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Zhong-Yin Zhang

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Yan-Bo Tang; Jin-Ying Tian; Li Wu; Zheng Chen; Chun Hu; Dianyun Lu; Ying Yang; Fei Ye; Zhong-Yin Zhang; Zhiyan Xiao
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.
Zhi-Hong Yu; Ruoyu Zhang; Sheng Zhang; Lan Chen; Sijiu Liu; Chad D Walls; Lina Wang; Li Wu; Jie Xu; Zhong-Yin Zhang
Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
Rongjun He; Yantao He; Li Wu; Li-Fan Zeng; Andrea Michelle Gunawan; Zhong-Yin Zhang
Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.

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All Publications

2013: Yan-Bo Tang; Jin-Ying Tian; Li Wu; Zheng Chen; Chun Hu; Dianyun Lu; Ying Yang; Fei Ye; Zhong-Yin Zhang; Zhiyan Xiao
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.
Bioorganic & medicinal chemistry letters 2013;23(8):2313-8.
2013: Zhi-Hong Yu; Ruoyu Zhang; Sheng Zhang; Lan Chen; Sijiu Liu; Chad D Walls; Lina Wang; Li Wu; Jie Xu; Zhong-Yin Zhang
Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
The Journal of biological chemistry 2013;288(15):10472-82.
2013: Rongjun He; Yantao He; Li Wu; Li-Fan Zeng; Andrea Michelle Gunawan; Zhong-Yin Zhang
Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.
Chemical communications (Cambridge, England) 2013;49(20):2064-6.
2013: Yantao He; Lina Wang; Li Wu; Jie Xu; Zhi-Hong Yu; Andrea M Gunawan; Zhong-Yin Zhang
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Journal of medicinal chemistry 2013;56(3):832-42.
2013: Fan-Guo Meng; Zhong-Yin Zhang
Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical.
Biochimica et biophysica acta 2013;1834(1):464-9.
2013: Rongjun He; Yantao He; Li-Fan Zeng; Sheng Zhang; Zhong-Yin Zhang
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
The FEBS journal 2013;280(2):731-50.
2012: Christopher J Carbone; Darren P Baker; Kendra K Bence; Sabyasachi Bhattacharya; Paula Henthorn; John R Lewis; Alexander M Reiter; Radha Ukkiramapandian; Zhong-Yin Zhang; Hui Zheng; Serge Y Fuchs
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19226-31.
2012: Sheng Zhang; Lan Chen; Xiaocheng C Dong; David R Jones; Sijiu Liu; Weihua Shen; Rongya Tao; Lina Wang; Dan Wei; Zhi-Hong Yu; Zhong-Yin Zhang
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Journal of the American Chemical Society 2012;134(43):18116-24.
2012: Raghuveer S Mali; Holly Martin; Veerendra Munugalavadla; Sarah Nabinger; Baskar Ramdas; George Sandusky; Namit Sharma; Emily Sims; Li-Fan Zeng; Zhong-Yin Zhang; Kevin D Bunting; Rebecca J Chan; Anindya Chatterjee; Andrew W B Craig; Gen-Sheng Feng; Joydeep Ghosh; Yantao He; Shuo Li; Peilin Ma; Reuben Kapur
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood 2012;120(13):2669-78.
2012: Yuanshu Dong; Wei Li; Simon J Rhodes; Weinian Shou; Xiaoxin Sun; Weidong Yong; Lujuan Zhang; Sheng Zhang; Yunpeng Bai; Hanying Chen; Stephanie C Colvin; Zhong-Yin Zhang
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.
The Journal of biological chemistry 2012;287(38):32172-9.
2012: Stephanie M Stanford; Logan M Walker; Dennis J Wu; Sheng Zhang; Zhong-Yin Zhang; Sagar S Damle; Matthew D Falk; Teodora Kaltcheva; Sayantan Mitra; Rekha G Panchal; David Ruble; Amy M Barrios; Sina Bavari; Nunzio Bottini
High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):13972-7.
2012: Namit Sharma; Li-Fan Zeng; Zhong-Yin Zhang; Stephanie Everingham; Gen-Sheng Feng; Karin Hartmann; Reuben Kapur; Vijay Kumar; Raghuveer Singh Mali; Axel Roers; Andrew W B Craig
SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice.
Molecular and cellular biology 2012;32(14):2653-63.
2012: Roberto Negro; Zhong-Yin Zhang; Stefania Gobessi; Yantao He; Luca Laurenti; Pablo G Longo; Dimitar G Efremov
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
Blood 2012;119(26):6278-87.
