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Dong-Er Zhang

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Russell C Dekelver; Wei-Jong Shia; Nancy A Speck; Ming Yan; Eun-Young Ahn; Dong-Er Zhang
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.
Dan Ran; Wei-Jong Shia; Ming Yan; Zhaohui Ye; Linzhao Cheng; Jun-Bao Fan; Patrick I Ferrell; Dan S Kaufman; David A Knorr; Miao-Chia Lo; Dong-Er Zhang
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells.
Erin Eun-Young Ahn; Russell C DeKelver; Christopher J Hickey; Tsunehito Higashi; Miao-Chia Lo; Shinobu Matsuura; Wei-Jong Shia; Ming Yan; Dong-Er Zhang
SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.

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2013: Russell C Dekelver; Wei-Jong Shia; Nancy A Speck; Ming Yan; Eun-Young Ahn; Dong-Er Zhang
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.
Blood 2013;121(18):3714-7.
2013: Dan Ran; Wei-Jong Shia; Ming Yan; Zhaohui Ye; Linzhao Cheng; Jun-Bao Fan; Patrick I Ferrell; Dan S Kaufman; David A Knorr; Miao-Chia Lo; Dong-Er Zhang
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells.
Blood 2013;121(15):2882-90.
2013: Erin Eun-Young Ahn; Russell C DeKelver; Christopher J Hickey; Tsunehito Higashi; Miao-Chia Lo; Shinobu Matsuura; Wei-Jong Shia; Ming Yan; Dong-Er Zhang
SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.
The Journal of biological chemistry 2013;288(8):5381-8.
2013: Jun-Bao Fan; Dong-Er Zhang
ISG15 regulates IFN-γ immunity in human mycobacterial disease.
Cell research 2013;23(2):173-5.
2013: Fumihiko Okumura; Keiji Uematsu; Dong-Er Zhang; Shigetsugu Hatakeyama; Akiko J Okumura; Takumi Kamura
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.
The Journal of biological chemistry 2013;288(4):2839-47.
2012: Shinobu Matsuura; Donna Neuberg; Kristen E Stevenson; Tingdong Tang; Ming Yan; Joseph R Biggs; Xiuli Cong; Yukiko Komeno; Kentson Lam; Miao-Chia Lo; Dong-Er Zhang
Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome.
Blood 2012;120(19):4028-37.
2012: Miao-Chia Lo; Minh Ly; Shinobu Matsuura; Hans B Ommen; Luke Peterson; Bing Ren; Wei-Jong Shia; Cheryl L Willman; Ming Yan; Eun-Young Ahn; I-Ming Chen; Xiuli Cong; Peter Hokland; Fulai Jin; Yukiko Komeno; Dong-Er Zhang
Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.
Blood 2012;120(7):1473-84.
2012: Hwa Young Yim; Dong-Er Zhang; Myeong Seok Lee; Jong-Seok Lim; Young Yang; Keun Il Kim
The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells.
Biochemical and biophysical research communications 2012;423(2):436-40.
2012: Wei-Jong Shia; Ming Yan; John R Yates; Yukiko Komeno; Miao-Chia Lo; Shinobu Matsuura; Stephen D Nimer; Akiko J Okumura; Ali Sarkeshik; Xinyang Zhao; Dong-Er Zhang
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
Blood 2012;119(21):4953-62.
2012: Xiu-Li Cong; Jun-Bao Fan; Miao-Chia Lo; Brian A Reuter; Ming Yan; Dong-Er Zhang
Usp18 promotes conventional CD11b+ dendritic cell development.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):4776-81.
2012: Shinobu Matsuura; Stephanie Weng; Ming Yan; Eun-Young Ahn; David Dangoor; Gen-Sheng Feng; Tsunehito Higashi; Miao-Chia Lo; Mahan Matin; Dong-Er Zhang
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.
Blood 2012;119(13):3155-63.
2012: Christoph Burkart; Jun-Bao Fan; Dong-Er Zhang
Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.
The Journal of biological chemistry 2012;287(7):4883-93.
2011: Venkata P Nakka; Robert J Dempsey; Bradley T Lang; Deborah J Lenschow; Dong-Er Zhang; Raghu Vemuganti
Increased cerebral protein ISGylation after focal ischemia is neuroprotective.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(12):2375-84.
