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Changyu Zheng

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Anne M Rowzee; Changyu Zheng; Bruce J Baum; Sarah Krygowski; Paola J Perez-Riveros; Niamh X Cawley
Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.
Bruce J Baum; Jaime Brahim; Peter D Burbelo; Clara C Chen; John A Chiorini; Deborah E Citrin; Ana P Cotrim; Stamatina Danielides; Corinne M Goldsmith; Shuying Liu; Linda McCullagh; James B Mitchell; Nikolay P Nikolov; Liesl K Nottingham; Nicholas J Patronas; Susan F Rudy; R James Turner; Carter Van Waes; Millie A Whatley; Changyu Zheng; Ilias Alevizos; Gabor G Illei
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Lizheng Qin; Qifei Sun; Dengsheng Xia; Chunmei Zhang; Changyu Zheng; David Adams; Indu S Ambudkar; Dajun Deng; Gang Ding; Zhipeng Fan; William A Gahl; Liankun Gu; Junqi He; Luyuan Jin; Xibao Liu; Hwei Ling Ong; Senrong Qi; Songlin Wang
Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane.

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All Publications

2013: Anne M Rowzee; Changyu Zheng; Bruce J Baum; Sarah Krygowski; Paola J Perez-Riveros; Niamh X Cawley
Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.
PloS one 2013;8(3):e59222.
2012: Bruce J Baum; Jaime Brahim; Peter D Burbelo; Clara C Chen; John A Chiorini; Deborah E Citrin; Ana P Cotrim; Stamatina Danielides; Corinne M Goldsmith; Shuying Liu; Linda McCullagh; James B Mitchell; Nikolay P Nikolov; Liesl K Nottingham; Nicholas J Patronas; Susan F Rudy; R James Turner; Carter Van Waes; Millie A Whatley; Changyu Zheng; Ilias Alevizos; Gabor G Illei
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19403-7.
2012: Lizheng Qin; Qifei Sun; Dengsheng Xia; Chunmei Zhang; Changyu Zheng; David Adams; Indu S Ambudkar; Dajun Deng; Gang Ding; Zhipeng Fan; William A Gahl; Liankun Gu; Junqi He; Luyuan Jin; Xibao Liu; Hwei Ling Ong; Senrong Qi; Songlin Wang
Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(33):13434-9.
2012: Ana P Cotrim; James B Mitchell; Anastasia L Sowers; Abraham N Sunshine; Angela D Thetford; Masanobu Yoshikawa; Changyu Zheng; John A Cook; Bruce J Baum
Pharmacological protection from radiation ± cisplatin-induced oral mucositis.
International journal of radiation oncology, biology, physics 2012;83(4):1284-90.
2012: Changyu Zheng; B J Baum
Including the p53 ELAV-like protein-binding site in vector cassettes enhances transgene expression in rat submandibular gland.
Oral diseases 2012;18(5):477-84.
2012: Changyu Zheng; Ana P Cotrim; Fumi Mineshiba; Nikolay Nikolov; William D Swaim; Bruce J Baum
A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands.
Human gene therapy methods 2012;23(3):169-81.
2012: Giovanni Di Pasquale; Ilaria Dicembrini; Josephine M Egan; Andrea Loreto; Mario Maggi; Maria E Manni; Edoardo Mannucci; Drew G Michael; Annamaria Morelli; Claudio Pagano; Laura Raimondi; Silvia Berretti; John A Chiorini; Lorenzo Cinci; Andrea Cozzi; Roberto Vettor; Changyu Zheng; Carlo M Rotella
Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.
PloS one 2012;7(7):e40074.
2011: Changyu Zheng; Sandra Afione; Molly Boyle; John A Chiorini; Tim Clackson; Benjamin Goldstein; Richard D Irwin; Abraham Nyska; Victor M Rivera; Molly K Vallant; Antonis Voutetakis; Martin L Wenk; Bruce J Baum
Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(1):247-55.
2011: P Perez; Janik Adriaansen; Changyu Zheng; C M Goldsmith; B J Baum
Transgenic α-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active.
Oral diseases 2011;17(5):476-83.
2011: Janik Adriaansen; P Perez; Changyu Zheng; Michael T Collins; Bruce J Baum
Human parathyroid hormone is secreted primarily into the bloodstream after rat parotid gland gene transfer.
