies virus are blocked by antithrombin III.
Medical microbiology and immunology 1995;184(2):97-103.
1992: R H Barnert; Heinz Zeichhardt; K O Habermehl
Identification of 50- and 23-/25-kDa HeLa cell membrane glycoproteins involved in poliovirus infection: occurrence of poliovirus specific binding sites on susceptible and nonsusceptible cells.
Virology 1992;186(2):533-42.
1991: R H Barnert; Heinz Zeichhardt; K O Habermehl
A rapid and sensitive micro scale assay for quantitative detection of cell protective effects: application for the isolation of a monoclonal antibody against HeLa cell proteins involved in poliovirus attachment.
Journal of virological methods 1991;35(1):1-14.
1989: P Willingmann; H Barnert; Heinz Zeichhardt; K O Habermehl
Recovery of structurally intact and infectious poliovirus type 1 from HeLa cells during receptor-mediated endocytosis.
Virology 1989;168(2):417-20.
1987: Heinz Zeichhardt; M J Otto; M A McKinlay; P Willingmann; K O Habermehl
Inhibition of poliovirus uncoating by disoxaril (WIN 51711).
Virology 1987;160(1):281-5.
1986: K Wetz; P Willingmann; Heinz Zeichhardt; K O Habermehl
Neutralization of poliovirus by polyclonal antibodies requires binding of a single IgG molecule per virion.
Archives of virology 1986;91(3-4):207-20.
1985: Heinz Zeichhardt; K Wetz; P Willingmann; K O Habermehl
Entry of poliovirus type 1 and Mouse Elberfeld (ME) virus into HEp-2 cells: receptor-mediated endocytosis and endosomal or lysosomal uncoating.
The Journal of general virology 1985;66 ( Pt 3)():483-92.
1983: K Wetz; Heinz Zeichhardt; P Willingmann; K O Habermehl
Dense particles and slow sedimenting particles produced by ultraviolet irradiation of poliovirus.
The Journal of general virology 1983;64 (Pt 6)():1263-75.
1983: Heinz Zeichhardt; K O Habermehl; K Wetz
A poliovirus-induced cytoplasmic membrane complex is exploited by the RNA polymerase of superinfecting Mouse Elberfeld (ME) virus.
The Journal of general virology 1983;64 (Pt 4)():951-5.
1982: Heinz Zeichhardt; J R Schlehofer; K Wetz; H Hampl; K O Habermehl
Mouse Elberfeld (ME) virus determines the cell surface alterations when mixedly infecting poliovirus-infected cells.
The Journal of general virology 1982;58(Pt 2):417-28.
1981: Heinz Zeichhardt; K O Habermehl; W Diefenthal
Modification and exploitation of a poliovirus-induced membrane complex by superinfecting ME virus.
The Journal of general virology 1981;55(Pt 2):265-74.