2012: Victoria A Martin; Laurie L Parker; Wen-Horng Wang; Sheng Zhang; Zhong-Yin Zhang; Yantao He; Andrew M Lipchik; Robert L Geahlen
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.
Cellular signalling 2012;24(5):1064-73.
2012: Yantao He; Sijiu Liu; Zhi-Hong Yu; Li-Fan Zeng; Rongjun He; Zhong-Yin Zhang
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Bioorganic & medicinal chemistry 2012;20(6):1940-6.
2012: Li-Sha Zheng; Jia-Wei Wu; Zhenguo Wu; Yuan-Yuan Zhang; Zhong-Yin Zhang; Zhi-Xin Wang
A continuous spectrophotometric assay for mitogen-activated protein kinase kinases.
Analytical biochemistry 2012;421(1):191-7.
2012: Sheng Zhang; Lan Chen; David S Lawrence; Zhong-Yin Zhang
A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2012;928():53-65.
2011: Yunpeng Bai; Youjia Cao; Yuanshu Dong; Sijiu Liu; Yong Luo; Lawrence A Quilliam; Kui Shen; Chad D Walls; Clark D Wells; Lujuan Zhang; Zhong-Yin Zhang
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
The Journal of biological chemistry 2011;286(49):42316-24.
2011: Kim Loh; Benjamin G Neel; Alexander Reichenbach; Stephanie Simonds; Natalie A Sims; Florian Wiede; Sheng Zhang; Xinmei Zhang; Zhong-Yin Zhang; Zane B Andrews; Kendra K Bence; Dana Briggs; Michael Alexander cowley; Pablo J Enriori; Atsushi Fukushima; Sandra Galic; Christine Hauser; Barbara B Kahn; Tony Tiganis
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Cell metabolism 2011;14(5):684-99.
2011: Shashi Kant; Benjamin G Neel; Wojciech Swat; Sheng Zhang; Zhong-Yin Zhang; Richard A Flavell; Roger J Davis
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Genes & development 2011;25(19):2069-78.
2011: Xiao Yu; Zhi-Hong Yu; Sheng Zhang; Ming Chen; Tsuyoshi Imasaki; Sijiu Liu; Jin-Peng Sun; Yuichiro Takagi; Lina Wang; Zhong-Yin Zhang
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.
The Journal of biological chemistry 2011;286(35):30526-34.
2011: Zhi-Hong Yu; Lan Chen; Sijiu Liu; Lina Wang; Li Wu; Zhong-Yin Zhang
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.
Bioorganic & medicinal chemistry letters 2011;21(14):4238-42.
2011: Hui Li; Gang Wei; Caryl Antalis; Robert Emerson; Sheng Zhang; Zhong-Yin Zhang; Zhenwen Zhao; Zhanzhong Zhao; Yan Xu
Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.
The American journal of pathology 2011;179(1):452-61.
2011: Stephanie M Stanford; Divya Krishnamurthy; Matthew D Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew C Chan; Zhong-Yin Zhang; Amy M Barrios; Virgil L Woods; Nouri Neamati; Nunzio Bottini
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
Journal of medicinal chemistry 2011;54(6):1640-54.
2011: Leandro Piovan; Li Wu; Zhong-Yin Zhang; Leandro H Andrade
Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases.
Organic & biomolecular chemistry 2011;9(5):1347-51.
2011: Sijiu Liu; Zhihong Yu; Xiao Yu; Sheng-Xiong Huang; Yinggang Luo; Li Wu; Weihua Shen; Zhenyun Yang; Lina Wang; Andrea M Gunawan; Rebecca J Chan; Ben Shen; Zhong-Yin Zhang
SHP2 is a target of the immunosuppressant tautomycetin.
Chemistry & biology 2011;18(1):101-10.
2010: Rongjun He; Zhihong Yu; Yantao He; Li-Fan Zeng; Jie Xu; Li Wu; Andrea M Gunawan; Lina Wang; Zhong Jiang; Zhong-Yin Zhang
Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.
ChemMedChem 2010;5(12):2051-6.
2010: Zunnan Huang; Yantao He; Xian Zhang; Andrea Gunawan; Li Wu; Zhong-Yin Zhang; Chung F Wong
Derivatives of salicylic acid as inhibitors of YopH in Yersinia pestis.
Chemical biology & drug design 2010;76(2):85-99.
2010: Xian Zhang; Yantao He; Sijiu Liu; Zhihong Yu; Zhong Jiang; Zhenyun Yang; Yuanshu Dong; Sarah C Nabinger; Li Wu; Andrea M Gunawan; Lina Wang; Rebecca J Chan; Zhong-Yin Zhang
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Journal of medicinal chemistry 2010;53(6):2482-93.