2011: Elena Levantini; Yutaka Okuno; Hanna S Radomska; Nicola K Wilson; Dong-Er Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jorda; Giovanni Amabile; Daniela S Basseres; Constanze Bonifer; Alexander K Ebralidze; David A Gonzalez; Bertie Gottgens; Christopher J Hetherington; Gang Huang; Steffen Koschmieder; Sanghoon Lee; Daniel G Tenen
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
The EMBO journal 2011;30(19):4059-70.
2011: Anita Boyapati; Bing Ren; Dong-Er Zhang
SERPINB13 is a novel RUNX1 target gene.
Biochemical and biophysical research communications 2011;411(1):115-20.
2011: Helen He Zhu; Kaihong Ji; Nazilla Alderson; Zhao He; Shuangwei Li; Wen Liu; Dong-Er Zhang; Linheng Li; Gen-Sheng Feng
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.
Blood 2011;117(20):5350-61.
2011: Christopher P Arnold; Ruoying Tan; Baiyu Zhou; Si-Biao Yue; Steven Schaffert; Joseph R Biggs; Regis Doyonnas; Miao-Chia Lo; John M Perry; Valerie Renault; Alessandra Sacco; Tim Somervaille; Patrick Viatour; Anne Brunet; Michael L Cleary; Linheng Li; Julien Sage; Dong-Er Zhang; Helen M Blau; Caifu Chen; Chang-Zheng Chen
MicroRNA programs in normal and aberrant stem and progenitor cells.
Genome research 2011;21(5):798-810.
2011: Eun-Young Ahn; Russell C DeKelver; Miao-Chia Lo; Tuyet Ann Nguyen; Shinobu Matsuura; Anita Boyapati; Shatakshi Pandit; Xiang-Dong Fu; Dong-Er Zhang
SON controls cell-cycle progression by coordinated regulation of RNA splicing.
Molecular cell 2011;42(2):185-98.
2011: Ana Leticia Maragno; Martine Pironin; Frederic Tangy; Dong-Er Zhang; Hélène Alcalde; Xiuli Cong; Jacques Ghysdael; Klaus-Peter Knobeloch; Christine Tran Quang
ISG15 modulates development of the erythroid lineage.
PloS one 2011;6(10):e26068.
2011: Dongxian Zhang; Dong-Er Zhang
Interferon-stimulated gene 15 and the protein ISGylation system.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(1):119-30.
2010: Etienne Richer; Caitlin Prendergast; Dong-Er Zhang; Salman T Qureshi; Silvia M Vidal; Danielle Malo
N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3593-601.
2010: Xiuli Cong; Ming Yan; Xiaoyan Yin; Dong-Er Zhang
Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation.
Blood cells, molecules & diseases 2010;45(2):103-11.
2010: Hiroshi Kawabe; Antje Neeb; Kalina Dimova; Samuel M Young; Michiko Takeda; Shutaro Katsurabayashi; Miso Mitkovski; Oxana A Malakhova; Dong-Er Zhang; Masato Umikawa; Ken-ichi Kariya; Sandra Goebbels; Klaus-Armin Nave; christian rosenmund; Olaf Jahn; JeongSeop Rhee; Nils Brose
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Neuron 2010;65(3):358-72.
2010: Hans B Ommen; Mette Ostergaard; Ming Yan; Karin Braendstrup; Dong-Er Zhang; Peter Hokland
Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse.
European journal of haematology 2010;84(2):128-32.
2009: Magdalena Sarasin-Filipowicz; Xueya Wang; Ming Yan; Francois H T Duong; Valeria Poli; Douglas J Hilton; Dong-Er Zhang; Markus H Heim
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43.
Molecular and cellular biology 2009;29(17):4841-51.
2009: Xiaoyan Yin; Xiuli Cong; Ming Yan; Dong-Er Zhang
Alteration of tumor spectrum by ISGylation in p53-deficient mice.
Cancer biology & therapy 2009;8(12):1167-72.
2009: Young Joo Jeon; Joon Seok Choi; Jung Yun Lee; Kyung Ryun Yu; Sangman Michael Kim; Seung Hyeun Ka; Kyu Hee Oh; Keun Il Kim; Dong-Er Zhang; Ok-Sun Bang; Chin Ha Chung
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
EMBO reports 2009;10(4):374-80.
