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Margaret Brosnan

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Robin da Silva; Oliver Levillain; Silvia Araneda; John T Brosnan; Margaret E Brosnan
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.
Rafael Deminice; George N Furey; René L Jacobs; Alceu Afonso Jordao; Karen B Kelly; Kirst King-Jones; Simon G. Lamarre; Shannon A McCarter; Margaret E Brosnan; Colin Brown; Robin P da Silva; John T Brosnan
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
John T Brosnan; Robin P da Silva; Margaret E Brosnan
The metabolic burden of creatine synthesis.

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All Publications

2013: Robin da Silva; Oliver Levillain; Silvia Araneda; John T Brosnan; Margaret E Brosnan
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.
Canadian journal of physiology and pharmacology 2013;91(5):362-8.
2011: Rafael Deminice; George N Furey; René L Jacobs; Alceu Afonso Jordao; Karen B Kelly; Kirst King-Jones; Simon G. Lamarre; Shannon A McCarter; Margaret E Brosnan; Colin Brown; Robin P da Silva; John T Brosnan
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
The Journal of nutrition 2011;141(10):1799-804.
2011: John T Brosnan; Robin P da Silva; Margaret E Brosnan
The metabolic burden of creatine synthesis.
Amino acids 2011;40(5):1325-31.
2010: Jason R Treberg; Margaret E Brosnan; John T Brosnan
The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase.
Molecular and cellular biochemistry 2010;344(1-2):253-9.
2010: Simon G. Lamarre; Erica E Edison; Enoka P Wijekoon; Margaret E Brosnan; John T Brosnan
Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk.
The Journal of nutrition 2010;140(9):1570-3.
2010: Jason R Treberg; Kathy A Clow; Katie A Greene; Margaret E Brosnan; John T Brosnan
Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome.
American journal of physiology. Endocrinology and metabolism 2010;298(6):E1219-25.
2010: Jason R Treberg; Margaret E Brosnan; Malcolm Watford; John T Brosnan
On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome.
Advances in enzyme regulation 2010;50(1):34-43.
2009: Margaret E Brosnan; John T Brosnan
Hepatic glutamate metabolism: a tale of 2 hepatocytes.
The American journal of clinical nutrition 2009;90(3):857S-861S.
2009: John T Brosnan; Enoka P Wijekoon; Lori Warford-Woolgar; Nathalie L Trottier; Margaret E Brosnan; Janet A Brunton; Robert F P Bertolo
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.
The Journal of nutrition 2009;139(7):1292-7.
2008: Kathy A Clow; Jason R Treberg; Margaret E Brosnan; John T Brosnan
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis.
The Journal of nutrition 2008;138(9):1641-6.
2007: Enoka P Wijekoon; Margaret E Brosnan; John T Brosnan
Homocysteine metabolism in diabetes.
Biochemical Society transactions 2007;35(Pt 5):1175-9.
2007: Margaret E Brosnan; John T Brosnan
Orotic acid excretion and arginine metabolism.
The Journal of nutrition 2007;137(6 Suppl 2):1656S-1661S.
2007: John T Brosnan; Margaret E Brosnan
Creatine: endogenous metabolite, dietary, and therapeutic supplement.
Annual review of nutrition 2007;27():241-61.
2007: Margaret E Brosnan; Erica E Edison; Robin da Silva; John T Brosnan
New insights into creatine function and synthesis.
Advances in enzyme regulation 2007;47():252-60.
2007: S Harvey Mudd; John T Brosnan; Margaret E Brosnan; René L Jacobs; Sally P Stabler; Robert H Allen; Dennis E Vance; Conrad Wagner
Methyl balance and transmethylation fluxes in humans.
The American journal of clinical nutrition 2007;85(1):19-25.
2007: John T Brosnan; Robin da Silva; Margaret E Brosnan
Amino acids and the regulation of methyl balance in humans.
Current opinion in clinical nutrition and metabolic care 2007;10(1):52-7.
2006: John T Brosnan; Margaret E Brosnan
The sulfur-containing amino acids: an overview.
The Journal of nutrition 2006;136(6 Suppl):1636S-1640S.
2006: Shobhitha Ratnam; Enoka P Wijekoon; Beatrice Hall; Timothy A Garrow; Margaret E Brosnan; John T Brosnan
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E933-9.
2006: Lori M Stead; John T Brosnan; Margaret E Brosnan; Dennis E Vance; René L Jacobs
Is it time to reevaluate methyl balance in humans?
The American journal of clinical nutrition 2006;83(1):5-10.
2006: John T Brosnan; Margaret E Brosnan
Branched-chain amino acids: enzyme and substrate regulation.