2010: Bo Zhou; Yantao He; Xian Zhang; Jie Xu; Yong Luo; Yuehong Wang; Scott Franzblau; Zhenyun Yang; Rebecca J Chan; Yan Liu; Jianyu Zheng; Zhong-Yin Zhang
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4573-8.
2010: S Alice Long; Karen Cerosaletti; Paul L Bollyky; Megan Tatum; Heather Shilling; Sheng Zhang; Zhong-Yin Zhang; Catherine Pihoker; Srinath Sanda; Carla J Greenbaum; Jane H Buckner
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.
Diabetes 2010;59(2):407-15.
2009: Sheng Zhang; Lan Chen; Yong Luo; Andrea Gunawan; David S Lawrence; Zhong-Yin Zhang
Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy.
Journal of the American Chemical Society 2009;131(36):13072-9.
2009: Wenjun Zhang; Rebecca J Chan; Hanying Chen; Zhenyun Yang; Yantao He; Xian Zhang; Yong Luo; Fuqing Yin; Akira Moh; Lucy C Miller; R Mark Payne; Zhong-Yin Zhang; Xin-Yuan Fu; Weinian Shou
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
The Journal of biological chemistry 2009;284(33):22353-63.
2009: Luis Enrique Arias-Romero; Sayanti Saha; Olga Villamar-Cruz; Shu-Chin Yip; Stephen Ethier; Zhong-Yin Zhang; Jonathan Chernoff
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.
Cancer research 2009;69(11):4582-8.
2009: Adrian F Arechiga; Tania Habib; Yantao He; Xian Zhang; Zhong-Yin Zhang; Andrew Funk; Jane H Buckner
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3343-7.
2009: Y Luo; Fubo Liang; Zhong-Yin Zhang
PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways.
Biochemistry 2009;48(8):1838-46.
2009: Valeria Orrú; Sophia J Tsai; Blanca Rueda; Edoardo Fiorillo; Stephanie M Stanford; Jhimli Dasgupta; Jaana Hartiala; Lei Zhao; Norberto Ortego Centeno; Sandra D'Alfonso; Frank C Arnett; Hui Wu; Miguel A Gonzalez-Gay; Betty P Tsao; Bernardo Pons-Estel; Marta Eugenia ALARCON-RIQUELME; Yantao He; Zhong-Yin Zhang; Hooman Allayee; Xiaojiang S Chen; Javier Martin; Nunzio Bottini
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
Human molecular genetics 2009;18(3):569-79.
2009: Chad Walls; Bo Zhou; Zhong-Yin Zhang
Activity-based protein profiling of protein tyrosine phosphatases.
Methods in molecular biology (Clifton, N.J.) 2009;519():417-29.
2008: Mohannad Abdo; Sijiu Liu; Bo Zhou; Chad D Walls; Li Wu; Spencer Knapp; Zhong-Yin Zhang
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Journal of the American Chemical Society 2008;130(40):13196-7.
2008: Benoit Boivin; Sheng Zhang; Jack L Arbiser; Zhong-Yin Zhang; Nicholas K Tonks
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9959-64.
2008: Sijiu Liu; Bo Zhou; Heyi Yang; Yantao He; Zhong Jiang; Sanjai Kumar; Li Wu; Zhong-Yin Zhang
Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.
Journal of the American Chemical Society 2008;130(26):8251-60.
2008: Zhong Jiang; Zhong-Yin Zhang
Targeting PTPs with small molecule inhibitors in cancer treatment.
Cancer metastasis reviews 2008;27(2):263-72.
2008: Fubo Liang; Yong Luo; Yuanshu Dong; Chad D Walls; Jiao Liang; Hao-Yuan Jiang; Jeremy Sanford; Ronald C Wek; Zhong-Yin Zhang
Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase.
The Journal of biological chemistry 2008;283(16):10339-46.
2008: Christa L Cortesio; Keefe T Chan; Benjamin J Perrin; Nicholas O Burton; Sheng Zhang; Zhong-Yin Zhang; Anna Huttenlocher
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
The Journal of cell biology 2008;180(5):957-71.
2007: Xiao Yu; Jin-Peng Sun; Yantao He; Xiaoling Guo; Sijiu Liu; Bo Zhou; Andy Hudmon; Zhong-Yin Zhang
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19767-72.
2007: Jin-Peng Sun; Yong Luo; Xiao Yu; Wei-Qing Wang; Bo Zhou; Fubo Liang; Zhong-Yin Zhang
Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration.
