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John Brosnan

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Robin da Silva; Oliver Levillain; Silvia Araneda; John T Brosnan; Margaret E Brosnan
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.
Rafael Deminice; George N Furey; René L Jacobs; Alceu Afonso Jordao; Karen B Kelly; Kirst King-Jones; Simon G. Lamarre; Shannon A McCarter; Margaret E Brosnan; Colin Brown; Robin P da Silva; John T Brosnan
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
John T Brosnan; Robin P da Silva; Margaret E Brosnan
The metabolic burden of creatine synthesis.

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All Publications

2013: Robin da Silva; Oliver Levillain; Silvia Araneda; John T Brosnan; Margaret E Brosnan
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.
Canadian journal of physiology and pharmacology 2013;91(5):362-8.
2011: Rafael Deminice; George N Furey; René L Jacobs; Alceu Afonso Jordao; Karen B Kelly; Kirst King-Jones; Simon G. Lamarre; Shannon A McCarter; Margaret E Brosnan; Colin Brown; Robin P da Silva; John T Brosnan
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
The Journal of nutrition 2011;141(10):1799-804.
2011: John T Brosnan; Robin P da Silva; Margaret E Brosnan
The metabolic burden of creatine synthesis.
Amino acids 2011;40(5):1325-31.
2010: Jason R Treberg; Margaret E Brosnan; John T Brosnan
The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase.
Molecular and cellular biochemistry 2010;344(1-2):253-9.
2010: Simon G. Lamarre; Erica E Edison; Enoka P Wijekoon; Margaret E Brosnan; John T Brosnan
Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk.
The Journal of nutrition 2010;140(9):1570-3.
2010: Jason R Treberg; Kathy A Clow; Katie A Greene; Margaret E Brosnan; John T Brosnan
Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome.
American journal of physiology. Endocrinology and metabolism 2010;298(6):E1219-25.
2010: Jason R Treberg; Margaret E Brosnan; Malcolm Watford; John T Brosnan
On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome.
Advances in enzyme regulation 2010;50(1):34-43.
2009: Margaret E Brosnan; John T Brosnan
Hepatic glutamate metabolism: a tale of 2 hepatocytes.
The American journal of clinical nutrition 2009;90(3):857S-861S.
2009: Yang Zhao; Brian Su; René L Jacobs; Brian Kennedy; Gordon A Francis; Emma Waddington; John T Brosnan; Jean E Vance; Dennis E Vance
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1349-55.
2009: John T Brosnan; Enoka P Wijekoon; Lori Warford-Woolgar; Nathalie L Trottier; Margaret E Brosnan; Janet A Brunton; Robert F P Bertolo
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.
The Journal of nutrition 2009;139(7):1292-7.
2009: Robin P da Silva; Itzhak Nissim; Margaret E Brosnan; John T Brosnan
Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.
American journal of physiology. Endocrinology and metabolism 2009;296(2):E256-61.
2008: Kathy A Clow; Jason R Treberg; Margaret E Brosnan; John T Brosnan
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis.
The Journal of nutrition 2008;138(9):1641-6.
2007: Erica E Edison; Margaret E Brosnan; Christian Meyer; John T Brosnan
Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo.
American journal of physiology. Renal physiology 2007;293(6):F1799-804.
2007: Enoka P Wijekoon; Margaret E Brosnan; John T Brosnan
Homocysteine metabolism in diabetes.
Biochemical Society transactions 2007;35(Pt 5):1175-9.
2007: Margaret E Brosnan; John T Brosnan
Orotic acid excretion and arginine metabolism.
The Journal of nutrition 2007;137(6 Suppl 2):1656S-1661S.
2007: John T Brosnan; Margaret E Brosnan
Creatine: endogenous metabolite, dietary, and therapeutic supplement.
Annual review of nutrition 2007;27():241-61.
2007: Margaret E Brosnan; Erica E Edison; Robin da Silva; John T Brosnan
New insights into creatine function and synthesis.
Advances in enzyme regulation 2007;47():252-60.
2007: S Harvey Mudd; John T Brosnan; Margaret E Brosnan; René L Jacobs; Sally P Stabler; Robert H Allen; Dennis E Vance; Conrad Wagner
Methyl balance and transmethylation fluxes in humans.
The American journal of clinical nutrition 2007;85(1):19-25.
2007: John T Brosnan; Robin da Silva; Margaret E Brosnan
Amino acids and the regulation of methyl balance in humans.
Current opinion in clinical nutrition and metabolic care 2007;10(1):52-7.
2006: John T Brosnan; Margaret E Brosnan
The sulfur-containing amino acids: an overview.