2009: Xiaoyan Yin; Xiuli Cong; Ming Yan; Dong-Er Zhang
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice.
Lung cancer (Amsterdam, Netherlands) 2009;63(2):194-200.
2009: Ming Yan; Eun-Young Ahn; Scott W Hiebert; Dong-Er Zhang
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.
Blood 2009;113(4):883-6.
2009: Caroline Lai; Jessica J Struckhoff; Jana Schneider; Luis Martinez-Sobrido; Thorsten Wolff; Adolfo García-Sastre; Dong-Er Zhang; Deborah J Lenschow
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
Journal of virology 2009;83(2):1147-51.
2008: Eun-Young Ahn; Ming Yan; Oxana A Malakhova; Miao-Chia Lo; Anita Boyapati; Hans Beier Ommen; Robert Hines; Peter Hokland; Dong-Er Zhang
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17103-8.
2008: Alessandro Gardini; matteo cesaroni; Lucilla Luzi; Akiko J Okumura; Joseph R Biggs; Simone P Minardi; Elisa Venturini; Dong-Er Zhang; Pier Giuseppe Pelicci; Myriam Alcalay
AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.
PLoS genetics 2008;4(11):e1000275.
2008: Jung-Hwan Kim; Jiann-Kae Luo; Dong-Er Zhang
The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6467-72.
2008: Zejuan Li; Jun Lu; Miao Sun; Shuangli Mi; Hao Zhang; Roger T Luo; Ping Chen; Yungui Wang; Ming Yan; Zhijian Qian; Mary Beth Neilly; Jie Jin; Yanming Zhang; Stefan K Bohlander; Dong-Er Zhang; Richard A Larson; Michelle M Le Beau; Michael J Thirman; Todd R Golub; Janet D Rowley; Jianjun Chen
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15535-40.
2008: Fumihiko Okumura; Deborah J Lenschow; Dong-Er Zhang
Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.
The Journal of biological chemistry 2008;283(36):24484-8.
2008: Akiko J Okumura; Luke Peterson; Fumihiko Okumura; Anita Boyapati; Dong-Er Zhang
t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.
Blood 2008;112(4):1392-401.
2008: Yong-Gang Chang; Xian-Zhong Yan; Yuan-Yuan Xie; Xue-Chao Gao; Ai-Xin Song; Dong-Er Zhang; Hong-Yu Hu
Different roles for two ubiquitin-like domains of ISG15 in protein modification.
The Journal of biological chemistry 2008;283(19):13370-7.
2008: Farshid Dayyani; Jianfeng Wang; Jing-Ruey J Yeh; Eun-Young Ahn; Erica Tobey; Dong-Er Zhang; Irwin D Bernstein; Randall T Peterson; David A Sweetser
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Blood 2008;111(8):4338-47.
2008: Oxana A Malakhova; Dong-Er Zhang
ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.
The Journal of biological chemistry 2008;283(14):8783-7.
2008: Mili Kapoor; Quansheng Zhou; Francella J Otero; Christopher A Myers; Alison Bates; Rajesh Belani; Jianming Liu; Jiann-Kae Luo; Eleni Tzima; Dong-Er Zhang; Xiang-Lei Yang; Paul Schimmel
Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS.
The Journal of biological chemistry 2008;283(4):2070-7.
2007: Luke Peterson; Miao-Chia Lo; Akiko Joo Okumura; Dong-Er Zhang
Inability of RUNX1/AML1 to breach AML1-ETO block of embryonic stem cell definitive hematopoiesis.
Blood cells, molecules & diseases 2007;39(3):321-8.
2007: Robert Hines; Anita Boyapati; Dong-Er Zhang
Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.
Blood cells, molecules & diseases 2007;39(3):297-306.
2007: Luke Peterson; Y Wang; Miao-Chia Lo; Ming Yan; Eiki Kanbe; Dong-Er Zhang
The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.
Leukemia 2007;21(9):2010-9.
2007: Luke Peterson; Anita Boyapati; Eun-Young Ahn; Joseph R Biggs; Akiko Joo Okumura; Miao-Chia Lo; Ming Yan; Dong-Er Zhang
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.