The Journal of biological chemistry 2007;282(39):29043-51.
2007: Steven C Almo; Jeffrey B Bonanno; J Michael Sauder; Spencer Emtage; Teresa P DiLorenzo; Vladimir N Malashkevich; Steven R Wasserman; S Swaminathan; Subramaniam Eswaramoorthy; Rakhi Agarwal; Desigan Kumaran; Mahendra Madegowda; Sugadev Ragumani; Yury Patskovsky; Johnjeff Alvarado; Udupi A Ramagopal; Joana Faber-Barata; Mark R Chance; Andrej Sali; András Fiser; Zhong-Yin Zhang; David S Lawrence; Stephen K Burley
Structural genomics of protein phosphatases.
Journal of structural and functional genomics 2007;8(2-3):121-40.
2007: Sheng Zhang; Lan Chen; Sanjai Kumar; Li Wu; David S Lawrence; Zhong-Yin Zhang
An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.
Methods (San Diego, Calif.) 2007;42(3):261-7.
2007: Bo Zhou; Zhong-Yin Zhang
Application of hydrogen/deuterium exchange mass spectrometry to study protein tyrosine phosphatase dynamics, ligand binding, and substrate specificity.
Methods (San Diego, Calif.) 2007;42(3):227-33.
2007: Sheng Zhang; Zhong-Yin Zhang
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.
Drug discovery today 2007;12(9-10):373-81.
2007: Fubo Liang; Sanjai Kumar; Zhong-Yin Zhang
Proteomic approaches to studying protein tyrosine phosphatases.
Molecular bioSystems 2007;3(5):308-16.
2007: Mazdak Khajehpour; Li Wu; Sijiu Liu; Nick Zhadin; Zhong-Yin Zhang; Robert Callender
Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase.
Biochemistry 2007;46(14):4370-8.
2007: Fubo Liang; Jiao Liang; Wei-Qing Wang; Jin-Peng Sun; Eshwar Udho; Zhong-Yin Zhang
PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.
The Journal of biological chemistry 2007;282(8):5413-9.
2007: Irene G Boutselis; Xiao Yu; Zhong-Yin Zhang; Richard F Borch
Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.
Journal of medicinal chemistry 2007;50(4):856-64.
2007: Christopher D Morrison; Christy L White; Zhong Wang; Seung-Yub Lee; David S Lawrence; William T Cefalu; Zhong-Yin Zhang; Thomas W Gettys
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age.
Endocrinology 2007;148(1):433-40.
2006: Bo Zhou; Jialin Zhang; Sijiu Liu; Sharanya Reddy; Fang Wang; Zhong-Yin Zhang
Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry.
The Journal of biological chemistry 2006;281(50):38834-44.
2006: Sanjai Kumar; Bo Zhou; Fubo Liang; Heyi Yang; Wei-Qing Wang; Zhong-Yin Zhang
Global analysis of protein tyrosine phosphatase activity with ultra-sensitive fluorescent probes.
Journal of proteome research 2006;5(8):1898-905.
2006: Yukun Cui; Irma Parra; Mao Zhang; Susan G Hilsenbeck; Anna Tsimelzon; Toru Furukawa; Akira Horii; Zhong-Yin Zhang; Robert I Nicholson; Suzanne A W Fuqua
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance.
Cancer research 2006;66(11):5950-9.
2006: Sijiu Liu; Jin-Peng Sun; Bo Zhou; Zhong-Yin Zhang
Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5326-31.
2006: Chengsen Xue; Fubo Liang; Radma Mahmood; Magalis Vuolo; Jeffrey Bruce Wyckoff; Hong Qian; Kun-Lin Tsai; Mimi Y Kim; Joseph Locker; Zhong-Yin Zhang; Jeffrey E Segall
ErbB3-dependent motility and intravasation in breast cancer metastasis.
Cancer research 2006;66(3):1418-26.
2006: Hyangkyu Lee; Laiping Xie; Yong Luo; Seung-Yub Lee; David S Lawrence; Xiao Bo Wang; Federica Sotgia; Michael P Lisanti; Zhong-Yin Zhang
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.
Biochemistry 2006;45(1):234-40.
2006: Chengsen Xue; Jeffrey Bruce Wyckoff; Fubo Liang; Mazen Sidani; Stefania Violini; Kun-Lin Tsai; Zhong-Yin Zhang; Erik Sahai; John Condeelis; Jeffrey E Segall
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis.
Cancer research 2006;66(1):192-7.
2005: Zhong-Yin Zhang
Functional studies of protein tyrosine phosphatases with chemical approaches.
