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Zhizhuang Joe Zhao

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Jian Zhong Tang; Zhizhuang Joe Zhao; Catherine L Carmichael; Neal G Copeland; Viive M Howell; Craig D Hyland; Nancy A Jenkins; Benjamin T Kile; Donald Metcalf; Ashley Ng; Wei Shi; Gordon K Smyth; Warren S Alexander
Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Andrew Chow; Jalal Ahmed; Aviv Bergman; Daigo Hashimoto; Matthew Huggins; Yuya Kunisaki; Marylene Leboeuf; Daniel Lucas; Miriam Merad; Clara Noizat; Sandra Pinho; Masato Tanaka; Nico van Rooijen; Zhizhuang Joe Zhao; Paul S. Frenette
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Rebekah Baskin; Kirpal S Bisht; Meghanath Gali; György M Keseru; Sung O Park; Zhizhuang Joe Zhao; Peter P Sayeski
Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation.

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All Publications

2013: Jian Zhong Tang; Zhizhuang Joe Zhao; Catherine L Carmichael; Neal G Copeland; Viive M Howell; Craig D Hyland; Nancy A Jenkins; Benjamin T Kile; Donald Metcalf; Ashley Ng; Wei Shi; Gordon K Smyth; Warren S Alexander
Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6091-6.
2013: Andrew Chow; Jalal Ahmed; Aviv Bergman; Daigo Hashimoto; Matthew Huggins; Yuya Kunisaki; Marylene Leboeuf; Daniel Lucas; Miriam Merad; Clara Noizat; Sandra Pinho; Masato Tanaka; Nico van Rooijen; Zhizhuang Joe Zhao; Paul S. Frenette
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Nature medicine 2013;19(4):429-36.
2012: Rebekah Baskin; Kirpal S Bisht; Meghanath Gali; György M Keseru; Sung O Park; Zhizhuang Joe Zhao; Peter P Sayeski
Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation.
Bioorganic & medicinal chemistry letters 2012;22(3):1402-7.
2012: Yao Guo; Xuesong Xu; Yun Chen; Xueqi Fu; Zhizhuang Joe Zhao
SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells.
Journal of hematology & oncology 2012;5():72.
2012: Wanke Zhao; Yanhong Du; Xueqi Fu; Wanting Tina Ho; Zhizhuang Joe Zhao
JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines.
Experimental hematology & oncology 2012;1(1):15.
2012: Xiaokun Yu; Wanke Zhao; Xueqi Fu; Feng Lin; Junfeng Ma; Zhizhuang Joe Zhao
Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans.
BMC cell biology 2012;13():28.
2012: Yun Chen; Xueqi Fu; Yao Guo; Jiayu Han; Wanting Tina Ho; Shibo Li; Zhizhuang Joe Zhao
Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity.
Journal of hematology & oncology 2012;5():39.
2012: Anurima Majumder; Sung O Park; Zhizhuang Joe Zhao; Robert W Allan; Rebekah Baskin; Kirpal S Bisht; Nicholas C Figueroa; György M Keseru; Annet Kirabo; Andrew T Magis; Peter P Sayeski
A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.
Experimental hematology 2012;40(1):22-34.
2011: Annet Kirabo; Anurima Majumder; Sung O Park; Mary K Reinhard; Kirpal S Bisht; Christopher R Cogle; Meghanath Gali; György M Keserü; Heather L Wamsley; Zhizhuang Joe Zhao; Peter P Sayeski
The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Neoplasia (New York, N.Y.) 2011;13(11):1058-68.
2011: Wei Wang; Zhizhuang Joe Zhao; Henry D Bellamy; Chandrasekhar Komma; Lijun Liu; Yi Mo; Xi Song; G Wayne Zhou
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
Journal of cellular biochemistry 2011;112(8):2062-71.
