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Betsy Brotman

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Mohamed Tarek Shata; Wolfram Pfahler; Betsy Brotman; Dong-Hun Lee; Nancy Tricoche; Krishna K Murthy; Alfred M Prince
Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load.
Zhi Qiang Yao; Mohamed Tarek Shata; Nancy Tricoche; Mei Mei Shan; Betsy Brotman; Wolfram Pfahler; Young S Hahn; Alfred M Prince
gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection.
Alfred M Prince; Betsy Brotman; Dong-Hun Lee; Wolfram Pfahler; Nancy Tricoche; Linda Andrus; Mohamed Tarek Shata
Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model.

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All Publications

2006: Mohamed Tarek Shata; Wolfram Pfahler; Betsy Brotman; Dong-Hun Lee; Nancy Tricoche; Krishna K Murthy; Alfred M Prince
Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load.
Journal of medical primatology 2006;35(3):165-71.
2006: Zhi Qiang Yao; Mohamed Tarek Shata; Nancy Tricoche; Mei Mei Shan; Betsy Brotman; Wolfram Pfahler; Young S Hahn; Alfred M Prince
gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection.
Virology 2006;346(2):324-37.
2005: Alfred M Prince; Betsy Brotman; Dong-Hun Lee; Wolfram Pfahler; Nancy Tricoche; Linda Andrus; Mohamed Tarek Shata
Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model.
The Journal of infectious diseases 2005;192(10):1701-9.
2004: Alfred M Prince; J-M Pawlotsky; A Soulier; L Tobler; Betsy Brotman; Wolfram Pfahler; Dong-Hun Lee; Liping Li; Mohamed Tarek Shata
Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections.
Journal of viral hepatitis 2004;11(3):236-42.
2003: Mohamed Tarek Shata; Nancy Tricoche; Marion Perkus; Darley Tom; Betsy Brotman; Patricia McCormack; Wolfram Pfahler; Dong-Hun Lee; Leslie H Tobler; Michael Busch; Alfred M Prince
Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees.
Virology 2003;314(2):601-16.
2002: Mohamed Tarek Shata; Donald D Anthony; Nicole Yonkers; Linda Andrus; Betsy Brotman; Nancy Tricoche; Patricia McCormack; A Prince
Characterization of the immune response against hepatitis C infection in recovered, and chronically infected chimpanzees.
Journal of viral hepatitis 2002;9(6):400-10.
2002: Alfred M Prince; Betsy Brotman; Dong-Hun Lee; Linda Andrus; Jay Valinsky; Preston Marx
Lack of evidence for HIV type 1-related SIVcpz infection in captive and wild chimpanzees (Pan troglodytes verus) in West Africa.
AIDS research and human retroviruses 2002;18(9):657-60.
2001: Alfred M Prince; D H Lee; Betsy Brotman
Infectivity of blood from PCR-positive, HBsAg-negative, anti-HBs-positive cases of resolved hepatitis B infection.
Transfusion 2001;41(3):329-32.
2001: Preeti Pancholi; Dong-Hun Lee; Qingyan Liu; C Tackney; P Taylor; Marion Perkus; Linda Andrus; Betsy Brotman; Alfred M Prince
DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee.
Hepatology (Baltimore, Md.) 2001;33(2):448-54.
2001: Alfred M Prince; Betsy Brotman
Perspectives on hepatitis B studies with chimpanzees.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2001;42(2):85-8.
2000: Kazuaki Takahashi; Betsy Brotman; Sadakazu Usuda; Shunji Mishiro; Alfred M Prince
Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: implications for an origin of HBV.
Virology 2000;267(1):58-64.
1999: Alfred M Prince; Betsy Brotman; Dong-Hun Lee; L Ren; B S Moore; JW Scheffel
Significance of the anti-E2 response in self-limited and chronic hepatitis C virus infections in chimpanzees and in humans.
The Journal of infectious diseases 1999;180(4):987-91.
1999: Alfred M Prince; J Allan; Linda Andrus; Betsy Brotman; J Eichber; R Fouts; J Goodall; P Marx; Krishna K Murthy; S McGreal; C Noon
Virulent HIV strains, chimpanzees, and trial vaccines.
Science (New York, N.Y.) 1999;283(5405):1117-8.
1998: M Cohard; Qingyan Liu; Marion Perkus; E Gordon; Betsy Brotman; Alfred M Prince
Hepatitis C virus-specific CTL responses in PBMC from chimpanzees with chronic hepatitis C: determination of CTL and CTL precursor frequencies using a recombinant canarypox virus (ALVAC).