Biochimica et biophysica acta 2005;1754(1-2):100-7.
2005: Kyeong Lee; Shanthaveerappa K Boovanahalli; Ky-Youb Nam; Sang-Uk Kang; Mijeoung Lee; Jason Phan; Li Wu; David S Waugh; Zhong-Yin Zhang; Kyoung Tai No; Jung Jun Lee; Terrence R Burke
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):4037-42.
2005: Jin-Peng Sun; Wei-Qing Wang; Heyi Yang; Sijiu Liu; Fubo Liang; Alexander A Fedorov; Steven C Almo; Zhong-Yin Zhang
Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion.
Biochemistry 2005;44(36):12009-21.
2005: Seung-Yub Lee; Fubo Liang; Xiao-Ling Guo; Laiping Xie; Sean M Cahill; Michael Blumenstein; Heyi Yang; David S Lawrence; Zhong-Yin Zhang
Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor.
Angewandte Chemie (International ed. in English) 2005;44(27):4242-4.
2005: Fubo Liang; Seung-Yub Lee; Jiao Liang; David S Lawrence; Zhong-Yin Zhang
The role of protein-tyrosine phosphatase 1B in integrin signaling.
The Journal of biological chemistry 2005;280(26):24857-63.
2005: Sanjai Kumar; Fubo Liang; David S Lawrence; Zhong-Yin Zhang
Small molecule approach to studying protein tyrosine phosphatase.
Methods (San Diego, Calif.) 2005;35(1):9-21.
2004: Zhonghui Huang; Bo Zhou; Zhong-Yin Zhang
Molecular determinants of substrate recognition in hematopoietic protein-tyrosine phosphatase.
The Journal of biological chemistry 2004;279(50):52150-9.
2004: Yuling Chi; Bo Zhou; Wei-Qing Wang; Sung-Kee Chung; Yong-Uk Kwon; Young-Hoon Ahn; Young-Tae Chang; Yosuke Tsujishita; James H Hurley; Zhong-Yin Zhang
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.
The Journal of biological chemistry 2004;279(43):44987-95.
2004: Wei-Qing Wang; Joshua Bembenek; Kyle R Gee; Hongtao Yu; Harry Charbonneau; Zhong-Yin Zhang
Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14.
The Journal of biological chemistry 2004;279(29):30459-68.
2004: Daniel F McCain; Piotr K Grzyska; Li Wu; Alvan C Hengge; Zhong-Yin Zhang
Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate.
Biochemistry 2004;43(25):8256-64.
2004: Sanjai Kumar; Bo Zhou; Fubo Liang; Wei-Qing Wang; Zhonghui Huang; Zhong-Yin Zhang
Activity-based probes for protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7943-8.
2004: Daniel F McCain; Li Wu; Peter Nickel; Matthias U Kassack; Annett Kreimeyer; Antonio Gagliardi; Delwood C Collins; Zhong-Yin Zhang
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.
The Journal of biological chemistry 2004;279(15):14713-25.
2004: Sang-Uk Kang; Yang Gao; Li Wu; Zhong-Yin Zhang; Terrence R Burke
Enantioselective synthesis of (S)-3-carboxy-4-((carboxy)difluoromethyl)phenylalanine in protected form and its incorporation into a PTP-1B-directed tripeptide.
Chemistry & biodiversity 2004;1(4):626-33.
2004: Xuewu Zhang; Jean-Claude D Schwartz; Xiaoling Guo; Sumeena Bhatia; Erhu Cao; Michael Lorenz; Michael Cammer; Lieping Chen; Zhong-Yin Zhang; Michael Edidin; Stanley G Nathenson; Steven C Almo
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity 2004;20(3):337-47.
2004: Anja K Pedersen; Xiao-Ling Guo; Karin B Møller; Günther H Peters; Henrik Sune Andersen; Jette S Kastrup; Steen Mortensen; Lars F Iversen; Zhong-Yin Zhang; Niels Peter H Møller
Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.
The Biochemical journal 2004;378(Pt 2):421-33.
2003: Gary S Goldberg; David B Alexander; Patricia Pellicena; Zhong-Yin Zhang; Hiroyuki Tsuda; W Todd Miller
Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.
The Journal of biological chemistry 2003;278(47):46533-40.
2003: Laiping Xie; Seung-Yub Lee; jannik andersen; Steve Waters; Kui Shen; Xiao-Ling Guo; Niels Peter H Moller; Jerrold M Olefsky; David S Lawrence; Zhong-Yin Zhang
Cellular effects of small molecule PTP1B inhibitors on insulin signaling.
