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Li-He Zhang

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Publications

TOP 3
Zhu Guan; Pierre Sinaÿ; Li-He Zhang; Yongmin Zhang
Study on metal-induced reactions of α-diazocarbonyl glucosides.
Wen-Jie Wei; Li-He Zhang; Hon Cheung Lee; Gui-Rong Li; Hai-Ying Sun; Kai Yiu Ting; Jianbo Yue
Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.
Jun Zhang; Liang-Ren Zhang; Yue Chen; Ye Huang; Hong-Wei Jin; Ren-Ping Qiao; Lei Xing; Zhen-Jun Yang; Li-He Zhang
Synthesis and properties of novel L-isonucleoside modified oligonucleotides and siRNAs.

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All Publications

2012: Zhu Guan; Pierre Sinaÿ; Li-He Zhang; Yongmin Zhang
Study on metal-induced reactions of α-diazocarbonyl glucosides.
The Journal of organic chemistry 2012;77(20):8888-95.
2012: Wen-Jie Wei; Li-He Zhang; Hon Cheung Lee; Gui-Rong Li; Hai-Ying Sun; Kai Yiu Ting; Jianbo Yue
Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.
The Journal of biological chemistry 2012;287(42):35599-611.
2012: Jun Zhang; Liang-Ren Zhang; Yue Chen; Ye Huang; Hong-Wei Jin; Ren-Ping Qiao; Lei Xing; Zhen-Jun Yang; Li-He Zhang
Synthesis and properties of novel L-isonucleoside modified oligonucleotides and siRNAs.
Organic & biomolecular chemistry 2012;10(37):7566-77.
2012: Su-long Xiao; Ming Yang; Fei Yu; Li-He Zhang; Yong-min Zhang; Yi-yun Peng; Pierre Sinaÿ; Matthieu Sollogoub; Qi Wang; De-min Zhou
Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors.
Bioorganic & medicinal chemistry 2012;20(18):5616-22.
2012: Pei-Lin Yu; Bai-Xia Hao; Hon Cheung Lee; Liangren Zhang; Li-He Zhang; Zhe-Hao Zhang; Yong-Juan Zhao; Jianbo Yue
A novel fluorescent cell membrane-permeable caged cyclic ADP-ribose analogue.
The Journal of biological chemistry 2012;287(29):24774-83.
2012: Guan-Nan Wang; Terry D Butters; Gabriele Twigg; Liangren Zhang; Li-He Zhang; Siwei Zhang; Xin-Shan Ye
Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
Organic & biomolecular chemistry 2012;10(15):2923-7.
2012: Yu-Heng Ma; Bo Xu; Zhen-Jun Yang; Jing-Rong Cui; Liang-Ren Zhang; Li-He Zhang
[Design, synthesis and biological assay of novel tripeptidic tetrazoles as inhibitors of 20S proteasome].
Yao xue xue bao = Acta pharmaceutica Sinica 2012;47(4):472-8.
2011: N Qi; M Wang; Z J Yang; Andreas H Guse; K Jung; L X Na; Liang-Ren Zhang; Li-He Zhang
A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
Chemical communications (Cambridge, England) 2011;47(33):9462-4.
2011: Shi-Kai Xiang; Bo Zhang; Li-He Zhang; Yuxin Cui; Ning Jiao
Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes.
Chemical communications (Cambridge, England) 2011;47(28):8097-9.
2011: Min Dong; Yuan-Qi Si; Shuang-Yong Sun; Xiao-Ping Pu; Zhen-Jun Yang; Liang-Ren Zhang; Li-He Zhang; Fung Ping Leung; Connie Mo Ching Lam; Anna Ka Yee Kwong; Jianbo Yue; Yeyun Zhou; Irina A Kriksunov; Quan Hao; Hon Cheung Lee
Design, synthesis and biological characterization of novel inhibitors of CD38.
Organic & biomolecular chemistry 2011;9(9):3246-57.
