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Lei Zeng

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Nuclear Magnetic Resonance, Biomolecular

Chemicals & Drugs

Phenomena

Occupations

Drug Design

Co-author Network

Publications

TOP 3
Lei Zeng; Qiang Zhang; Kelley Yan; Ming-Ming Zhou
Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Jagat C Borah; Shiraz Mujtaba; Ioannis Karakikes; Lei Zeng; Michaela Muller; Jigneshkumar Patel; Natasha Moshkina; Keita Morohashi; Weijia Zhang; Guillermo Gerona-Navarro; Roger J Hajjar; Ming-Ming Zhou
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Guillermo Gerona-Navarro; Shiraz Mujtaba; Antonio Frasca; Jigneshkumar Patel; Lei Zeng; Alexander N Plotnikov; Roman Osman; Ming-Ming Zhou
Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors.

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All Publications

2011: Lei Zeng; Qiang Zhang; Kelley Yan; Ming-Ming Zhou
Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins 2011;79(6):2004-9.
2011: Jagat C Borah; Shiraz Mujtaba; Ioannis Karakikes; Lei Zeng; Michaela Muller; Jigneshkumar Patel; Natasha Moshkina; Keita Morohashi; Weijia Zhang; Guillermo Gerona-Navarro; Roger J Hajjar; Ming-Ming Zhou
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Chemistry & biology 2011;18(4):531-41.
2011: Guillermo Gerona-Navarro; Shiraz Mujtaba; Antonio Frasca; Jigneshkumar Patel; Lei Zeng; Alexander N Plotnikov; Roman Osman; Ming-Ming Zhou
Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors.
Journal of the American Chemical Society 2011;133(7):2040-3.
2010: Lei Zeng; Qiang Zhang; Side Li; Alexander N Plotnikov; Martin J Walsh; Ming-Ming Zhou
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature 2010;466(7303):258-62.
2010: Kyoko L Yap; Side Li; Ana M Muñoz-Cabello; Selina Raguz; Lei Zeng; Shiraz Mujtaba; Jesús Gil; Martin J Walsh; Ming-Ming Zhou
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Molecular cell 2010;38(5):662-74.
2010: Zachary Charlop-Powers; Lei Zeng; Qiang Zhang; Ming-Ming Zhou
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Cell research 2010;20(5):529-38.
2010: Qiang Zhang; Suvobrata Chakravarty; Dario Ghersi; Lei Zeng; Alexander N Plotnikov; Roberto Sanchez; Ming-Ming Zhou
Biochemical profiling of histone binding selectivity of the yeast bromodomain family.
PloS one 2010;5(1):e8903.
2009: Suvobrata Chakravarty; Lei Zeng; Ming-Ming Zhou
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.
Structure (London, England : 1993) 2009;17(5):670-9.
2008: Lei Zeng; Kyoko L Yap; Alexey Ivanov; Xueqi Wang; Shiraz Mujtaba; Olga Plotnikova; Frank J Rauscher; Ming-Ming Zhou
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.
Nature structural & molecular biology 2008;15(6):626-33.
2008: Luis Cunha; Miklos Kuti; David F Bishop; Mihaly Mezei; Lei Zeng; Ming-Ming Zhou; Robert J Desnick
Human uroporphyrinogen III synthase: NMR-based mapping of the active site.
Proteins 2008;71(2):855-73.
2008: Lei Zeng; Qiang Zhang; Guillermo Gerona-Navarro; Natalia Moshkina; Ming-Ming Zhou
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.
Structure (London, England : 1993) 2008;16(4):643-52.
2007: Chongfeng Pan; Mihaly Mezei; Shiraz Mujtaba; Michaela Muller; Lei Zeng; Jiaming Li; Zhiyong Wang; Ming-Ming Zhou
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor.
Journal of medicinal chemistry 2007;50(10):2285-8.
2006: Shiraz Mujtaba; Lei Zeng; Ming-Ming Zhou
Modulating molecular functions of p53 with small molecules.
Cell cycle (Georgetown, Tex.) 2006;5(22):2575-8.
2006: Chengmin Qian; Xueqi Wang; Karishma L Manzur; Amjad Farooq; Lei Zeng; Rong Wang; Ming-Ming Zhou
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
Journal of molecular biology 2006;359(1):86-96.
2006: Thomas A Edwards; Joel A Butterwick; Lei Zeng; Yogesh K Gupta; Xin Wang; Robin P Wharton; Arthur G Palmer; Aneel K Aggarwal
Solution structure of the Vts1 SAM domain in the presence of RNA.
