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Roy Zent

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Chandramohan Natarajan; Roy Zent; Heidi E Hamm; Aaron N Hata; Richard M Breyer
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Leslie Gewin; Raymond C Harris; Surekha Neelisetty; Paisit Paueksakon; Ambra Pozzi; Manakan B Srichai; Sangeetha Vadivelu; Roy Zent
Deleting the TGF-β receptor attenuates acute proximal tubule injury.
Christina S Bartlett; Kelli L Boyd; Raymond C Harris; Roy Zent; Richard M Breyer
EP1 disruption attenuates end-organ damage in a mouse model of hypertension.

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All Publications

2013: Chandramohan Natarajan; Roy Zent; Heidi E Hamm; Aaron N Hata; Richard M Breyer
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Molecular pharmacology 2013;83(1):206-16.
2012: Leslie Gewin; Raymond C Harris; Surekha Neelisetty; Paisit Paueksakon; Ambra Pozzi; Manakan B Srichai; Sangeetha Vadivelu; Roy Zent
Deleting the TGF-β receptor attenuates acute proximal tubule injury.
Journal of the American Society of Nephrology : JASN 2012;23(12):2001-11.
2012: Christina S Bartlett; Kelli L Boyd; Raymond C Harris; Roy Zent; Richard M Breyer
EP1 disruption attenuates end-organ damage in a mouse model of hypertension.
Hypertension 2012;60(5):1184-91.
2012: Mingjian Shi; Wade D Van Horn; Roy Zent; Charles R Sanders; Samuel A Santoro; Brandt F Eichman; Briana H Greer; Billy G Hudson; Vadim Pedchenko; Ambra Pozzi
Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.
The Journal of biological chemistry 2012;287(42):35139-52.
2012: Roy Zent; Ambra Pozzi
Connecting the segments.
Journal of the American Society of Nephrology : JASN 2012;23(10):1603-5.
2012: Sijo Mathew; Glenda Mernaugh; Alexander Meves; Riya J Palamuttam; Ambra Pozzi; Charles R Sanders; Markus Voehler; Christoph Ballestrem; Nada Bulus; Jiang Chen; Reinhard Fässler; Leslie S Gewin; Arina Hadziselimovic; Zhenwei Lu; Roy Zent
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.
Molecular and cellular biology 2012;32(20):4080-91.
2012: Corina M Borza; Xiwu Chen; Sergei Chetyrkin; William F Degrado; Beate Eckes; Billy G Hudson; Hyunil Jo; Stacey Mont; Yan Su; Paul A Voziyan; Ling Yu; Roy Zent; Joel S Bennett; Paul C Billings; Ambra Pozzi
Inhibition of integrin α2β1 ameliorates glomerular injury.
Journal of the American Society of Nephrology : JASN 2012;23(6):1027-38.
2012: Ling Yu; Roy Zent; Yan Su; Hongtao Wang; Xiwu Chen; Huifang Cheng; Raymond C Harris; Paisit Paueksakon; Ambra Pozzi
Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
Kidney international 2012;81(11):1086-97.
2012: Sijo Mathew; Ambra Pozzi; Xiwu Chen; Roy Zent
Integrins in renal development.
Pediatric nephrology (Berlin, Germany) 2012;27(6):891-900.
2012: Leslie Gewin; Roy Zent
How does TGF-β mediate tubulointerstitial fibrosis?
Seminars in nephrology 2012;32(3):228-35.
2012: Nada Bulus; Chloe Feral; Ambra Pozzi; Roy Zent
CD98 increases renal epithelial cell proliferation by activating MAPKs.
PloS one 2012;7(6):e40026.
2011: Peter E Clark; Cheryl Coffin; Hernan Correa; Mark de Caestecker; Harold Love; Harold L Moses; Elizabeth J Perlman; Dina Polosukhina; Roy Zent
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
The American journal of pathology 2011;179(6):3045-55.
2011: Ambra Pozzi; Roy Zent
Extracellular matrix receptors in branched organs.
Current opinion in cell biology 2011;23(5):547-53.
2011: Ambra Pozzi; Roy Zent
TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation.
The American journal of pathology 2011;178(2):485-9.
2010: Corina M Borza; Xiwu Chen; Sijo Mathew; Stacey Mont; Charles R Sanders; Roy Zent; Ambra Pozzi
Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase.
The Journal of biological chemistry 2010;285(51):40114-24.