Human gene therapy 2011;22(1):84-92.
2011: R Gao; X Yan; Changyu Zheng; Corinne M Goldsmith; Sandra Afione; B Hai; Jianguo Xu; Jing Zhou; Chunmei Zhang; John A Chiorini; Bruce J Baum; Shixuan Wang
AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands.
Gene therapy 2011;18(1):38-42.
2011: Changyu Zheng; T Shinomiya; Corinne M Goldsmith; Giovanni Di Pasquale; Bruce J Baum
Convenient and reproducible in vivo gene transfer to mouse parotid glands.
Oral diseases 2011;17(1):77-82.
2010: Junji Xu; Xing Yan; Runtao Gao; Lisha Mao; Ana P Cotrim; Changyu Zheng; Chunmei Zhang; Bruce J Baum; Songlin Wang
Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig.
International journal of radiation oncology, biology, physics 2010;78(3):897-903.
2010: Paola Perez; Anne M Rowzee; Changyu Zheng; Janik Adriaansen; Bruce J Baum
Salivary epithelial cells: an unassuming target site for gene therapeutics.
The international journal of biochemistry & cell biology 2010;42(6):773-7.
2010: Changyu Zheng; Antonis Voutetakis; M Metzger; Sandra Afione; Ana P Cotrim; Michael Eckhaus; V M Rivera; Tim Clackson; John A Chiorini; R E Donahue; C E Dunbar; Bruce J Baum
Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.
Oral diseases 2010;16(3):269-77.
2010: Bruce J Baum; Janik Adriaansen; Ana P Cotrim; Corinne M Goldsmith; Paola Perez; Senrong Qi; Anne M Rowzee; Changyu Zheng
Gene therapy of salivary diseases.
Methods in molecular biology (Clifton, N.J.) 2010;666():3-20.
2010: Janik Adriaansen; Changyu Zheng; Paola Perez; Bruce J Baum
Production and sorting of transgenic, modified human parathyroid hormone in vivo in rat salivary glands.
Biochemical and biophysical research communications 2010;391(1):768-72.
2010: Changyu Zheng; Nikolay P Nikolov; Ilias Alevizos; Ana P Cotrim; Shuying Liu; Linda McCullagh; John A Chiorini; Gabor G Illei; Bruce J Baum
Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.
The journal of gene medicine 2010;12(1):3-10.
2010: Bruce J Baum; Changyu Zheng; Ilias Alevizos; Ana P Cotrim; Shuying Liu; Linda McCullagh; Corinne M Goldsmith; Nancy McDermott; John A Chiorini; Nikolay P Nikolov; Gabor G Illei
Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.
Oral oncology 2010;46(1):4-8.
2010: Antonis Voutetakis; Changyu Zheng; Ana P Cotrim; Fumi Mineshiba; Sandra Afione; N Roescher; William D Swaim; M Metzger; Michael Eckhaus; R E Donahue; C E Dunbar; John A Chiorini; Bruce J Baum
AAV5-mediated gene transfer to the parotid glands of non-human primates.
Gene therapy 2010;17(1):50-60.
2009: Changyu Zheng; Ana P Cotrim; Abraham N Sunshine; Takayuki Sugito; Lina Liu; Anastasia Sowers; James B Mitchell; Bruce J Baum
Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4641-8.
2009: Gabor Z Racz; Paola Perez-Riveros; Janik Adriaansen; Changyu Zheng; Bruce J Baum
In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands.
The journal of gene medicine 2009;11(7):580-7.
2009: Bo Hai; Xing Yan; Antonis Voutetakis; Changyu Zheng; Ana P Cotrim; Zhaochen Shan; Gang Ding; Chunmei Zhang; Junji Xu; Corinne M Goldsmith; Sandra Afione; John A Chiorini; Bruce J Baum; Songlin Wang
Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors.
The journal of gene medicine 2009;11(6):506-14.
2008: Antonis Voutetakis; Changyu Zheng; Mark Metzger; Ana P Cotrim; Robert E Donahue; Cynthia E Dunbar; Bruce J Baum
Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.
Human gene therapy 2008;19(12):1401-5.
2008: J Adriaansen; P Perez; Corinne M Goldsmith; Changyu Zheng; Bruce J Baum
Differential sorting of human parathyroid hormone after transduction of mouse and rat salivary glands.
