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Qian Zhang

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Chemicals & Drugs

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Ida Holst Pedersen; Claudia Vetter-Kauczok; Mariusz A Wasik; Andreas Willerslev-Olsen; Anders Woetmann; Qian Zhang; Jurgen C Becker; Charlotte Menné Bonefeld; Sally Dabelsteen; Carsten Geisler; Katharina Luise Kopp; Thorbjørn Krejsgaard; Britt Lauenborg; Niels Odum
Vascular endothelial growth factor receptor-3 expression in mycosis fungoides.
Kanchan Kantekure; Niels Odum; Puthiyaveettil Raghunath; Andras Schaffer; Anders Woetmann; Yusong Yang; Qian Zhang; Mariusz A Wasik
Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides.
Ronnie M Abraham; Niels Odum; Qian Zhang; Mariusz A Wasik
The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma.

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2013: Ida Holst Pedersen; Claudia Vetter-Kauczok; Mariusz A Wasik; Andreas Willerslev-Olsen; Anders Woetmann; Qian Zhang; Jurgen C Becker; Charlotte Menné Bonefeld; Sally Dabelsteen; Carsten Geisler; Katharina Luise Kopp; Thorbjørn Krejsgaard; Britt Lauenborg; Niels Odum
Vascular endothelial growth factor receptor-3 expression in mycosis fungoides.
Leukemia & lymphoma 2013;54(4):819-26.
2012: Kanchan Kantekure; Niels Odum; Puthiyaveettil Raghunath; Andras Schaffer; Anders Woetmann; Yusong Yang; Qian Zhang; Mariusz A Wasik
Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides.
The American Journal of dermatopathology 2012;34(1):126-8.
2011: Ronnie M Abraham; Niels Odum; Qian Zhang; Mariusz A Wasik
The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma.
Cancer biology & therapy 2011;12(12):1019-22.
2011: Qian Zhang; Kanchan Kantekure; Xiaobin Liu; Teresa Marafioti; Michael C Milone; Niels Odum; Jennifer C Paterson; Chrystal M Paulos; Andras Schaffer; Suzanne Turner; Hongyi Wang; Mariusz A Wasik
Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS.
Blood 2011;118(11):3062-71.
2011: Qian Zhang; Gauri Bhutani; Kanchan Kantekure; Xiaobin Liu; Hong Yi Wang; Mariusz A Wasik
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):11977-82.
2010: Thorbjørn Krejsgaard; Katharina Kopp; Elisabeth Ralfkiaer; Ayelah E Willumsgaard; Karsten Wessel Eriksen; tord labuda; Susanne Rasmussen; Anne-Merete Mathiesen; Carsten Geisler; Britt Lauenborg; Jürgen C Becker; Qian Zhang; Mariusz A Wasik; Niels Odum; Anders Woetmann
A novel xenograft model of cutaneous T-cell lymphoma.
Experimental dermatology 2010;19(12):1096-102.
2010: Britt Lauenborg; Katharina Kopp; Thorbjørn Krejsgaard; Karsten W Eriksen; Carsten Geisler; Sally Dabelsteen; Robert Gniadecki; Qian Zhang; Mariusz A Wasik; Anders Woetmann; Niels Odum
Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010;118(10):719-28.
2009: Qian Zhang; Hong Y Wang; Gauri Bhutani; Xiaobin Liu; Michele Paessler; John W Tobias; Donald Baldwin; Kunchithapadam Swaminathan; Michael C Milone; Mariusz A Wasik
Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15843-8.
2009: Mariusz A Wasik; Qian Zhang; Michal Marzec; Monika Kasprzycka; Hong Yi Wang; Xiaobin Liu
Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches.
Seminars in oncology 2009;36(2 Suppl 1):S27-35.
2008: Michal Marzec; Qian Zhang; Ami Goradia; Puthiyaveettil N Raghunath; Xiaobin Liu; Michele Paessler; Hong Yi Wang; Maria Wysocka; Mangeng Cheng; Bruce Ruggeri; Mariusz A Wasik
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20852-7.