Biochemistry 2003;42(44):12792-804.
2003: Fubo Liang; Zhonghui Huang; Seung-Yub Lee; Jiao Liang; Maya I Ivanov; Andres Alonso; James B Bliska; David S Lawrence; Tomas Mustelin; Zhong-Yin Zhang
Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.
The Journal of biological chemistry 2003;278(43):41734-41.
2003: Ding-Guo Liu; Yang Gao; Johannes H Voigt; Kyeong Lee; Marc C Nicklaus; Li Wu; Zhong-Yin Zhang; Terrence R Burke
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Bioorganic & medicinal chemistry letters 2003;13(18):3005-7.
2003: Jin-Peng Sun; Li Wu; Alexander A Fedorov; Steven C Almo; Zhong-Yin Zhang
Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor.
The Journal of biological chemistry 2003;278(35):33392-9.
2003: Jialin Zhang; Bo Zhou; Chao-feng Zheng; Zhong-Yin Zhang
A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates.
The Journal of biological chemistry 2003;278(32):29901-12.
2003: Kyeong Lee; Yang Gao; Zhu-Jun Yao; Jason Phan; Li Wu; Jiao Liang; David S Waugh; Zhong-Yin Zhang; Terrence R Burke
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
Bioorganic & medicinal chemistry letters 2003;13(15):2577-81.
2003: Zhong-Yin Zhang
Chemical and mechanistic approaches to the study of protein tyrosine phosphatases.
Accounts of chemical research 2003;36(6):385-92.
2003: Jin-Peng Sun; Alexander A Fedorov; Seung-Yub Lee; Xiao-Ling Guo; Kui Shen; David S Lawrence; Steven C Almo; Zhong-Yin Zhang
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
The Journal of biological chemistry 2003;278(14):12406-14.
2003: Zhong-Yin Zhang; Seung-Yub Lee
PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity.
Expert opinion on investigational drugs 2003;12(2):223-33.
2003: Stefan W Vetter; Zhong-Yin Zhang
Combinatorial chemistry and peptide library methods to characterize protein phosphatases.
Methods in enzymology 2003;366():260-82.
2003: Bo Zhou; Zhong-Yin Zhang
Measuring protein phosphatase activity with physiological substrates.
Methods in enzymology 2003;366():34-43.
2003: Zhong-Yin Zhang
Mechanistic studies on protein tyrosine phosphatases.
Progress in nucleic acid research and molecular biology 2003;73():171-220.
2003: Wei-Qing Wang; Jin-Peng Sun; Zhong-Yin Zhang
An overview of the protein tyrosine phosphatase superfamily.
Current topics in medicinal chemistry 2003;3(7):739-48.
2002: Xiao-Ling Guo; Kui Shen; Fang Wang; David S Lawrence; Zhong-Yin Zhang
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.
The Journal of biological chemistry 2002;277(43):41014-22.
2002: Hu Cheng; Ivana Nikolic-Hughes; Jianghua H Wang; Hua Deng; Patrick O'Brien; Li Wu; Zhong-Yin Zhang; Daniel Herschlag; Robert Callender
Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis.
Journal of the American Chemical Society 2002;124(38):11295-306.
2002: Bo Zhou; Zhi-Xin Wang; Yu Zhao; David L Brautigan; Zhong-Yin Zhang
The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases.
The Journal of biological chemistry 2002;277(35):31818-25.
2002: Stefan W Vetter; Zhong-Yin Zhang
Probing the phosphopeptide specificities of protein tyrosine phosphatases, SH2 and PTB domains with combinatorial library methods.
Current protein & peptide science 2002;3(4):365-97.
2002: Zhi-Xin Wang; Bo Zhou; Q May Wang; Zhong-Yin Zhang
A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity.
Biochemistry 2002;41(24):7849-57.
2002: Hua Deng; Robert Callender; Zhonghui Huang; Zhong-Yin Zhang
Is the PTPase-vanadate complex a true transition state analogue?
Biochemistry 2002;41(18):5865-72.
2002: Bo Zhou; Zhong-Yin Zhang
The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.
The Journal of biological chemistry 2002;277(16):13889-99.
2002: Daniel F McCain; Irina Catrina; Alvan C Hengge; Zhong-Yin Zhang
The catalytic mechanism of Cdc25A phosphatase.
The Journal of biological chemistry 2002;277(13):11190-200.
2002: Laiping Xie; Yan-Ling Zhang; Zhong-Yin Zhang
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant.
Biochemistry 2002;41(12):4032-9.
