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Alex Brown

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Disorders

Hyperparathyroidism, Secondary

Physiology

Gene Expression Regulation

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Publications

TOP 3
Cynthia S Ritter; Bruce H Haughey; Brent Miller; Alex J Brown
Differential gene expression by oxyphil and chief cells of human parathyroid glands.
Alex J Brown; Daniel W Coyne
Bioavailable vitamin D in chronic kidney disease.
Cynthia S Ritter; Bruce H Haughey; H James Armbrecht; Alex J Brown
Distribution and regulation of the 25-hydroxyvitamin D3 1α-hydroxylase in human parathyroid glands.

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All Publications

2012: Cynthia S Ritter; Bruce H Haughey; Brent Miller; Alex J Brown
Differential gene expression by oxyphil and chief cells of human parathyroid glands.
The Journal of clinical endocrinology and metabolism 2012;97(8):E1499-505.
2012: Alex J Brown; Daniel W Coyne
Bioavailable vitamin D in chronic kidney disease.
Kidney international 2012;82(1):5-7.
2012: Cynthia S Ritter; Bruce H Haughey; H James Armbrecht; Alex J Brown
Distribution and regulation of the 25-hydroxyvitamin D3 1α-hydroxylase in human parathyroid glands.
The Journal of steroid biochemistry and molecular biology 2012;130(1-2):73-80.
2011: Alex J Brown; Cynthia S Ritter
The vitamin D analog 1α,25-Dihydroxy-2β-(3-Hydroxypropyloxy) vitamin D(3) (Eldecalcitol) is a potent regulator of calcium and phosphate metabolism.
Calcified tissue international 2011;89(5):372-8.
2011: Cynthia S Ritter; Alex J Brown
Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.
Journal of cellular biochemistry 2011;112(5):1348-52.
2011: Cynthia S Ritter; Alex J Brown
Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor.
Journal of molecular endocrinology 2011;46(2):63-6.
2009: Masahide Mizobuchi; Cynthia S Ritter; Irina Krits; Eduardo Slatopolsky; Gregorio Sicard; Alex J Brown
Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(7):1173-9.
2008: Alex J Brown; Eduardo Slatopolsky
Vitamin D analogs: therapeutic applications and mechanisms for selectivity.
Molecular aspects of medicine 2008;29(6):433-52.
2008: Cynthia S Ritter; Sangeeta Pande; Irina Krits; Eduardo Slatopolsky; Alex J Brown
Destabilization of parathyroid hormone mRNA by extracellular Ca2+ and the calcimimetic R-568 in parathyroid cells: role of cytosolic Ca and requirement for gene transcription.
Journal of molecular endocrinology 2008;40(1):13-21.
2007: Eduardo Slatopolsky; Jane L Finch; Alex J Brown; Cynthia S Ritter; Masahide Mizobuchi; Lori A Plum; Margaret Clagett-Dame; Rafal R Sicinski; Hector F Deluca
Effect of 2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(5):686-94.
2007: Alex J Brown
Vitamin D analogs for secondary hyperparathyroidism: what does the future hold?
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):578-83.
2007: H James Armbrecht; MA Boltz; Cynthia S Ritter; Alex J Brown
Parathyroid hormone stimulation of the renal 25-hydroxyvitamin D-1alpha-hydroxylase--effect of age and free radicals.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):330-3.
2007: Alex J Brown; Eduardo Slatopolsky
Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.
Nature clinical practice. Endocrinology & metabolism 2007;3(2):134-44.
2006: Cynthia S Ritter; H James Armbrecht; Eduardo Slatopolsky; Alex J Brown
25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells.
Kidney international 2006;70(4):654-9.
2006: Alex J Brown; Cynthia S Ritter; Joyce C Knutson; Stephen A Strugnell
The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(3):644-50.
2006: Sangeeta Pande; Cynthia S Ritter; Marcos Rothstein; Karen Wiesen; John Vassiliadis; Rajiv Kumar; Susan C Schiavi; Eduardo Slatapolsky; Alex J Brown
FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation.
Nephron. Physiology 2006;104(1):p23-32.
2005: Daniel R Martin; Cynthia S Ritter; Eduardo Slatopolsky; Alex J Brown
Acute regulation of parathyroid hormone by dietary phosphate.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E729-34.
2005: Adriana S Dusso; Alex J Brown; Eduardo Slatopolsky
Vitamin D.
American journal of physiology. Renal physiology 2005;289(1):F8-28.
2005: Alex J Brown; Irina Krits; H James Armbrecht
Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels.
Archives of biochemistry and biophysics 2005;437(1):51-8.
2004: Alex J Brown; Cynthia S Ritter; L Shannon Holliday; Joyce C Knutson; Stephen A Strugnell
Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo.