The Journal of nutrition 2006;136(6 Suppl):1636S-1640S.
2006: Shobhitha Ratnam; Enoka P Wijekoon; Beatrice Hall; Timothy A Garrow; Margaret E Brosnan; John T Brosnan
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E933-9.
2006: Lori M Stead; John T Brosnan; Margaret E Brosnan; Dennis E Vance; René L Jacobs
Is it time to reevaluate methyl balance in humans?
The American journal of clinical nutrition 2006;83(1):5-10.
2006: John T Brosnan; Margaret E Brosnan
Branched-chain amino acids: enzyme and substrate regulation.
The Journal of nutrition 2006;136(1 Suppl):207S-11S.
2005: Tyra M Dickson; Erica Edison; John T Brosnan; James House
Hyperglycinemia due to folate deficiency in rats: evidence for the lack of involvement of the hepatic glycine cleavage system.
The Journal of nutritional biochemistry 2005;16(12):736-42.
2005: Enoka P Wijekoon; Beatrice Hall; Shobhitha Ratnam; Margaret E Brosnan; Steven H Zeisel; John T Brosnan
Homocysteine metabolism in ZDF (type 2) diabetic rats.
Diabetes 2005;54(11):3245-51.
2005: René L Jacobs; Lori M Stead; Cecilia Devlin; Ira Tabas; Margaret E Brosnan; John T Brosnan; Dennis E Vance
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.
The Journal of biological chemistry 2005;280(31):28299-305.
2005: David J Shields; Susanne Lingrell; Luis B Agellon; John T Brosnan; Dennis E Vance
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.
The Journal of biological chemistry 2005;280(29):27339-44.
2005: John T Brosnan
The Fourth Workshop on the Assessment of Adequate intake of Dietary Amino Acids: general discussion of sessions 1 and 2.
The Journal of nutrition 2005;135(6 Suppl):1576S-9S.
2005: John T Brosnan
Metabolic design principles: chemical and physical determinants of cell chemistry.
Advances in enzyme regulation 2005;45():27-36.
2004: John T Brosnan
Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 2004;29(6):773-80.
2004: Margaret E Brosnan; John T Brosnan
Renal arginine metabolism.
The Journal of nutrition 2004;134(10 Suppl):2791S-2795S; discussion 2796S-2797S.
2004: Enoka P Wijekoon; Craig Skinner; Margaret E Brosnan; John T Brosnan
Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.
Canadian journal of physiology and pharmacology 2004;82(7):506-14.
2004: Lori M Stead; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism.
Advances in enzyme regulation 2004;44():321-33.
2004: John T Brosnan; René L Jacobs; Lori M Stead; Margaret E Brosnan
Methylation demand: a key determinant of homocysteine metabolism.
Acta biochimica Polonica 2004;51(2):405-13.
2004: John T Brosnan; Margaret E Brosnan; Itzhak Nissim
A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.
Metabolic engineering 2004;6(1):6-11.
2003: John T Brosnan
Interorgan amino acid transport and its regulation.
The Journal of nutrition 2003;133(6 Suppl 1):2068S-2072S.
2003: Anna A Noga; Lori M Stead; Yang Zhao; Margaret E Brosnan; John T Brosnan; Dennis E Vance
Plasma homocysteine is regulated by phospholipid methylation.
The Journal of biological chemistry 2003;278(8):5952-5.
2002: Shobhitha Ratnam; Kenneth N Maclean; René L Jacobs; Margaret E Brosnan; Jan P Kraus; John T Brosnan
Hormonal regulation of cystathionine beta-synthase expression in liver.
The Journal of biological chemistry 2002;277(45):42912-8.
2002: John T Brosnan; Margaret E Brosnan
Hepatic glutaminase--a special role in urea synthesis?
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(6):455-7.
2002: John T Brosnan; Margaret E Brosnan; Itzhak Nissim
Application of 15N to the study of hepatic nitrogen metabolism.
Advances in enzyme regulation 2002;42():305-15.
2001: John T Brosnan
Amino acids, then and now--a reflection on Sir Hans Krebs' contribution to nitrogen metabolism.
IUBMB life 2001;52(6):265-70.
2001: James House; B N Hall; John T Brosnan
Threonine metabolism in isolated rat hepatocytes.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1300-7.
2001: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.
The Journal of biological chemistry 2001;276(47):43740-7.
2001: Lori M Stead; K P Au; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.
American journal of physiology. Endocrinology and metabolism 2001;281(5):E1095-100.
2001: John T Brosnan; Margaret E Brosnan; Marc Yudkoff; Itzhak Nissim; Yevgeny Daikhin; Adam Lazarow; Oksana Horyn; I Nissim
Alanine metabolism in the perfused rat liver. Studies with (15)N.