2011: Shi-Kai Xiang; Bo Zhang; Li-He Zhang; Yuxin Cui; Ning Jiao
The versatile roles of ammonium salt catalysts in enantioselective reduction and alkylation of α,β-unsaturated aldehydes: iminium catalysis, enamine catalysis and acid catalysis.
Chemical communications (Cambridge, England) 2011;47(17):5007-9.
2011: Guan-Nan Wang; Lin Yang; Li-He Zhang; Xin-Shan Ye
A versatile approach to N-alkylated 1,4-dideoxy-1,4-imino-D-arabinitols and 1,4-dideoxy-1,4-imino-L-xylitols.
The Journal of organic chemistry 2011;76(7):2001-9.
2011: Dan Wang; Yu-Huan Li; Yu-Ping Wang; Rong-Mei Gao; Li-He Zhang; Xin-Shan Ye
Synthesis and in vitro anti-hepatitis B virus activity of six-membered azanucleoside analogues.
Bioorganic & medicinal chemistry 2011;19(1):41-51.
2010: Guo-Liang Zhang; Li-He Zhang; Xin-Shan Ye
Concise syntheses of selective inhibitors against α-1,3-galactosyltransferase.
Organic & biomolecular chemistry 2010;8(22):5062-8.
2010: Ning Wang; Li-He Zhang; Xin-Shan Ye
A new synthetic access to bicyclic polyhydroxylated alkaloid analogues from pyranosides.
Organic & biomolecular chemistry 2010;8(11):2639-49.
2010: Guo-Liang Zhang; Changshui Chen; Yulan Xiong; Li-He Zhang; Jia Ye; Xin-Shan Ye
Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities.
Carbohydrate research 2010;345(6):780-6.
2009: Shi-Kai Xiang; Li-He Zhang; Ning Jiao
Sp-sp(3) C-C bond formation via Fe(OTf)(3)/TfOH cocatalyzed coupling reaction of terminal alkynes with benzylic alcohols.
Chemical communications (Cambridge, England) 2009;(42):6487-9.
2009: Jianbo Yue; Wenjie Wei; Connie M C Lam; Yong-Juan Zhao; Min Dong; Liang-Ren Zhang; Li-He Zhang; Hon Cheung Lee
CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells.
The Journal of biological chemistry 2009;284(43):29335-42.
2009: Li-Juan Pang; Dan Wang; Jian Zhou; Li-He Zhang; Xin-Shan Ye
Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations.
Organic & biomolecular chemistry 2009;7(20):4252-66.
2009: Guan-Nan Wang; Gabriele Reinkensmeier; Si-Wei Zhang; Jian Zhou; Liang-Ren Zhang; Li-He Zhang; Terry D Butters; Xin-Shan Ye
Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
Journal of medicinal chemistry 2009;52(10):3146-9.
2009: Lei Zhang; Fang Sun; Qilong Wang; Jing Zhou; Li-He Zhang; Xiao-Lian Zhang; Xin-Shan Ye
Discovery of iminosugar derivatives with strong IFN-gamma inducing activity.
ChemMedChem 2009;4(5):756-60.
2009: De-Cai Xiong; Li-He Zhang; Xin-Shan Ye
Oxidant-controlled heck-type C-glycosylation of glycals with arylboronic acids: stereoselective synthesis of aryl 2-deoxy-C-glycosides.
Organic letters 2009;11(8):1709-12.
2009: Qin Li; Guichun Lin; Li Liu; Zhenjun Yang; Li-He Zhang
Methyl carbonium ion migration during the reaction of 4-chloro-5-methoxyl-3(2H)-pyridazinone with trifluoroethylation agents.
Molecules (Basel, Switzerland) 2009;14(2):777-84.
2008: Peng Zhao; Hong-Wei Jin; Zhen-Jun Yang; Liang-Ren Zhang; Li-He Zhang
Solid-phase synthesis and evaluation of TAR RNA targeted beta-carboline-nucleoside conjugates.
Organic & biomolecular chemistry 2008;6(20):3741-50.
