FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kim Brouwer

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Concepts & Ideas

Biological Models

Procedures

Physiology

Biological Transport

Phenomena

Metabolic Clearance Rate

Co-author Network

Publications

TOP 3
Brandon Swift; Dhiren R Thakker; Mark J Gnoth; Tianxiang Han; Dieter Lang; Jin Kyung Lee; Noelia Nebot; William R Proctor; Martin Radtke; Kim L R Brouwer
Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.
Kathleen Köck; Nicholas H. Oberlies; Ying Xie; Roy L Hawke; Kim L R Brouwer
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
LaToya M Griffin; Cassandra H Perry; Robert L St Claire; Paul B Watkins; Kim L R Brouwer
Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kim Brouwer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Brandon Swift; Dhiren R Thakker; Mark J Gnoth; Tianxiang Han; Dieter Lang; Jin Kyung Lee; Noelia Nebot; William R Proctor; Martin Radtke; Kim L R Brouwer
Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(6):1179-86.
2013: Kathleen Köck; Nicholas H. Oberlies; Ying Xie; Roy L Hawke; Kim L R Brouwer
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(5):958-65.
2013: LaToya M Griffin; Cassandra H Perry; Robert L St Claire; Paul B Watkins; Kim L R Brouwer
Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):188-96.
2012: Kevin M Watt; Ganesh Moorthy; P Brian Smith; Kelly C Wade; Daniel K Benjamin; Kim L R Brouwer; Edmund V Capparelli; Ira M Cheifetz; Michael Cohen-Wolkowiez
Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation.
The Pediatric infectious disease journal 2012;31(10):1042-7.
2012: Melanie S Joy; Mary La; Jinzhao Wang; Joyce A Blaisdell; Arlene S Bridges; Kim L R Brouwer; Mary Anne Dooley; Reginald F Frye; Joyce A Goldstein; Susan L Hogan; Yichun Hu; Ronald J Falk
Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.
British journal of clinical pharmacology 2012;74(3):445-55.
2012: Tracy L Marion; Cassandra H Perry; Robert L St Claire; Kim L R Brouwer
Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes.
Toxicology and applied pharmacology 2012;261(1):1-9.
2011: Latoya Griffin; Pieter Annaert; Kim L R Brouwer
Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.
Journal of pharmaceutical sciences 2011;100(9):3636-54.
2011: Grace Zhixia Yan; Kim L R Brouwer; Gary M Pollack; Michael Zhuo Wang; Richard R Tidwell; James E Hall; Mary F Paine
Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.
The Journal of pharmacology and experimental therapeutics 2011;337(2):503-12.
2011: Tracy L Marion; Cassandra H Perry; Robert L St Claire; Wei Yue; Kim L R Brouwer
Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(2):371-80.
2011: Wei Yue; Jin Kyung Lee; Koji Abe; Yuichi Sugiyama; Kim L R Brouwer
Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(3):441-7.
2010: Souzan B Yanni; Patrick Augustijns; Daniel K Benjamin; Kim L R Brouwer; Dhiren R Thakker; Pieter Annaert
In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(10):1848-56.
2010: Brandon Swift; Wei Yue; Kim L R Brouwer
Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes.
Pharmaceutical research 2010;27(9):1987-98.
2010: Jin Kyung Lee; Mary F Paine; Kim L R Brouwer
Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.
The Journal of pharmacology and experimental therapeutics 2010;334(2):410-8.
2010: Brandon Swift; Nathan D Pfeifer; Kim L R Brouwer
Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.
Drug metabolism reviews 2010;42(3):446-71.
2010: Brandon Swift; Kim L R Brouwer
Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.
Molecular pharmaceutics 2010;7(2):491-500.
2010: Kathleen M Giacomini; Shiew-Mei Huang; Donald J Tweedie; Leslie Z Benet; Kim L R Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M Hillgren; Keith A Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B Kim; Caroline A Lee; Mikko Niemi; Joseph W Polli; Yuichi Sugiyama; Peter Swaan; Joseph A Ware; Stephen H Wright; Sook Wah Yee; Maciej J Zamek-Gliszczynski; Lei Zhang
Membrane transporters in drug development.