2002: Zhong-Yin Zhang; Bo Zhou; Laiping Xie
Modulation of protein kinase signaling by protein phosphatases and inhibitors.
Pharmacology & therapeutics 2002;93(2-3):307-17.
2002: Zhong-Yin Zhang
Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development.
Annual review of pharmacology and toxicology 2002;42():209-34.
2002: Daniel F McCain; Zhong-Yin Zhang
Assays for protein-tyrosine phosphatases.
Methods in enzymology 2002;345():507-18.
2001: Kui Shen; YF Keng; Li Wu; X L Guo; David S Lawrence; Zhong-Yin Zhang
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure.
The Journal of biological chemistry 2001;276(50):47311-9.
2001: Yang Gao; J Voigt; H Zhao; Godwin C G Pais; Xuechun Zhang; L Wu; Zhong-Yin Zhang; Terrence R Burke
Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.
Journal of medicinal chemistry 2001;44(18):2869-78.
2001: Yu Zhao; Zhong-Yin Zhang
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3.
The Journal of biological chemistry 2001;276(34):32382-91.
2001: Bo Zhou; Li Wu; Kui Shen; J Zhang; David S Lawrence; Zhong-Yin Zhang
Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.
The Journal of biological chemistry 2001;276(9):6506-15.
2000: Yan-Ling Zhang; Z J Yao; M Sarmiento; Li Wu; T R Burke; Zhong-Yin Zhang
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.
The Journal of biological chemistry 2000;275(44):34205-12.
2000: M Sarmiento; Yoram A Puius; S W Vetter; YF Keng; Li Wu; Y Zhao; David S Lawrence; Steven C Almo; Zhong-Yin Zhang
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry 2000;39(28):8171-9.
2000: S W Vetter; YF Keng; David S Lawrence; Zhong-Yin Zhang
Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning".
The Journal of biological chemistry 2000;275(4):2265-8.
2000: M Sarmiento; L Wu; YF Keng; L Song; Z Luo; Z Huang; G Z Wu; A K Yuan; Zhong-Yin Zhang
Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B.
Journal of medicinal chemistry 2000;43(2):146-55.
1999: Bo Zhou; Zhong-Yin Zhang
Mechanism of mitogen-activated protein kinase phosphatase-3 activation by ERK2.
The Journal of biological chemistry 1999;274(50):35526-34.
1999: Yan-Ling Zhang; F Hollfelder; S J Gordon; L Chen; YF Keng; Li Wu; D Herschlag; Zhong-Yin Zhang
Impaired transition state complementarity in the hydrolysis of O-arylphosphorothioates by protein-tyrosine phosphatases.
Biochemistry 1999;38(37):12111-23.
1999: M Taing; YF Keng; Kui Shen; Li Wu; David S Lawrence; Zhong-Yin Zhang
Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.
Biochemistry 1999;38(12):3793-803.
1999: YF Keng; Li Wu; Zhong-Yin Zhang
Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein-tyrosine phosphatase.
European journal of biochemistry / FEBS 1999;259(3):809-14.
1999: A Buist; Y L Zhang; Y F Keng; Li Wu; Zhong-Yin Zhang; Jeroen den Hertog
Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha.
Biochemistry 1999;38(3):914-22.
1998: Fang Wang; W Li; Mark R Emmett; Christopher L Hendrickson; A G Marshall; Yan-Ling Zhang; Li Wu; Zhong-Yin Zhang
Conformational and dynamic changes of Yersinia protein tyrosine phosphatase induced by ligand binding and active site mutation and revealed by H/D exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
Biochemistry 1998;37(44):15289-99.
1998: M Sarmiento; Y Zhao; S J Gordon; Zhong-Yin Zhang
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
The Journal of biological chemistry 1998;273(41):26368-74.
1998: Yan-Ling Zhang; Zhong-Yin Zhang
Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand: a thermodynamic study of ligand binding to protein tyrosine phosphatase 1B.
Analytical biochemistry 1998;261(2):139-48.
1998: Yan-Ling Zhang; YF Keng; Yu Zhao; Li Wu; Zhong-Yin Zhang
Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases.
The Journal of biological chemistry 1998;273(20):12281-7.
1998: Yu Zhao; Li Wu; S J Noh; K L Guan; Zhong-Yin Zhang
Altering the nucleophile specificity of a protein-tyrosine phosphatase-catalyzed reaction. Probing the function of the invariant glutamine residues.
The Journal of biological chemistry 1998;273(10):5484-92.
1997: Yoram A Puius; Y Zhao; M Sullivan; David S Lawrence; Steven C Almo; Zhong-Yin Zhang
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13420-5.