2011: Junfeng Ma; Zhe Li; Shu Xing; Wan-Ting Tina Ho; Xueqi Fu; Zhizhuang Joe Zhao
Tea contains potent inhibitors of tyrosine phosphatase PTP1B.
Biochemical and biophysical research communications 2011;407(1):98-102.
2011: Anne-Laure Talbot; Zhizhuang Joe Zhao; Grant C Bullock; Lorrie L Delehanty; Martin Sattler; Adam N Goldfarb
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.
PloS one 2011;6(8):e23850.
2009: Chaitali Tophkhane; Shihe Yang; Zhizhuang Joe Zhao; Xiaohe Yang
Cell density-dependent regulation of p73 in breast cancer cells.
International journal of oncology 2009;35(6):1429-34.
2008: Junfeng Ma; Fenghua Zeng; Wanting Tina Ho; Lirong Teng; Qingshan Li; Xueqi Fu; Zhizhuang Joe Zhao
Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans.
Journal of cellular biochemistry 2008;104(5):1843-52.
2008: Shu Xing; Tina Ho Wanting; Wanming Zhao; Junfeng Ma; Shaofeng Wang; Xuesong Xu; Qingshan Li; Xueqi Fu; Mingjiang Xu; Zhizhuang Joe Zhao
Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.
Blood 2008;111(10):5109-17.
2007: Zhe Li; Shu Xing; Shaofeng Wang; Wan-Ting Ho; Zhizhuang Joe Zhao
Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity.
Experimental hematology 2007;35(11):1624-32.
2007: Zhe Li; Mingjiang Xu; Shu Xing; Wan-Ting Ho; Takefumi Ishii; Qingshan Li; Xueqi Fu; Zhizhuang Joe Zhao
Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth.
The Journal of biological chemistry 2007;282(6):3428-32.
2007: Bobbie Collett Sutton; Richard A Allen; Zhizhuang Joe Zhao; S Terence Dunn
Detection of the JAK2V617F mutation by asymmetric PCR and melt curve analysis.
Cancer biomarkers : section A of Disease markers 2007;3(6):315-24.
2007: Xuesong Xu; Qi Zhang; Jian Luo; Shu Xing; Qingshan Li; Sanford B Krantz; Xueqi Fu; Zhizhuang Joe Zhao
JAK2(V617F): Prevalence in a large Chinese hospital population.
Blood 2007;109(1):339-42.
2006: Chunlei zheng; Ziyang Lin; Zhizhuang Joe Zhao; Yajun Yang; Hanben Niu; Xun Shen
MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27.
The Journal of biological chemistry 2006;281(48):37215-26.
2006: Ning Wang; Zhe Li; Ronghua Ding; Gerald D Frank; Takaaki Senbonmatsu; Erwin J Landon; Tadashi Inagami; Zhizhuang Joe Zhao
Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling.
The Journal of biological chemistry 2006;281(31):21878-83.
2005: Yingchun Wang; Eric Vachon; Jinyi Zhang; Vera Cherepanov; Joshua Kruger; Jun Li; Kan Saito; Patrick Shannon; Nunzio Bottini; Huong Huynh; Heyu Ni; Hong Yang; Colin McKerlie; Sue Quaggin; Zhizhuang Joe Zhao; Philip A Marsden; Tomas Mustelin; Katherine A Siminovitch; Gregory P Downey
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.
The Journal of experimental medicine 2005;202(11):1587-97.
2005: Zhizhuang Joe Zhao; William Vainchenker; Sanford B Krantz; Nicole Casadevall; Stefan N Constantinescu
Role of tyrosine kinases and phosphatases in polycythemia vera.
Seminars in hematology 2005;42(4):221-9.
2005: Hua Tang; Qin Hao; Stacey A Rutherford; Brad Low; Zhizhuang Joe Zhao
Inactivation of SRC family tyrosine kinases by reactive oxygen species in vivo.
The Journal of biological chemistry 2005;280(25):23918-25.