2008: Ruolin Guo; Motozo Yamashita; Qian Zhang; Quan Zhou; Di Chen; David G Reynolds; Hani A Awad; Laura Yanoso; Lan Zhao; Edward M Schwarz; Ying E Zhang; Brendan F Boyce; Lianping Xing
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.
The Journal of biological chemistry 2008;283(34):23084-92.
2008: Monika Kasprzycka; Qian Zhang; Agnieszka Witkiewicz; Michal Marzec; Magdalena Potoczek; Xiaobin Liu; Hong Yi Wang; Michael Milone; Samik Basu; Joanne Mauger; John K Choi; JT Abrams; J Steven Hou; Alain H Rook; Eric Vonderheid; Anders Woetmann; Niels Odum; Mariusz A Wasik
Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2506-12.
2008: Qian Zhang; Ruolin Guo; Yan Lu; Lan Zhao; Quan Zhou; Edward M Schwarz; Jing Huang; Di Chen; Zheng-Gen Jin; Brendan F Boyce; Lianping Xing
VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.
The Journal of biological chemistry 2008;283(19):13491-9.
2008: Michal Marzec; Krzysztof Halasa; Monika Kasprzycka; Maria Wysocka; Xiaobin Liu; John W Tobias; Donald Baldwin; Qian Zhang; Niels Odum; Alain H Rook; Mariusz A Wasik
Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells.
Cancer research 2008;68(4):1083-91.
2008: Qian Zhang; Ruolin Guo; Edward M Schwarz; Brendan F Boyce; Lianping Xing
TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood.
Arthritis research & therapy 2008;10(2):R37.
2007: Brendan F Boyce; Zhenqiang Yao; Qian Zhang; Roulin Guo; Yan Lu; Edward M Schwarz; Lianping Xing
New roles for osteoclasts in bone.
Annals of the New York Academy of Sciences 2007;1116():245-54.
2007: Qian Zhang; Hong Y Wang; Xiaobin Liu; Mariusz A Wasik
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.
Nature medicine 2007;13(11):1341-8.
2007: Teruhito Yamashita; Zhenqiang Yao; Fang Li; Qian Zhang; I Raul Badell; Edward M Schwarz; Sunao Takeshita; Erwin F Wagner; Masaki Noda; Koichi Matsuo; Lianping Xing; Brendan F Boyce
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.
The Journal of biological chemistry 2007;282(25):18245-53.
2007: Pawel Wlodarski; Qian Zhang; Xiaobin Liu; Monika Kasprzycka; Michal Marzec; Mariusz A Wasik
PU.1 activates transcription of SHP-1 gene in hematopoietic cells.
The Journal of biological chemistry 2007;282(9):6316-23.
2007: Qian Zhang; Yan Lu; Steven T Proulx; Ruolin Guo; Zhenqiang Yao; Edward M Schwarz; Brendan F Boyce; Lianping Xing
Increased lymphangiogenesis in joints of mice with inflammatory arthritis.
Arthritis research & therapy 2007;9(6):R118.
2006: Qian Zhang; Hong Y Wang; Anders Woetmann; Puthiyaveettil N Raghunath; Niels Odum; Mariusz A Wasik
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.
Blood 2006;108(3):1058-64.
2006: Monika Kasprzycka; Michal Marzec; Xiaobin Liu; Qian Zhang; Mariusz A Wasik
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9964-9.
2006: Monika Kasprzycka; Miroslaw Majewski; Zhi-Jong Wang; Andrzej Ptasznik; Maria Wysocka; Qian Zhang; Michal Marzec; Phyllis A Gimotty; Mark R Crompton; Mariusz A Wasik
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
The American journal of pathology 2006;168(5):1631-41.
2006: T Nagasawa; Qian Zhang; Puthiyaveettil N Raghunath; H Y Wong; Mouna El-Salem; Arpad Szallasi; Michal Marzec; Phyllis A Gimotty; Alain H Rook; Eric Vonderheid; Niels Odum; Mariusz A Wasik
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing.
Leukemia research 2006;30(3):303-12.
