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Barbara Brown

Research Profile

Anatomy

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Permeability

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Hydrogen-Ion Concentration

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Publications

TOP 3
Karin M Aberg; Mao-Qiang Man; Richard L Gallo; Tomas Ganz; Debra Crumrine; Barbara E Brown; Eung Ho Choi; Dong-Kun Kim; Jens Schröder; Kenneth R Feingold; Peter M Elias
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.
Dusko Ilic; Man Mao-Qiang; Debra Crumrine; Gregory M Dolganov; Nicholas Larocque; Pu Xu; Marianne Demerjian; Barbara E Brown; Ssang-Taek Lim; Valeria Ossovskaya; David D Schlaepfer; Susan J Fisher; Kenneth R Feingold; Peter M Elias; Theodora M Mauro
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
Eung Ho Choi; Marianne Demerjian; Debra Crumrine; Barbara E Brown; Theodora M Mauro; Peter M Elias; Kenneth R Feingold
Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function.

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All Publications

2008: Karin M Aberg; Mao-Qiang Man; Richard L Gallo; Tomas Ganz; Debra Crumrine; Barbara E Brown; Eung Ho Choi; Dong-Kun Kim; Jens Schröder; Kenneth R Feingold; Peter M Elias
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.
The Journal of investigative dermatology 2008;128(4):917-25.
2007: Dusko Ilic; Man Mao-Qiang; Debra Crumrine; Gregory M Dolganov; Nicholas Larocque; Pu Xu; Marianne Demerjian; Barbara E Brown; Ssang-Taek Lim; Valeria Ossovskaya; David D Schlaepfer; Susan J Fisher; Kenneth R Feingold; Peter M Elias; Theodora M Mauro
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
The American journal of pathology 2007;170(6):2055-67.
2006: Eung Ho Choi; Marianne Demerjian; Debra Crumrine; Barbara E Brown; Theodora M Mauro; Peter M Elias; Kenneth R Feingold
Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(6):R1657-62.
2006: Jean-Pierre Hachem; Evi Houben; Debra Crumrine; Mao-Qiang Man; Nanna Schurer; Truus Roelandt; Eung Ho Choi; Yoshikazu Uchida; Barbara E Brown; Kenneth R Feingold; Peter M Elias
Serine protease signaling of epidermal permeability barrier homeostasis.
The Journal of investigative dermatology 2006;126(9):2074-86.
2006: Marianne Demerjian; Mao-Qiang Man; Eung Ho Choi; Barbara E Brown; Debra Crumrine; Sandra Chang; Theodora M Mauro; Peter M Elias; Kenneth R Feingold
Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model.
Experimental dermatology 2006;15(3):154-60.
2005: Jean-Pierre Hachem; Mao-Qiang Man; Debra Crumrine; Yoshikazu Uchida; Barbara E Brown; Vera Rogiers; Diane Roseeuw; Kenneth R Feingold; Peter M Elias
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.
The Journal of investigative dermatology 2005;125(3):510-20.
2005: Eung Ho Choi; Mao-Qiang Man; Fusheng Wang; Xinjiang Zhang; Barbara E Brown; Kenneth R Feingold; Peter M Elias
Is endogenous glycerol a determinant of stratum corneum hydration in humans?
The Journal of investigative dermatology 2005;125(2):288-93.
2005: Eung Ho Choi; Barbara E Brown; Debra Crumrine; Sandra Chang; Mao-Qiang Man; Peter M Elias; Kenneth R Feingold
Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity.
The Journal of investigative dermatology 2005;124(3):587-95.
2004: Man Mao-Qiang; Ashley J Fowler; Matthias Schmuth; Peggy Lau; Sandra Chang; Barbara E Brown; Arthur H Moser; Liliane Michalik; Béatrice Desvergne; Walter Wahli; Mei Li; Daniel Metzger; Pierre H Chambon; Peter M Elias; Kenneth R Feingold
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.
The Journal of investigative dermatology 2004;123(2):305-12.
2004: Joachim W Fluhr; Man Mao-Qiang; Barbara E Brown; Jean-Pierre Hachem; David G Moskowitz; Marianne Demerjian; Marek Haftek; Guy Serre; Debra Crumrine; Theodora M Mauro; Peter M Elias; Kenneth R Feingold
Functional consequences of a neutral pH in neonatal rat stratum corneum.
The Journal of investigative dermatology 2004;123(1):140-51.