Blood 2007;110(3):799-805.
2007: Ming Yan; Jiann-Kae Luo; Kenneth J Ritchie; Ikuya Sakai; Kasuto Takeuchi; Ruibao Ren; Dong-Er Zhang
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.
Blood 2007;110(1):305-12.
2007: Akiko Joo Okumura; Luke Peterson; Miao-Chia Lo; Dong-Er Zhang
Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells.
Experimental hematology 2007;35(6):978-88.
2007: Luke Peterson; Ming Yan; Dong-Er Zhang
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.
Blood 2007;109(10):4392-8.
2007: Anita Boyapati; Ming Yan; Luke Peterson; Joseph R Biggs; Michelle M Le Beau; Dong-Er Zhang
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.
Blood 2007;109(9):3963-71.
2007: Weiguo Zou; Jung-Hwan Kim; Adedayo Handidu; Xiang Li; Keun Il Kim; Ming Yan; Jun Li; Dong-Er Zhang
Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.
Biochemical and biophysical research communications 2007;356(1):193-9.
2007: Guang-Biao Zhou; Hui Kang; Lan Wang; Li Gao; Ping Liu; Jun Xie; Feng-Xiang Zhang; Xiang-Qin Weng; Zhi-Xiang Shen; Jue Chen; Long-jun Gu; Ming Yan; Dong-Er Zhang; Sai-Juan Chen; wang zhenyi; Zhu Chen
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Blood 2007;109(8):3441-50.
2007: Weiguo Zou; Ji Wang; Dong-Er Zhang
Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.
Biochemical and biophysical research communications 2007;354(1):321-7.
2007: Fumihiko Okumura; Weiguo Zou; Dong-Er Zhang
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
Genes & development 2007;21(3):255-60.
2007: Yu-qing Miao; Zi-xing Chen; Jun He; Jian-nong Cen; Xiao-jing Bao; Qiao-cheng Qiu; Dong-Er Zhang; Ming Yan
[Expression of AML1/ETO9a isoform in acute myeloid leukemia-M2 subtype].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2007;28(1):27-9.
2007: Lea A Rempel; Kathleen J Austin; Kenneth J Ritchie; Ming Yan; Meifeng Shen; Dong-Er Zhang; Luiz E Henkes; Thomas R Hansen
Ubp43 gene expression is required for normal Isg15 expression and fetal development.
Reproductive biology and endocrinology : RB&E 2007;5():13.
2006: Joseph R Biggs; Luke Peterson; Youhong Zhang; Andrew Kraft; Dong-Er Zhang
AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.
Molecular and cellular biology 2006;26(20):7420-9.
2006: Ming Yan; Eiki Kanbe; Luke Peterson; Anita Boyapati; Yuqin Miao; Yang Wang; I-Ming Chen; Zixing Chen; Janet D Rowley; Cheryl L Willman; Dong-Er Zhang
A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.
Nature medicine 2006;12(8):945-9.
2006: Oxana A Malakhova; Keun Il Kim; Jiann-Kae Luo; Weiguo Zou; K G Suresh Kumar; Serge Y Fuchs; Ke Shuai; Dong-Er Zhang
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
The EMBO journal 2006;25(11):2358-67.
2006: Chinh T Dao; Jiann-Kae Luo; Dong-Er Zhang
Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction.
Blood cells, molecules & diseases 2006;36(3):406-13.
2006: Weiguo Zou; Dong-Er Zhang
The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.
The Journal of biological chemistry 2006;281(7):3989-94.
2006: Keun Il Kim; Ming Yan; Oxana A Malakhova; Jiann-Kae Luo; Mei-Feng Shen; Weiguo Zou; Juan Carlos de la Torre; Dong-Er Zhang
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.
Molecular and cellular biology 2006;26(2):472-9.
2005: Luke Peterson; Anita Boyapati; Velvizhi Ranganathan; Atsushi Iwama; Daniel G Tenen; Schickwann Tsai; Dong-Er Zhang
The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.
Molecular and cellular biology 2005;25(23):10205-19.