Nature reviews. Drug discovery 2010;9(3):215-36.
2010: Kristina K Wolf; Sapana Vora; Lindsey O Webster; Grant T Generaux; Joseph W Polli; Kim L R Brouwer
Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(1):297-309.
2010: MaryPeace McRae; Abdel Naser La Rezk; Arlene Bridges; Amanda H Corbett; Hsiao-Chuan Tien; Kim L R Brouwer; Angela D M Kashuba
Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity.
Pharmacotherapy 2010;30(1):17-24.
2010: Jin Kyung Lee; Tracy L Marion; Koji Abe; Changwon Lim; Gary M Pollock; Kim L R Brouwer
Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
The Journal of pharmacology and experimental therapeutics 2010;332(1):26-34.
2009: Jin Kyung Lee; Koji Abe; Arlene Bridges; Nita J Patel; Thomas J Raub; Gary M Pollack; Kim L R Brouwer
Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1916-21.
2009: Brandon Swift; Xianbin Tian; Kim L R Brouwer
Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function.
Pharmaceutical research 2009;26(8):1942-51.
2009: Koji Abe; Arlene Bridges; Kim L R Brouwer
Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):447-52.
2009: Maciej J Zamek-Gliszczynski; J Cory Kalvass; Gary M Pollack; Kim L R Brouwer
Relationship between drug/metabolite exposure and impairment of excretory transport function.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):386-90.
2009: Wei Yue; Koji Abe; Kim L R Brouwer
Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion.
Molecular pharmaceutics 2009;6(1):134-43.
2008: Maciej J Zamek-Gliszczynski; Keith A Hoffmaster; Ken-Ichi Nezasa; Kim L R Brouwer
Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2156-8.
2008: Sonia R Miranda; Jin Kyung Lee; Kim L R Brouwer; Zhiming Wen; Philip C Smith; Roy L Hawke
Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2219-26.
2008: Kristina K Wolf; Kenneth Brouwer; Gary M Pollack; Kim L R Brouwer
Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2086-92.
2008: Koji Abe; Arlene Bridges; Wei Yue; Kim L R Brouwer
In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.
The Journal of pharmacology and experimental therapeutics 2008;326(3):983-90.
2008: Giulia Ghibellini; Elaine M Leslie; Gary M Pollack; Kim L R Brouwer
Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies.
Pharmaceutical research 2008;25(8):1851-60.
2008: Xianbin Tian; Brandon Swift; Maciej J Zamek-Gliszczynski; Martin G Belinsky; Gary Kruh; Kim L R Brouwer
Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(5):911-5.
2008: Jin Kyung Lee; Elaine M Leslie; Maciej J Zamek-Gliszczynski; Kim L R Brouwer
Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity.
Toxicology and applied pharmacology 2008;228(1):17-23.
2008: Daniel A J Bow; Jennifer Perry; David S Miller; John B Pritchard; Kim L R Brouwer
Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):198-202.
2008: Xianbin Tian; Maciej J Zamek-Gliszczynski; Jun Li; Arlene Bridges; Ken-Ichi Nezasa; Nita J Patel; Thomas J Raub; Kim L R Brouwer
Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):61-4.
2007: Elaine M Leslie; Giulia Ghibellini; Ken-Ichi Nezasa; Kim L R Brouwer
Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats.
Carcinogenesis 2007;28(12):2650-6.
2007: Tracy L Marion; Elaine M Leslie; Kim L R Brouwer
Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.
Molecular pharmaceutics 2007;4(6):911-8.
2007: Xianbin Tian; Jun Li; Maciej J Zamek-Gliszczynski; Arlene Bridges; Peijin Zhang; Nita J Patel; Thomas J Raub; Gary M Pollack; Kim L R Brouwer
Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
Antimicrobial agents and chemotherapy 2007;51(9):3230-4.
