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Guang-Yi Zhang

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S H Qi; J Yue; L Y Hao; Yan-Yan Zong; Guang-Yi Zhang
Exogenous nitric oxide negatively regulates the S-nitrosylation p38 mitogen-activated protein kinase activation during cerebral ischaemia and reperfusion.
D-H Liu; T Song; Y-P Wu; F-G Yuan; F Diao; Shu-Qun Hu; C Li; Yan-Yan Zong; Guang-Yi Zhang
Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion.
Hai-Jian Zhang; Chong Li; Guang-Yi Zhang
ATPA induced GluR5-containing kainite receptor S-nitrosylation via activation of GluR5-Gq-PLC-IP(3)R pathway and signalling module GluR5·PSD-95·nNOS.

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2013: S H Qi; J Yue; L Y Hao; Yan-Yan Zong; Guang-Yi Zhang
Exogenous nitric oxide negatively regulates the S-nitrosylation p38 mitogen-activated protein kinase activation during cerebral ischaemia and reperfusion.
Neuropathology and applied neurobiology 2013;39(3):284-97.
2013: D-H Liu; T Song; Y-P Wu; F-G Yuan; F Diao; Shu-Qun Hu; C Li; Yan-Yan Zong; Guang-Yi Zhang
Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion.
Neuroscience 2013;229():36-48.
2012: Hai-Jian Zhang; Chong Li; Guang-Yi Zhang
ATPA induced GluR5-containing kainite receptor S-nitrosylation via activation of GluR5-Gq-PLC-IP(3)R pathway and signalling module GluR5·PSD-95·nNOS.
The international journal of biochemistry & cell biology 2012;44(12):2261-71.
2012: Xue-Wen Wei; Yong-Ping Wu; Bo Xu; Hui Yan; Chong Li; Guang-Yi Zhang
Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures.
Brain research bulletin 2012;88(6):617-23.
2012: Chong Li; Yong-Ping Wu; Jun-Jun Feng; Guang-Yi Zhang
Cerebral ischemia-reperfusion induces GAPDH S-nitrosylation and nuclear translocation.
Biochemistry. Biokhimii͡a 2012;77(6):671-8.
2012: Li-Juan Tang; Yong-Ping Wu; Fa Zhang; Shu-Qun Hu; Chong Li; Chang-Cheng Sun; Yan-Yan Zong; Guang-Yi Zhang
S-nitrosylation of c-Src via NMDAR-nNOS module promotes c-Src activation and NR2A phosphorylation in cerebral ischemia/reperfusion.
Molecular and cellular biochemistry 2012;365(1-2):363-77.
2012: Jie-Hui Di; Chong Li; Hong-Min Yu; Jun-Nian Zheng; Guang-Yi Zhang
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion.
Biochemical and biophysical research communications 2012;420(3):594-9.
2012: Shu-Qun Hu; Dong-Hai Liu; Tao Song; Chang-Cheng Sun; Yong-Ping Wu; Jun-Song Ye; Yan-Yan Zong; Guang-Yi Zhang
S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.
The Journal of biological chemistry 2012;287(4):2364-77.
2012: Zhong-Wei Qu; Yong-Ping Wu; Shu-Qun Hu; Chong Li; Wan-Ying Miao; Xing-Li Zhuo; Yan-Yan Zong; Guang-Yi Zhang
N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity.
PloS one 2012;7(12):e52788.
2011: Yong Liu; Wei Wang; Jing-Zhi Yan; Ying-Hui Gu; Xiao-Yu Hou; Yan-Yan Zong; Guang-Yi Zhang
Depolarization induces NR2A tyrosine phosphorylation and neuronal apoptosis.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2011;38(6):880-6.
2011: Yu-Lan Niu; Chong Li; Guang-Yi Zhang
Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region.
Archives of biochemistry and biophysics 2011;515(1-2):89-98.
