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B Zheng

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TOP 3
Shih-En Chang; Linjie Guo; Zhuxiu Guo; Yang Liu; Jun Tian; B Zheng; Shuhua Han
Autoimmune bone marrow environment severely inhibits B cell development by inducing extensive cell death and inhibiting proliferation.
Linjie Guo; J Tian; Z Guo; B Zheng; Shuhua Han
The absence of immunoglobulin D B cell receptor-mediated signals promotes the production of autoantibodies and exacerbates glomerulonephritis in murine lupus.
Limo Chen; Linjie Guo; Jun Tian; Hongxia He; Ekaterina Marinova; Pumin Zhang; B Zheng; Shuhua Han
Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis.

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All Publications

2012: Shih-En Chang; Linjie Guo; Zhuxiu Guo; Yang Liu; Jun Tian; B Zheng; Shuhua Han
Autoimmune bone marrow environment severely inhibits B cell development by inducing extensive cell death and inhibiting proliferation.
Autoimmunity 2012;45(3):210-7.
2011: Linjie Guo; J Tian; Z Guo; B Zheng; Shuhua Han
The absence of immunoglobulin D B cell receptor-mediated signals promotes the production of autoantibodies and exacerbates glomerulonephritis in murine lupus.
Clinical and experimental immunology 2011;164(2):227-35.
2010: Limo Chen; Linjie Guo; Jun Tian; Hongxia He; Ekaterina Marinova; Pumin Zhang; B Zheng; Shuhua Han
Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4455-9.
2010: L Chen; Linjie Guo; J Tian; B Zheng; Shuhua Han
Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity in lpr mice on a C57BL/6 background.
Clinical and experimental immunology 2010;159(2):169-75.
2010: Linjie Guo; Jun Tian; Ekaterina Marinova; B Zheng; Shuhua Han
Inhibition of clonal expansion by Foxp3 expression as a mechanism of controlled T-cell responses and autoimmune disease.
European journal of immunology 2010;40(1):71-80.
2009: Kui Shin Voo; Yui-Hsi Wang; Fabio R Santori; Cesar Boggiano; Yui-Hsi Wang; Kazuhiko Arima; Laura Bover; Shino Hanabuchi; Jahan Khalili; Ekaterina Marinova; B Zheng; Dan R Littman; Yong-Jun Liu
Identification of IL-17-producing FOXP3+ regulatory T cells in humans.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4793-8.
2008: George Booth; Peter Newham; Rachel Barlow; Stephanie Raines; B Zheng; S Han
Gene expression profiles at different stages of collagen-induced arthritis.
Autoimmunity 2008;41(7):512-21.
2008: B Zheng; Kirsten Switzer; Ekaterina Marinova; Jinwu Zhang; Shuhua Han
Exacerbation of autoimmune arthritis by copolymer-I through promoting type 1 immune response and autoantibody production.
Autoimmunity 2008;41(5):363-71.
2008: Linjie Guo; Xuejun Zhang; B Zheng; Shuhua Han
IgM-mediated signaling is required for the development of a normal B cell memory response.
Molecular immunology 2008;45(4):1071-7.
2007: B Zheng; Ekaterina Marinova; Kirsten Switzer; Daniel Wansley; Hongxia He; Roy Bheekha-Escura; timothy wayne behrens; Shuhua Han
Overexpression of Bcl(XL) in B cells promotes Th1 response and exacerbates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7087-92.
2007: B Zheng; Yongxin Zhang; Hongxia He; Ekaterina Marinova; Kirsten Switzer; Daniel Wansley; Innocent N Mbawuike; Shuhua Han
Rectification of age-associated deficiency in cytotoxic T cell response to influenza A virus by immunization with immune complexes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6153-9.
2007: B Zheng; Xuejun Zhang; Linjie Guo; Shuhua Han
IgM plays an important role in induction of collagen-induced arthritis.
Clinical and experimental immunology 2007;149(3):579-85.
2007: B Zheng; Kirsten Switzer; Ekaterina Marinova; Daniel Wansley; Shuhua Han
Correction of age-associated deficiency in germinal center response by immunization with immune complexes.
Clinical immunology (Orlando, Fla.) 2007;124(2):131-7.
2007: Ekaterina Marinova; Shuhua Han; B Zheng
Germinal center helper T cells are dual functional regulatory cells with suppressive activity to conventional CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5010-7.
