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Rongbao Zhao

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Chemicals & Drugs

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Leukemia L1210

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Rongbao Zhao; I David Goldman
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
Daniel Sanghoon Shin; Rongbao Zhao; András Fiser; David I Goldman
Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.
Rongbao Zhao; Daniel Sanghoon Shin; András Fiser; I David Goldman
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).

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All Publications

2013: Rongbao Zhao; I David Goldman
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
Molecular aspects of medicine 2013;34(2-3):373-85.
2012: Daniel Sanghoon Shin; Rongbao Zhao; András Fiser; David I Goldman
Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.
American journal of physiology. Cell physiology 2012;303(8):C834-42.
2012: Rongbao Zhao; Daniel Sanghoon Shin; András Fiser; I David Goldman
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
American journal of physiology. Cell physiology 2012;303(6):C673-81.
2012: Michele Visentin; Rongbao Zhao; I David Goldman
The antifolates.
Hematology/oncology clinics of North America 2012;26(3):629-48, ix.
2012: Daniel Sanghoon Shin; Enghui H Yap; Rongbao Zhao; András Fiser; I David Goldman
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
American journal of physiology. Cell physiology 2012;302(9):C1405-12.
2012: Michele Visentin; Rongbao Zhao; Min-Hwang Chang; Michael F Romero; I David Goldman
Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
Molecular pharmacology 2012;81(2):134-42.
2011: Rongbao Zhao; Michele Visentin; Ndeye Diop-Bove; I David Goldman
Mechanisms of membrane transport of folates into cells and across epithelia.
Annual review of nutrition 2011;31():177-201.
2011: Rongbao Zhao; Ndeye Diop-Bove; Channa Gila Ovits; Daniel Sanghoon Shin; I David Goldman
Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.
The Journal of biological chemistry 2011;286(27):24150-8.
2011: Daniel Sanghoon Shin; Kris Michael Mahadeo; Sang Hee Min; Ndeye Diop-Bove; Peter Clayton; Rongbao Zhao; I David Goldman
Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.
Molecular genetics and metabolism 2011;103(1):33-7.
2011: Rongbao Zhao; Daniel Sanghoon Shin; I David Goldman
Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.
Biochimica et biophysica acta 2011;1808(4):1140-5.
2010: Daniel Sanghoon Shin; Sang Hee Min; Laura Russell; Rongbao Zhao; András Fiser; I David Goldman
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.
Blood 2010;116(24):5162-9.
2010: I David Goldman; Shrikanta Chattopadhyay; Rongbao Zhao; Richard Moran
The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs.
Current opinion in investigational drugs (London, England : 2000) 2010;11(12):1409-23.
2010: Kris Michael Mahadeo; Ndeye Diop-Bove; Daniel Shin; ERSIN SELCUK UNAL; Juliana Teo; Rongbao Zhao; Min-Hwang Chang; Andreas Fulterer; Michael F Romero; I David Goldman
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.
American journal of physiology. Cell physiology 2010;299(5):C1153-61.
2010: Rongbao Zhao; ERSIN SELCUK UNAL; Daniel Sanghoon Shin; I David Goldman
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.
Biochemistry 2010;49(13):2925-31.
2009: Ndeye Khady Diop-Bove; Julia Wu; Rongbao Zhao; Joseph Locker; I David Goldman
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.
Molecular cancer therapeutics 2009;8(8):2424-31.
2009: ERSIN SELCUK UNAL; Rongbao Zhao; I David Goldman
Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
American journal of physiology. Cell physiology 2009;297(1):C66-74.
2009: ERSIN SELCUK UNAL; Rongbao Zhao; Min-Hwang Chang; András Fiser; Michael F Romero; I David Goldman
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.
The Journal of biological chemistry 2009;284(26):17846-57.
2009: Rongbao Zhao; Sang Hee Min; Yanhua Wang; Estela Campanella; Philip S Low; I David Goldman
A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.
The Journal of biological chemistry 2009;284(7):4267-74.