2011: Qing Wang; Xiao-Hui Yin; Yong Liu; Guang-Yi Zhang
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Journal of receptor and signal transduction research 2011;31(4):307-13.
2011: Jia Zhang; Hui Yan; Yong-Ping Wu; Chong Li; Guang-Yi Zhang
Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment.
The Journal of biological chemistry 2011;286(9):7669-80.
2010: Wei-Wei Wang; Shu-Qun Hu; Chong Li; Cui Zhou; Su-Hua Qi; Guang-Yi Zhang
Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia.
Brain research 2010;1328():162-70.
2010: Chong Li; Bo Xu; Wei-Wei Wang; Xiu-Ju Yu; Jie Zhu; Hong-Min Yu; Dong Han; Dong-Sheng Pei; Guang-Yi Zhang
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Epilepsia 2010;51(3):391-403.
2010: Quanguang Zhang; Dong Han; Shu-Qun Hu; Chong Li; Chang-Zhou Yu; Ran Wang; Guang-Yi Zhang
Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia.
Hippocampus 2010;20(1):65-77.
2009: Ting Li; Hong-Min Yu; Ya-Feng Sun; Yuan-Jian Song; Guang-Yi Zhang; Dong-Sheng Pei
Inhibition of cerebral ischemia/reperfusion-induced injury by adenovirus expressed C-terminal amino acids of GluR6.
Brain research 2009;1300():169-76.
2009: Shu-Qun Hu; Jie Zhu; Dong-Sheng Pei; Yan-Yan Zong; Jing-Zhi Yan; Xiao-Yu Hou; Guang-Yi Zhang
Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6.PSD-95.MLK3 pathway.
Journal of neuroscience research 2009;87(16):3626-38.
2009: Chang-Zhou Yu; Chong Li; Dong-Sheng Pei; Yan-Yan Zong; Qiong Shi; Xiang-Ru Wen; Qiu-Hua Guan; Dong Hang; Xiao-Yu Hou; Guang-Yi Zhang
Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.
Neurochemical research 2009;34(11):2008-21.
2009: Y Du; C Li; W-W Hu; Y-J Song; Guang-Yi Zhang
Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways.
Neuroscience 2009;161(2):370-80.
2009: Su-Hua Qi; Yong Liu; Wei-Wei Wang; Min Wang; Guang-Yi Zhang
Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.
Brain research 2009;1276():151-8.
2009: Juan Chen; Chong Li; Dong-Sheng Pei; Dong Han; Xiao-Mei Liu; Hai-Xia Jiang; Xiao-Tian Wang; Qiu-Hua Guan; Xiang-Ru Wen; Xiao-Yu Hou; Guang-Yi Zhang
GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury.
Hippocampus 2009;19(1):79-89.
2008: Jie Xu; Yong Liu; Guang-Yi Zhang
Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase.
The Journal of biological chemistry 2008;283(43):29355-66.
2008: X-R Wen; C Li; Yan-Yan Zong; C-Z Yu; Jing Xu; Dong Han; Guang-Yi Zhang
Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury.
Neuroscience 2008;156(3):483-97.
2008: Cui Zhou; Chong Li; Hong-Min Yu; Fa Zhang; Dong Han; Guang-Yi Zhang
Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebral ischemia.
Journal of neuroscience research 2008;86(13):2973-83.
2008: H-M Yu; Jing Xu; C Li; C Zhou; F Zhang; Dong Han; Guang-Yi Zhang
Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death.
Neuroscience 2008;155(4):1120-32.
2008: Dong-Sheng Pei; Yuan-Jian Song; Hong-Min Yu; Wei-Wei Hu; Yang Du; Guang-Yi Zhang
Exogenous nitric oxide negatively regulates c-Jun N-terminal kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral ischemia and reperfusion in rat hippocampus.
Journal of neurochemistry 2008;106(4):1952-63.
2008: Ting Li; Xiu-Ju Yu; Guang-Yi Zhang
Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region.
FEBS letters 2008;582(13):1894-900.