Journal of molecular biology 2006;356(5):1065-72.
2006: Lois Resnick-Silverman; Sherry Yan; Shiraz Mutjaba; Wen-Jun Liu; Lei Zeng; James J Manfredi; Ming-Ming Zhou
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.
Chemistry & biology 2006;13(1):81-90.
2005: Qiang Zhang; Michaela Muller; Can Hao Chen; Lei Zeng; Amjad Farooq; Ming-Ming Zhou
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
Journal of molecular biology 2005;354(4):777-88.
2005: Chengmin Qian; Qiang Zhang; SiDe Li; Lei Zeng; Martin J Walsh; Ming-Ming Zhou
Structure and chromosomal DNA binding of the SWIRM domain.
Nature structural & molecular biology 2005;12(12):1078-85.
2005: Chengmin Qian; Qiang Zhang; Xueqi Wang; Lei Zeng; Amjad Farooq; Ming-Ming Zhou
Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function.
Journal of molecular biology 2005;347(2):309-21.
2005: Lei Zeng; Jiaming Li; Michaela Muller; Sherry Yan; Shiraz Mujtaba; Chongfeng Pan; Zhiyong Wang; Ming-Ming Zhou
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association.
Journal of the American Chemical Society 2005;127(8):2376-7.
2004: Alexander W Koch; Amjad Farooq; Weisong Shan; Lei Zeng; David R Colman; Ming-Ming Zhou
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics.
Structure (London, England : 1993) 2004;12(5):793-805.
2004: Shiraz Mujtaba; Yan He; Lei Zeng; Sherry Yan; Olga Plotnikova; Roberto Sanchez; Nancy J Zeleznik-Le; Ze'ev Ronai; Ming-Ming Zhou
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Molecular cell 2004;13(2):251-63.
2004: Lei Zeng; Ken Chen; Michaela Muller; Ming-Ming Zhou
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors.
Journal of molecular neuroscience : MN 2004;24(1):81-4.
2004: Alexander W Koch; Amjad Farooq; Lei Zeng; David R Colman; Ming-Ming Zhou
1H, 13C and 15N resonance assignments for the N-cadherin prodomain.
Journal of biomolecular NMR 2004;28(1):87-8.
2003: Kelley S Yan; Sherry Yan; Amjad Farooq; Arnold Han; Lei Zeng; Ming-Ming Zhou
Structure and conserved RNA binding of the PAZ domain.
Nature 2003;426(6965):468-74.
2003: Amjad Farooq; Lei Zeng; Kelley S Yan; Kodi S Ravichandran; Ming-Ming Zhou
Coupling of folding and binding in the PTB domain of the signaling protein Shc.
Structure (London, England : 1993) 2003;11(8):905-13.
2003: Karishma L Manzur; Amjad Farooq; Lei Zeng; Ming-Ming Zhou
1H, 13C and 15N resonance assignments of a viral SET domain histone lysine methyltransferase.
Journal of biomolecular NMR 2003;26(3):279-80.
2003: Karishma L Manzur; Amjad Farooq; Lei Zeng; Olga Plotnikova; Alexander W Koch; Ming-Ming Zhou
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nature structural biology 2003;10(3):187-96.
2003: An-Qiang Sun; Rachita Salkar; Shuhua Xu; Lei Zeng; Ming-Ming Zhou; Frederick J Suchy
A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter.
The Journal of biological chemistry 2003;278(6):4000-9.
2003: Amjad Farooq; Olga Plotnikova; Gaurav Chaturvedi; Sherry Yan; Lei Zeng; Qiang Zhang; Ming-Ming Zhou
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.
Structure (London, England : 1993) 2003;11(2):155-64.
2003: Lei Zeng; Can Hao Chen; Michaela Muller; Ming-Ming Zhou
Structure-based rational design of chemical ligands for AMPA-subtype glutamate receptors.
Journal of molecular neuroscience : MN 2003;20(3):345-8.
2003: Gaurav Chaturvedi; Amjad Farooq; Lei Zeng; Ming-Ming Zhou
1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1.
Journal of biomolecular NMR 2003;25(1):79-80.
2002: Lei Zeng; Luying Lu; Michaela Muller; James Eric Gouaux; Ming-Ming Zhou
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors.
Journal of molecular neuroscience : MN 2002;19(1-2):113-6.
2002: Shiraz Mujtaba; Yan He; Lei Zeng; Amjad Farooq; Justin E Carlson; Melanie Ott; Eric Verdin; Ming-Ming Zhou
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
Molecular cell 2002;9(3):575-86.
2002: Lei Zeng; Ming-Ming Zhou
Bromodomain: an acetyl-lysine binding domain.
FEBS letters 2002;513(1):124-8.