2005: Runxiang Zhao; Shu Xing; Zhe Li; Xueqi Fu; Qingshan Li; Sanford B Krantz; Zhizhuang Joe Zhao
Identification of an acquired JAK2 mutation in polycythemia vera.
The Journal of biological chemistry 2005;280(24):22788-92.
2005: Wan-Ting Ho; Zhi Xie; Zhizhuang Joe Zhao; John H Exton
Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation.
Cellular signalling 2005;17(6):691-9.
2004: Yuan Ren; Songshu Meng; Lin Mei; Zhizhuang Joe Zhao; Richard Jove; Jie Wu
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
The Journal of biological chemistry 2004;279(9):8497-505.
2004: Ming-Zhi Zhang; Weiyi Mai; Cunxi Li; Sae-youll Cho; Chuanming Hao; Gilbert W Moeckel; Runxiang Zhao; Ingyu Kim; Jikui Wang; Huaqi Xiong; Hong Wang; Yasunori Sato; Yizhong Wu; Yasuni Nakanuma; Marusia Lilova; York Pei; Raymond C Harris; Song Li; Robert J Coffey; Le Sun; Dianqing Wu; Xing-Zhen Chen; Matthew D Breyer; Zhizhuang Joe Zhao; James A McKanna; Guanqing Wu
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2311-6.
2003: Ming-Jiang Xu; Xingwei Sui; Runxiang Zhao; Chunhua Dai; Sanford B Krantz; Zhizhuang Joe Zhao
PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells.
Blood 2003;102(13):4354-60.
2003: Chengyu Wu; Qin Guan; Yingjian Wang; Zhizhuang Joe Zhao; G Wayne Zhou
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.
Journal of cellular biochemistry 2003;90(5):1026-37.
2003: Runxiang Zhao; Xueqi Fu; Lirong Teng; Qingshan Li; Zhizhuang Joe Zhao
Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains.
The Journal of biological chemistry 2003;278(44):42893-8.
2003: Runxiang Zhao; Xueqi Fu; Qingshan Li; Sanford B Krantz; Zhizhuang Joe Zhao
Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine.
The Journal of biological chemistry 2003;278(25):22609-14.
2003: Runxiang Zhao; Zhizhuang Joe Zhao
Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.
Biochemical and biophysical research communications 2003;303(4):1028-33.
2003: Jian Yang; Lijun Liu; Dandan He; Xi Song; Xiaoshan Liang; Zhizhuang Joe Zhao; G Wayne Zhou
Crystal structure of human protein-tyrosine phosphatase SHP-1.
The Journal of biological chemistry 2003;278(8):6516-20.
2002: Huaqi Xiong; Yongxiong Chen; Yajun Yi; Karen Tsuchiya; Gilbert W Moeckel; Joseph Cheung; Dan Liang; Kyi Tham; Xiaohu Xu; Xing-Zhen Chen; York Pei; Zhizhuang Joe Zhao; Guanqing Wu
A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease.
Genomics 2002;80(1):96-104.
2002: Ming-Jiang Xu; Runxiang Zhao; Hongxi Cao; Zhizhuang Joe Zhao
SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
Biochemical and biophysical research communications 2002;293(3):1037-46.
2002: Runxiang Zhao; Abdelmadjid Guerrah; Hua Tang; Zhizhuang Joe Zhao
Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.
The Journal of biological chemistry 2002;277(10):7882-8.
2002: Ying Qi; Runxiang Zhao; Hongxi Cao; Xingwei Sui; Sanford B Krantz; Zhizhuang Joe Zhao
Purification and characterization of protein tyrosine phosphatase PTP-MEG2.
Journal of cellular biochemistry 2002;86(1):79-89.
2002: Ashwini K Mishra; Aihua Zhang; Tianqi Niu; Jian Yang; Xiaoshan Liang; Zhizhuang Joe Zhao; G Wayne Zhou
Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1.