2008: Ya-Feng Sun; Dong-Sheng Pei; Qing-Xiu Zhang; Guang-Yi Zhang
Neuroprotection of GST, an extract of traditional Chinese herb, against ischemic brain injury induced by transient brain ischemia and reperfusion in rat hippocampus.
Neurological research 2008;30(5):471-5.
2008: Jing Xu; Chong Li; Xiao-Hui Yin; Guang-Yi Zhang
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Neuropharmacology 2008;54(7):1029-40.
2008: Ting Li; Dong Han; Juan Chen; Xiu-Ju Yu; Guang-Yi Zhang
Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression.
Neuroreport 2008;19(6):647-51.
2008: Dong Han; Quanguang Zhang; Chong Li; Yan-Yan Zong; Chang-Zhou Yu; Wei Wang; Jing-Zhi Yan; Guang-Yi Zhang
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
FEBS letters 2008;582(9):1298-306.
2008: Wei-Wei Hu; Yang Du; Chong Li; Yuan-Jian Song; Guang-Yi Zhang
Neuroprotection of hypothermia against neuronal death in rat hippocampus through inhibiting the increased assembly of GluR6-PSD95-MLK3 signaling module induced by cerebral ischemia/reperfusion.
Hippocampus 2008;18(4):386-97.
2007: F Zhang; C Li; Ran Wang; Dong Han; Quanguang Zhang; C Zhou; H-M Yu; Guang-Yi Zhang
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Neuroscience 2007;150(4):938-49.
2007: Chong Li; Dong Han; Fa Zhang; Cui Zhou; Hong-Min Yu; Guang-Yi Zhang
Preconditioning ischemia attenuates increased neurexin-neuroligin1-PSD-95 interaction after transient cerebral ischemia in rat hippocampus.
Neuroscience letters 2007;426(3):192-7.
2007: Hai-Xia Jiang; Qiu-Hua Guan; Dong-Sheng Pei; Guang-Yi Zhang
Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury.
Journal of neuroscience research 2007;85(13):2960-70.
2007: Xiao-Tian Wang; Dong-Sheng Pei; Jing Xu; Qiu-Hua Guan; Ya-Feng Sun; Xiao-Mei Liu; Guang-Yi Zhang
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury.
Cellular signalling 2007;19(9):1844-56.
2007: Xiao-Yu Hou; Yong Liu; Guang-Yi Zhang
PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia.
Neuroscience letters 2007;420(3):235-9.
2007: Qing-Xiu Zhang; Dong-Sheng Pei; Qiu-Hua Guan; Ya-Feng Sun; Xiao-Mei Liu; Guang-Yi Zhang
Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia.
Biochemistry 2007;46(13):4006-16.
2007: Jie Zhao; Dong-Sheng Pei; Quanguang Zhang; Guang-Yi Zhang
Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus.
Cellular signalling 2007;19(4):831-43.
2007: Quanguang Zhang; Dong-Na Wu; Dong Han; Guang-Yi Zhang
Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury.
FEBS letters 2007;581(3):495-505.
2007: Jing Xu; Quanguang Zhang; Chong Li; Guang-Yi Zhang
Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation.
Hippocampus 2007;17(7):525-37.
2007: Qing Wang; Quanguang Zhang; Dong-Na Wu; Xiao-Hui Yin; Guang-Yi Zhang
Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway.
Acta pharmacologica Sinica 2007;28(1):19-27.
2006: Ran Wang; Quanguang Zhang; Dong Han; Jing Xu; Qian Lü; Guang-Yi Zhang
Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.
Journal of neurochemistry 2006;99(6):1543-54.
2006: Quanguang Zhang; Dong Han; Jing Xu; Q Lv; Ran Wang; Xiao-Hui Yin; Tian-Le Xu; Guang-Yi Zhang
Ischemic preconditioning negatively regulates plenty of SH3s-mixed lineage kinase 3-Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt.
Neuroscience 2006;143(2):431-44.