2007: Elaine M Leslie; Paul B Watkins; Richard B Kim; Kim L R Brouwer
Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1170-8.
2007: Gang Luo; C Edwin Garner; Hao Xiong; Hanbo Hu; Lauren E Richards; Kim L R Brouwer; Jingwu Duan; Carl P Decicco; Thomas Maduskuie; Helen Shen; Frank W Lee; Liang-Shang Gan
Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):835-40.
2007: Giulia Ghibellini; L S Vasist; Elaine M Leslie; William D Heizer; Richard Kowalsky; Benjamin F Calvo; Kim L R Brouwer
In vitro-in vivo correlation of hepatobiliary drug clearance in humans.
Clinical pharmacology and therapeutics 2007;81(3):406-13.
2007: Giulia Ghibellini; Arlene Bridges; Claudia N Generaux; Kim L R Brouwer
In vitro and in vivo determination of piperacillin metabolism in humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):345-9.
2006: Maciej J Zamek-Gliszczynski; Ken-Ichi Nezasa; Xianbin Tian; Arlene Bridges; Kun Lee; Martin G Belinsky; Gary Kruh; Kim L R Brouwer
Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1485-91.
2006: Maciej J Zamek-Gliszczynski; Ken-Ichi Nezasa; Xianbin Tian; J Cory Kalvass; Nita J Patel; Thomas J Raub; Kim L R Brouwer
The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.
Molecular pharmacology 2006;70(6):2127-33.
2006: Maciej J Zamek-Gliszczynski; Keith A Hoffmaster; Joan E Humphreys; Xianbin Tian; Ken-Ichi Nezasa; Kim L R Brouwer
Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.
The Journal of pharmacology and experimental therapeutics 2006;319(1):459-67.
2006: Giulia Ghibellini; Lakshmi S Vasist; Terence E Hill; William D Heizer; Richard Kowalsky; Kim L R Brouwer
Determination of the biliary excretion of piperacillin in humans using a novel method.
British journal of clinical pharmacology 2006;62(3):304-8.
2006: Mary Peace McRae; Carolina M Lowe; Xianbin Tian; David L Bourdet; Richard H Ho; Brenda F Leake; Richard B Kim; Kim L R Brouwer; Angela D M Kashuba
Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1068-75.
2006: Ryan Z Turncliff; Keith A Hoffmaster; J Cory Kalvass; Gary M Pollack; Kim L R Brouwer
Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 2006;318(2):881-9.
2006: Ryan Z Turncliff; Xianbin Tian; Kim L R Brouwer
Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes.
Biochemical pharmacology 2006;71(10):1520-9.
2006: Giulia Ghibellini; Elaine M Leslie; Kim L R Brouwer
Methods to evaluate biliary excretion of drugs in humans: an updated review.
Molecular pharmaceutics 2006;3(3):198-211.
2006: Maciej J Zamek-Gliszczynski; Keith A Hoffmaster; Ken-Ichi Nezasa; Melanie N Tallman; Kim L R Brouwer
Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(5):447-86.
2006: Ken-Ichi Nezasa; Xianbin Tian; Maciej J Zamek-Gliszczynski; Nita J Patel; Thomas J Raub; Kim L R Brouwer
Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):718-23.
2006: Brendan M Johnson; Peijin Zhang; John D Schuetz; Kim L R Brouwer
Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):556-62.
2005: Priyamvada Chandra; Brendan M Johnson; Peijin Zhang; Gary M Pollack; Kim L R Brouwer
Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1238-43.
2005: Maciej J Zamek-Gliszczynski; Keith A Hoffmaster; Xianbin Tian; Rong Zhao; Joseph W Polli; Joan E Humphreys; Lindsey O Webster; Arlene Bridges; J Cory Kalvass; Kim L R Brouwer
Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1158-65.
2005: Priyamvada Chandra; Peijin Zhang; Kim L R Brouwer
Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(6):G1252-8.
2005: Peijin Zhang; Xianbin Tian; Priyamvada Chandra; Kim L R Brouwer
Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes.