Human gene therapy 2008;19(10):1021-8.
2008: Yuval Samuni; Changyu Zheng; Niamh X Cawley; Ana P Cotrim; Y Peng Loh; Bruce J Baum
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands.
Biochemical and biophysical research communications 2008;373(1):136-9.
2008: Changyu Zheng; Joseph M Vitolo; Weitian Zhang; Fumi Mineshiba; John A Chiorini; Bruce J Baum
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1089-97.
2008: Yuval Samuni; Niamh X Cawley; Changyu Zheng; Ana P Cotrim; Y Peng Loh; Bruce J Baum
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands.
Human gene therapy 2008;19(3):279-86.
2008: Michael Schmidt; Antonis Voutetakis; Sandra Afione; Changyu Zheng; Danielle Mandikian; John A Chiorini
Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity.
Journal of virology 2008;82(3):1399-406.
2008: Changyu Zheng; Bruce J Baum
Evaluation of promoters for use in tissue-specific gene delivery.
Methods in molecular biology (Clifton, N.J.) 2008;434():205-19.
2007: Antonis Voutetakis; Changyu Zheng; Jianghua Wang; Corinne M Goldsmith; Sandra Afione; John A Chiorini; M L Wenk; Molly K Vallant; Richard D Irwin; Bruce J Baum
Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.
Human gene therapy 2007;18(11):1109-18.
2007: Seshagiri R Nandula; Shoba Amarnath; Alfredo A Molinolo; Bidhan Bandyopadhyay; Bradford Hall; Corinne M Goldsmith; Changyu Zheng; Jonas Larsson; Taduru Sreenath; WanJun Chen; Indu S Ambudkar; Stefan Karlsson; Bruce J Baum; Ashok Kulkarni
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.
Arthritis and rheumatism 2007;56(6):1798-805.
2007: Antonis Voutetakis; Changyu Zheng; Fumi Mineshiba; Ana P Cotrim; Corinne M Goldsmith; Michael Schmidt; Sandra Afione; Nienke Roescher; Mark Metzger; Michael Eckhaus; John A Chiorini; Cynthia E Dunbar; Robert E Donahue; Bruce J Baum
Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.
Human gene therapy 2007;18(2):142-50.
2006: Changyu Zheng; Corinne M Goldsmith; Fumi Mineshiba; John A Chiorini; Andrew Kerr; Martin L Wenk; Molly K Vallant; Richard D Irwin; Bruce J Baum
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
Human gene therapy 2006;17(11):1122-33.
2006: Beatrijs M Lodde; Fumi Mineshiba; Marc R Kok; Jianghua Wang; Changyu Zheng; Michael Schmidt; Ana P Cotrim; MF Kriete; Paul P Tak; Bruce J Baum
NOD mouse model for Sjögren's syndrome: lack of longitudinal stability.
Oral diseases 2006;12(6):566-72.
2006: Changyu Zheng; Antonis Voutetakis; Marc R Kok; Corinne M Goldsmith; G B J Smith; S Elmore; A Nyska; Molly K Vallant; Richard D Irwin; Bruce J Baum
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland.
Oral diseases 2006;12(2):137-44.
2005: Changyu Zheng; Bruce J Baum
Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):528-36.
2005: Antonis Voutetakis; Ioannis Bossis; Marc R Kok; Weitian Zhang; Jianghua Wang; Ana P Cotrim; Changyu Zheng; John A Chiorini; Lynnette K Nieman; Bruce J Baum
Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.
The Journal of endocrinology 2005;185(3):363-72.
2005: Simon D Tran; Jianghua Wang; Bidhan Bandyopadhyay; Robert S Redman; Amalia Dutra; Evgenia Pak; William D Swaim; J A Gerstenhaber; J M Bryant; Changyu Zheng; Corinne M Goldsmith; Marc R Kok; Robert B Wellner; Bruce J Baum
Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland.
Tissue engineering 2005;11(1-2):172-81.
2004: Antonis Voutetakis; Marc R Kok; Changyu Zheng; Ioannis Bossis; Jianghua Wang; Ana P Cotrim; Natanya Marracino; Corinne M Goldsmith; John A Chiorini; Y Peng Loh; Lynnette K Nieman; Bruce J Baum
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3053-8.