2006: Quanguang Zhang; Hui Tian; Hong-Chun Li; Guang-Yi Zhang
Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral ischemia in rat hippocampus.
Neuroscience letters 2006;408(3):159-64.
2006: Quanguang Zhang; Xiao-Tian Wang; Dong Han; Xiao-Hui Yin; Guang-Yi Zhang; Tian-Le Xu
Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury.
Journal of neurochemistry 2006;98(6):1886-98.
2006: Dong-Na Wu; Dong-Sheng Pei; Qing Wang; Guang-Yi Zhang
Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus.
Neuroscience letters 2006;404(1-2):98-102.
2006: Qing-Xiu Zhang; Dong-Sheng Pei; Qiu-Hua Guan; Ya-Feng Sun; Xiao-Mei Liu; Guang-Yi Zhang
Blockade of the translocation and activation of mitogen-activated protein kinase kinase 4 (MKK4) signaling attenuates neuronal damage during later ischemia-reperfusion.
Journal of neurochemistry 2006;98(1):170-9.
2006: Xiao-Mei Liu; Dong-Sheng Pei; Qiu-Hua Guan; Ya-Feng Sun; Xiao-Tian Wang; Qing-Xiu Zhang; Guang-Yi Zhang
Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways.
The Journal of biological chemistry 2006;281(25):17432-45.
2006: Qiu-Hua Guan; Dong-Sheng Pei; Xiao-Mei Liu; Xiao-Tian Wang; Tian-Le Xu; Guang-Yi Zhang
Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis.
Brain research 2006;1092(1):36-46.
2006: Qiu-Hua Guan; Dong-Sheng Pei; Yan-Yan Zong; Tian-Le Xu; Guang-Yi Zhang
Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways.
Neuroscience 2006;139(2):609-27.
2006: Quanguang Zhang; Yong-Ling Xu; Hong-Chun Li; Dong Han; Guang-Yi Zhang
NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus.
Neuroscience letters 2006;398(3):268-73.
2006: Dong-Sheng Pei; Xiao-Tian Wang; Yong Liu; Ya-Feng Sun; Qiu-Hua Guan; Wei Wang; Jing-Zhi Yan; Yan-Yan Zong; Tian-Le Xu; Guang-Yi Zhang
Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
Brain : a journal of neurology 2006;129(Pt 2):465-79.
2006: Qiu-Hua Guan; Dong-Sheng Pei; Tian-Le Xu; Guang-Yi Zhang
Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway.
Neuroscience letters 2006;393(2-3):226-30.
2006: Jing Pan; Dong-Sheng Pei; Xiao-Hui Yin; Liang Hui; Guang-Yi Zhang
Involvement of oxidative stress in the rapid Akt1 regulating a JNK scaffold during ischemia in rat hippocampus.
Neuroscience letters 2006;392(1-2):47-51.
2005: Dong-Sheng Pei; Qiu-Hua Guan; Ya-Feng Sun; Qing-Xiu Zhang; Tian-Le Xu; Guang-Yi Zhang
N-Acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus.
Neuroscience letters 2005;391(1-2):38-42.
2005: Dong-Sheng Pei; Qiu-Hua Guan; Ya-Feng Sun; Qing-Xiu Zhang; Tian-Le Xu; Guang-Yi Zhang
Neuroprotective effects of GluR6 antisense oligodeoxynucleotides on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 region.
Journal of neuroscience research 2005;82(5):642-9.
2005: Hui Tian; Quanguang Zhang; Guang-Xuan Zhu; Dong-Sheng Pei; Qiu-Hua Guan; Guang-Yi Zhang
Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus.
Brain research 2005;1061(1):57-66.
2005: Guang-Yi Zhang; Quanguang Zhang
Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
Expert opinion on investigational drugs 2005;14(11):1373-83.
2005: Quanguang Zhang; Rui-Min Wang; Xiao-Hui Yin; Jing Pan; Tian-Le Xu; Guang-Yi Zhang
Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield.