Molecular pharmacology 2005;67(4):1334-41.
2005: Pieter Annaert; Kim L R Brouwer
Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):388-94.
2005: Keith A Hoffmaster; Maciej J Zamek-Gliszczynski; Gary M Pollack; Kim L R Brouwer
Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(2):287-93.
2005: Daniel C Kemp; Maciej J Zamek-Gliszczynski; Kim L R Brouwer
Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):207-14.
2005: Xianbin Tian; Peijin Zhang; Maciej J Zamek-Gliszczynski; Kim L R Brouwer
Knocking down transport: applications of RNA interference in the study of drug transport proteins.
Drug metabolism reviews 2005;37(4):705-23.
2004: Daniel C Kemp; Kim L R Brouwer
Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure.
Toxicology in vitro : an international journal published in association with BIBRA 2004;18(6):869-77.
2004: Keith A Hoffmaster; Maciej J Zamek-Gliszczynski; Gary M Pollack; Kim L R Brouwer
Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1203-10.
2004: Xianbin Tian; Maciej J Zamek-Gliszczynski; Peijin Zhang; Kim L R Brouwer
Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes.
Molecular pharmacology 2004;66(4):1004-10.
2004: Adam M Persky; C Ng; M H Song; M E Lancaster; D E Balderson; Mark A Paulik; Kim L R Brouwer
Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers.
International journal of clinical pharmacology and therapeutics 2004;42(8):442-8.
2004: Ryan Z Turncliff; Peter J Meier Abt; Kim L R Brouwer
Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):834-9.
2004: Keith A Hoffmaster; Ryan Z Turncliff; Edward LeCluyse; Richard B Kim; Peter J Meier Abt; Kim L R Brouwer
P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.
Pharmaceutical research 2004;21(7):1294-302.
2004: Priyamvada Chandra; Kim L R Brouwer
The complexities of hepatic drug transport: current knowledge and emerging concepts.
Pharmaceutical research 2004;21(5):719-35.
2004: Adam M Persky; N Seth Berry; Gary M Pollack; Kim L R Brouwer
Modelling the cardiovascular effects of ephedrine.
British journal of clinical pharmacology 2004;57(5):552-62.
2004: Giulia Ghibellini; Brendan M Johnson; Richard Kowalsky; William D Heizer; Kim L R Brouwer
A novel method for the determination of biliary clearance in humans.
The AAPS journal 2004;6(4):e33.
2003: Nita J Patel; Maciej J Zamek-Gliszczynski; Peijin Zhang; Yong-Hee Han; Peter L M Jansen; Peter J Meier Abt; Bruno Stieger; Kim L R Brouwer
Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions.
Molecular pharmacology 2003;64(1):154-9.
2003: Mary Peace McRae; Kim L R Brouwer; Angela D M Kashuba
Cytokine regulation of P-glycoprotein.
Drug metabolism reviews 2003;35(1):19-33.
2003: Maciej J Zamek-Gliszczynski; Hao Xiong; Nita J Patel; Ryan Z Turncliff; Gary M Pollack; Kim L R Brouwer
Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver.
The Journal of pharmacology and experimental therapeutics 2003;304(2):801-9.
2002: Kim L R Brouwer; Gary M Pollack
Pharmacogenetics: is the right drug for the right patient sufficient?
Advanced drug delivery reviews 2002;54(10):1243-4.
2002: Kiho Lee; Chee Ng; Kim L R Brouwer; Dhiren R Thakker
Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers.
The Journal of pharmacology and experimental therapeutics 2002;303(2):574-80.
2002: Hao Xiong; Hiroshi Suzuki; Yuichi Sugiyama; Peter J Meier Abt; Gary M Pollack; Kim L R Brouwer
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):962-9.
2002: Hao Xiong; Kouichi Yoshinari; Kim L R Brouwer; Masahiko Negishi
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(8):918-23.
2002: Bindu R Murthy; Gary M Pollack; Kim L R Brouwer
Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers.