The Journal of nutrition 2006;136(1 Suppl):207S-11S.
2005: Enoka P Wijekoon; Beatrice Hall; Shobhitha Ratnam; Margaret E Brosnan; Steven H Zeisel; John T Brosnan
Homocysteine metabolism in ZDF (type 2) diabetic rats.
Diabetes 2005;54(11):3245-51.
2005: René L Jacobs; Lori M Stead; Cecilia Devlin; Ira Tabas; Margaret E Brosnan; John T Brosnan; Dennis E Vance
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.
The Journal of biological chemistry 2005;280(31):28299-305.
2004: Michael R Haslett; Desmond Pink; Barry Walters; Margaret E Brosnan
Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver.
Biochimica et biophysica acta 2004;1675(1-3):81-6.
2004: Margaret E Brosnan; John T Brosnan
Renal arginine metabolism.
The Journal of nutrition 2004;134(10 Suppl):2791S-2795S; discussion 2796S-2797S.
2004: Enoka P Wijekoon; Craig Skinner; Margaret E Brosnan; John T Brosnan
Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes.
Canadian journal of physiology and pharmacology 2004;82(7):506-14.
2004: Lori M Stead; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism.
Advances in enzyme regulation 2004;44():321-33.
2004: John T Brosnan; René L Jacobs; Lori M Stead; Margaret E Brosnan
Methylation demand: a key determinant of homocysteine metabolism.
Acta biochimica Polonica 2004;51(2):405-13.
2004: John T Brosnan; Margaret E Brosnan; Itzhak Nissim
A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.
Metabolic engineering 2004;6(1):6-11.
2003: Anna A Noga; Lori M Stead; Yang Zhao; Margaret E Brosnan; John T Brosnan; Dennis E Vance
Plasma homocysteine is regulated by phospholipid methylation.
The Journal of biological chemistry 2003;278(8):5952-5.
2002: Shobhitha Ratnam; Kenneth N Maclean; René L Jacobs; Margaret E Brosnan; Jan P Kraus; John T Brosnan
Hormonal regulation of cystathionine beta-synthase expression in liver.
The Journal of biological chemistry 2002;277(45):42912-8.
2002: John T Brosnan; Margaret E Brosnan
Hepatic glutaminase--a special role in urea synthesis?
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(6):455-7.
2002: John T Brosnan; Margaret E Brosnan; Itzhak Nissim
Application of 15N to the study of hepatic nitrogen metabolism.
Advances in enzyme regulation 2002;42():305-15.
2001: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.
The Journal of biological chemistry 2001;276(47):43740-7.
2001: Lori M Stead; K P Au; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.
American journal of physiology. Endocrinology and metabolism 2001;281(5):E1095-100.
2001: John T Brosnan; Margaret E Brosnan; Marc Yudkoff; Itzhak Nissim; Yevgeny Daikhin; Adam Lazarow; Oksana Horyn; I Nissim
Alanine metabolism in the perfused rat liver. Studies with (15)N.
The Journal of biological chemistry 2001;276(34):31876-82.
2000: Lori M Stead; Margaret E Brosnan; John T Brosnan
Characterization of homocysteine metabolism in the rat liver.
The Biochemical journal 2000;350 Pt 3():685-92.
2000: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Plasma homocysteine is decreased in the hypothyroid rat.
Canadian journal of physiology and pharmacology 2000;78(7):565-70.
2000: D O'Sullivan; John T Brosnan; Margaret E Brosnan
Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E516-21.
1999: James House; René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Regulation of homocysteine metabolism.
Advances in enzyme regulation 1999;39():69-91.
1998: René L Jacobs; James House; Margaret E Brosnan; John T Brosnan
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.
Diabetes 1998;47(12):1967-70.
1998: James House; Margaret E Brosnan; John T Brosnan
Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia.
Kidney international 1998;54(5):1601-7.
1998: D O'sullivan; John T Brosnan; Margaret E Brosnan
Hepatic zonation of the catabolism of arginine and ornithine in the perfused rat liver.
The Biochemical journal 1998;330 ( Pt 2)():627-32.
1997: S A Squires; H S Ewart; C McCarthy; Margaret E Brosnan; John T Brosnan
Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat.
Diabetes 1997;46(12):1945-9.
1997: James House; Margaret E Brosnan; John T Brosnan
Characterization of homocysteine metabolism in the rat kidney.
The Biochemical journal 1997;328 ( Pt 1)():287-92.
1997: John T Brosnan; Margaret E Brosnan; R Charron; Itzhak Nissim
Incorporation of 15N-labelled precursors into urea isotopomers.