Journal of neurochemistry 2005;95(3):784-95.
2005: Zhi-Bin Hao; Dong-Sheng Pei; Qiu-Hua Guan; Guang-Yi Zhang
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Brain research. Molecular brain research 2005;140(1-2):55-62.
2005: Xiao-Yu Hou; Guang-Yi Zhang; De-Guang Wang; Qiu-Hua Guan; Jing-Zhi Yan
Suppression of postsynaptic density protein 95 by antisense oligonucleotides diminishes postischemic pyramidal cell death in rat hippocampal CA1 subfield.
Neuroscience letters 2005;385(3):230-3.
2005: Liang Hui; Dong-Sheng Pei; Quanguang Zhang; Qiu-Hua Guan; Guang-Yi Zhang
The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation.
Brain research 2005;1052(1):1-9.
2005: Bei Miao; Xiao-Hui Yin; Dong-Sheng Pei; Quanguang Zhang; Guang-Yi Zhang
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
The Journal of biological chemistry 2005;280(23):21693-9.
2005: Xiao-Hui Yin; Quanguang Zhang; Bei Miao; Guang-Yi Zhang
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
Journal of neurochemistry 2005;93(4):1021-9.
2005: Rui-Min Wang; Quanguang Zhang; Chun-Hong Li; Guang-Yi Zhang
Activation of extracellular signal-regulated kinase 5 may play a neuroprotective role in hippocampal CA3/DG region after cerebral ischemia.
Journal of neuroscience research 2005;80(3):391-9.
2005: Yong Liu; Guang-Yi Zhang; Jing-Zhi Yan; Tian-Le Xu
Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus.
Neuroscience letters 2005;379(1):55-8.
2005: Chun-Hong Li; Rui-Min Wang; Quanguang Zhang; Guang-Yi Zhang
Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.
Journal of neurochemistry 2005;93(2):290-8.
2005: Qiu-Hua Guan; Dong-Sheng Pei; Quanguang Zhang; Zhi-Bin Hao; Tian-Le Xu; Guang-Yi Zhang
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways.
Brain research 2005;1035(1):51-9.
2005: Jing Pan; Quanguang Zhang; Guang-Yi Zhang
The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.
Neuroscience 2005;131(1):147-59.
2004: Dong-Sheng Pei; Ya-Feng Sun; Qiu-Hua Guan; Zhi-Bin Hao; Tian-Le Xu; Guang-Yi Zhang
Postsynaptic density protein 95 antisense oligodeoxynucleotides inhibits the activation of MLK3 and JNK3 via the GluR6.PSD-95.MLK3 signaling module after transient cerebral ischemia in rat hippocampus.
Neuroscience letters 2004;367(1):71-5.
2004: Juan Ma; Guang-Yi Zhang; Yong Liu; Jing-Zhi Yan; Zhi-Bin Hao
Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia.
Neuroscience research 2004;49(4):357-62.
2004: Wei Wang; Can Gao; Xiao-Yu Hou; Yong Liu; Yan-Yan Zong; Guang-Yi Zhang
Activation and involvement of JNK1/2 in hydrogen peroxide-induced neurotoxicity in cultured rat cortical neurons.
Acta pharmacologica Sinica 2004;25(5):630-6.
2004: Xue-bo Yan; Fan-jie Meng; Bo Song; Guang-Yi Zhang
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Acta pharmacologica Sinica 2004;25(5):617-22.
2004: Chun-Yi Zhang; Wan-Hua Shen; Guang-Yi Zhang
Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus.
Sheng li xue bao : [Acta physiologica Sinica] 2004;56(2):147-52.
2004: Bo Song; Xue-bo Yan; Guang-Yi Zhang
PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Brain research 2004;1005(1-2):44-50.
2004: Rui-Min Wang; Quanguang Zhang; Guang-Yi Zhang
Activation of ERK5 is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated calcium channel via Src involving oxidative stress after cerebral ischemia in rat hippocampus.