Journal of clinical pharmacology 2002;42(5):569-76.
2001: Pieter Annaert; Ryan Z Turncliff; C L Booth; Dhiren R Thakker; Kim L R Brouwer
P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(10):1277-83.
2001: P Chandra; Edward LeCluyse; Kim L R Brouwer
Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes.
In vitro cellular & developmental biology. Animal 2001;37(6):380-5.
2001: K R Crews; B P Murthy; E K Hussey; Anthony Passannante; J L Palmer; William Maixner; Kim L R Brouwer
Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers.
British journal of clinical pharmacology 2001;51(4):309-16.
2001: ES Ward; Gary M Pollack; Kim L R Brouwer
Probenecid-associated alterations in valproate glucuronide hepatobiliary disposition: mechanistic assessment using mathematical modeling.
The Journal of pharmacology and experimental therapeutics 2001;297(1):141-7.
2000: ES Ward; Gary M Pollack; Kim L R Brouwer
Probenecid-associated alterations in valproic acid pharmacokinetics in rats: can in vivo disposition of valproate glucuronide be predicted from in vitro formation data?
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1433-9.
2000: Hao Xiong; K C Turner; ES Ward; P L Jansen; Kim L R Brouwer
Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.
The Journal of pharmacology and experimental therapeutics 2000;295(2):512-8.
2000: J D Fischer; M H Song; A B Suttle; William D Heizer; C B Burns; D L Vargo; Kim L R Brouwer
Comparison of zafirlukast (Accolate) absorption after oral and colonic administration in humans.
Pharmaceutical research 2000;17(2):154-9.
2000: C L Aquilante; SP Letrent; Gary M Pollack; Kim L R Brouwer
Increased brain P-glycoprotein in morphine tolerant rats.
Life sciences 2000;66(4):PL47-51.
1999: SP Letrent; Joseph W Polli; Joan E Humphreys; Gary M Pollack; Kenneth Brouwer; Kim L R Brouwer
P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells.
Biochemical pharmacology 1999;58(6):951-7.
1999: X Liu; Edward LeCluyse; Kenneth Brouwer; Liang-Shang Gan; John J Lemasters; B Stieger; Peter J Meier Abt; Kim L R Brouwer
Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.
The American journal of physiology 1999;277(1 Pt 1):G12-21.
1999: SP Letrent; Gary M Pollack; Kenneth Brouwer; Kim L R Brouwer
Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(7):827-34.
1999: X Liu; J P Chism; Edward LeCluyse; Kenneth Brouwer; Kim L R Brouwer
Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):637-44.
1999: X Liu; Edward LeCluyse; Kenneth Brouwer; R M Lightfoot; J I Lee; Kim L R Brouwer
Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1592-9.
1998: Y K Pithavala; William D Heizer; A F Parr; R L O'Connor-Semmes; Kim L R Brouwer
Use of the InteliSite capsule to study ranitidine absorption from various sites within the human intestinal tract.
Pharmaceutical research 1998;15(12):1869-75.
1998: X Liu; Kim L R Brouwer; Liang-Shang Gan; Kenneth Brouwer; B Stieger; Peter J Meier Abt; K L Audus; Edward LeCluyse
Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration.
Pharmaceutical research 1998;15(10):1533-9.
1998: C L Booth; Kenneth Brouwer; Kim L R Brouwer
Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver.
Cancer research 1998;58(16):3641-8.
1998: Mark A Socinski; P N Mudd; K M Radomski; A Steagall; P Lawrence; Stephen A Bernard; SP Letrent; P Gonzalez; Kim L R Brouwer
Phase I trial of a 96 h paclitaxel infusion with filgrastim support in refractory solid tumor patients.
Anti-cancer drugs 1998;9(7):611-9.
1998: Kimberly Reynolds; M H Song; William D Heizer; C B Burns; D A Sica; Kim L R Brouwer
Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans.
Pharmaceutical research 1998;15(8):1281-5.