The Journal of biological chemistry 2001;276(34):31876-82.
2000: Lori M Stead; Margaret E Brosnan; John T Brosnan
Characterization of homocysteine metabolism in the rat liver.
The Biochemical journal 2000;350 Pt 3():685-92.
2000: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Plasma homocysteine is decreased in the hypothyroid rat.
Canadian journal of physiology and pharmacology 2000;78(7):565-70.
2000: James House; S B March; S Ratnam; E Ives; John T Brosnan; James K Friel
Folate and vitamin B12 status of women in Newfoundland at their first prenatal visit.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2000;162(11):1557-9.
2000: John T Brosnan
Glutamate, at the interface between amino acid and carbohydrate metabolism.
The Journal of nutrition 2000;130(4S Suppl):988S-90S.
2000: D O'Sullivan; John T Brosnan; Margaret E Brosnan
Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E516-21.
1999: Itzhak Nissim; M E Brosnan; Marc Yudkoff; John T Brosnan
Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.
The Journal of biological chemistry 1999;274(41):28958-65.
1999: John T Brosnan
Comments on metabolic needs for glucose and the role of gluconeogenesis.
European journal of clinical nutrition 1999;53 Suppl 1():S107-11.
1999: James House; René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Regulation of homocysteine metabolism.
Advances in enzyme regulation 1999;39():69-91.
1998: René L Jacobs; James House; Margaret E Brosnan; John T Brosnan
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.
Diabetes 1998;47(12):1967-70.
1998: James House; Margaret E Brosnan; John T Brosnan
Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia.
Kidney international 1998;54(5):1601-7.
1998: Gehan Mabrouk; M Jois; John T Brosnan
Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon.
The Biochemical journal 1998;330 ( Pt 2)():759-63.
1998: D O'sullivan; John T Brosnan; Margaret E Brosnan
Hepatic zonation of the catabolism of arginine and ornithine in the perfused rat liver.
The Biochemical journal 1998;330 ( Pt 2)():627-32.
1997: S A Squires; H S Ewart; C McCarthy; Margaret E Brosnan; John T Brosnan
Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat.
Diabetes 1997;46(12):1945-9.
1997: James House; Margaret E Brosnan; John T Brosnan
Characterization of homocysteine metabolism in the rat kidney.
The Biochemical journal 1997;328 ( Pt 1)():287-92.
1997: Gehan Mabrouk; John T Brosnan
Activation of the hepatic glycine cleavage enzyme system by glucagon and glucagon-related peptides.
Canadian journal of physiology and pharmacology 1997;75(9):1096-100.
1997: John T Brosnan; Margaret E Brosnan; R Charron; Itzhak Nissim
Incorporation of 15N-labelled precursors into urea isotopomers.
Contributions to nephrology 1997;121():156-62.
1997: James House; Margaret E Brosnan; John T Brosnan
Renal homocysteine metabolism.
Contributions to nephrology 1997;121():79-84.
1996: D O'Sullivan; John T Brosnan; Margaret E Brosnan
Catabolism of arginine and ornithine in perfused rat liver; localisation and regulation.
Biochemical Society transactions 1996;24(3):488S.
1996: John T Brosnan; Margaret E Brosnan; R Charron; I Nissim
A mass isotopomer study of urea and glutamine synthesis from 15N-labeled ammonia in the perfused rat liver.
The Journal of biological chemistry 1996;271(27):16199-207.
1996: D Qian; John T Brosnan
Administration of Escherichia coli endotoxin to rat increases liver mass and hepatocyte volume in vivo.
The Biochemical journal 1996;313 ( Pt 2)():479-86.
1995: John T Brosnan; B Hall; J Selhub; Marie Nadeau; A G Bostom
Renal metabolism of homocysteine in vivo.
Biochemical Society transactions 1995;23(3):470S.
1995: H S Ewart; D Qian; John T Brosnan
Activation of hepatic glutaminase in the endotoxin-treated rat.
The Journal of surgical research 1995;59(2):245-9.
1995: Z Kovacevic; S H Day; V Collett; John T Brosnan; Margaret E Brosnan
Activation of hepatic glutaminase by spermine.
The Biochemical journal 1995;305 ( Pt 3)():837-41.
1995: John T Brosnan; H S Ewart; S A Squires
Hormonal control of hepatic glutaminase.
Advances in enzyme regulation 1995;35():131-46.
1994: John T Brosnan; D Qian
Endotoxin-induced increase in liver mass and hepatocyte volume.
Biochemical Society transactions 1994;22(2):529-32.