2003: Bruce J Baum; Corinne M Goldsmith; Marc R Kok; Beatrijs M Lodde; Norah M van Mello; Antonis Voutetakis; Jianghua Wang; Seiichi Yamano; Changyu Zheng
Advances in vector-mediated gene transfer.
Immunology letters 2003;90(2-3):145-9.
2003: Changyu Zheng; Brian C O'Connell; Bruce J Baum
Inclusion of Moloney murine leukemia virus elements upstream of the transgene cassette in an E1-deleted adenovirus leads to an unusual genomic integration in epithelial cells.
Virology 2003;313(2):460-72.
2003: Brian C O'Connell; Changyu Zheng; David Jacobson-Kram; Bruce J Baum
Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2003;32(7):414-21.
2003: Changyu Zheng; Jianghua Wang; Bruce J Baum
Integration efficiency of a hybrid adenoretroviral vector.
Biochemical and biophysical research communications 2003;300(1):115-20.
2002: Changyu Zheng; Bruce J Baum
Long-term expression after infection by the hybrid vector AdLTR-luc is from integrated transgene.
Biochemical and biophysical research communications 2002;291(1):34-40.
2002: Bruce J Baum; Robert B Wellner; Changyu Zheng
Gene transfer to salivary glands.
International review of cytology 2002;213():93-146.
2001: Changyu Zheng; A T M Shamsul Hoque; VR Braddon; Bruce J Baum; Brian C O'Connell
Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors.
Human gene therapy 2001;12(18):2215-23.
2001: DJ Aframian; Changyu Zheng; Corinne M Goldsmith; J Nikolovski; Edna Cukierman; Kenneth M Yamada; DJ Mooney; Henning Birkedal-Hansen; Bruce J Baum
Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line.
Tissue engineering 2001;7(4):405-13.
2001: Brij B Singh; Changyu Zheng; Xibao Liu; Timothy P Lockwich; D Liao; Michael X Zhu; Lutz Birnbaumer; Indu S Ambudkar
Trp1-dependent enhancement of salivary gland fluid secretion: role of store-operated calcium entry.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1652-4.
2000: Changyu Zheng; Corinne M Goldsmith; Brian C O'Connell; Bruce J Baum
Adenoviral vector cytotoxicity depends in part on the transgene encoded.
Biochemical and biophysical research communications 2000;274(3):767-71.
2000: Bruce J Baum; Corinne M Goldsmith; A T M Shamsul Hoque; Robert B Wellner; Lorena Baccaglini; Chuantian Ding; Seiichi Yamano; C Zheng; DJ Aframian; Changyu Zheng; D J Aframian; Brian C O'Connell
Salivary glands as a model for craniofacial applications of gene transfer.
International journal of oral and maxillofacial surgery 2000;29(3):163-6.
2000: Changyu Zheng; Bruce J Baum; Michael Iadarola; Brian C O'Connell
Genomic integration and gene expression by a modified adenoviral vector.
Nature biotechnology 2000;18(2):176-80.
1999: S Wang; Bruce J Baum; H Kagami; Changyu Zheng; Brian C O'Connell; Jane C Atkinson
Effect of clodronate on macrophage depletion and adenoviral-mediated transgene expression in salivary glands.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1999;28(4):145-51.
1998: Changyu Zheng; Matthew P Hoffman; T McMillan; Hynda K Kleinman; Brian C O'Connell
Growth factor regulation of the amylase promoter in a differentiating salivary acinar cell line.
Journal of cellular physiology 1998;177(4):628-35.
1998: AC O'Connell; CD Lillibridge; Changyu Zheng; Bruce J Baum; Brian C O'Connell; Indu S Ambudkar
Gamma-irradiation-induced cell cycle arrest and cell death in a human submandibular gland cell line: effect of E2F1 expression.
Journal of cellular physiology 1998;177(2):264-73.
1998: Brian C O'Connell; Robert S Redman; Changyu Zheng
In vivo use of adenoviral vectors: effects on salivary gland structure.
European journal of morphology 1998;36 Suppl():55-60.
1998: X He; G A Kuijpers; Gertrud Goping; J A Kulakusky; Changyu Zheng; Christine Delporte; Chung-Ming Tse; Robert S Redman; Mark Donowitz; Harvey B Pollard; Bruce J Baum
A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro.
Pflügers Archiv : European journal of physiology 1998;435(3):375-81.