2009: Rongbao Zhao; Larry H Matherly; I David Goldman
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.
Expert reviews in molecular medicine 2009;11():e4.
2008: Sang Hee Min; Sun Young Oh; George I Karp; Mortimer Poncz; Rongbao Zhao; I David Goldman
The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption.
The Journal of pediatrics 2008;153(3):435-7.
2008: Rongbao Zhao; Andong Qiu; Eugenia Tsai; Michaela Jansen; Myles H Akabas; I David Goldman
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
Molecular pharmacology 2008;74(3):854-62.
2008: Ersin Selcuk Unal; Rongbao Zhao; Andong Qiu; I David Goldman
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).
Biochimica et biophysica acta 2008;1778(6):1407-14.
2008: Sang Hee Min; I David Goldman; Rongbao Zhao
Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed.
Cancer chemotherapy and pharmacology 2008;61(5):819-27.
2007: Andong Qiu; Sang Hee Min; Michaela Jansen; Usha Malhotra; Eugenia Tsai; Diane C Cabelof; Larry H Matherly; Rongbao Zhao; Myles H Akabas; I David Goldman
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
American journal of physiology. Cell physiology 2007;293(5):C1669-78.
2007: Rongbao Zhao; Sang Hee Min; Andong Qiu; Antoinette Sakaris; Gary L Goldberg; Claudio Sandoval; J Jeffrey Malatack; David S Rosenblatt; I David Goldman
The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.
Blood 2007;110(4):1147-52.
2007: Shrikanta Chattopadhyay; Roni Tamari; Sang Hee Min; Rongbao Zhao; Eugenia Tsai; I David Goldman
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability.
The oncologist 2007;12(7):808-15.
2007: Rongbao Zhao; I David Goldman
The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.
Cancer metastasis reviews 2007;26(1):129-39.
2006: Andong Qiu; Michaela Jansen; Antoinette Sakaris; Sang Hee Min; Shrikanta Chattopadhyay; Eugenia Tsai; Claudio Sandoval; Rongbao Zhao; Myles H Akabas; I David Goldman
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
Cell 2006;127(5):917-28.
2006: Shrikanta Chattopadhyay; Rongbao Zhao; Eugenia Tsai; Vern L Schramm; I David Goldman
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Molecular cancer therapeutics 2006;5(10):2549-55.
2006: Shrikanta Chattopadhyay; Rongbao Zhao; Sergey A Krupenko; Natalia I Krupenko; I David Goldman
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Molecular cancer therapeutics 2006;5(2):438-49.
2005: Rongbao Zhao; Marie Hanscom; I David Goldman
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
Biochimica et biophysica acta 2005;1715(1):57-64.
2005: Rongbao Zhao; Shubing Zhang; Marie Hanscom; Shrikanta Chattopadhyay; I David Goldman
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1294-301.
2005: Yanhua Wang; Arun Rajgopal; I David Goldman; Rongbao Zhao
Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function.
American journal of physiology. Cell physiology 2005;288(1):C65-71.
2004: Rongbao Zhao; Shrikanta Chattopadhyay; Marie Hanscom; I David Goldman
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8735-42.
2004: Shrikanta Chattopadhyay; Yanhua Wang; Rongbao Zhao; I David Goldman
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7986-93.
2004: Yanhua Wang; Rongbao Zhao; I David Goldman
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6256-64.
2004: Rongbao Zhao; Marie Hanscom; Shrikanta Chattopadhyay; I David Goldman
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Cancer research 2004;64(9):3313-9.
2004: Rongbao Zhao; Feng Gao; Marie Hanscom; I David Goldman
A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):718-27.
2004: Rongbao Zhao; I David Goldman
Enter Alimta: a new generation antifolate.
The oncologist 2004;9(3):242-4.
2003: Rongbao Zhao; I David Goldman
Resistance to antifolates.
Oncogene 2003;22(47):7431-57.
2003: Rongbao Zhao; Yanhua Wang; Feng Gao; I David Goldman
Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
Biochimica et biophysica acta 2003;1613(1-2):49-56.
2003: Yanhua Wang; Rongbao Zhao; I David Goldman
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Biochemical pharmacology 2003;65(7):1163-70.
2002: I David Goldman; Rongbao Zhao
Molecular, biochemical, and cellular pharmacology of pemetrexed.
Seminars in oncology 2002;29(6 Suppl 18):3-17.