Neuroscience letters 2004;357(1):13-6.
2004: Fan-jie Meng; Jun Guo; Bo Song; Xue-bo Yan; Guang-Yi Zhang
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
Acta pharmacologica Sinica 2004;25(2):176-80.
2004: Xue-bo Yan; Bo Song; Guang-Yi Zhang
Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus.
Neuroscience letters 2004;355(3):197-200.
2004: Xin-Zhen Fu; Quanguang Zhang; Fan-jie Meng; Guang-Yi Zhang
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
Neuroscience research 2004;48(1):85-91.
2003: Min Chen; Yao Wang; Yong Liu; Xiao-Yu Hou; Quanguang Zhang; Fan-jie Meng; Guang-Yi Zhang
Possible mechanisms underlying the protective effects of SY-21, an extract of a traditional Chinese herb, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampus.
Brain research 2003;989(2):180-6.
2003: Hong-Chun Li; Guang-Yi Zhang
Inhibitory effect of genistein on activation of STAT3 induced by brain ischemia/reperfusion in rat hippocampus.
Acta pharmacologica Sinica 2003;24(11):1131-6.
2003: Wan-Hua Shen; Chun-Yi Zhang; Guang-Yi Zhang
Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats.
Acta pharmacologica Sinica 2003;24(11):1125-30.
2003: Juan Ma; Guang-Yi Zhang
Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia.
Neuroscience letters 2003;348(3):185-9.
2003: Yong Liu; Guang-Yi Zhang; Xiao-Yu Hou; Tian-Le Xu
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus.
Neuroscience letters 2003;348(3):127-30.
2003: Xiao-Yu Hou; Guang-Yi Zhang; Jing-Zhi Yan; Yong Liu
Increased tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels and interactions among Src/Fyn, PSD-95 and alpha(1C) in rat hippocampus after transient brain ischemia.
Brain research 2003;979(1-2):43-50.
2003: Hong-Chun Li; Guang-Yi Zhang
Activation of STAT3 induced by cerebral ischemia in rat hippocampus and its possible mechanisms.
Sheng li xue bao : [Acta physiologica Sinica] 2003;55(3):311-6.
2003: Xiao-Yu Hou; Guang-Yi Zhang; Yan-Yan Zong
Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus.
Neuroscience letters 2003;343(2):125-8.
2003: Yong Liu; Xiao-Yu Hou; Guang-Yi Zhang; Tian-Le Xu
L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia.
Brain research 2003;972(1-2):142-8.
2003: Wan-Hua Shen; Chun-Yi Zhang; Guang-Yi Zhang
Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia.
Acta pharmacologica Sinica 2003;24(4):311-5.
2003: Wei Wang; Xiao-Yu Hou; Can Gao; Yong Liu; Yan-Yan Zong; Guang-Yi Zhang
Regulation of c-Jun N-terminal kinase activation in hydrogen peroxide induced neurotoxicity.
Journal of neurocytology 2003;32(2):143-51.
2002: Xiao-Yu Hou; Guang-Yi Zhang; Jing-Zhi Yan; Min Chen; Yong Liu
Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia.
Brain research 2002;955(1-2):123-32.
2001: Xiao-Yu Hou; FM Tang; Guang-Yi Zhang
Stimulation of dopamine receptors inhibited Ca2+-calmodulin-dependent protein kinase II activity in rat striatal slices.
Acta pharmacologica Sinica 2001;22(11):966-70.
2001: Ya-Feng Sun; FM Tang; R Wang; Guang-Yi Zhang; Guo-Zhang Jin
[Changes in the state of phosphorylation of DARPP-32 of gerbil striatum during ischemia].
Sheng li xue bao : [Acta physiologica Sinica] 2001;53(2):108-10.
2001: Ya-Feng Sun; FM Tang; YM Ding; Y T Chen; Guang-Yi Zhang; Guo-Zhang Jin
Effect of dopamine depletion on DARPP-32 protein in ischemic rat striatum.
