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Sheng-Jun Zhang

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Khalid Chakir; Yang Xiang; Dongmei Yang; Sheng-Jun Zhang; Heping Cheng; Brian K Kobilka; Rui-Ping Xiao
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
Rui-Ping Xiao; Sheng-Jun Zhang; Khalid Chakir; Pavel Avdonin; Weizhong Zhu; Richard A Bond; C William Balke; Edward G Lakatta; Heping Cheng
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Ming Zheng; Sheng-Jun Zhang; Wei-Zhong Zhu; Bruce D Ziman; Brian K Kobilka; Rui-Ping Xiao
beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes.

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All Publications

2003: Khalid Chakir; Yang Xiang; Dongmei Yang; Sheng-Jun Zhang; Heping Cheng; Brian K Kobilka; Rui-Ping Xiao
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
Molecular pharmacology 2003;64(5):1048-58.
2003: Rui-Ping Xiao; Sheng-Jun Zhang; Khalid Chakir; Pavel Avdonin; Weizhong Zhu; Richard A Bond; C William Balke; Edward G Lakatta; Heping Cheng
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Circulation 2003;108(13):1633-9.
2000: Ming Zheng; Sheng-Jun Zhang; Wei-Zhong Zhu; Bruce D Ziman; Brian K Kobilka; Rui-Ping Xiao
beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes.
The Journal of biological chemistry 2000;275(51):40635-40.
2000: Ying-Ying Zhou; Dongmei Yang; Wei-Zhong Zhu; Sheng-Jun Zhang; D J Wang; Daniel K Rohrer; E Devic; Brian K Kobilka; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice.
Molecular pharmacology 2000;58(5):887-94.
2000: Sheng-Jun Zhang; Heping Cheng; Ying-Ying Zhou; D J Wang; Weizhong Zhu; Bruce D Ziman; H Spurgoen; RJ Lefkowitz; Edward G Lakatta; Walter J Koch; Rui-Ping Xiao
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
1999: Meike Kuschel; Ying-Ying Zhou; Heping Cheng; Sheng-Jun Zhang; Ye Chen-Izu; Edward G Lakatta; Rui-Ping Xiao
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
The Journal of biological chemistry 1999;274(31):22048-52.
1999: Meike Kuschel; Ying-Ying Zhou; Harold A Spurgeon; Sabine Bartel; Peter Karczewski; Sheng-Jun Zhang; Ernst-Georg Krause; Edward G Lakatta; Rui-Ping Xiao
beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart.
Circulation 1999;99(18):2458-65.