1994: John T Brosnan; H S Ewart; S A Squires; S H Day; Z Kovacevic; Margaret E Brosnan
Hormonal and dietary control of hepatic glutamine catabolism.
Contributions to nephrology 1994;110():109-14.
1993: H S Ewart; John T Brosnan
Rapid activation of hepatic glutaminase in rats fed on a single high-protein meal.
The Biochemical journal 1993;293 ( Pt 2)():339-44.
1992: S N Dhanakoti; John T Brosnan; Margaret E Brosnan; G R Herzberg
Net renal arginine flux in rats is not affected by dietary arginine or dietary protein intake.
The Journal of nutrition 1992;122(5):1127-34.
1992: H S Ewart; M Jois; John T Brosnan
Rapid stimulation of the hepatic glycine-cleavage system in rats fed on a single high-protein meal.
The Biochemical journal 1992;283 ( Pt 2)():441-7.
1992: M Jois; H S Ewart; John T Brosnan
Regulation of glycine catabolism in rat liver mitochondria.
The Biochemical journal 1992;283 ( Pt 2)():435-9.
1992: S N Dhanakoti; Margaret E Brosnan; G R Herzberg; John T Brosnan
Cellular and subcellular localization of enzymes of arginine metabolism in rat kidney.
The Biochemical journal 1992;282 ( Pt 2)():369-75.
1992: G Y Wu; John T Brosnan
Macrophages can convert citrulline into arginine.
The Biochemical journal 1992;281 ( Pt 1)():45-8.
1990: S N Dhanakoti; John T Brosnan; G R Herzberg; Margaret E Brosnan
Renal arginine synthesis: studies in vitro and in vivo.
The American journal of physiology 1990;259(3 Pt 1):E437-42.
1990: M Jois; B Hall; V M Collett; John T Brosnan
Flux through glycine cleavage system in isolated hepatocytes: effects of glucagon, cAMP, and calcium.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(2):543-6.
1990: M Jois; B Hall; John T Brosnan
Stimulation of glycine catabolism in isolated perfused rat liver by calcium mobilizing hormones and in isolated rat liver mitochondria by submicromolar concentrations of calcium.
The Journal of biological chemistry 1990;265(3):1246-8.
1990: J Letto; John T Brosnan; Margaret E Brosnan
Oxidation of 2-oxoisocaproate and 2-oxoisovalerate by the perfused rat heart. Interactions with fatty acid oxidation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):260-5.
1989: John T Brosnan; B Hall
Renal serine production in vivo: effects of dietary manipulation of serine status.
Canadian journal of physiology and pharmacology 1989;67(9):1058-61.
1989: M Jois; B Hall; K Fewer; John T Brosnan
Regulation of hepatic glycine catabolism by glucagon.
The Journal of biological chemistry 1989;264(6):3347-51.
1988: G R Herzberg; John T Brosnan; B Hall; M Rogerson
Gluconeogenesis in liver and kidney of common murre (Uria aalge).
The American journal of physiology 1988;254(6 Pt 2):R903-7.
1988: M Jois; D E Hall; John T Brosnan
Serine synthesis by the rat kidney.
Contributions to nephrology 1988;63():136-40.
1987: John T Brosnan
The 1986 Borden award lecture. The role of the kidney in amino acid metabolism and nutrition.
Canadian journal of physiology and pharmacology 1987;65(12):2355-62.
1987: M Lowry; D E Hall; M S Hall; John T Brosnan
Renal metabolism of amino acids in vivo: studies on serine and glycine fluxes.
The American journal of physiology 1987;252(2 Pt 2):F304-9.
1986: M Lowry; D E Hall; John T Brosnan
Serine synthesis in rat kidney: studies with perfused kidney and cortical tubules.
The American journal of physiology 1986;250(4 Pt 2):F649-58.
1985: M Lowry; D E Hall; John T Brosnan
Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis.
The Biochemical journal 1985;231(2):477-80.
1985: M Lowry; D E Hall; John T Brosnan
Hydroxyproline metabolism by the rat kidney: distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine.
Metabolism: clinical and experimental 1985;34(10):955-61.
1985: M Lowry; D E Hall; John T Brosnan
Metabolism of glycine- and hydroxyproline-containing peptides by the isolated perfused rat kidney.
The Biochemical journal 1985;229(2):545-9.
1985: M Lowry; B Hall; D E Hall; John T Brosnan
Pathways of serine synthesis in the rat kidney.
Contributions to nephrology 1985;47():203-8.
1983: John T Brosnan; K C Man; D E Hall; S A Colbourne; Margaret E Brosnan
Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat.
The American journal of physiology 1983;244(2):E151-8.