1998: SP Letrent; Gary M Pollack; Kenneth Brouwer; Kim L R Brouwer
Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat.
Pharmaceutical research 1998;15(4):599-605.
1997: Peadar G Noone; JA Regnis; X Liu; Kim L R Brouwer; M Robinson; Lloyd J Edwards; Michael Knowles
Airway deposition and clearance and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways.
Chest 1997;112(5):1283-90.
1997: K C Turner; Kim L R Brouwer
In vitro mechanisms of probenecid-associated alterations in acetaminophen glucuronide hepatic disposition.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(9):1017-21.
1997: A K Mosley; Kim L R Brouwer
Heat treatment of human serum to inactivate HIV does not alter protein binding of selected drugs.
Therapeutic drug monitoring 1997;19(4):477-9.
1997: A Nolting; Robert DeLong; M H Fisher; Eric Wickstrom; Gary M Pollack; Rudy L Juliano; Kim L R Brouwer
Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver.
Pharmaceutical research 1997;14(4):516-21.
1997: X Liu; Kim L R Brouwer; Gary M Pollack
A modified residual method to estimate the zero-order absorption rate constant in a one-compartment model.
Biopharmaceutics & drug disposition 1997;18(2):93-101.
1997: Don Farthing; Kim L R Brouwer; Itaf Fakhry; Domenic A Sica
Solid-phase extraction and determination of ranitidine in human plasma by a high-performance liquid chromatographic method utilizing midbore chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(2):350-3.
1996: H J Peckman; Robert E Dupuis; W T Sawyer; Kim L R Brouwer; R E Cross
Vancomycin serum concentrations in patients with renal dysfunction: a comparison of fluorescence polarization immunoassay and the enzyme-multiplied immunoassay technique.
Therapeutic drug monitoring 1996;18(6):647-53.
1996: Christopher Matheny; D R Taft; Kim L R Brouwer; Gary M Pollack
Evidence for reversible sequestration of morphine in rat liver.
Biochemical pharmacology 1996;52(4):535-41.
1996: Gary M Pollack; Kim L R Brouwer
Maternal-fetal pharmacokinetics of methanol.
Research report (Health Effects Institute) 1996;(74):1-48; discussion 49-53.
1996: L D Carlton; Gary M Pollack; Kim L R Brouwer
Physiologic pharmacokinetic modeling of gastrointestinal blood flow as a rate-limiting step in the oral absorption of digoxin: implications for patients with congestive heart failure receiving epoprostenol.
Journal of pharmaceutical sciences 1996;85(5):473-7.
1996: Patricia W Slattum; A E Cato; Gary M Pollack; Kim L R Brouwer
Age-related changes in valproic acid binding to rat serum proteins in vitro.
Journal of pharmaceutical sciences 1996;85(4):373-6.
1996: C L Booth; Gary M Pollack; Kim L R Brouwer
Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions.
Hepatology (Baltimore, Md.) 1996;23(4):771-80.
1996: C Chen; Patricia W Slattum; Kim L R Brouwer; Gary M Pollack
Influence of age and gender on valproic acid glucuronidation in rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(3):367-70.
1996: Kim L R Brouwer; R G Thurman
Isolated perfused liver.
Pharmaceutical biotechnology 1996;8():161-92.
1995: Katy H P Moore; Ralph H Raasch; Kim L R Brouwer; K Opheim; S H Cheeseman; E Eyster; S M Lemon; Charles van der Horst
Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).
Antimicrobial agents and chemotherapy 1995;39(12):2732-7.
1995: L D Carlton; V D Schmith; Kim L R Brouwer
Intravenous epoprostenol sodium does not increase hepatic microsomal enzyme activity in rats.
Prostaglandins 1995;50(5-6):341-7.
1995: A B Suttle; Kim L R Brouwer
Gastrointestinal transit and distribution of ranitidine in the rat.
Pharmaceutical research 1995;12(9):1316-22.
1995: A B Suttle; Kim L R Brouwer
Regional gastrointestinal absorption of ranitidine in the rat.