Acta pharmacologica Sinica 2001;22(3):243-8.
2000: YM Ding; FM Tang; Lei Ping Yu; Yu Fu; Guang-Yi Zhang; Guo-Zhang Jin
Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats.
Acta pharmacologica Sinica 2000;21(10):885-92.
2000: L Pei; Y Li; Jing-Zhi Yan; Guang-Yi Zhang; Z C Cui; Z M Zhu
Changes and mechanisms of protein-tyrosine kinase and protein-tyrosine phosphatase activities after brain ischemia/reperfusion.
Acta pharmacologica Sinica 2000;21(8):715-20.
2000: L Pei; Y Li; Guang-Yi Zhang; Z C Cui; Z M Zhu
Mechanisms of regulation of tyrosine phosphorylation of NMDA receptor subunit 2B after cerebral ischemia/reperfusion.
Acta pharmacologica Sinica 2000;21(8):695-700.
2000: Y Li; L Pei; Guang-Yi Zhang
[Effect of ischemia/reperfusion on the phosphorylation of synaptosomal tyrosine of hippocampus of Mongolian gerbils].
Sheng li xue bao : [Acta physiologica Sinica] 2000;52(2):137-42.
2000: FM Tang; Ya-Feng Sun; R Wang; YM Ding; Guang-Yi Zhang; Guo-Zhang Jin
Dopamine-glutamate interaction in rat striatal slices: changes of CCDPK II, PKA, and LDH activity by receptor-mediated mechanisms.
Acta pharmacologica Sinica 2000;21(2):145-50.
1999: FM Tang; YM Ding; Y T Chen; Y F Sun; R Wang; Guang-Yi Zhang; Guo-Zhang Jin
Antagonistic effect of l-stepholidine on striatal ischemic injury in rat.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(12):1073-8.
1999: Xiao-Yu Hou; Guang-Yi Zhang
Protection of dopaminergic antagonists against anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II activity in rat brain.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(11):995-9.
1999: C Gao; Guang-Yi Zhang
KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(11):991-4.
1999: Xiao-Yu Hou; Guang-Yi Zhang
Inhibitory effect of dopamine on Ca(2+)-calmodulin-dependent protein kinase II activity in rat hippocampal slices.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(10):902-6.
1997: L Pei; Yan-Yan Zong; L Zhang; Ya-Feng Sun; Guang-Yi Zhang
[Studies on mechanism of the inhibition of Ca2+/CaM PKII activity induced by hypoxia in rat hippocampal slices].
Sheng li xue bao : [Acta physiologica Sinica] 1997;49(1):61-6.
1996: L Pei; Yan-Yan Zong; Y F Sun; Guang-Yi Zhang
[Ketamine and nifedipine protect cultured cortical neurons against injurious effect of glutamate].
Yao xue xue bao = Acta pharmaceutica Sinica 1996;31(11):812-6.
1993: M Z Zhang; Guang-Yi Zhang; YM Ding; S H Zhao
[Studies on the phospho-tyrosine proteins during the proliferation cycle of cultured aortic smooth muscle cells].
Shi yan sheng wu xue bao 1993;26(2):133-9.
1993: J M Chen; M Z Zhang; S L Gu; Guang-Yi Zhang
[Effects of atropine on contraction of rabbit aortic smooth muscle and cell proliferation].
Yao xue xue bao = Acta pharmaceutica Sinica 1993;28(4):246-50.
1992: J M Chen; M Z Zhang; S L Gu; Guang-Yi Zhang
[Calcium antagonism of anisodamine on isolated rabbit thoracic aorta].
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1992;13(5):445-8.
1992: Guang-Yi Zhang; M Z Zhang; S H Zhao
[The dynamics of two types of tyrosine protein kinases in the proliferation of cultivated vascular smooth muscle cells].
Shi yan sheng wu xue bao 1992;25(2):83-8.