2002: Yanhua Wang; Rongbao Zhao; Shrikanta Chattopadhyay; I David Goldman
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
Cancer research 2002;62(22):6434-7.
2002: Rongbao Zhao; Feng Gao; I David Goldman
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.
American journal of physiology. Cell physiology 2002;282(6):C1512-7.
2002: Iraida G Sharina; Rongbao Zhao; Yanhua Wang; Solomon Babani; I David Goldman
Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function.
Biochemical pharmacology 2002;63(9):1717-24.
2001: Arun Rajgopal; A Edmondnson; I David Goldman; Rongbao Zhao
SLC19A3 encodes a second thiamine transporter ThTr2.
Biochimica et biophysica acta 2001;1537(3):175-8.
2001: Arun Rajgopal; EE Sierra; Rongbao Zhao; I David Goldman
Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities.
American journal of physiology. Cell physiology 2001;281(5):C1579-86.
2001: Yanhua Wang; Rongbao Zhao; R G Russell; I David Goldman
Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis.
Biochimica et biophysica acta 2001;1513(1):49-54.
2001: Iraida G Sharina; Rongbao Zhao; Yanhua Wang; Solomon Babani; I David Goldman
Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier.
Molecular pharmacology 2001;59(5):1022-8.
2001: Rongbao Zhao; F Gao; I David Goldman
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Biochemical pharmacology 2001;61(7):857-65.
2001: Rongbao Zhao; Robert G Russell; Yanhua Wang; L Liu; F Gao; Burkhard Kneitz; Winfried Edelmann; I David Goldman
Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs.
The Journal of biological chemistry 2001;276(13):10224-8.
2001: Rongbao Zhao; Feng Gao; I David Goldman
Molecular cloning of human thiamin pyrophosphokinase.
Biochimica et biophysica acta 2001;1517(2):320-2.
2001: Rongbao Zhao; F Gao; Yanhua Wang; George A Diaz; Bruce D Gelb; I David Goldman
Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.
The Journal of biological chemistry 2001;276(2):1114-8.
2000: Rongbao Zhao; Solomon Babani; F Gao; L Liu; I David Goldman
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3687-95.
2000: Rongbao Zhao; Steven A Titus; F Gao; Richard G Moran; I David Goldman
Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.
The Journal of biological chemistry 2000;275(34):26599-606.
2000: Rongbao Zhao; F Gao; Solomon Babani; I David Goldman
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3304-11.
2000: Rongbao Zhao; F Gao; L Liu; I David Goldman
The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein.
Biochimica et biophysica acta 2000;1466(1-2):7-10.
2000: Rongbao Zhao; F Gao; P J Wang; I David Goldman
Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
Molecular pharmacology 2000;57(2):317-23.
1999: Rongbao Zhao; F Gao; I David Goldman
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Biochemical pharmacology 1999;58(10):1615-24.
1999: Rongbao Zhao; Iraida G Sharina; I David Goldman
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis.
Molecular pharmacology 1999;56(1):68-76.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
The Journal of biological chemistry 1998;273(30):19065-71.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.
The Journal of biological chemistry 1998;273(14):7873-9.
1998: S Khan; Rongbao Zhao; T S Reese
Architectural features of the Salmonella typhimurium flagellar motor switch revealed by disrupted C-rings.
Journal of structural biology 1998;122(3):311-9.
1997: Rongbao Zhao; Richard Seither; Kevin E Brigle; Iraida G Sharina; P J Wang; I David Goldman
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
The Journal of biological chemistry 1997;272(34):21207-12.
1996: Rongbao Zhao; N Pathak; H Jaffe; T S Reese; Shahid Khan
FliN is a major structural protein of the C-ring in the Salmonella typhimurium flagellar basal body.
Journal of molecular biology 1996;261(2):195-208.
1996: Rongbao Zhao; C D Amsler; Philip Matsumura; S Khan
FliG and FliM distribution in the Salmonella typhimurium cell and flagellar basal bodies.
Journal of bacteriology 1996;178(1):258-65.
1995: Rongbao Zhao; S C Schuster; S Khan
Structural effects of mutations in Salmonella typhimurium flagellar switch complex.
Journal of molecular biology 1995;251(3):400-12.