2005: Nadia V Giannakopoulos; Jiann-Kae Luo; Vladimir Papov; Weiguo Zou; Deborah J Lenschow; Barbara S Jacobs; Ernest C Borden; Jun Li; Herbert W Virgin; Dong-Er Zhang
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
Biochemical and biophysical research communications 2005;336(2):496-506.
2005: Weiguo Zou; Vladimir Papov; Oxana A Malakhova; Keun Il Kim; Chinh T Dao; Jun Li; Dong-Er Zhang
ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.
Biochemical and biophysical research communications 2005;336(1):61-8.
2005: Keun Il Kim; Oxana A Malakhova; Kasper Hoebe; Ming Yan; Bruce Beutler; Dong-Er Zhang
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):847-54.
2005: Joseph R Biggs; Youhong Zhang; Luke Peterson; Marileila Garcia; Dong-Er Zhang; Andrew Kraft
Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.
Molecular cancer research : MCR 2005;3(7):391-401.
2005: Edward M Chan; Elisha M Comer; Frank C Brown; Kathleen E Richkind; Melissa L Holmes; Beng H Chong; Roger Shiffman; Dong-Er Zhang; Marilyn L Slovak; Cheryl L Willman; Constance T Noguchi; Yanjun Li; Devan J Heiber; Lori Kwan; Rebecca J Chan; Gail H Vance; Heather Ramsey; Robert Hromas
AML1-FOG2 fusion protein in myelodysplasia.
Blood 2005;105(11):4523-6.
2005: Keun Il Kim; Dong-Er Zhang
UBP43, an ISG15-specific deconjugating enzyme: expression, purification, and enzymatic assays.
Methods in enzymology 2005;398():491-9.
2005: Chinh T Dao; Dong-Er Zhang
ISG15: a ubiquitin-like enigma.
Frontiers in bioscience : a journal and virtual library 2005;10():2701-22.
2004: Ming Yan; Sebastien A Burel; Luke Peterson; Eiki Kanbe; Hiromi Iwasaki; Anita Boyapati; Robert Hines; Koichi Akashi; Dong-Er Zhang
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17186-91.
2004: Kenneth J Ritchie; Chang S Hahn; Keun Il Kim; Ming Yan; Debralee Rosario; Li Li; Juan Carlos de la Torre; Dong-Er Zhang
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.
Nature medicine 2004;10(12):1374-8.
2004: Sara Tokarz; Catherine Berset; Janna La Rue; Kevin Friedman; Kei-Ichi Nakayama; Keiko Nakayama; Dong-Er Zhang; Stefan Lanker
The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.
The Journal of biological chemistry 2004;279(45):46424-30.
2004: Keun Il Kim; Nadia V Giannakopoulos; Herbert W Virgin; Dong-Er Zhang
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.
Molecular and cellular biology 2004;24(21):9592-600.
2004: Eiki Kanbe; Dong-Er Zhang
A simple and quick method to concentrate MSCV retrovirus.
Blood cells, molecules & diseases 2004;33(1):64-7.
2004: Luke Peterson; Dong-Er Zhang
The 8;21 translocation in leukemogenesis.
Oncogene 2004;23(24):4255-62.
2004: Je-Yoel Cho; Yasmin Akbarali; Luiz F Zerbini; Xuesong Gu; Jay Boltax; Yihong Wang; Peter Oettgen; Dong-Er Zhang; Towia Libermann
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.
The Journal of biological chemistry 2004;279(19):19512-22.
2004: Kenneth J Ritchie; Dong-Er Zhang
ISG15: the immunological kin of ubiquitin.
Seminars in cell & developmental biology 2004;15(2):237-46.
2004: Anita Boyapati; Eiki Kanbe; Dong-Er Zhang
p53 alterations in myeloid leukemia.
Acta haematologica 2004;111(1-2):100-6.
2003: Annika Elsässer; Michael Franzen; Alexander Kohlmann; Martin Weisser; Susanne Schnittger; Claudia Schoch; Venkateshwar A Reddy; Sebastien A Burel; Dong-Er Zhang; Marius Ueffing; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.
Oncogene 2003;22(36):5646-57.
2003: Keun Il Kim; Dong-Er Zhang
ISG15, not just another ubiquitin-like protein.
Biochemical and biophysical research communications 2003;307(3):431-4.