2006: Karim Iskander; Jessica Li; Shuhua Han; B Zheng; Anil K Jaiswal
NQO1 and NQO2 regulation of humoral immunity and autoimmunity.
The Journal of biological chemistry 2006;281(41):30917-24.
2006: Ekaterina Marinova; Shuhua Han; B Zheng
Human germinal center T cells are unique Th cells with high propensity for apoptosis induction.
International immunology 2006;18(8):1337-45.
2006: Robert K Chin; Mingzhao Zhu; Peter A Christiansen; Wenhua Liu; Carl Ware; Leena Peltonen; Xuejun Zhang; Linjie Guo; S Han; B Zheng; Yang-Xin Fu
Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):290-7.
2005: Shuhua Han; Xuejun Zhang; Ekaterina Marinova; Zeynep Ozen; Roy Bheekha-Escura; Linjie Guo; Daniel Wansley; George Booth; Yang-Xin Fu; B Zheng
Blockade of lymphotoxin pathway exacerbates autoimmune arthritis by enhancing the Th1 response.
Arthritis and rheumatism 2005;52(10):3202-9.
2005: Jin Han; Jr-Wen Shui; Xuejun Zhang; B Zheng; Shuhua Han; Tse-Hua Tan
HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.
Molecular and cellular biology 2005;25(16):6869-78.
2005: Jian Hong; Ningli Li; Xuejun Zhang; B Zheng; Jingwu Z Zhang
Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6449-54.
2005: Ekaterina Marinova; Shuhua Han; B Zheng
Age-associated deficiency in activation-induced up-regulation of telomerase activity in CD4+ T cells.
Clinical and experimental immunology 2005;140(2):258-64.
2005: B Zheng; Zeynep Ozen; Xuejun Zhang; Swanthri De Silva; Ekaterina Marinova; Linjie Guo; Daniel Wansley; David P Huston; Michael R West; Shuhua Han
CXCL13 neutralization reduces the severity of collagen-induced arthritis.
Arthritis and rheumatism 2005;52(2):620-6.
2005: Swanthri De Silva; Shuhua Han; Xuejun Zhang; David P Huston; Astar Winoto; B Zheng
Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage.
Arthritis and rheumatism 2005;52(1):333-8.
2004: Shuhua Han; Xuejun Zhang; Gangdou Wang; Hui Guan; Gabriela Garcia; Ping Li; Lili Feng; B Zheng
FTY720 suppresses humoral immunity by inhibiting germinal center reaction.
Blood 2004;104(13):4129-33.
2004: Shuhua Han; Ekaterina Marinova; B Zheng
Rectification of age-related impairment in Ig gene hypermutation during a memory response.
International immunology 2004;16(4):525-32.
2004: Shuhua Han; Xuejun Zhang; Renling Xu; Fred D Finkelman; Frank Brombacher; B Zheng
IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire.
European journal of immunology 2004;34(3):661-8.
2004: Lihua Pan; Curtis Bradney; B Zheng; Yuan Zhuang
Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
Immunology 2004;111(2):147-54.
2003: B Zheng; Ekaterina Marinova; Jin Han; Tse-Hua Tan; Shuhua Han
Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):4979-83.
2003: Shuhua Han; Kaiyong Yang; Zeynep Ozen; Weiyi Peng; Ekaterina Marinova; Garnett Kelsoe; B Zheng
Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1267-73.
2002: B Zheng; Zeynep Ozen; Shutong Cao; Ye Zhang; Shuhua Han
CD4-deficient T helper cells are capable of supporting somatic hypermutation and affinity maturation of germinal center B cells.
European journal of immunology 2002;32(11):3315-25.
2002: Tong-Tong Li; Shuhua Han; Mike Cubbage; B Zheng
Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells.
European journal of immunology 2002;32(10):2792-9.
2002: Wei He; Allen G Li; Dongyan Wang; Shuhua Han; B Zheng; Marie-José Goumans; Peter ten Dijke; Xiao-Jing Wang
Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues.
The EMBO journal 2002;21(11):2580-90.
2001: Shuhua Han; S Cao; Roy Bheekha-Escura; B Zheng
Germinal center reaction in the joints of mice with collagen-induced arthritis: an animal model of lymphocyte activation and differentiation in arthritis joints.