2010: Karen S Riggins; Glenda Mernaugh; Yan Su; Vito Quaranta; Naohiko Koshikawa; Motoharu Seiki; Ambra Pozzi; Roy Zent
MT1-MMP-mediated basement membrane remodeling modulates renal development.
Experimental cell research 2010;316(17):2993-3005.
2010: Peter E Clark; Dina A Polosukhina; Kenneth Gyabaah; Harold L Moses; Andrew Thorburn; Roy Zent
TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis.
The Journal of urology 2010;184(3):1166-74.
2010: Leslie Gewin; Nada Bulus; Glenda Mernaugh; Gilbert W Moeckel; Raymond C Harris; Harold L Moses; Ambra Pozzi; Roy Zent
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.
Journal of the American Society of Nephrology : JASN 2010;21(8):1334-43.
2010: Hironobu Yamashita; Manisha Tripathi; Mark P Harris; Shanshan Liu; Brandy Weidow; Roy Zent; Vito Quaranta
The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration.
Biomaterials 2010;31(19):5110-21.
2010: Xiwu Chen; Carrie Whiting; Corina Borza; Wen Hu; Stacey Mont; Nada Bulus; Ming-Zhi Zhang; Raymond C Harris; Roy Zent; Ambra Pozzi
Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression.
Molecular and cellular biology 2010;30(12):3048-58.
2010: Ambra Pozzi; Roy Zent
ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation.
Journal of the American Society of Nephrology : JASN 2010;21(3):388-90.
2009: Xi Zhang; Glenda Mernaugh; Dong-Hua Yang; Leslie Gewin; Manakan B Srichai; Raymond C Harris; Juan M Iturregui; Raoul D Nelson; Donald E Kohan; Dale Abrahamson; Reinhard Fässler; Peter Yurchenco; Ambra Pozzi; Roy Zent
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Development (Cambridge, England) 2009;136(19):3357-66.
2009: Ambra Pozzi; Roy Zent; Sergei Chetyrkin; Corina M Borza; Nada Bulus; Peale Chuang; Dong Chen; Billy Hudson; Paul A Voziyan
Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.
Journal of the American Society of Nephrology : JASN 2009;20(10):2119-25.
2009: Ambra Pozzi; Roy Zent
Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products.
Wiley interdisciplinary reviews. Systems biology and medicine 2009;1(2):254-72.
2009: Huifang Cheng; Xiaofeng Fan; Youfei Guan; Gilbert W Moeckel; Roy Zent; Raymond C Harris
Distinct roles for basal and induced COX-2 in podocyte injury.
Journal of the American Society of Nephrology : JASN 2009;20(9):1953-62.
2009: Ambra Pozzi; Paul A Voziyan; Billy G Hudson; Roy Zent
Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis.
Current pharmaceutical design 2009;15(12):1318-33.
2008: Tristin D Abair; Munirathinam Sundaramoorthy; Dong Chen; Jyrki Heino; Johanna Ivaska; Billy G Hudson; Charles R Sanders; Ambra Pozzi; Roy Zent
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.
Experimental cell research 2008;314(19):3593-604.
2008: Tristin D Abair; Nada Bulus; Corina Borza; Munirathinam Sundaramoorthy; Roy Zent; Ambra Pozzi
Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells.
Blood 2008;112(8):3242-54.
2008: Mete Erdogan; Ambra Pozzi; Neil A Bhowmick; Harold L Moses; Roy Zent
Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells.
Cancer research 2008;68(15):6224-31.
2008: Ines Macias-Perez; Corina Borza; Xiwu Chen; Xuexian Yan; Raquel Ibanez; Glenda Mernaugh; Lynn M Matrisian; Roy Zent; Ambra Pozzi
Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
Cancer research 2008;68(15):6127-35.
2008: Manakan B Srichai; Chuanming Hao; Linda Davis; Anastasia Golovin; Min Zhao; Gilbert W Moeckel; Steve Dunn; Nada Bulus; Raymond C Harris; Roy Zent; Matthew D Breyer
Apoptosis of the thick ascending limb results in acute kidney injury.
Journal of the American Society of Nephrology : JASN 2008;19(8):1538-46.
2008: Ines Macias-Perez; Roy Zent; Monica Carmosino; Matthew D Breyer; Richard M Breyer; Ambra Pozzi
Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.
The Journal of biological chemistry 2008;283(18):12538-45.
2008: Ambra Pozzi; George Jarad; Gilbert W Moeckel; Sergio Coffa; Xi Zhang; Leslie Gewin; Vera Eremina; Billy G Hudson; Dorin-Bogdan Borza; Raymond C Harris; Lawrence B Holzman; Carrie L Phillips; Reinhard Fassler; Susan E Quaggin; Jeffrey H Miner; Roy Zent
Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity.