2003: Heather Ramsey; Dong-Er Zhang; Kathleen E Richkind; A Burcoglu-O'Ral; Robert Hromas
Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation.
Leukemia 2003;17(8):1665-6.
2003: Michael P Malakhov; Keun Il Kim; Oxana A Malakhova; Barbara S Jacobs; Ernest C Borden; Dong-Er Zhang
High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.
The Journal of biological chemistry 2003;278(19):16608-13.
2003: Oxana A Malakhova; Ming Yan; Michael P Malakhov; Youzhong Yuan; Kenneth J Ritchie; Keun Il Kim; Luke Peterson; Ke Shuai; Dong-Er Zhang
Protein ISGylation modulates the JAK-STAT signaling pathway.
Genes & development 2003;17(4):455-60.
2002: Kenneth J Ritchie; Michael P Malakhov; Christopher J Hetherington; Liming Zhou; Marie-Térèse Little; Oxana A Malakhova; Jack C Sipe; Stuart H Orkin; Dong-Er Zhang
Dysregulation of protein modification by ISG15 results in brain cell injury.
Genes & development 2002;16(17):2207-12.
2002: Oxana A Malakhova; Michael P Malakhov; Christopher J Hetherington; Dong-Er Zhang
Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3.
The Journal of biological chemistry 2002;277(17):14703-11.
2002: Michael P Malakhov; Oxana A Malakhova; Keun Il Kim; Kenneth J Ritchie; Dong-Er Zhang
UBP43 (USP18) specifically removes ISG15 from conjugated proteins.
The Journal of biological chemistry 2002;277(12):9976-81.
2001: Y Yuan; Liming Zhou; T Miyamoto; H Iwasaki; N Harakawa; Christopher J Hetherington; Sebastien A Burel; E Lagasse; I L Weissman; Koichi Akashi; Dong-Er Zhang
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10398-403.
2001: Sebastien A Burel; N Harakawa; Liming Zhou; Thomas Pabst; Daniel G Tenen; Dong-Er Zhang
Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation.
Molecular and cellular biology 2001;21(16):5577-90.
2001: Thomas Pabst; Beatrice U Mueller; N Harakawa; C Schoch; T Haferlach; Gerhard Behre; Wolfgang Hiddemann; Dong-Er Zhang; Daniel G Tenen
AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.
Nature medicine 2001;7(4):444-51.
2001: Robert Hromas; T Busse; A Carroll; D Mack; R Shopnick; Dong-Er Zhang; Harikrishna Nakshatri; Kathleen E Richkind
Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein.
Blood 2001;97(7):2168-70.
2001: Dong-Er Zhang; Sebastien A Burel; Liming Zhou; Christopher J Hetherington; Y Yuan
AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis.
Blood cells, molecules & diseases 2001;27(2):368-76.
2000: Z Pan; Liming Zhou; Christopher J Hetherington; Dong-Er Zhang
Hepatocytes contribute to soluble CD14 production, and CD14 expression is differentially regulated in hepatocytes and monocytes.
The Journal of biological chemistry 2000;275(46):36430-5.
2000: K L Rhoades; Christopher J Hetherington; N Harakawa; DA Yergeau; Liming Zhou; LQ Liu; Marie-Térèse Little; Daniel G Tenen; Dong-Er Zhang
Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.
Blood 2000;96(6):2108-15.
2000: H Schwer; LQ Liu; L Zhou; Marie-Térèse Little; Z Pan; Christopher J Hetherington; Dong-Er Zhang
Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).
Genomics 2000;65(1):44-52.
1999: Towia Libermann; Z Pan; Yasmin Akbarali; Christopher J Hetherington; Jay Boltax; DA Yergeau; Dong-Er Zhang
AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.
The Journal of biological chemistry 1999;274(35):24671-6.
1999: Z Pan; Christopher J Hetherington; Dong-Er Zhang
CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development.
The Journal of biological chemistry 1999;274(33):23242-8.
1999: LQ Liu; RL Ilaria; Paul D Kingsley; A Iwama; Richard A Van Etten; James Palis; Dong-Er Zhang
A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation.
Molecular and cellular biology 1999;19(4):3029-38.
1999: Gerhard Behre; P Zhang; Dong-Er Zhang; D G Tenen
Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis.