Arthritis and rheumatism 2001;44(6):1438-43.
2001: B Zheng; Urs Albrecht; Krista Kaasik; M Sage; W Lu; S Vaishnav; Q Li; ZS Sun; Gregor Eichele; Allan Bradley; Cheng Chi Lee
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Cell 2001;105(5):683-94.
2001: B Zheng; Alea A Mills; Allan Bradley
Introducing defined chromosomal rearrangements into the mouse genome.
Methods (San Diego, Calif.) 2001;24(1):81-94.
2000: B Zheng; M Sage; E A Sheppeard; V Jurecic; Allan Bradley
Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications.
Molecular and cellular biology 2000;20(2):648-55.
1999: B Zheng; M Sage; Wei-Wen Cai; D M Thompson; Beril C Tavsanli; Y C Cheah; Allan Bradley
Engineering a mouse balancer chromosome.
Nature genetics 1999;22(4):375-8.
1999: B Zheng; D W Larkin; Urs Albrecht; ZS Sun; M Sage; Gregor Eichele; Cheng Chi Lee; Allan Bradley
The mPer2 gene encodes a functional component of the mammalian circadian clock.
Nature 1999;400(6740):169-73.
1999: Alea A Mills; B Zheng; Xiao-Jing Wang; H Vogel; Dennis R Roop; Allan Bradley
p63 is a p53 homologue required for limb and epidermal morphogenesis.
Nature 1999;398(6729):708-13.
1998: B Zheng; S Han; E Spanopoulou; Garnett Kelsoe
Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.
Immunological reviews 1998;162():133-41.
1998: TA Prolla; Sean M Baker; A C Harris; Jen-Lan Tsao; X Yao; CE Bronner; B Zheng; M Gordon; J Reneker; Norman Arnheim; Darryl Shibata; Allan Bradley; R Michael Liskay
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.
Nature genetics 1998;18(3):276-9.
1997: B Zheng; S Han; Y Takahashi; Garnett Kelsoe
Immunosenescence and germinal center reaction.
Immunological reviews 1997;160():63-77.
1997: S Han; S R Dillon; B Zheng; Michiko Shimoda; Mark S Schlissel; Garnett Kelsoe
V(D)J recombinase activity in a subset of germinal center B lymphocytes.
Science (New York, N.Y.) 1997;278(5336):301-5.
1997: S Han; B Zheng; Y Takahashi; Garnett Kelsoe
Distinctive characteristics of germinal center B cells.
Seminars in immunology 1997;9(4):255-60.
1996: S Han; B Zheng; David G Schatz; E Spanopoulou; Garnett Kelsoe
Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
Science (New York, N.Y.) 1996;274(5295):2094-7.
1996: B Zheng; S Han; Q Zhu; R Goldsby; Garnett Kelsoe
Alternative pathways for the selection of antigen-specific peripheral T cells.
Nature 1996;384(6606):263-6.
1996: W Pao; Li Wen; AL Smith; A Gulbranson-Judge; B Zheng; Garnett Kelsoe; I C MacLennan; MJ Owen; Adrian C Hayday
Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.
Current biology : CB 1996;6(10):1317-25.
1996: B Zheng; S Han; Garnett Kelsoe
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
The Journal of experimental medicine 1996;184(3):1083-91.
1996: Li Wen; W Pao; F Susan Wong; Q Peng; Joe Craft; B Zheng; Garnett Kelsoe; L Dianda; MJ Owen; Adrian C Hayday
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
The Journal of experimental medicine 1996;183(5):2271-82.
1996: B Zheng; Garnett Kelsoe; S Han
Somatic diversification of antibody responses.
Journal of clinical immunology 1996;16(1):1-11.
1995: S Han; B Zheng; Joseph M Dal Porto; Garnett Kelsoe
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
The Journal of experimental medicine 1995;182(6):1635-44.
1995: S Han; Karen S Hathcock; B Zheng; Thomas B Kepler; Richard J Hodes; Garnett Kelsoe
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):556-67.
1994: B Zheng; W Xue; Garnett Kelsoe
Locus-specific somatic hypermutation in germinal centre T cells.
Nature 1994;372(6506):556-9.
1993: Garnett Kelsoe; B Zheng
Sites of B-cell activation in vivo.
Current opinion in immunology 1993;5(3):418-22.