1997: Li Wu; A Buist; Jeroen den Hertog; Zhong-Yin Zhang
Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine phosphatase alpha.
The Journal of biological chemistry 1997;272(11):6994-7002.
1997: Zhong-Yin Zhang; Li Wu
The single sulfur to oxygen substitution in the active site nucleophile of the Yersinia protein-tyrosine phosphatase leads to substantial structural and functional perturbations.
Biochemistry 1997;36(6):1362-9.
1997: Zhong-Yin Zhang
Structure, mechanism, and specificity of protein-tyrosine phosphatases.
Current topics in cellular regulation 1997;35():21-68.
1996: Yu Zhao; Zhong-Yin Zhang
Reactivity of alcohols toward the phosphoenzyme intermediate in the protein-tyrosine phosphatase-catalyzed reaction: probing the transition state of the dephosphorylation step.
Biochemistry 1996;35(36):11797-804.
1996: L Chen; J Montserat; David S Lawrence; Zhong-Yin Zhang
VHR and PTP1 protein phosphatases exhibit remarkably different active site specificities toward low molecular weight nonpeptidic substrates.
Biochemistry 1996;35(29):9349-54.
1996: Li Wu; Zhong-Yin Zhang
Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation.
Biochemistry 1996;35(17):5426-34.
1996: Zhong-Yin Zhang; A B Walsh; Li Wu; Dennis J McNamara; Ellen M Dobrusin; W Todd Miller
Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1.
The Journal of biological chemistry 1996;271(10):5386-92.
1995: Zhong-Yin Zhang; Bruce A Palfey; Li Wu; Yu Zhao
Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif.
Biochemistry 1995;34(50):16389-96.
1995: Zhong-Yin Zhang; Li Wu; L Chen
Transition state and rate-limiting step of the reaction catalyzed by the human dual-specificity phosphatase, VHR.
Biochemistry 1995;34(49):16088-96.
1995: Zhong-Yin Zhang; G Zhou; John M Denu; Li Wu; X Tang; O Mondesert; P Russell; Elizabeth R Butch; K L Guan
Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe.
Biochemistry 1995;34(33):10560-8.
1995: Zhong-Yin Zhang
Are protein-tyrosine phosphatases specific for phosphotyrosine?
The Journal of biological chemistry 1995;270(27):16052-5.
1995: Zhong-Yin Zhang
Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1.
The Journal of biological chemistry 1995;270(19):11199-204.
1994: Zhong-Yin Zhang; Y Wang; L Wu; E B Fauman; Jeanne A Stuckey; H L Schubert; Mark Saper; Jack E Dixon
The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.
Biochemistry 1994;33(51):15266-70.
1994: Jeanne A Stuckey; H L Schubert; E B Fauman; Zhong-Yin Zhang; Jack E Dixon; Mark Saper
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate.
Nature 1994;370(6490):571-5.
1994: Zhong-Yin Zhang; W P Malachowski; R L Van Etten; Jack E Dixon
Nature of the rate-determining steps of the reaction catalyzed by the Yersinia protein-tyrosine phosphatase.
The Journal of biological chemistry 1994;269(11):8140-5.
1994: Zhong-Yin Zhang; Y Wang; Jack E Dixon
Dissecting the catalytic mechanism of protein-tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1624-7.
1994: Zhong-Yin Zhang; D Maclean; Dennis J McNamara; T K Sawyer; Jack E Dixon
Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates.
Biochemistry 1994;33(8):2285-90.
1993: K L Milarski; G Zhu; C G Pearl; Dennis J McNamara; Ellen M Dobrusin; D MacLean; A Thieme-Sefler; Zhong-Yin Zhang; T Sawyer; S J Decker
Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.
The Journal of biological chemistry 1993;268(31):23634-9.
1993: Zhong-Yin Zhang; Jack E Dixon
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.
Biochemistry 1993;32(36):9340-5.
1993: Zhong-Yin Zhang; D Maclean; A M Thieme-Sefler; R W Roeske; Jack E Dixon
A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides.
Analytical biochemistry 1993;211(1):7-15.
1993: Zhong-Yin Zhang; A M Thieme-Sefler; D Maclean; Dennis J McNamara; Ellen M Dobrusin; T K Sawyer; Jack E Dixon
Substrate specificity of the protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4446-50.
1992: Zhong-Yin Zhang; James C Clemens; H L Schubert; Jeanne A Stuckey; M W Fischer; D M Hume; Mark Saper; Jack E Dixon
Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.
The Journal of biological chemistry 1992;267(33):23759-66.