Methods (San Diego, Calif.) 1999;17(3):231-7.
1999: Gerhard Behre; A J Whitmarsh; Matthew P Coghlan; T Hoang; Christopher L Carpenter; Dong-Er Zhang; R J Davis; Daniel G Tenen
c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.
The Journal of biological chemistry 1999;274(8):4939-46.
1999: Christopher J Hetherington; Paul D Kingsley; F Crocicchio; P Zhang; M S Rabin; James Palis; Dong-Er Zhang
Characterization of human endotoxin lipopolysaccharide receptor CD14 expression in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):503-9.
1998: M S Petrovick; S W Hiebert; Alan D Friedman; Christopher J Hetherington; Daniel G Tenen; Dong-Er Zhang
Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1.
Molecular and cellular biology 1998;18(7):3915-25.
1998: H M Chen; David A Gonzalez; Hanna S Radomska; M T Voso; Z Sun; P Zhang; Dong-Er Zhang; Daniel G Tenen
Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor.
Gene 1998;207(2):209-18.
1997: Daniel G Tenen; R Hromas; Jonathan D Licht; Dong-Er Zhang
Transcription factors, normal myeloid development, and leukemia.
Blood 1997;90(2):489-519.
1997: Dong-Er Zhang
AML1 gene in human leukemias: dominant negative effects of the chimeric proteins over wild-type AML1.
Japanese journal of cancer research : Gann 1997;88(6):inside front cover.
1997: Scott C Fears; M Gavin; Dong-Er Zhang; Christopher J Hetherington; Y Ben-David; Janet D Rowley; Giuseppina Nucifora
Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1949-54.
1997: DA Yergeau; Christopher J Hetherington; Qingru Wang; P Zhang; A H Sharpe; Michael Binder; M Marín-Padilla; Daniel G Tenen; Nancy A Speck; Dong-Er Zhang
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.
Nature genetics 1997;15(3):303-6.
1997: Dong-Er Zhang; P Zhang; N D Wang; Christopher J Hetherington; Gretchen Darlington; Daniel G Tenen
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):569-74.
1996: K L Rhoades; Christopher J Hetherington; Janet D Rowley; Scott W Hiebert; Giuseppina Nucifora; Daniel G Tenen; Dong-Er Zhang
Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11895-900.
1996: H Chen; P Zhang; Hanna S Radomska; Christopher J Hetherington; Dong-Er Zhang; Daniel G Tenen
Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
The Journal of biological chemistry 1996;271(26):15743-52.
1996: Dong-Er Zhang; Christopher J Hetherington; S Meyers; K L Rhoades; C J Larson; H M Chen; Scott W Hiebert; Daniel G Tenen
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.
Molecular and cellular biology 1996;16(3):1231-40.
1996: C S Zent; C Mathieu; D F Claxton; Dong-Er Zhang; Daniel G Tenen; Janet D Rowley; Giuseppina Nucifora
The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1044-8.
1996: C Zent; N Kim; Scott W Hiebert; Dong-Er Zhang; Daniel G Tenen; Janet D Rowley; Giuseppina Nucifora
Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.
Current topics in microbiology and immunology 1996;211():243-52.
1996: Dong-Er Zhang; Stefan Hohaus; Maria Teresa Voso; H M Chen; L T Smith; Christopher J Hetherington; Daniel G Tenen
Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Current topics in microbiology and immunology 1996;211():137-47.
1995: H Chen; D Ray-Gallet; P Zhang; Christopher J Hetherington; D A Gonzalez; Dong-Er Zhang; Françoise Moreau-Gachelin; Daniel G Tenen
PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Oncogene 1995;11(8):1549-60.
1995: Stefan Hohaus; M S Petrovick; Maria Teresa Voso; Z Sun; Dong-Er Zhang; Daniel G Tenen
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.
Molecular and cellular biology 1995;15(10):5830-45.
1995: H M Chen; P Zhang; Maria Teresa Voso; Stefan Hohaus; D A Gonzalez; C K Glass; Dong-Er Zhang; Daniel G Tenen
Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.
Blood 1995;85(10):2918-28.
1994: Dong-Er Zhang; K Fujioka; Christopher J Hetherington; Linda H. Shapiro; H M Chen; A T Look; Daniel G Tenen
Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
Molecular and cellular biology 1994;14(12):8085-95.