Contributions to nephrology 1997;121():156-62.
1997: Margaret E Brosnan; S Ray; B Walters; Desmond Pink
How does the kidney handle plasma polyamines?
Contributions to nephrology 1997;121():129-35.
1997: James House; Margaret E Brosnan; John T Brosnan
Renal homocysteine metabolism.
Contributions to nephrology 1997;121():79-84.
1996: D O'Sullivan; John T Brosnan; Margaret E Brosnan
Catabolism of arginine and ornithine in perfused rat liver; localisation and regulation.
Biochemical Society transactions 1996;24(3):488S.
1996: John T Brosnan; Margaret E Brosnan; R Charron; I Nissim
A mass isotopomer study of urea and glutamine synthesis from 15N-labeled ammonia in the perfused rat liver.
The Journal of biological chemistry 1996;271(27):16199-207.
1995: Margaret E Brosnan; S Ray; B Walters
How does the kidney deal with plasma polyamines?
Biochemical Society transactions 1995;23(3):469S.
1995: Z Kovacevic; S H Day; V Collett; John T Brosnan; Margaret E Brosnan
Activation of hepatic glutaminase by spermine.
The Biochemical journal 1995;305 ( Pt 3)():837-41.
1994: John T Brosnan; H S Ewart; S A Squires; S H Day; Z Kovacevic; Margaret E Brosnan
Hormonal and dietary control of hepatic glutamine catabolism.
Contributions to nephrology 1994;110():109-14.
1992: S N Dhanakoti; John T Brosnan; Margaret E Brosnan; G R Herzberg
Net renal arginine flux in rats is not affected by dietary arginine or dietary protein intake.
The Journal of nutrition 1992;122(5):1127-34.
1992: S N Dhanakoti; Margaret E Brosnan; G R Herzberg; John T Brosnan
Cellular and subcellular localization of enzymes of arginine metabolism in rat kidney.
The Biochemical journal 1992;282 ( Pt 2)():369-75.
1990: S N Dhanakoti; John T Brosnan; G R Herzberg; Margaret E Brosnan
Renal arginine synthesis: studies in vitro and in vivo.
The American journal of physiology 1990;259(3 Pt 1):E437-42.
1990: J Letto; John T Brosnan; Margaret E Brosnan
Oxidation of 2-oxoisocaproate and 2-oxoisovalerate by the perfused rat heart. Interactions with fatty acid oxidation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):260-5.
1988: Margaret E Brosnan; Y W Hu
Ornithine decarboxylase antizyme in mammalian tissues.
Advances in experimental medicine and biology 1988;250():37-43.
1987: Y W Hu; Margaret E Brosnan
Properties of ornithine decarboxylase-antizyme from mammary gland of lactating rats.
Archives of biochemistry and biophysics 1987;254(2):637-41.
1986: J Letto; Margaret E Brosnan; J T Brosnan
Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate.
The Biochemical journal 1986;240(3):909-12.
1986: Margaret E Brosnan; A Lowry; J T Brosnan
Diabetes increases active fraction of branched-chain 2-oxoacid dehydrogenase in rat brain.
Diabetes 1986;35(9):1041-3.
1985: Margaret E Brosnan; A Lowry; Y Wasi; M Lowry; J T Brosnan
Regional and subcellular distribution of enzymes of branched-chain amino acid metabolism in brains of normal and diabetic rats.
Canadian journal of physiology and pharmacology 1985;63(10):1234-8.
1984: J T Brosnan; R G Forsey; Margaret E Brosnan
Uptake of tyrosine and leucine in vivo by brain of diabetic and control rats.
The American journal of physiology 1984;247(5 Pt 1):C450-3.
1983: John T Brosnan; K C Man; D E Hall; S A Colbourne; Margaret E Brosnan
Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat.
The American journal of physiology 1983;244(2):E151-8.
1982: Y W Hu; D E Hall; Margaret E Brosnan
Effect of 1,3-diaminopropan-2-o1, an inhibitor of ornithine decarboxylase, on the metabolic response of liver to insulin.
Canadian journal of physiology and pharmacology 1982;60(12):1493-8.
1982: J T Brosnan; Margaret E Brosnan
Dietary protein, metabolic acidosis, and calcium balance.
Advances in nutritional research 1982;4():77-105.
1980: Margaret E Brosnan; B V Roebothan; D E Hall
Polyamine and amino acid content, and activity of polyamine-synthesizing decarboxylases, in liver of streptozotocin-induced diabetic and insulin-treated diabetic rats.
The Biochemical journal 1980;190(2):395-403.