2004: Matthias Schmuth; Christopher Haqq; William J Cairns; Julie C Holder; Sheri Tinnell Dorsam; Sandra Chang; Peggy Lau; Ashley J Fowler; Gary Chuang; Arthur H Moser; Barbara E Brown; Man Mao-Qiang; Yoshikazu Uchida; Kristina Schoonjans; Johan Auwerx; P Chambon; Timothy M Willson; Peter M Elias; Kenneth R Feingold
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
The Journal of investigative dermatology 2004;122(4):971-83.
2004: Joachim W Fluhr; Martin J Behne; Barbara E Brown; David G Moskowitz; Clare Selden; Man Mao-Qiang; Theodora M Mauro; Peter M Elias; Kenneth R Feingold
Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum.
The Journal of investigative dermatology 2004;122(2):320-9.
2003: Jean-Pierre Hachem; Debra Crumrine; Joachim W Fluhr; Barbara E Brown; Kenneth R Feingold; Peter M Elias
pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.
The Journal of investigative dermatology 2003;121(2):345-53.
2003: Joachim W Fluhr; Man Mao-Qiang; Barbara E Brown; Philip W Wertz; Debra Crumrine; John P Sundberg; Kenneth R Feingold; Peter M Elias
Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.
The Journal of investigative dermatology 2003;120(5):728-37.
2003: Jack S Kao; Joachim W Fluhr; Mao-Qiang Man; Ashley J Fowler; Jean-Pierre Hachem; Debra Crumrine; Sung K Ahn; Barbara E Brown; Peter M Elias; Kenneth R Feingold
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.
The Journal of investigative dermatology 2003;120(3):456-64.
2002: Peter M Elias; Sung K Ahn; Mitsuhiro Denda; Barbara E Brown; Debra Crumrine; Llewellyn K Kimutai; László G Kömüves; Seung H Lee; Kenneth R Feingold
Modulations in epidermal calcium regulate the expression of differentiation-specific markers.
The Journal of investigative dermatology 2002;119(5):1128-36.
2002: Hiroki Tsuruoka; Weerapan Khovidhunkit; Barbara E Brown; Joachim W Fluhr; Peter M Elias; Kenneth R Feingold
Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements.
The Journal of biological chemistry 2002;277(4):2916-22.
2001: Peter M Elias; Norihisa Matsuyoshi; H Wu; C Lin; Z H Wang; Barbara E Brown; John R Stanley
Desmoglein isoform distribution affects stratum corneum structure and function.
The Journal of cell biology 2001;153(2):243-9.
1998: Peter M Elias; C Cullander; Theodora M Mauro; Ulrich Rassner; László G Kömüves; Barbara E Brown; Gopinathan K Menon
The secretory granular cell: the outermost granular cell as a specialized secretory cell.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1998;3(2):87-100.
1998: N L Marchell; Yoshikazu Uchida; Barbara E Brown; Peter M Elias; Walter M Holleran
Glucosylceramides stimulate mitogenesis in aged murine epidermis.
The Journal of investigative dermatology 1998;110(4):383-7.
1997: Mitsuhiro Denda; Barbara E Brown; Peter M Elias; Kenneth R Feingold
Epidermal injury stimulates prenylation in the epidermis of hairless mice.
Archives of dermatological research 1997;289(2):104-10.
1996: Mitsuhiro Denda; L C Wood; S Emami; C Calhoun; Barbara E Brown; Peter M Elias; Kenneth R Feingold
The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss.
Archives of dermatological research 1996;288(5-6):230-8.
1996: Ruby Ghadially; Barbara E Brown; K Hanley; J T Reed; Kenneth R Feingold; Peter M Elias
Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice.
The Journal of investigative dermatology 1996;106(5):1064-9.
1995: M Mao-Qiang; Barbara E Brown; S Wu-Pong; Kenneth R Feingold; Peter M Elias
Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction.
Archives of dermatology 1995;131(7):809-16.
1995: Ruby Ghadially; Barbara E Brown; S M Sequeira-Martin; Kenneth R Feingold; Peter M Elias
The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.
The Journal of clinical investigation 1995;95(5):2281-90.
1992: Mary L Williams; J S Vogel; Ruby Ghadially; Barbara E Brown; Peter M Elias
Exogenous origin of n-alkanes in pathologic scale.
Archives of dermatology 1992;128(8):1065-71.
1989: D J Bibel; S J Miller; Barbara E Brown; B B Pandey; Peter M Elias; Henry Shinefield; Raza Aly
Antimicrobial activity of stratum corneum lipids from normal and essential fatty acid-deficient mice.
The Journal of investigative dermatology 1989;92(4):632-8.