Developmental biology 2008;316(2):288-301.
2008: Melissa S Maginnis; Bernardo A Mainou; Aaron Derdowski; Elizabeth M Johnson; Roy Zent; Terence S Dermody
NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.
Journal of virology 2008;82(7):3181-91.
2007: Fenghua Zeng; Ming-Zhi Zhang; Amar B Singh; Roy Zent; Raymond C Harris
ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis.
Molecular biology of the cell 2007;18(11):4446-56.
2007: Mete Erdogan; Ambra Pozzi; Neil A Bhowmick; Harold L Moses; Roy Zent
Signaling pathways regulating TC21-induced tumorigenesis.
The Journal of biological chemistry 2007;282(38):27713-20.
2007: Reena Rao; Reyadh Redha; Ines Macias-Perez; Yan Su; Chuanming Hao; Roy Zent; Matthew D Breyer; Ambra Pozzi
Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo.
The Journal of biological chemistry 2007;282(23):16959-68.
2007: Xiwu Chen; Tristin D Abair; Maria R Ibanez; Yan Su; Mark R Frey; Rebecca S Dise; D Brent Polk; Amar B Singh; Raymond C Harris; Roy Zent; Ambra Pozzi
Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.
Molecular and cellular biology 2007;27(9):3313-26.
2007: Bryan Voss; Joseph N McLaughlin; Michael Holinstat; Roy Zent; Heidi E Hamm
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis.
Molecular pharmacology 2007;71(5):1399-406.
2007: Roy Zent; Ambra Pozzi
Angiogenesis in diabetic nephropathy.
Seminars in nephrology 2007;27(2):161-71.
2007: J P Dwyer; K M Yates; E L Sumner; William J Stone; Y Wang; Mark J Koury; Agnes B Fogo; Roy Zent
Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy.
Clinical nephrology 2007;67(3):176-81.
2006: Roy Zent; X Yan; Yan Su; Billy G Hudson; Dorin-Bogdan Borza; Gilbert W Moeckel; Z Qi; Yoshikazu Sado; Matthew D Breyer; Paul A Voziyan; Ambra Pozzi
Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.
Kidney international 2006;70(3):460-70.
2006: Corina M Borza; Ambra Pozzi; Dorin-Bogdan Borza; Vadim Pedchenko; Thomas Hellmark; Billy G Hudson; Roy Zent
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.
The Journal of biological chemistry 2006;281(30):20932-9.
2006: Xiu-Bin Liang; Li-Jun Ma; Takashi Naito; Yihan Wang; Michael P. Madaio; Roy Zent; Ambra Pozzi; Agnes B Fogo
Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth.
Journal of the American Society of Nephrology : JASN 2006;17(7):1886-95.
2006: Rebecca Cook; Incheol Shin; Jae Youn Yi; E Easterly; Mary Helen Barcellos-Hoff; J M Yingling; Roy Zent; Carlos L Arteaga
Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression.
Oncogene 2006;25(24):3408-23.
2006: Kiyoshi Nakagawa; Vijaykumar R Holla; Yuan Wei; Wen-Hui Wang; Arnaldo Gatica; Shouzou Wei; Shaojun Mei; Crystal M Miller; Dae Ryong Cha; Edward Price; Roy Zent; Ambra Pozzi; Matthew D Breyer; Youfei Guan; John R Falck; Michael R Waterman; Jorge H Capdevila
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
The Journal of clinical investigation 2006;116(6):1696-702.
2006: Ambra Pozzi; Sergio Coffa; Nada Bulus; Wenqin Zhu; Dong Chen; Xiwu Chen; Glenda Mernaugh; Yan Su; Songmin Cai; Amar Singh; Marcela Brissova; Roy Zent
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.
Molecular biology of the cell 2006;17(4):2046-56.
2006: Roy Zent; Ambra Pozzi
Antiangiogenic therapy in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2006;17(2):325-7.
2006: Gilbert W Moeckel; Li Zhang; Xiwu Chen; Michele Rossini; Roy Zent; Ambra Pozzi
Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration.
American journal of physiology. Renal physiology 2006;290(1):F223-31.
2005: Raymond L Mernaugh; Heping Yan; Dong Chen; Jennifer Edl; Gregory Hanley; Ambra Pozzi; Roy Zent
Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening.
Journal of immunological methods 2005;306(1-2):115-27.