2008: Hui Mei; Lei Xing; Li Cai; Hong-Wei Jin; Peng Zhao; Zhen-Jun Yang; Liang-Ren Zhang; Li-He Zhang
Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA.
Bioorganic & medicinal chemistry letters 2008;18(20):5355-8.
2008: Yin-Suo Lu; Qin Li; Li-He Zhang; Xin-Shan Ye
Highly Direct alpha-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy- and 2,6-Dideoxythioglycosides by Preactivation Protocol.
Organic letters 2008;10(16):3445-8.
2008: Jing Zhou; Yongmin Zhang; Xia Zhou; Jing Zhou; Li-He Zhang; Xin-Shan Ye; Xiao-Lian Zhang
An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-gamma and IL-4.
Bioorganic & medicinal chemistry 2008;16(4):1605-12.
2008: Yiqun Geng; Li-He Zhang; Xin-Shan Ye
Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamines.
Chemical communications (Cambridge, England) 2008;(5):597-9.
2007: Lei Zhang; Fang Sun; Yingxia Li; Xue Sun; Xiaomin Liu; Yingshen Huang; Li-He Zhang; Xin-Shan Ye; Junjun Xiao
Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticancer activity.
ChemMedChem 2007;2(11):1594-7.
2007: Z Guan; H W Jin; Z J Yang; Liang-Ren Zhang; Li-He Zhang
Investigation of the binding behaviors of isonucleoside-incorporated oligonucleotides with complementary sequences.
Drug discoveries & therapeutics 2007;1(1):65-72.
2007: Yuhang Wang; Xin-Shan Ye; Li-He Zhang
Oligosaccharide assembly by one-pot multi-step strategy.
Organic & biomolecular chemistry 2007;5(14):2189-200.
2007: Zong-Sheng Li; Ren-Ping Qiao; Quan Du; Zhen-Jun Yang; Liang-Ren Zhang; Pei-Zhuo Zhang; Zi-Cai Liang; Li-He Zhang
Studies on aminoisonucleoside modified siRNAs: stability and silencing activity.
Bioconjugate chemistry 2007;18(4):1017-24.
2007: Jian Zhou; Guannan Wang; Li-He Zhang; Xin-Shan Ye
Modifications of aminoglycoside antibiotics targeting RNA.
Medicinal research reviews 2007;27(3):279-316.
2006: Jianfeng Xu; Zhenjun Yang; Werner Dammermann; Liangren Zhang; Andreas H Guse; Li-He Zhang
Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.
Journal of medicinal chemistry 2006;49(18):5501-12.
2006: Qiu-Hua Fan; Nan-Ting Ni; Qin Li; Li-He Zhang; Xin-Shan Ye
New one-carbon degradative transformation of beta-alkyl-beta-azido alcohols.
Organic letters 2006;8(5):1007-9.
2006: Yuhang Wang; Li-He Zhang; Xin-Shan Ye
Oligosaccharide synthesis and library assembly by one-pot sequential glycosylation strategy.
Combinatorial chemistry & high throughput screening 2006;9(1):63-75.
2005: Yuan Wang; Qin Li; Shuihong Cheng; Yanfen Wu; Dongjie Guo; Qiu-Hua Fan; Xiaofang Wang; Li-He Zhang; Xin-Shan Ye
Base-promoted rearrangement of sugar epoxides to unsaturated sugars.
Organic letters 2005;7(25):5577-9.
2005: Xin-Shan Ye; Fang Sun; Min Liu; Qin Li; Yuhang Wang; Guisheng Zhang; Li-He Zhang; Xiao-Lian Zhang
Synthetic iminosugar derivatives as new potential immunosuppressive agents.
Journal of medicinal chemistry 2005;48(11):3688-91.
2004: Yuhang Wang; Xuefei Huang; Li-He Zhang; Xin-Shan Ye
A four-component one-pot synthesis of alpha-Gal pentasaccharide.
Organic letters 2004;6(24):4415-7.
2004: Haisheng Wang; Ji She; Li-He Zhang; Xin-Shan Ye
Silver(I) oxide mediated selective monoprotection of diols in pyranosides.