Journal of immunological methods 1998;214(1-2):121-9.
1998: C A Wyatt; Linda Andrus; Betsy Brotman; F Huang; Dong-Hun Lee; Alfred M Prince
Immunity in chimpanzees chronically infected with hepatitis C virus: role of minor quasispecies in reinfection.
Journal of virology 1998;72(3):1725-30.
1998: Alfred M Prince; Betsy Brotman
Biological and immunological aspects of hepatitis C virus infection in chimpanzees.
Current studies in hematology and blood transfusion 1998;(62):250-65.
1997: Alfred M Prince; R Whalen; Betsy Brotman
Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus.
Vaccine 1997;15(8):916-9.
1996: Sara Lustigman; James H McKerrow; K Shah; J Lui; T Huima; M Hough; Betsy Brotman
Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae.
The Journal of biological chemistry 1996;271(47):30181-9.
1996: Y F Wang; Betsy Brotman; Linda Andrus; Alfred M Prince
Immune response to epitopes of hepatitis C virus (HCV) structural proteins in HCV-infected humans and chimpanzees.
The Journal of infectious diseases 1996;173(4):808-21.
1995: Sara Lustigman; Betsy Brotman; T Huima; A L Castelhano; R N Singh; K Mehta; Alfred M Prince
Transglutaminase-catalyzed reaction is important for molting of Onchocerca volvulus third-stage larvae.
Antimicrobial agents and chemotherapy 1995;39(9):1913-9.
1994: Alfred M Prince; Betsy Brotman
The biology of hepatitis C virus infection. Lessons learned from chimpanzees.
Current studies in hematology and blood transfusion 1994;(61):195-207.
1993: Alfred M Prince; Betsy Brotman; G Inchauspé; D Pascual; M Nasoff; B Hosein; C Y Wang
Patterns and prevalence of hepatitis C virus infection in posttransfusion non-A, non-B hepatitis.
The Journal of infectious diseases 1993;167(6):1296-301.
1992: Sara Lustigman; Betsy Brotman; T Huima; Alfred M Prince; James H McKerrow
Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus.
The Journal of biological chemistry 1992;267(24):17339-46.
1992: Alfred M Prince; Betsy Brotman; Eugene H Johnson; A Smith; D Pascual; Sara Lustigman
Onchocerca volvulus: immunization of chimpanzees with X-irradiated third-stage (L3) larvae.
Experimental parasitology 1992;74(3):239-50.
1992: Alfred M Prince; Betsy Brotman; T Huima; D Pascual; M Jaffery; G Inchauspé
Immunity in hepatitis C infection.
The Journal of infectious diseases 1992;165(3):438-43.
1992: B Horowitz; R Bonomo; Alfred M Prince; S N Chin; Betsy Brotman; R W Shulman
Solvent/detergent-treated plasma: a virus-inactivated substitute for fresh frozen plasma.
Blood 1992;79(3):826-31.
1992: Sara Lustigman; Betsy Brotman; Eugene H Johnson; A B Smith; T Huima; Alfred M Prince
Identification and characterization of an Onchocerca volvulus cDNA clone encoding a microfilarial surface-associated antigen.
Molecular and biochemical parasitology 1992;50(1):79-93.
1991: Eugene H Johnson; Sara Lustigman; Betsy Brotman; J Browne; Alfred M Prince
Onchocerca volvulus: in vitro killing of microfilaria by neutrophils and eosinophils from experimentally infected chimpanzees.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1991;42(4):351-5.
1991: K M Miller; Sara Lustigman; Betsy Brotman; Linda Andrus; N Weiss; C Hotze; Alfred M Prince
Onchocerca volvulus: characterization of monoclonal antibodies reactive with surface components of third-stage larvae.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1991;42(2):85-90.
1991: Sara Lustigman; Betsy Brotman; T Huima; Alfred M Prince
Characterization of an Onchocerca volvulus cDNA clone encoding a genus specific antigen present in infective larvae and adult worms.
Molecular and biochemical parasitology 1991;45(1):65-75.
1990: Sara Lustigman; T Huima; Betsy Brotman; K Miller; Alfred M Prince
Onchocerca volvulus: biochemical and morphological characteristics of the surface of third- and fourth-stage larvae.
Experimental parasitology 1990;71(4):489-95.