Biochemical pharmacology 2004;68(7):1289-96.
2004: Cynthia S Ritter; Eduardo Slatopolsky; Samuel Santoro; Alex J Brown
Parathyroid cells cultured in collagen matrix retain calcium responsiveness: importance of three-dimensional tissue architecture.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(3):491-8.
2002: Cynthia S Ritter; Daniel R Martin; Yan Lu; Eduardo Slatopolsky; Alex J Brown
Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(12):2206-13.
2002: Alex J Brown; Jane L Finch; Eduardo Slatopolsky
Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport.
The Journal of laboratory and clinical medicine 2002;139(5):279-84.
2002: Alex J Brown; Daniel W Coyne
Vitamin D analogs: new therapeutic agents for secondary hyperparathyroidism.
Treatments in endocrinology 2002;1(5):313-27.
2002: Alex J Brown; Adriana S Dusso; Eduardo Slatopolsky
Vitamin D analogues for secondary hyperparathyroidism.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17 Suppl 10():10-9.
2001: Cynthia S Ritter; Jane L Finch; Eduardo Slatopolsky; Alex J Brown
Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor.
Kidney international 2001;60(5):1737-44.
2001: Alex J Brown
Therapeutic uses of vitamin D analogues.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(5 Suppl 5):S3-S19.
2000: Alex J Brown; Jane L Finch; F Takahashi; Eduardo Slatopolsky
Calcemic activity of 19-Nor-1,25(OH)(2)D(2) decreases with duration of treatment.
Journal of the American Society of Nephrology : JASN 2000;11(11):2088-94.
2000: Alex J Brown
Mechanisms for the selective actions of vitamin D analogues.
Current pharmaceutical design 2000;6(7):701-16.
1999: Alex J Brown; Adriana S Dusso; Eduardo Slatopolsky
Vitamin D.
The American journal of physiology 1999;277(2 Pt 2):F157-75.
1999: Alex J Brown; Eduardo Slatopolsky
Vitamin D analogs: perspectives for treatment.
Mineral and electrolyte metabolism 1999;25(4-6):337-41.
1999: Alex J Brown; Cynthia S Ritter; Jane L Finch; Eduardo Slatopolsky
Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate.
Kidney international 1999;55(4):1284-92.
1999: Alex J Brown; C Ritter; Eduardo Slatopolsky; KR Muralidharan; William H Okamura; G Satyanarayana Reddy
1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion.
Journal of cellular biochemistry 1999;73(1):106-13.
1998: Alex J Brown
Vitamin D analogues.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1998;32(2 Suppl 2):S25-39.
1998: Adriana S Dusso; Alex J Brown
Mechanism of vitamin D action and its regulation.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1998;32(2 Suppl 2):S13-24.
1998: H James Armbrecht; TL Hodam; MA Boltz; N C Partridge; Alex J Brown; Vijaya B Kumar
Induction of the vitamin D 24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 is regulated by parathyroid hormone in UMR106 osteoblastic cells.
Endocrinology 1998;139(8):3375-81.
1997: S Wu; M Grieff; Alex J Brown
Regulation of renal vitamin D-24-hydroxylase by phosphate: effects of hypophysectomy, growth hormone and insulin-like growth factor I.
Biochemical and biophysical research communications 1997;233(3):813-7.
1996: M Grieff; M Zhong; J Finch; C S Ritter; Eduardo Slatopolsky; Alex J Brown
Renal calcitriol synthesis and serum phosphorus in response to dietary phosphorus restriction and anabolic agents.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1996;28(4):589-95.
1996: S Wu; J Finch; M Zhong; Eduardo Slatopolsky; M Grieff; Alex J Brown
Expression of the renal 25-hydroxyvitamin D-24-hydroxylase gene: regulation by dietary phosphate.
The American journal of physiology 1996;271(1 Pt 2):F203-8.
1995: Alex J Brown; M Zhong; C Ritter; E M Brown; Eduardo Slatopolsky
Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression.
Biochemical and biophysical research communications 1995;212(3):861-7.
1993: Alex J Brown; J Finch; M Grieff; C Ritter; N Kubodera; Y Nishii; Eduardo Slatopolsky
The mechanism for the disparate actions of calcitriol and 22-oxacalcitriol in the intestine.
Endocrinology 1993;133(3):1158-64.
1992: Alex J Brown; M Berkoben; C Ritter; N Kubodera; Y Nishii; Eduardo Slatopolsky
Metabolism of 22-oxacalcitriol by a vitamin D-inducible pathway in cultured parathyroid cells.
Biochemical and biophysical research communications 1992;189(2):759-64.
1992: M Grieff; Adriana S Dusso; T Mori; Y Nishii; Eduardo Slatopolsky; Alex J Brown
22-oxacalcitriol suppresses 25-hydroxycholecalciferol-1 alpha-hydroxylase in rat kidney.
Biochemical and biophysical research communications 1992;185(1):191-6.