2005: Michal Marzec; Monika Kasprzycka; Andrzej Ptasznik; Pawel Wlodarski; Qian Zhang; Niels Odum; Mariusz A Wasik
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.
Laboratory investigation; a journal of technical methods and pathology 2005;85(12):1544-54.
2005: Brendan F Boyce; Ping Li; Zhenqiang Yao; Qian Zhang; I Raul Badell; Edward M Schwarz; Regis J O'Keefe; Lianping Xing
TNF-alpha and pathologic bone resorption.
The Keio journal of medicine 2005;54(3):127-31.
2005: Qian Zhang; I Raul Badell; Edward M Schwarz; K E Boulukos; Zhenqiang Yao; Brendan F Boyce; Lianping Xing
Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.
Arthritis and rheumatism 2005;52(9):2708-18.
2005: Qian Zhang; Hong Y Wang; Michal Marzec; Puthiyaveettil N Raghunath; Tomohiko Nagasawa; Mariusz A Wasik
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6948-53.
2005: Brendan F Boyce; Teruhito Yamashita; Zhenqiang Yao; Qian Zhang; Fang Li; Lianping Xing
Roles for NF-kappaB and c-Fos in osteoclasts.
Journal of bone and mineral metabolism 2005;23 Suppl():11-5.
2003: Zhi-Yong Wang; Qian Zhang; John Wilson; Mariusz Z Ratajczak; Mariusz A Wasik
Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis.
The Journal of molecular diagnostics : JMD 2003;5(2):113-20.
2002: Michele Paessler; Plamen Kossev; Donald Tsai; Puthiyaveettil N Raghunath; Miroslaw Majewski; Qian Zhang; Preetha Ramalingam; Stephen Schuster; John Tomaszewski; Daniel A Arber; Eric Hsi; Mariusz A Wasik
Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1599-606.
2002: Qian Zhang; Renold J Capocasale; Floyd E Fox; Vahe Bedian; Eric Vonderheid; Alain H Rook; Jonni S Moore; Peter C Nowell; Dale S Haines; Mariusz A Wasik
Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches.
Archivum immunologiae et therapiae experimentalis 2002;50(6):421-9.
2002: Qian Zhang; Puthiyaveettil N Raghunath; Liquan Xue; Miroslaw Majewski; David F Carpentieri; Niels Odum; Stephan Morris; Tomasz Skorski; Mariusz A Wasik
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):466-74.
2000: Qian Zhang; Puthiyaveettil N Raghunath; Eric Vonderheid; Niels Odum; Mariusz A Wasik
Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter.
The American journal of pathology 2000;157(4):1137-46.
2000: Ning Tong; Seth W Perry; Qian Zhang; HJ James; Huang Guo; A Brooks; H Bal; S A Kinnear; S Fine; Leon G Epstein; Daniel J Dairaghi; Thomas J Schall; Howard E Gendelman; Stephen Dewhurst; Leroy R Sharer; Harris A Gelbard
Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1333-9.
1999: HJ James; Leroy R Sharer; Qian Zhang; Hong-Gang Wang; Leon G Epstein; J C Reed; Harris A Gelbard
Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis.
Neuropathology and applied neurobiology 1999;25(5):380-6.
1999: Qian Zhang; B Lee; Magdalena Korecka; G Li; C Weyland; Stephen L Eck; A Gessain; N Arima; Stuart R Lessin; Leslie M Shaw; Selina M Luger; M Kamoun; Mariusz A Wasik
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
Leukemia research 1999;23(4):373-84.
1998: Mariusz A Wasik; I Nowak; Qian Zhang; Leslie M Shaw
Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine.
Leukemia & lymphoma 1998;28(5-6):551-60.
1996: Qian Zhang; I Nowak; Eric Vonderheid; Alain H Rook; Marshall E Kadin; Peter C Nowell; L M Shaw; Mariusz A Wasik
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9148-53.
1996: Mariusz A Wasik; R Sackstein; D Novick; J R Butmarc; Qian Zhang; Eric Vonderheid; Marshall E Kadin
Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2.
Human pathology 1996;27(7):738-44.