1990: K M Miller; C Hotze; Betsy Brotman; A M Prince
An economical procedure for screening of hybridoma supernatants for surface reactive antibodies to filarial larvae.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1990;41(2):221-2.
1989: Betsy Brotman; W Boehle; Alfred M Prince
Absence of perinatal transmission of blood-borne non-A, non-B hepatitis virus by chimpanzees with acute and chronic infection.
Journal of medical virology 1989;28(1):13-5.
1989: Alfred M Prince; J Goodall; Betsy Brotman; H Dienske; H Schellekens; J W Eichberg
Appropriate conditions for maintenance of chimpanzees in studies with blood-borne viruses: an epidemiologic and psychosocial perspective.
Journal of medical primatology 1989;18(1):27-42.
1988: W Stephan; H Dichtelmüller; Alfred M Prince; Betsy Brotman; T Huima
Inactivation of the Hutchinson strain of hepatitis non-A, non-B virus in intravenous immunoglobulin by beta-propiolactone.
Journal of medical virology 1988;26(3):227-32.
1988: Alfred M Prince; B Horowitz; L Baker; R W Shulman; H Ralph; J Valinsky; A Cundell; Betsy Brotman; W Boehle; F Rey
Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6944-8.
1988: B Williams; Alfred M Prince; T Huima; Betsy Brotman
Spumaviruses isolated from sources containing agents of non-A, non-B (NANB) hepatitis do not cause NANB hepatitis.
Journal of medical virology 1988;24(3):263-74.
1988: Betsy Brotman; Alfred M Prince
Gamma-glutamyltransferase as a potential surrogate marker for detection of the non-A, non-B carrier state.
Vox sanguinis 1988;54(3):144-7.
1988: H Dichtelmüller; W Stephan; Alfred M Prince; Betsy Brotman
[Inactivation of hepatitis non-A, non-B virus in intravenous immunoglobulins by beta-propiolactone].
Beiträge zur Infusionstherapie = Contributions to infusion therapy 1988;21():202-4.
1985: Alfred M Prince; W Stephan; H Dichtelmüller; Betsy Brotman; T Huima
Inactivation of the Hutchinson strain of non-A, non-B hepatitis virus by combined use of beta-propiolactone and ultraviolet irradiation.
Journal of medical virology 1985;16(2):119-25.
1985: Betsy Brotman; Alfred M Prince; T Huima
Non-A, non-B hepatitis: is there more than a single blood-borne strain?
The Journal of infectious diseases 1985;151(4):618-25.
1984: Alfred M Prince; T Huima; B A Williams; L Bardina; Betsy Brotman
Isolation of a virus from chimpanzee liver cell cultures inoculated with sera containing the agent of non-A, non-B hepatitis.
Lancet 1984;2(8411):1071-5.
1984: Alfred M Prince; B Horowitz; Betsy Brotman; T Huima; L Richardson; M C van den Ende
Inactivation of hepatitis B and Hutchinson strain non-A, non-B hepatitis viruses by exposure to Tween 80 and ether.
Vox sanguinis 1984;46(1):36-43.
1983: Betsy Brotman; Alfred M Prince; T Huima; L Richardson; M C van den Ende
Blood-borne non-A, non-B hepatitis: lack of infectivity of feces from chimpanzees infected with a strain producing cytoplasmic tubular alterations.
The Journal of infectious diseases 1983;147(3):535-9.
1983: Betsy Brotman; Alfred M Prince; T Huima; L Richardson; U Pfeifer
Specificity and significance of hepatocellular ultrastructural changes in non-A, non-B hepatitis in chimpanzees.
Developments in biological standardization 1983;54():451-62.
1983: Betsy Brotman; Alfred M Prince; T Huima; L Richardson; M C van den Ende; U Pfeifer
Interference between non-A, non-B and hepatitis B virus infection in chimpanzees.
Journal of medical virology 1983;11(3):191-205.
1980: Alfred M Prince; W Stephan; Betsy Brotman; M C van den Ende
Evaluation of the effect of betapropiolactone/ultraviolet irradiation (BPL/UV) treatment of source plasma on hepatitis transmission by factor IX complex in chimpanzees.
Thrombosis and haemostasis 1980;44(3):138-42.
1980: M C van den Ende; Betsy Brotman; Alfred M Prince
An open air holding system for chimpanzees in medical experiments.
Developments in biological standardization 1980;45():95-8.