Pharmaceutical research 1995;12(9):1311-5.
1995: S D Studenberg; D L Price-Raybuck; S E Unger; John P Shockcor; Kim L R Brouwer
Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase.
Journal of pharmaceutical sciences 1995;84(9):1134-6.
1995: K H Moore; Kim L R Brouwer
High-performance liquid chromatographic evaluation of the effect of heat treatment on trimethoprim and sulfamethoxazole stability in serum.
Therapeutic drug monitoring 1995;17(4):356-60.
1995: Jeffrey A Hughes; Anna V Avrutskaya; Kim L R Brouwer; Eric Wickstrom; Rudy L Juliano
Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs.
Pharmaceutical research 1995;12(6):817-24.
1995: Patricia W Slattum; A E Cato; Gary M Pollack; Kim L R Brouwer
Age-dependent intestinal hydrolysis of valproate glucuronide in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(3):229-37.
1995: A Cato; Gary M Pollack; Kim L R Brouwer
Age-dependent intestinal absorption of valproic acid in the rat.
Pharmaceutical research 1995;12(2):284-90.
1995: P E Warner; Kim L R Brouwer; EK Hussey; G E Dukes; William D Heizer; K H Donn; I M Davis; J R Powell
Sumatriptan absorption from different regions of the human gastrointestinal tract.
Pharmaceutical research 1995;12(1):138-43.
1994: Pam Golden; P E Warner; J C Fleishaker; R C Jewell; S Millikin; J Lyon; Kim L R Brouwer
Effects of probenecid on the pharmacokinetics and pharmacodynamics of adinazolam in humans.
Clinical pharmacology and therapeutics 1994;56(2):133-41.
1994: A B Suttle; Kim L R Brouwer
Bile flow but not enterohepatic recirculation influences the pharmacokinetics of ranitidine in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):224-32.
1994: B D Jamerson; G E Dukes; Kim L R Brouwer; K H Donn; J A Messenheimer; J R Powell
Venous irritation related to intravenous administration of phenytoin versus fosphenytoin.
Pharmacotherapy 1994;14(1):47-52.
1994: Gary M Pollack; Anne P Spencer; T L Horton; Kim L R Brouwer
Site-dependent intestinal hydrolysis of valproate and morphine glucuronide in the developing rat.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):120-3.
1993: Pam Golden; Kim L R Brouwer; Gary M Pollack
Assessment of valproic acid serum-cerebrospinal fluid transport by microdialysis.
Pharmaceutical research 1993;10(12):1765-71.
1993: Kim L R Brouwer
Acute phenobarbital administration alters the disposition of acetaminophen metabolites in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1129-33.
1993: S D Studenberg; Kim L R Brouwer
Hepatic disposition of acetaminophen and metabolites. Pharmacokinetic modeling, protein binding and subcellular distribution.
Biochemical pharmacology 1993;46(4):739-46.
1993: Gary M Pollack; Kim L R Brouwer; J L Kawagoe
Toxicokinetics of intravenous methanol in the female rat.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(1):105-10.
1993: S D Studenberg; Kim L R Brouwer
Effect of phenobarbital and p-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: use of a kinetic model to examine the rates of formation and egress.
Journal of pharmacokinetics and biopharmaceutics 1993;21(2):175-94.
1993: Kim L R Brouwer; E S Hall; Gary M Pollack
Protein binding and hepatobiliary distribution of valproic acid and valproate glucuronide in rats.
Biochemical pharmacology 1993;45(3):735-42.
1992: M J Liu; Kim L R Brouwer; Gary M Pollack
Pharmacokinetics and pharmacodynamics of valproate analogs in rats. III. Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(6):810-5.
1992: A B Suttle; S S Songer; G E Dukes; Lawrence J Hak; Mark J Koruda; J C Fleishaker; Kim L R Brouwer
Ranitidine does not alter adinazolam pharmacokinetics or pharmacodynamics.
Journal of clinical psychopharmacology 1992;12(4):282-7.