Journal of cellular biochemistry 2002;84(4):840-6.
2002: Fengping Xu; Ming-jiang Xu; Runxiang Zhao; Abdelmadjid Guerrah; Fenghua Zeng; Zhizhuang Joe Zhao
Tyrosine phosphatases SHP-1 and SHP-2 are associated with distinct tyrosine-phosphorylated proteins.
Experimental cell research 2002;272(1):75-83.
2001: Fengping Xu; Runxiang Zhao; Y Peng; Abdelmadjid Guerrah; Zhizhuang Joe Zhao
Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities.
The Journal of biological chemistry 2001;276(31):29479-84.
2001: Jian Yang; Z Cheng; Tianqi Niu; Xiaoshan Liang; Zhizhuang Joe Zhao; G Wayne Zhou
Protein tyrosine phosphatase SHP-1 specifically recognizes C-terminal residues of its substrates via helix alpha0.
Journal of cellular biochemistry 2001;83(1):14-20.
2001: Runxiang Zhao; Y Qi; J Chen; Zhizhuang Joe Zhao
FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate.
Experimental cell research 2001;265(2):329-38.
2001: Ming-Jiang Xu; Runxiang Zhao; Zhizhuang Joe Zhao
Molecular cloning and characterization of SPAP1, an inhibitory receptor.
Biochemical and biophysical research communications 2001;280(3):768-75.
2001: Jian Yang; Tianqi Niu; Aihua Zhang; Ashwini K Mishra; Zhizhuang Joe Zhao; G Wayne Zhou
Relation between the flexibility of the WPD loop and the activity of the catalytic domain of protein tyrosine phosphatase SHP-1.
Journal of cellular biochemistry 2001;84(1):47-55.
2001: Fengping Xu; Zhizhuang Joe Zhao
Cell density regulates tyrosine phosphorylation and localization of focal adhesion kinase.
Experimental cell research 2001;262(1):49-58.
2000: Xingwei Sui; Sanford B Krantz; Zhizhuang Joe Zhao
Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways.
British journal of haematology 2000;110(1):63-70.
2000: M j Xu; Runxiang Zhao; Zhizhuang Joe Zhao
Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.
The Journal of biological chemistry 2000;275(23):17440-6.
2000: Runxiang Zhao; Y Qi; Zhizhuang Joe Zhao
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain.
Biochemical and biophysical research communications 2000;270(1):222-9.
2000: Hua Tang; Zhizhuang Joe Zhao; Erwin J Landon; Tadashi Inagami
Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2.
The Journal of biological chemistry 2000;275(12):8389-96.
2000: Runxiang Zhao; Zhizhuang Joe Zhao
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
The Journal of biological chemistry 2000;275(8):5453-9.
2000: Jian Yang; Z Cheng; Tianqi Niu; Xiaoshan Liang; Zhizhuang Joe Zhao; G Wayne Zhou
Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
The Journal of biological chemistry 2000;275(6):4066-71.
2000: M Xu; Runxiang Zhao; X Sui; Fengping Xu; Zhizhuang Joe Zhao
Tyrosine phosphorylation of myelin P(0) and its implication in signal transduction.
Biochemical and biophysical research communications 2000;267(3):820-5.
1999: R Shan; James O Price; William A Gaarde; Brett P Monia; Sanford B Krantz; Zhizhuang Joe Zhao
Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin.
Blood 1999;94(12):4067-76.
1999: Hua Tang; Zhizhuang Joe Zhao; X Y Huang; Erwin J Landon; Tadashi Inagami
Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1999;274(18):12401-7.
1999: Runxiang Zhao; Zhizhuang Joe Zhao
Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling.
The Biochemical journal 1999;338 ( Pt 1)():35-9.
1998: Zhizhuang Joe Zhao; Runxiang Zhao
Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.
The Journal of biological chemistry 1998;273(45):29367-72.