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Guangrong Zheng

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Chemicals & Drugs

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Kristin M Alvers; Joshua S Beckmann; Peter A Crooks; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
Joshua S Beckmann; Peter A Crooks; Emily D Denehy; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
David B Horton; Kiran B Siripurapu; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.

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2012: Kristin M Alvers; Joshua S Beckmann; Peter A Crooks; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
Psychopharmacology 2012;224(2):255-62.
2012: Joshua S Beckmann; Peter A Crooks; Emily D Denehy; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
Psychopharmacology 2012;220(2):395-403.
2011: David B Horton; Kiran B Siripurapu; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
The Journal of pharmacology and experimental therapeutics 2011;339(1):286-97.
2011: Guangrong Zheng; Zhenfa Zhang; Cheryl Dowell; Elzbieta Wala; Linda P Dwoskin; Joseph R Holtman; J Michael McIntosh; Peter A Crooks
Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
Bioorganic & medicinal chemistry letters 2011;21(8):2476-9.
2011: Justin R Nickell; Guangrong Zheng; Agripina G Deaciuc; Peter A Crooks; Linda P Dwoskin
Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2.
The Journal of pharmacology and experimental therapeutics 2011;336(3):724-33.
2011: Zhenfa Zhang; Guangrong Zheng; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2011;21(1):88-91.
2011: Peter A Crooks; Guangrong Zheng; Ashish P Vartak; John P Culver; Fang Zheng; David B Horton; Linda P Dwoskin
Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.
Current topics in medicinal chemistry 2011;11(9):1103-27.
2010: Andrew M Smith; Marharyta Pivavarchyk; Thomas E Wooters; Zhenfa Zhang; Guangrong Zheng; J Michael McIntosh; Peter A Crooks; Michael T Bardo; Linda P Dwoskin
Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release.
Biochemical pharmacology 2010;80(3):402-9.
2010: Guangrong Zheng; Zhenfa Zhang; Paul R Lockman; Werner J Geldenhuys; David D Allen; Linda P Dwoskin; Peter A Crooks
Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2010;20(11):3208-10.
2010: Justin R Nickell; Sairam Krishnamurthy; Seth D Norrholm; Gabriela Deaciuc; Kiran B Siripurapu; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.
The Journal of pharmacology and experimental therapeutics 2010;332(2):612-21.
2009: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.
The Journal of organic chemistry 2009;74(16):6072-6.
2009: Fang Zheng; Guangrong Zheng; Agripina G Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):157-68.
2009: Linda P Dwoskin; Marharyta Pivavarchyk; B Matthew Joyce; Nichole M Neugebauer; Guangrong Zheng; Zhenfa Zhang; Michael T Bardo; Peter A Crooks
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2009;55():31-63.
2008: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry letters 2008;18(24):6509-12.
2008: Zhenfa Zhang; Guangrong Zheng; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2008;18(21):5753-7.
2007: Guangrong Zheng; Zhenfa Zhang; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation.
Bioorganic & medicinal chemistry letters 2007;17(24):6734-8.
2007: Guangrong Zheng; Sangeetha P Sumithran; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2007;17(24):6701-6.
2007: Linda P Dwoskin; B Matthew Joyce; Guangrong Zheng; Nichole M Neugebauer; Vamshi K Manda; Paul R Lockman; Roger L Papke; Michael T Bardo; Peter A Crooks
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
Biochemical pharmacology 2007;74(8):1271-82.
2007: Fang Zheng; Guangrong Zheng; Agripina G Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2007;15(8):2975-92.
2006: Guangrong Zheng; David B Horton; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 2006;16(19):5018-21.
2006: Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Vesicular monoamine transporter 2: role as a novel target for drug development.
The AAPS journal 2006;8(4):E682-92.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
Bioorganic & medicinal chemistry letters 2005;15(20):4463-6.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Seth D Norrholm; Peter A Crooks
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
Journal of medicinal chemistry 2005;48(17):5551-60.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Jun Zhu; Marlon D Jones; Peter A Crooks
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2005;13(12):3899-909.
2004: Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine.
The Journal of organic chemistry 2004;69(24):8514-7.
2004: Dennis K Miller; Peter A Crooks; Guangrong Zheng; Vladimir P Grinevich; Seth D Norrholm; Linda P Dwoskin
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1035-45.
2004: Guangrong Zheng; Sean Parkin; Linda P Dwoskin; Peter A Crooks
Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o9-11.