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Zhichao Zhang

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TOP 3
Zhichao Zhang; Y Zhao; T Song; Z Xue; Z Li; F Liang; Y Liu; X Shen; H Sheng
An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.
Zhichao Zhang; Yan Zhao; Xiangqian Li; Xiaomeng Liang; Chengwu Liu; Xiaoyun Shen; Ting Song; Zhiyong Wu; Hongbo Chen
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.
Zhichao Zhang; Yingang Feng; Xiangqian Li; Chengwu Liu; Jianquan Qin; Ting Song; Zhiyong Wu; Feibo Xie; Hongbo Chen
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.

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2013: Zhichao Zhang; Y Zhao; T Song; Z Xue; Z Li; F Liang; Y Liu; X Shen; H Sheng
An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.
British journal of cancer 2013;108(9):1870-8.
2013: Zhichao Zhang; Yan Zhao; Xiangqian Li; Xiaomeng Liang; Chengwu Liu; Xiaoyun Shen; Ting Song; Zhiyong Wu; Hongbo Chen
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.
European journal of medicinal chemistry 2013;60():410-20.
2013: Zhichao Zhang; Yingang Feng; Xiangqian Li; Chengwu Liu; Jianquan Qin; Ting Song; Zhiyong Wu; Feibo Xie; Hongbo Chen
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.
European journal of medicinal chemistry 2013;59():141-9.
2013: Ting Song; Pengchen Su; Guiye Wu; Zhiyong Wu; Shenghui Xie; Xilong Chang; Yingang Feng; Xiangqian Li; Xiaomeng Liang; Yan Zhao; Zhichao Zhang
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.
Bioorganic & medicinal chemistry 2013;21(1):11-20.
2012: Cheng He; Lingyun Jia; Jian Wang; Pengyan Wu; Zhichao Zhang; Ying Bai; Chunying Duan
Fluorescent differentiation and quantificational detection of free tryptophan in serum within a confined metal-organic tetrahedron.
Chemical communications (Cambridge, England) 2012;48(97):11880-2.
2012: Zhichao Zhang; Yan Zhao; Xiangqian Li; Ting Song; Yingang Feng
An anthraquinone scaffold for putative, two-face Bim BH3 α-helix mimic.
Journal of medicinal chemistry 2012;55(23):10735-41.
2012: Ting Song; Zhichao Zhang; Xilong Chang; Yubo Liu; Xiaoyun Shen
S1, a novel pan-BH3 mimetic, induces apoptosis in Mcl-1-overexpressing cells through Bak.
Journal of pharmacological sciences 2012;119(4):330-40.
2011: Zhichao Zhang; Zhiqiang Li; Ting Song; Guiye Wu; Hongna Yang; Xiang Qian Li
Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
European journal of medicinal chemistry 2011;46(9):3909-16.
2011: Zhichao Zhang; Ting Song; Tiantai Zhang; Jin Gao; Guiye Wu; Lijia An; Guanhua Du
A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1.
International journal of cancer. Journal international du cancer 2011;128(7):1724-35.
2011: Zhichao Zhang; Guiye Wu; Feibo Xie; Ting Song; Xilong Chang
3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
Journal of medicinal chemistry 2011;54(4):1101-5.
2009: Zhichao Zhang; Jin Gao; Yuanyuan Wang; Ting Song; Jing Zhang; Guiye Wu; Tiantai Zhang; Guanhua Du
Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.
Biochemical pharmacology 2009;78(10):1316-22.
2009: Zhichao Zhang; Yuanyuan Wang; Ting Song; Jin Gao; Guiye Wu; Jing Zhang; Xuhong Qian
DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators.
Chemical research in toxicology 2009;22(3):483-91.
2008: Zhichao Zhang; Jing Zhang; Liji Jin; Ting Song; Guiye Wu; Jin Gao
Tanshinone IIA interacts with DNA by minor groove-binding.
Biological & pharmaceutical bulletin 2008;31(12):2342-5.
2008: Zhichao Zhang; Yuanyuan Wang; Jing Zhang; Ting Song; Xuhong Qian
Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.
Cell biochemistry and function 2008;26(7):808-12.
2007: Zhichao Zhang; Liji Jin; Xuhong Qian; Meijiao Wei; Yuanyuan Wang; Jing Wang; Yuanyuan Yang; Qin Xu; Yongting Xu; Fengyu Liu
Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.
Chembiochem : a European journal of chemical biology 2007;8(1):113-21.
2006: Zhichao Zhang; Yuanyuan Yang; Danni Zhang; Yuanyuan Wang; Xuhong Qian; Fengyu Liu
Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
Bioorganic & medicinal chemistry 2006;14(20):6962-70.
2006: Zhichao Zhang; Yuanyuan Yang; Fengyu Liu; Xuhong Qian; Qin Xu
Study on the interaction between 4-(2-diethylamino-ethylamino)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile and DNA by molecular spectra.
International journal of biological macromolecules 2006;38(1):59-64.
2005: Zhichao Zhang; Di Wu; Xiangfeng Guo; Xuhong Qian; Zhe Lu; Qin Xu; Yuanyuan Yang; Liping Duan; Yuke He; Zhe Feng
Visible study of mercuric ion and its conjugate in living cells of mammals and plants.
Chemical research in toxicology 2005;18(12):1814-20.
2005: Yunkou Wu; Xiaojun Peng; Binchen Guo; Jiangli Fan; Zhichao Zhang; Jingyun Wang; Aijun Cui; Yunling Gao
Boron dipyrromethene fluorophore based fluorescence sensor for the selective imaging of Zn(II) in living cells.
Organic & biomolecular chemistry 2005;3(8):1387-92.
2004: Zhichao Zhang; Xiangfeng Guo; Xuhong Qian; Zhe Lu; Fengyu Liu
Fluorescent imaging of acute mercuric chloride exposure on cultured human kidney tubular epithelial cells.
Kidney international 2004;66(6):2279-82.