The Journal of organic chemistry 2004;69(17):5774-7.
2004: Jun-Feng Wang; Liang-Ren Zhang; Zhen-Jun Yang; Li-He Zhang
Synthesis and biological evaluation of 6-substituted purine and 9-beta-d-ribofuranosyl purine analogues.
Bioorganic & medicinal chemistry 2004;12(6):1425-9.
2004: Yi Zhang; Jun Wu; Bo Xu; Li-He Zhang; Jing-Rong Cui
[Inhibition of 8-chloroadenosine on proteasome activity of HL-60 cells].
Ai zheng = Aizheng = Chinese journal of cancer 2004;23(2):155-9.
2003: Xiaofang Wang; Youhong Niu; Xiaoping Cao; Liangren Zhang; Li-He Zhang; Xin-Shan Ye
3D-QSAR analysis of sialyltransferase inhibitors.
Bioorganic & medicinal chemistry 2003;11(19):4217-24.
2003: Chang-Po Chen; Liang-Ren Zhang; Yue-Feng Peng; Xiao-Bo Wang; Sheng-Qi Wang; Li-He Zhang
A concise method for the preparation of peptide and arginine-rich peptide-conjugated antisense oligonucleotide.
Bioconjugate chemistry 2003;14(3):532-8.
2003: Xiaofang Wang; Li-He Zhang; Xin-Shan Ye
Recent development in the design of sialyltransferase inhibitors.
Medicinal research reviews 2003;23(1):32-47.
2002: Li-Jun Huang; Yong-Yuan Zhao; Lan Yuan; Ji-Mei Min; Li-He Zhang
Syntheses and calcium-mobilizing evaluations of N1-glycosyl-substituted stable mimics of cyclic ADP-ribose.
Journal of medicinal chemistry 2002;45(24):5340-52.
2002: Jun Chen; Liang-Ren Zhang; Ji-Mei Min; Li-He Zhang
Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure.
Nucleic acids research 2002;30(13):3005-14.
2002: Chang-Po Chen; Xiao-Xu Li; Liang-Ren Zhang; Ji-Mei Min; Judy Yuet-Wah Chan; Kwok-Pui Fung; Sheng-Qi Wang; Li-He Zhang
Synthesis of antisense oligonucleotide-peptide conjugate targeting to GLUT-1 in HepG-2 and MCF-7 Cells.
Bioconjugate chemistry 2002;13(3):525-9.
2002: Ye Xin-Shan; Li-He Zhang
Aminoglycoside mimetics as small-molecule drugs targeting RNA.
Current medicinal chemistry 2002;9(9):929-39.
2002: Min Li; Jing-Rong Ciu; Ying Ye; Ji-Mei Min; Li-He Zhang; Kui Wang; Michèle Gares; Jean Cros; Michel Wright; Jeanne Leung-Tack
Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.
Carcinogenesis 2002;23(4):573-9.
2002: Li-Jun Huang; Yong-Yuan Zhao; Lan Yuan; Ji-Mei Min; Li-He Zhang
Chemical synthesis and calcium release activity of N(1)-ether strand substituted cADPR mimic.
Bioorganic & medicinal chemistry letters 2002;12(6):887-9.
2002: Min Li; Ji-Mei Min; Jing-Rong Cui; Li-He Zhang; Kui Wang; Annie Valette; Christian Davrinche; Michel Wright; Jeanne Leung-Tack
Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.
Nutrition and cancer 2002;42(2):241-7.
2001: Z Lei; Lihe Zhang; Liang-Ren Zhang; Jun Chen; Ji-Mei Min; Li-He Zhang
Hybrid characteristics of oligonucleotides consisting of isonucleoside 2',5'-anhydro-3'-deoxy-3'-(thymin-1-yl)-D-mannitol with different linkage modes.
Nucleic acids research 2001;29(7):1470-5.
1997: T W Cai; Ji-Mei Min; Li-He Zhang
Synthesis of lactosyl phosphate diester derivatives of nucleosides.
Carbohydrate research 1997;303(1):113-7.