2005: Weiyi Mai; Dong Chen; Tianbing Ding; Ingyu Kim; Sujun Park; Sae-youll Cho; Julia S F Chu; Dan Liang; Ning Wang; Dianqing Wu; Song Li; Ping Zhao; Roy Zent; Guanqing Wu
Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
Molecular biology of the cell 2005;16(9):4398-409.
2005: Xiwu Chen; Yan Su; Barbara Fingleton; Heath Acuff Elrod; Lynn M Matrisian; Roy Zent; Ambra Pozzi
Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.
International journal of cancer. Journal international du cancer 2005;116(1):52-61.
2005: Ambra Pozzi; Ines Macias-Perez; Tristin Abair; Shouzuo Wei; Yan Su; Roy Zent; John R Falck; Jorge H Capdevila
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
The Journal of biological chemistry 2005;280(29):27138-46.
2005: Songmin Cai; Nada Bulus; Priscila M Fonseca-Siesser; Dong Chen; Steven K Hanks; Ambra Pozzi; Roy Zent
CD98 modulates integrin beta1 function in polarized epithelial cells.
Journal of cell science 2005;118(Pt 5):889-99.
2005: Denis Tvorogov; Xue-Jie Wang; Roy Zent; Graham Carpenter
Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion.
Journal of cell science 2005;118(Pt 3):601-10.
2005: Xiwu Chen; Yan Su; Barbara Fingleton; Heath Acuff Elrod; Lynn M Matrisian; Roy Zent; Ambra Pozzi
An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice.
Clinical & experimental metastasis 2005;22(2):185-93.
2004: Dong Chen; Richard Roberts; Martin Pohl; Sanjay Nigam; Jordan A Kreidberg; Zemin Wang; Jyrki Heino; Johanna Ivaska; Sergio Coffa; Raymond C Harris; Ambra Pozzi; Roy Zent
Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis.
American journal of physiology. Renal physiology 2004;287(4):F602-11.
2004: Maxwell E Fisher; Michele Rossini; Edith Simmons; Raymond C Harris; Gilbert W Moeckel; Roy Zent
A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;44(3):567-73.
2004: Xiwu Chen; Gilbert W Moeckel; Jason D Morrow; Dominic Cosgrove; Raymond C Harris; Agnes B Fogo; Roy Zent; Ambra Pozzi
Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury.
The American journal of pathology 2004;165(2):617-30.
2004: Amar B Singh; Toshiaki Tsukada; Roy Zent; Raymond C Harris
Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells.
Journal of cell science 2004;117(Pt 8):1365-79.
2004: Naohiko Koshikawa; Susann Schenk; Gilbert W Moeckel; Andrew Sharabi; Kaoru Miyazaki; Humphrey Gardner; Roy Zent; Vito Quaranta
Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):364-6.
2004: Vadim Pedchenko; Roy Zent; Billy G Hudson
Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion.
The Journal of biological chemistry 2004;279(4):2772-80.
2003: Aaron N Hata; Roy Zent; Matthew D Breyer; Richard M Breyer
Expression and molecular pharmacology of the mouse CRTH2 receptor.
The Journal of pharmacology and experimental therapeutics 2003;306(2):463-70.
2003: Ambra Pozzi; Roy Zent
Integrins: sensors of extracellular matrix and modulators of cell function.
Nephron. Experimental nephrology 2003;94(3):e77-84.
2001: Neil A Bhowmick; Roy Zent; Mayshan Ghiassi; M McDonnell; Harold L Moses
Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.
The Journal of biological chemistry 2001;276(50):46707-13.
2001: Roy Zent; Kevin T Bush; M L Pohl; Vito Quaranta; N Koshikawa; Z Wang; Jordan A Kreidberg; Hiroyuki Sakurai; Robert O Stuart; S K Nigám
Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development.
Developmental biology 2001;238(2):289-302.
2001: Csilla Anne Fenczik; Roy Zent; M Dellos; David A Calderwood; J Satriano; C Kelly; Mark H Ginsberg
Distinct domains of CD98hc regulate integrins and amino acid transport.
The Journal of biological chemistry 2001;276(12):8746-52.
2000: Roy Zent; Csilla Anne Fenczik; David A Calderwood; Shouchun Liu; M Dellos; Mark H Ginsberg
Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains.
The Journal of biological chemistry 2000;275(7):5059-64.
1999: David A Calderwood; Roy Zent; R Grant; D J Rees; R O Hynes; Mark H Ginsberg
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.
The Journal of biological chemistry 1999;274(40):28071-4.