1992: P M Savina; Kim L R Brouwer
Probenecid-impaired biliary excretion of acetaminophen glucuronide and sulfate in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(4):496-501.
1992: S D Studenberg; Kim L R Brouwer
Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1022-7.
1992: A B Suttle; Gary M Pollack; Kim L R Brouwer
Use of a pharmacokinetic model incorporating discontinuous gastrointestinal absorption to examine the occurrence of double peaks in oral concentration-time profiles.
Pharmaceutical research 1992;9(3):350-6.
1991: Gary M Pollack; Kim L R Brouwer
Physiologic and metabolic influences on enterohepatic recirculation: simulations based upon the disposition of valproic acid in the rat.
Journal of pharmacokinetics and biopharmaceutics 1991;19(2):189-225.
1991: S D Studenberg; Kim L R Brouwer
Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):423-9.
1991: Gary M Pollack; Kim L R Brouwer
Thermal injury decreases hepatic blood flow and the intrinsic clearance of indocyanine green in the rat.
Pharmaceutical research 1991;8(1):106-11.
1990: EK Hussey; G E Dukes; J A Messenheimer; Kim L R Brouwer; K H Donn; T F Krol; Lawrence J Hak
Evaluation of the pharmacokinetic interaction between diazepam and ACC-9653 (a phenytoin prodrug) in healthy male volunteers.
Pharmaceutical research 1990;7(11):1172-6.
1990: B D Jamerson; K H Donn; G E Dukes; J A Messenheimer; Kim L R Brouwer; J R Powell
Absolute bioavailability of phenytoin after 3-phosphoryloxymethyl phenytoin disodium (ACC-9653) administration to humans.
Epilepsia 1990;31(5):592-7.
1990: EK Hussey; G E Dukes; J A Messenheimer; Kim L R Brouwer; K H Donn; T F Krol; Lawrence J Hak
Correlation of delayed peak concentration with infusion-site irritation following diazepam administration.
DICP : the annals of pharmacotherapy 1990;24(7-8):678-81.
1990: Gary M Pollack; Kim L R Brouwer; K B Demby; J A Jones
Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(2):197-202.
1990: Kim L R Brouwer; J A Jones
Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier.
The Journal of pharmacology and experimental therapeutics 1990;252(2):657-64.
1989: R C Jewell; Kim L R Brouwer; P J McNamara
Alpha 1-acid glycoprotein high-performance liquid chromatography column (EnantioPAC) as a screening tool for protein binding.
Journal of chromatography 1989;487(2):257-64.
1987: Kim L R Brouwer; S Durham; Mary Vore
Multiple carriers for uptake of [3H]estradiol-17 beta(beta-D-glucuronide) in isolated rat hepatocytes.
Molecular pharmacology 1987;32(4):519-23.
1985: Kim L R Brouwer; Mary Vore
Effect of hypoxia and pregnancy on antipyrine metabolism in isolated perfused rat livers.
The Journal of pharmacology and experimental therapeutics 1985;234(3):584-9.
1985: S R Hamann; T G Tan; K E Kaltenborn; Kim L R Brouwer; R A Blouin; S L Chang; Mary Vore; R G McAllister
Effects of phenobarbital and SKF-525A on in vitro hepatic metabolism of verapamil and nifedipine.
Pharmacology 1985;30(3):121-8.
1985: R A Blouin; Kim L R Brouwer; K E Record; W O Griffen; P M Plezia; W John
Amikacin pharmacokinetics in morbidly obese patients undergoing gastric-bypass surgery.
Clinical pharmacy 1985;4(1):70-2.
1984: Kim L R Brouwer; H B Kostenbauder; P J McNamara; R A Blouin
Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction.
The Journal of pharmacology and experimental therapeutics 1984;231(3):654-9.
1984: Kim L R Brouwer; H B Kostenbauder; P J McNamara; R A Blouin
Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration.
The Journal of pharmacology and experimental therapeutics 1984;231(3):649-53.