1994: Dong-Er Zhang; Christopher J Hetherington; D A Gonzalez; H M Chen; Daniel G Tenen
Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3276-84.
1994: Y Yamaguchi; Dong-Er Zhang; Z Sun; E A Albee; S Nagata; Daniel G Tenen; Steven J Ackerman
Functional characterization of the promoter for the gene encoding human eosinophil peroxidase.
The Journal of biological chemistry 1994;269(30):19410-9.
1994: Jeffrey P Rabek; Dong-Er Zhang; Carlos A Torres-Ramos; John Papaconstantinou
Analysis of the mechanism of glucocorticoid-mediated down regulation of the mouse alpha-fetoprotein gene.
Biochimica et biophysica acta 1994;1218(2):136-44.
1994: Dong-Er Zhang; Christopher J Hetherington; S Tan; Suzan Dziennis; D A Gonzalez; H M Chen; Daniel G Tenen
Sp1 is a critical factor for the monocytic specific expression of human CD14.
The Journal of biological chemistry 1994;269(15):11425-34.
1994: Dong-Er Zhang; Christopher J Hetherington; H M Chen; Daniel G Tenen
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
Molecular and cellular biology 1994;14(1):373-81.
1993: S Fukuoka; Dong-Er Zhang; Y Taniguchi; George Scheele
Structure of the canine pancreatic colipase gene includes two protein-binding sites in the promoter region.
The Journal of biological chemistry 1993;268(15):11312-20.
1993: H M Chen; H L Pahl; R J Scheibe; Dong-Er Zhang; Daniel G Tenen
The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.
The Journal of biological chemistry 1993;268(11):8230-9.
1993: H L Pahl; R J Scheibe; Dong-Er Zhang; H M Chen; D L Galson; R A Maki; Daniel G Tenen
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.
The Journal of biological chemistry 1993;268(7):5014-20.
1992: Dong-Er Zhang; Jeffrey P Rabek; CC Hsieh; Carlos A Torres-Ramos; John Papaconstantinou
Functional analysis of the mouse alpha-fetoprotein enhancers and their subfragments in primary mouse hepatocyte cultures.
The Journal of biological chemistry 1992;267(15):10676-82.
1991: Dong-Er Zhang; X Ge; Jeffrey P Rabek; John Papaconstantinou
Functional analysis of the trans-acting factor binding sites of the mouse alpha-fetoprotein proximal promoter by site-directed mutagenesis.
The Journal of biological chemistry 1991;266(31):21179-85.
1990: Jeffrey P Rabek; P R Hoyt; Dong-Er Zhang; Michael G Izban; John Papaconstantinou
Derepression of a mouse alpha-fetoprotein expression vector in COS-1 cells by amplification of specific cis-acting sequences of the AFP promoter.
Nucleic acids research 1990;18(22):6677-82.
1990: Dong-Er Zhang; P R Hoyt; John Papaconstantinou
Localization of DNA protein-binding sites in the proximal and distal promoter regions of the mouse alpha-fetoprotein gene.
The Journal of biological chemistry 1990;265(6):3382-91.
1988: Dong-Er Zhang; D A Nelson
Histone acetylation in chicken erythrocytes. Rates of deacetylation in immature and mature red blood cells.
The Biochemical journal 1988;250(1):241-5.
1988: Dong-Er Zhang; D A Nelson
Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified.
The Biochemical journal 1988;250(1):233-40.
1987: W R Alonso; R C Ferris; Dong-Er Zhang; D A Nelson
Chicken erythrocyte beta-globin chromatin: enhanced solubility is a direct consequence of induced histone hyperacetylation.
Nucleic acids research 1987;15(22):9325-37.
1987: Q A Vu; Dong-Er Zhang; Z C Chroneos; D A Nelson
Polyamines inhibit the yeast histone deacetylase.
FEBS letters 1987;220(1):79-83.
1986: D A Nelson; R C Ferris; Dong-Er Zhang; C R Ferenz
The beta-globin domain in immature chicken erythrocytes: enhanced solubility is coincident with histone hyperacetylation.
Nucleic acids research 1986;14(4):1667-82.